LOCUS       NM_001003980            1508 bp    mRNA    linear   VRT 11-MAY-2024
DEFINITION  Danio rerio LIM homeobox 8a (lhx8a), mRNA.
ACCESSION   NM_001003980
VERSION     NM_001003980.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Jackson,A., Lin,S.J., Jones,E.A., Chandler,K.E., Orr,D., Moss,C.,
            Haider,Z., Ryan,G., Holden,S., Harrison,M., Burrows,N., Jones,W.D.,
            Loveless,M., Petree,C., Stewart,H., Low,K., Donnelly,D., Lovell,S.,
            Drosou,K., Varshney,G.K. and Banka,S.
  CONSRTM   Genomics England Research Consortium; Solve-RD consortium
  TITLE     Clinical, genetic, epidemiologic, evolutionary, and functional
            delineation of TSPEAR-related autosomal recessive ectodermal
            dysplasia 14
  JOURNAL   HGG Adv 4 (2), 100186 (2023)
   PUBMED   37009414
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1508)
  AUTHORS   Ncube,D., Tallafuss,A., Serafin,J., Bruckner,J., Farnsworth,D.R.,
            Miller,A.C., Eisen,J.S. and Washbourne,P.
  TITLE     A conserved transcriptional fingerprint of multi-neurotransmitter
            neurons necessary for social behavior
  JOURNAL   BMC Genomics 23 (1), 675 (2022)
   PUBMED   36175871
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1508)
  AUTHORS   Paudel,S., Gjorcheska,S., Bump,P. and Barske,L.
  TITLE     Patterning of cartilaginous condensations in the developing facial
            skeleton
  JOURNAL   Dev Biol 486, 44-55 (2022)
   PUBMED   35358504
REFERENCE   4  (bases 1 to 1508)
  AUTHORS   Stednitz,S.J., McDermott,E.M., Ncube,D., Tallafuss,A., Eisen,J.S.
            and Washbourne,P.
  TITLE     Forebrain Control of Behaviorally Driven Social Orienting in
            Zebrafish
  JOURNAL   Curr Biol 28 (15), 2445-2451 (2018)
   PUBMED   30057306
REFERENCE   5  (bases 1 to 1508)
  AUTHORS   Nakayama,Y., Inomata,C., Yuikawa,T., Tsuda,S. and Yamasu,K.
  TITLE     Comprehensive analysis of target genes in zebrafish embryos reveals
            gbx2 involvement in neurogenesis
  JOURNAL   Dev Biol 430 (1), 237-248 (2017)
   PUBMED   28756106
REFERENCE   6  (bases 1 to 1508)
  AUTHORS   Jackman,W.R., Yoo,J.J. and Stock,D.W.
  TITLE     Hedgehog signaling is required at multiple stages of zebrafish
            tooth development
  JOURNAL   BMC Dev Biol 10, 119 (2010)
   PUBMED   21118524
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1508)
  AUTHORS   Kassahn,K.S., Dang,V.T., Wilkins,S.J., Perkins,A.C. and Ragan,M.A.
  TITLE     Evolution of gene function and regulatory control after
            whole-genome duplication: comparative analyses in vertebrates
  JOURNAL   Genome Res 19 (8), 1404-1418 (2009)
   PUBMED   19439512
REFERENCE   8  (bases 1 to 1508)
  AUTHORS   Webb,K.J., Norton,W.H., Trumbach,D., Meijer,A.H., Ninkovic,J.,
            Topp,S., Heck,D., Marr,C., Wurst,W., Theis,F.J., Spaink,H.P. and
            Bally-Cuif,L.
  TITLE     Zebrafish reward mutants reveal novel transcripts mediating the
            behavioral effects of amphetamine
  JOURNAL   Genome Biol 10 (7), R81 (2009)
   PUBMED   19646228
REFERENCE   9  (bases 1 to 1508)
  AUTHORS   Mueller,T., Wullimann,M.F. and Guo,S.
  TITLE     Early teleostean basal ganglia development visualized by zebrafish
            Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression
  JOURNAL   J Comp Neurol 507 (2), 1245-1257 (2008)
   PUBMED   18181142
REFERENCE   10 (bases 1 to 1508)
  AUTHORS   Jackman,W.R., Draper,B.W. and Stock,D.W.
  TITLE     Fgf signaling is required for zebrafish tooth development
  JOURNAL   Dev Biol 274 (1), 139-157 (2004)
   PUBMED   15355794
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY664404.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001003980.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY664404.1, BC117601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505377
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1508              AY664404.1         2-1509
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     gene            1..1508
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /note="LIM homeobox 8a"
                     /db_xref="GeneID:378959"
                     /db_xref="ZFIN:ZDB-GENE-031008-2"
     exon            1..187
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    80..82
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /note="upstream in-frame stop codon"
     CDS             134..1132
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /note="LIM homeobox 8"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx8a"
                     /protein_id="NP_001003980.1"
                     /db_xref="GeneID:378959"
                     /db_xref="ZFIN:ZDB-GENE-031008-2"
                     /translation="

MYWKNEQTTSKESPSKNTAKTQDLFEEVSCSSSLSLSPSSSPHTMTEKAICTSCGTEIVDKYLLKVNDMCWHVRCLSCSVCQTSLGRHISCYIKEKEIFCKLDYFRKYGTRCAHCGRNIHSNDWVRRAKGNTYHLACFACFSCKRQLSTGEEFALVDERVLCRVHYDCMLDNLKRAMENGKGVNVEGAVPSEQEVNQPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSAAPVSSLQSAHLSPPLIDELQYTAFAPVDTPMLTALHSYMDVHSPTSLVLQPLLPHSMTQLPISHA"

     misc_feature    281..448
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /note="The first LIM domain of Lhx7 and Lhx8; Region:
                     LIM1_Lhx7_Lhx8; cd09381"
                     /db_xref="CDD:188767"
     misc_feature    order(284..286,293..295,347..349,356..358,365..367,
                     374..376,431..433,440..442)
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188767"
     misc_feature    467..631
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /note="The second LIM domain of Lhx7 and Lhx8; Region:
                     LIM2_Lhx7_Lhx8; cd09383"
                     /db_xref="CDD:188769"
     misc_feature    order(467..469,476..478,533..535,542..544,551..553,
                     560..562,617..619,626..628)
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188769"
     misc_feature    737..907
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            188..328
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /inference="alignment:Splign:2.1.0"
     exon            329..450
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /inference="alignment:Splign:2.1.0"
     exon            451..671
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /inference="alignment:Splign:2.1.0"
     exon            672..775
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /inference="alignment:Splign:2.1.0"
     exon            776..871
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1055
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1508
                     /gene="lhx8a"
                     /gene_synonym="cb875; fk78g12; lhx7; lhx8; wu:fk78g12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

acggaggaaaacaaaagtttgagttaaaacatggtcgcgacgtgcgttcagcagcagcggcagcagcacctatatggattaattctctctgtacaggagatctgagagtggatatagcctgtcatactggacaatgtactggaaaaatgaacaaaccacatcgaaagagagcccaagcaagaacactgctaaaactcaagacctgtttgaagaggtatcgtgttcgtcgtcgttgtctttgtcgccaagctcttcacctcataccatgacagagaaagccatatgtaccagttgcggaactgagattgtagataaatatctcctcaaggtgaacgacatgtgctggcacgtgagatgcctgtcctgcagcgtgtgccaaacatctctgggcagacacatcagctgttatataaaagaaaaggagatattttgtaaactkgattacttcaggaaatacggaacacgttgcgctcactgtggcagaaacatccattcaaacgactgggttcgcagagcaaaaggaaacacctaccacctggcatgttttgcttgcttctcctgcaagaggcagctgtctacaggagaagagtttgccctggtggatgagagggttttgtgtcgtgtccactatgactgcatgttggacaacctgaagcgtgcyatggagaatggaaaaggagtgaatgtggagggagctgttccctcagagcaggaagtaaatcagcctaaaccggccaagagggcacgcacaagttttacagctgaccagttacaggtgatgcaagcccagtttgctcaggacaacaatccagatgctcagactttacaaaagttggcagaaaggactggtcttagccgaagggtaattcaggtttggttccaaaactgtcgagctcgtcataagaagcatgtcagcccgaaccactcttcagctgcaccagtgtcatcactgcagtcggcccatctctctcctccactaatagatgaacttcagtacactgcttttgcccctgtggacacaccaatgctgactgcactacactcctacatggacgtccactctcccacttccctggtgctgcagccactcctgccrcactcgatgacacagctgcccatcagccatgcctgagacttcactgcagacccaccgtcaggtcagaggacagcatgaggaaatattgactgagtcttgaacaagacccatgcttctttctttcatgggcacttactgaaggatttgcaaagatcgaaaaaaacgtttcagcttaattgtgagagtctgaagtttttgtttaatatatattatattatctatatagtgatggaataaatggtgtttaatttatttcttgtatgtgactgagcactttgttttaaaataaatctaccatggatttcttagtttctggtttagtcaacacatttttggtttgttgtgtggtggatctaaagaaaattggaagctgaagaaaaggcaataaatttaatttttccactagtgttga

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