LOCUS       NM_001002638            1809 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio prolactin regulatory element binding (preb), mRNA.
ACCESSION   NM_001002638
VERSION     NM_001002638.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1809)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 1809)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC075936.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075936.1, BC154581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1809
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="16"
                     /map="16"
     gene            1..1809
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /note="prolactin regulatory element binding"
                     /db_xref="GeneID:436911"
                     /db_xref="ZFIN:ZDB-GENE-040718-385"
     exon            1..130
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    80..82
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /note="upstream in-frame stop codon"
     exon            131..292
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1435
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /codon_start=1
                     /product="guanine nucleotide-exchange factor SEC12"
                     /protein_id="NP_001002638.1"
                     /db_xref="GeneID:436911"
                     /db_xref="ZFIN:ZDB-GENE-040718-385"
                     /translation="

MGKRRAPELYRAPFPLYTVKMDPRTGLIITAGGGGASKTGIKNAVHFLSLDLVGGAHSATLLHTHETDTRATMNMCLGGDVMAAGQDDTCRLMKFSLHEAKHNKKPAAKDGTGDKGGARKRAGKGQNADGGEGDAAQMKQDSTQISVQDLGSVQADFSPQDPCVKCVRFSLDLTLLLSGGADGFVRVWEFPSLKEKLNFRAHKDELEDIDISPDKKHIVTVGRDFECSVWSGDQLAVGLCWHENMPQITEKTYRYKACRFAKVEDQKDALRLYTVQIPHKRDRKPPPCYITKWDGRAFLPLLTKPCGNEVISCLTASDSGTFLGLGTVTGSVAIYIAFSLQKLYYIQESHGIVVTDLTFLPDAPKTKAVKGDNEVVMLSVAVDSRCQVHAVSNRRSFPLWLVLFFCGLMVVAVILLLQSFFPGFI"

     misc_feature    <647..>868
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cl29593"
                     /db_xref="CDD:475233"
     misc_feature    650..760
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    773..946
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1088..1195
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1217..1297
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            293..488
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /inference="alignment:Splign:2.1.0"
     exon            489..724
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /inference="alignment:Splign:2.1.0"
     exon            725..805
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /inference="alignment:Splign:2.1.0"
     exon            806..933
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1107
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1180
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1340
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1782
                     /gene="preb"
                     /gene_synonym="sb:cb385; wu:fj59h11; zgc:92203"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggtaaaccaaggaagtaaatggtggttctatgactgatgttgtgagacatccagaagggaaatacagtggcatgagctctaaacaccgggaaaactccagcacgacaccggagagcgtccgcagacacagaccagaatacagagagcagagagcatcatgggtaaacgcagagcacctgagctttacagagcgccgttccctctgtatacagtgaagatggaccccaggaccggcttgatcatcactgctggaggaggaggagcgtccaaaacgggcatcaagaacgctgtgcattttctgagtctggatctggtgggcggtgcacacagcgccaccttgctgcacactcatgaaacagacactcgagccaccatgaacatgtgtctgggaggagatgtgatggcggcaggacaggacgacacgtgcagattaatgaagttcagtcttcatgaagccaaacacaacaagaaacctgcggccaaagatgggactggagataagggtggagccaggaagagagcagggaaaggccagaatgcggatggaggagaaggagacgcagcccagatgaagcaggattctacgcagatctccgtgcaggatttgggatcagtacaggcggatttcagcccgcaggacccctgtgtgaagtgtgttcgcttcagtctggatctaacgcttctgctgagtggaggagctgacgggttcgtcagggtgtgggagttcccctcgctgaaggagaagctgaacttcagagcccacaaggatgagctggaggatatagacatcagcccggataaaaagcacatcgtgacggtgggccgtgatttcgagtgcagcgtgtggagcggagatcagctggctgtggggttgtgttggcatgaaaatatgcctcagatcacagagaagacgtaccgatacaaggcatgcaggtttgcaaaggtagaggaccaaaaagatgctttaaggctgtatacagtccaaatcccccacaaacgagaccgcaaaccccctccatgctacatcaccaaatgggacggtcgagctttcctgccgctgctcaccaagccctgtgggaatgaagtgatctcctgtctgacagcgagtgattcggggacatttcttggtcttggaactgtgacgggatctgtggccatctatatagcgttttccctgcagaagctctactacatccaggagtctcatggcattgttgtgactgacctgacgtttttacctgacgctcctaaaactaaagccgtcaaaggagataatgaagtggtgatgctgagcgtggcggtcgacagccgctgtcaggtgcacgccgtctccaaccgcaggtcgttcccgctctggctggtgctgtttttctgtggtctgatggtggttgcagtcattttgctcctgcagtcatttttcccaggattcatctaagctctgagcgtaagcttttacacagtcaaatgacttgaagcaaactgggatctatgaaatggttgtaatcagttggaaatagtgatgggaatggcctcatctctggagttctctgaatcagattggatgaagaatttgggcataacctgagtgagcagtttctccctcatcattgagcgaaaagctgcttgtatacaggactggatttcctggtatggacgtctgccgctccaccagtatgtcaagaaatgccttttagtgaaacggagaagaagaaagcgtgcagggaatttcaatggtgaattattttaaatatttaaaaaatctaaatatacatctgaaaacaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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