LOCUS       NM_001002475            2045 bp    mRNA    linear   VRT 14-OCT-2024
DEFINITION  Danio rerio NK6 homeobox 1 (nkx6.1), mRNA.
ACCESSION   NM_001002475
VERSION     NM_001002475.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Mi,J. and Andersson,O.
  TITLE     Efficient knock-in method enabling lineage tracing in zebrafish
  JOURNAL   Life Sci Alliance 6 (5), e202301944 (2023)
   PUBMED   36878640
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Chen,Y., Jia,J., Zhao,Q., Zhang,Y., Huang,B., Wang,L., Tian,J.,
            Huang,C., Li,M. and Li,X.
  TITLE     Novel Loss-of-Function Variant in HNF1a Induces beta-Cell
            Dysfunction through Endoplasmic Reticulum Stress
  JOURNAL   Int J Mol Sci 23 (21), 13022 (2022)
   PUBMED   36361808
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Yang,L., Webb,S.E., Jin,N., Lee,H.M., Chan,T.F., Xu,G., Chan,J.C.,
            Miller,A.L. and Ma,R.C.
  TITLE     Investigating the role of dachshund b in the development of the
            pancreatic islet in zebrafish
  JOURNAL   J Diabetes Investig 12 (5), 710-727 (2021)
   PUBMED   33449448
REFERENCE   4  (bases 1 to 2045)
  AUTHORS   Tschaikner,P.M., Regele,D., Rock,R., Salvenmoser,W., Meyer,D.,
            Bouvier,M., Geley,S., Stefan,E. and Aanstad,P.
  TITLE     Feedback control of the Gpr161-Galphas-PKA axis contributes to
            basal Hedgehog repression in zebrafish
  JOURNAL   Development 148 (4) (2021)
   PUBMED   33531430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2045)
  AUTHORS   Mi,P., Gao,Q., Feng,Z.Y., Zhang,J.W., Zhao,X., Chen,D.Y. and
            Feng,X.Z.
  TITLE     Melatonin attenuates 17beta-trenbolone induced insomnia-like
            phenotype and movement deficiency in zebrafish
  JOURNAL   Chemosphere 253, 126762 (2020)
   PUBMED   32302915
REFERENCE   6  (bases 1 to 2045)
  AUTHORS   Gribble,S.L., Nikolaus,O.B. and Dorsky,R.I.
  TITLE     Regulation and function of Dbx genes in the zebrafish spinal cord
  JOURNAL   Dev Dyn 236 (12), 3472-3483 (2007)
   PUBMED   17994542
REFERENCE   7  (bases 1 to 2045)
  AUTHORS   Hutchinson,S.A., Cheesman,S.E., Hale,L.A., Boone,J.Q. and
            Eisen,J.S.
  TITLE     Nkx6 proteins specify one zebrafish primary motoneuron subtype by
            regulating late islet1 expression
  JOURNAL   Development 134 (9), 1671-1677 (2007)
   PUBMED   17376808
  REMARK    GeneRIF: Study shows that zebrafish primary motoneurons express two
            related transcription factors Nkx6.1 and Nkx6.2; in their absence,
            the CaP motoneuron subtype develops normally, whereas the MiP
            motoneuron subtype develops a interneuron-like morphology.
REFERENCE   8  (bases 1 to 2045)
  AUTHORS   Guner,B. and Karlstrom,R.O.
  TITLE     Cloning of zebrafish nkx6.2 and a comprehensive analysis of the
            conserved transcriptional response to Hedgehog/Gli signaling in the
            zebrafish neural tube
  JOURNAL   Gene Expr Patterns 7 (5), 596-605 (2007)
   PUBMED   17307034
REFERENCE   9  (bases 1 to 2045)
  AUTHORS   Cheesman,S.E. and Eisen,J.S.
  TITLE     gsh1 demarcates hypothalamus and intermediate spinal cord in
            zebrafish
  JOURNAL   Gene Expr Patterns 5 (1), 107-112 (2004)
   PUBMED   15533825
REFERENCE   10 (bases 1 to 2045)
  AUTHORS   Cheesman,S.E., Layden,M.J., Von Ohlen,T., Doe,C.Q. and Eisen,J.S.
  TITLE     Zebrafish and fly Nkx6 proteins have similar CNS expression
            patterns and regulate motoneuron formation
  JOURNAL   Development 131 (21), 5221-5232 (2004)
   PUBMED   15456722
  REMARK    GeneRIF: In zebrafish, Nkx6.1 is expressed in early-born primary
            and later-born secondary motoneurons
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076337.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076337.1, BC164096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="21"
                     /map="21"
     gene            1..2045
                     /gene="nkx6.1"
                     /gene_synonym="zgc:92879"
                     /note="NK6 homeobox 1"
                     /db_xref="GeneID:436748"
                     /db_xref="ZFIN:ZDB-GENE-040718-178"
     misc_feature    255..257
                     /gene="nkx6.1"
                     /gene_synonym="zgc:92879"
                     /note="upstream in-frame stop codon"
     CDS             345..1283
                     /gene="nkx6.1"
                     /gene_synonym="zgc:92879"
                     /note="NK6 transcription factor related, locus 1"
                     /codon_start=1
                     /product="homeobox protein Nkx-6.1"
                     /protein_id="NP_001002475.1"
                     /db_xref="GeneID:436748"
                     /db_xref="ZFIN:ZDB-GENE-040718-178"
                     /translation="

MLAVGQMDGSRQSAFLLNTPPLAALHSMTEMKTPLYPAYPLSSTGPASSTSPTATSPNPGGIPVSSPGIKTSSGLSALASAQQCAIATPHGINDILSRPSVACSPAGILSGLPRFSSLSPPPPPGLYFSPSAAAVAVARYPKPLTELPGRTPIFWPGVMQSPHWRDARFACSPHQNSVLLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMASAKKKQDSETERLKGASENEDDDDDYNKPLDPNSDDEKITQLLKKHKPNSALIIHTSENESS"

     misc_feature    897..1073
                     /gene="nkx6.1"
                     /gene_synonym="zgc:92879"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
ORIGIN      

aattatctcccagatcttcatgtgaactacccagaaagactctctttttatttatagatttcaaaaacactctcttttgaaaggacgacgctctgttgtatcatgcaagatctaaaagaacagaatggatattggccagaggagatgagtatgaagctccagtacaactgattgggatttttttagagaaattactttttttggctccatatcgcaaggtgtcttttgtttatttttcgtttctcctcttcatttagtattctgcgtttgttttcacgttttcccgggtcactgtccttcttcttgcgcgatatttagttaaagttgtagtttgtgtcttggttatgttagcggtggggcaaatggacgggtctcgccaaagcgctttcctactcaataccccacctttagctgctttacacagtatgaccgagatgaagacgccgctttacccagcctacccgttatcttccactggaccagcatcctccacttcaccgacagctacctctccgaatccaggtgggatcccggtctcgtccccggggatcaaaacctccagtggactttcagctctcgcatcagcccagcagtgcgcgatcgccacacctcacggaataaacgacatcctcagccgaccctcggtggcttgttcccccgcaggaatcttgtctggactgccccgtttcagcagcctgagtcccccaccgcctccagggctttatttcagccctagtgccgcggctgtagcggtggctcgctatcccaaacccctgacagagcttcccggcagaaccccgatattctggcctggagttatgcaaagcccacactggagagatgccagatttgcgtgctcaccacatcaaaactcagttctgctcgacaaagatgggaaaaggaaacacacgcgaccgacgttttccgggcagcaaatttttgcactggaaaaaacatttgagcaaacgaaatatttagccggccctgaaagagcccgactagcctactctttaggaatgacagagagtcaagtcaaggtgtggtttcaaaaccgaagaacaaaatggagaaaacggcacgcggctgaaatggcctcggcgaagaaaaaacaagattcagaaaccgagaggctgaaaggagcttcggaaaatgaagacgacgacgacgactacaataaacctttagacccaaactcggacgatgaaaaaattacacagttactgaaaaaacacaaaccgaactcagctcttatcattcacacgtcggaaaacgagagctcgtaaaaaggaaacgggaaatgggttgtcagattcttcaagaagtgtcaaaattaatataggctacttttcccccaccaagtttgagctctggtttgagaggaaggatgcagatcagaggaatatgcactattggtggaactgaacgtgcatcagtgtctgctatagacacgtttcaacataaagacaacggtacttttttgtaaattaacagcgtgagttgtatcgcataggaattatattactgtgaatatttatgtgtaaaatattttgaatagtaaacatgacagaattcgttcacttcgcttcagtttaatttttggttaaggctttgtgatttgcatttttttcatatcattaatttgtgtaggtgcttatcaccacgagttattttattttttctctgagtgtaagttccctcaaccatttgatctttaaaaataaacaacaatagaaatatataacacctttcagaatttaccacactaatggcaaaagacatatgagcgacagctcaaattgaggctcagtcaaaagatttatctggctttgccaagtgtaaatacaaacacctaaccgtatatttgtaatataatgcatagtgttcgtctcccaatgttaggatgtttcttttattttcccccatgattaatttatgatattttaagtttgtaacggtgttttggatcctgcaaaatgcgccatgcaggttcgtgtgtattgcacttttatttaataaaatgttaaacgtaaaaaaaaaaaaaaaaa

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