LOCUS       XM_022369716            2745 bp    mRNA    linear   INV 14-MAY-2021
DEFINITION  PREDICTED: Drosophila obscura protein argonaute-2 (LOC111076093),
            transcript variant X3, mRNA.
ACCESSION   XM_022369716
VERSION     XM_022369716.2
DBLINK      BioProject: PRJNA728747
KEYWORDS    RefSeq.
SOURCE      Drosophila obscura
  ORGANISM  Drosophila obscura
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_024542791.1) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 14, 2021 this sequence version replaced XM_022369716.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila obscura Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2745
                     /organism="Drosophila obscura"
                     /mol_type="mRNA"
                     /isolate="BZ-5 IFL"
                     /db_xref="taxon:7282"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="whole fly"
                     /dev_stage="Adult fly"
                     /country="Serbia: Babin Zub"
                     /collection_date="2017"
     gene            1..2745
                     /gene="LOC111076093"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 13 mRNAs, 136 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:111076093"
     CDS             87..2669
                     /gene="LOC111076093"
                     /codon_start=1
                     /product="protein argonaute-2"
                     /protein_id="XP_022225408.1"
                     /db_xref="GeneID:111076093"
                     /translation="

MPKVKNYKKKKPFPDLAAVADALECVNVQPELGQGDLLRPVAGAVAVAVVPPRPAVKPIKRGTLGRIGEIAVNYLQVNMDRMPAVAYHYDVKFVPELPKKFYREAFEQHRVQYLGNAVAAFDGRASCYSVDKLHCRSQGEQVSVFDSYGRELKYLVEIMATAEPEVDLSSLRTYMRDRIYEKPMRALQCLEVVLAAPCHSKAIRSGRCFFQKSEPGKSQALGNGEEILLGLFQAFVLGDRPFVNVDITHKCFPLPMPIIEYLERYQLGQKITAQTNLESKRSEIDGYLSGVAIAYAPPASFASFTRVYKVNALTKLPASKQTFVADKGRLTVAEYFQSRGHSLRYPNLHCLHVGSPQKTIYLPIELCAIEGKQSVNRKDSTLQSAAMIKIAATSTNARRCKIMELLQYFSHNTDPTIARFGFRLQTDFVTVQTRTLSAPIIQYRNRATCMVRHGSWRNDCSHFYESKQKAHKWAIVHGGLNYNKMRDLEQLILAQSRSVNLSLAAKANIRAYRDIQSLDPHFKEYKSSQYDLVIVVVPNAGHFYDELKQKAELQYGILTQCIKRNTVERNCNPQVIGNLLLKINSKLNGINHTLKLDGCTELRNVMYLGADVTHPSPDQREIPSVVGVAGSHDPFGASYNMQYRLQRSALEEIEDMESITAAILRTYHHYRKCYPEHIMYYRDGVSDGQFPKIKNEELRGISVACAKLGIKPKICCIIVVKRHHTRFFPSGAPSQHNKYNNVEPGTVVDRTIVHPNEVQWFMVSHQSIQGTARPTRYNVIANTGSLDIDLLQQLTHNLCHMFPRCNRAVSYPAPAYLAHLAASRGRVYLTGTTTFAAPELEYKKRLISTSLTSKNPMYFI"

     misc_feature    450..668
                     /gene="LOC111076093"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    699..845
                     /gene="LOC111076093"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    849..1193
                     /gene="LOC111076093"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1008..1010,1053..1055,1080..1082,1092..1094,
                     1143..1145,1164..1166,1170..1172)
                     /gene="LOC111076093"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1329..2573
                     /gene="LOC111076093"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1716..1718,1728..1730,1764..1775,1782..1784,
                     1809..1811,1818..1820,1830..1832,1842..1844)
                     /gene="LOC111076093"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1917..1919,1923..1925,2133..2135,2541..2543)
                     /gene="LOC111076093"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

ttcgtctggcaacattcggaggagactcgtaactagagtagaataaatttagtgatcgttttttactcaagcaaacggcagtggaaatgcctaaagttaaaaattataaaaaaaagaaaccgtttccggatctcgcggccgtagccgacgctttggaatgcgtcaacgtgcagccagagctgggccaaggagatctcctgcgtccggtggcaggggcagtggcagtggcagtggtcccgccccggccagcggtcaagcccataaagcgcggtacactgggcagaatcggggagattgcagtgaactatctgcaagtgaacatggacagaatgccggcagtggcgtaccactacgatgtgaaattcgtgccggaactgccgaagaagttctaccgggaggccttcgagcagcatcgcgttcagtatttgggcaatgctgtggcggccttcgatggacgggcctcgtgctactccgtggacaagctccactgccgatcgcagggcgagcaggttagcgtcttcgacagctatggacgtgagctcaagtatctggtggagattatggcgacggcggaaccggaggtcgacctaagctccctgcgcacctacatgagggacaggatctacgagaagccgatgcgtgcgctgcagtgtctggaggttgtgctggccgcgccatgccacagcaaggcgatacgttcgggtcgctgtttctttcagaaatccgaaccgggaaagtcccaggccctgggcaacggcgaggagattctgctgggcctctttcaggcgtttgtgctgggcgatcgtccgtttgtgaatgtggacatcacacacaagtgcttcccactgccgatgcccattatcgagtacttggagcgctatcagctgggccagaagatcacggcccaaacgaatctcgagagcaagcgctcggagatagatggatacctgagtggcgttgccatcgcctatgcgccgccagcatcattcgcaagtttcaccagagtctacaaggtgaatgcgctgaccaagctgccggccagcaagcagacattcgtggcggataagggccggctgaccgtggccgagtacttccagtcccgtggccacagtctacggtatccgaatctgcactgcctgcacgttggctcgccacagaaaacaatttatctgcccattgagctgtgtgccattgagggcaagcagtcggtgaatcgcaaggactccacgctgcagtcggcggcaatgattaagattgcggccacatccacgaacgcacgcaggtgcaagatcatggagctgctgcagtacttcagccacaacacggacccgaccatagcgcgctttggctttcgcctgcagaccgatttcgttacggtgcagacgcgcaccctcagtgcccccattatccagtatcggaacagggccacatgcatggtgaggcacggctcgtggcgcaacgactgctcgcatttctacgagtccaagcagaaggcgcacaagtgggccatcgtgcacggcggcctcaactacaacaagatgcgggaccttgagcagttgatcctggcacaaagtcgcagcgtcaatttgtcgctggctgccaaggcaaacatacgagcgtacagggacatccagagcctggatccgcacttcaaggagtacaaatcgagtcagtacgatttggtgattgtcgttgtgcccaatgccggccatttctacgacgaactgaaacagaaagccgaactgcagtacgggattctcacgcagtgcatcaagcgcaacaccgtcgagcggaactgcaatccgcaggtgattggcaatctgctgctgaagatcaactccaagctgaatggcatcaaccacacgctgaagctggatgggtgcaccgagctgaggaacgtcatgtacctgggcgccgatgtgacgcatccgtcgcccgatcaacgcgaaatacccagtgtggtgggcgtggcgggatctcacgatccctttggggcatcctacaacatgcagtaccgcctgcaacgctccgctttggaggagatcgaggacatggagtcgataacagccgcgattttgcgcacctatcatcactaccggaagtgctatccggagcacattatgtactaccgggacggggtcagcgatgggcagttcccgaagattaagaacgaggagctgcgcggcatctccgtggcctgtgccaagctgggcattaagccgaaaatctgctgcatcatagtggtgaagcggcatcacacgcgcttctttccgagtggcgccccctcgcagcacaacaaatacaacaacgtggagccgggcaccgtggtcgatcgcaccatagtgcatcccaatgaggtgcagtggttcatggtcagccaccagtccattcagggcacggccaggccgacccgctacaatgtgatcgcgaacacgggcagcctggacattgacctgctgcagcagctgacacacaacctctgccacatgttcccccgctgcaaccgcgctgtgtcctacccggcaccggcgtacttggcccatttggctgcctcccgtgggcgggtgtatctcacgggcaccacgacgtttgcggcgccagagctggagtacaaaaagcgcttgataagcacgagccttacatcgaaaaatccaatgtactttatttagttttgtttagtttagtttcgcttgtttaaattttgtttgttcaactacatatatacatttaaaatccaaataaaaa

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