LOCUS       NR_191001              19180 bp    RNA     linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens X inactive specific transcript (XIST), transcript
            variant 6, long non-coding RNA.
ACCESSION   NR_191001
VERSION     NR_191001.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 19180)
  AUTHORS   Gupta,K., Czerminski,J.T. and Lawrence,J.B.
  TITLE     Trisomy silencing by XIST: translational prospects and challenges
  JOURNAL   Hum Genet 143 (7), 843-855 (2024)
   PUBMED   38459355
  REMARK    GeneRIF: Trisomy silencing by XIST: translational prospects and
            challenges.
            Review article
REFERENCE   2  (bases 1 to 19180)
  AUTHORS   Wang,K., Bhattacharya,A., Haratake,N., Daimon,T., Nakashoji,A.,
            Ozawa,H., Peng,B., Li,W. and Kufe,D.
  TITLE     XIST and MUC1-C form an auto-regulatory pathway in driving cancer
            progression
  JOURNAL   Cell Death Dis 15 (5), 330 (2024)
   PUBMED   38740827
  REMARK    GeneRIF: XIST and MUC1-C form an auto-regulatory pathway in driving
            cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 19180)
  AUTHORS   Guo,B., He,M., Ma,M., Tian,Z., Jin,J. and Tian,G.
  TITLE     Long Non-coding RNA X-Inactive Specific Transcript Promotes
            Esophageal Squamous Cell Carcinoma Progression via the MicroRNA
            34a/Zinc Finger E-box-Binding Homeobox 1 Pathway
  JOURNAL   Dig Dis Sci 69 (4), 1169-1181 (2024)
   PUBMED   38366093
  REMARK    GeneRIF: Long Non-coding RNA X-Inactive Specific Transcript
            Promotes Esophageal Squamous Cell Carcinoma Progression via the
            MicroRNA 34a/Zinc Finger E-box-Binding Homeobox 1 Pathway.
REFERENCE   4  (bases 1 to 19180)
  AUTHORS   Berenji,E., Valipour Motlagh,A., Fathi,M., Esmaeili,M., Izadi,T.,
            Rezvanian,P., Zanjirband,M., Safaeinejad,Z. and Nasr-Esfahani,M.H.
  TITLE     Discovering therapeutic possibilities for polycystic ovary syndrome
            by targeting XIST and its associated ceRNA network through the
            analysis of transcriptome data
  JOURNAL   Sci Rep 14 (1), 6180 (2024)
   PUBMED   38486041
  REMARK    GeneRIF: Discovering therapeutic possibilities for polycystic ovary
            syndrome by targeting XIST and its associated ceRNA network through
            the analysis of transcriptome data.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 19180)
  AUTHORS   Daniels,R., Zuccotti,M., Kinis,T., Serhal,P. and Monk,M.
  TITLE     XIST expression in human oocytes and preimplantation embryos
  JOURNAL   Am J Hum Genet 61 (1), 33-39 (1997)
   PUBMED   9245982
REFERENCE   6  (bases 1 to 19180)
  AUTHORS   Brown,C.J. and Robinson,W.P.
  TITLE     XIST expression and X-chromosome inactivation in human
            preimplantation embryos
  JOURNAL   Am J Hum Genet 61 (1), 5-8 (1997)
   PUBMED   9245976
  REMARK    Review article
REFERENCE   7  (bases 1 to 19180)
  AUTHORS   Brown,C.J., Hendrich,B.D., Rupert,J.L., Lafreniere,R.G., Xing,Y.,
            Lawrence,J. and Willard,H.F.
  TITLE     The human XIST gene: analysis of a 17 kb inactive X-specific RNA
            that contains conserved repeats and is highly localized within the
            nucleus
  JOURNAL   Cell 71 (3), 527-542 (1992)
   PUBMED   1423611
REFERENCE   8  (bases 1 to 19180)
  AUTHORS   Brockdorff,N., Ashworth,A., Kay,G.F., Cooper,P., Smith,S.,
            McCabe,V.M., Norris,D.P., Penny,G.D., Patel,D. and Rastan,S.
  TITLE     Conservation of position and exclusive expression of mouse Xist
            from the inactive X chromosome
  JOURNAL   Nature 351 (6324), 329-331 (1991)
   PUBMED   2034279
REFERENCE   9  (bases 1 to 19180)
  AUTHORS   Brown,C.J., Lafreniere,R.G., Powers,V.E., Sebastio,G., Ballabio,A.,
            Pettigrew,A.L., Ledbetter,D.H., Levy,E., Craig,I.W. and
            Willard,H.F.
  TITLE     Localization of the X inactivation centre on the human X chromosome
            in Xq13
  JOURNAL   Nature 349 (6304), 82-84 (1991)
   PUBMED   1985270
REFERENCE   10 (bases 1 to 19180)
  AUTHORS   Brown,C.J., Ballabio,A., Rupert,J.L., Lafreniere,R.G., Grompe,M.,
            Tonlorenzi,R. and Willard,H.F.
  TITLE     A gene from the region of the human X inactivation centre is
            expressed exclusively from the inactive X chromosome
  JOURNAL   Nature 349 (6304), 38-44 (1991)
   PUBMED   1985261
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353804.22.
            
            Summary: X inactivation is an early developmental process in
            mammalian females that transcriptionally silences one of the pair
            of X chromosomes, thus providing dosage equivalence between males
            and females. The process is regulated by several factors, including
            a region of chromosome X called the X inactivation center (XIC).
            The XIC comprises several non-coding and protein-coding genes, and
            this gene was the first non-coding gene identified within the XIC.
            This gene is expressed exclusively from the XIC of the inactive X
            chromosome, and is essential for the initiation and spread of
            X-inactivation. The transcript is a spliced RNA. Alternatively
            spliced transcript variants have been identified, but their full
            length sequences have not been determined. Mutations in the XIST
            promoter cause familial skewed X inactivation. [provided by RefSeq,
            Apr 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: OA989460.1, SRR14038192.527915.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11333             AL353804.22        24785-36117         c
            11334-11397         AL353804.22        20843-20906         c
            11398-11534         AL353804.22        16641-16777         c
            11535-11743         AL353804.22        14469-14677         c
            11744-11907         AL353804.22        12471-12634         c
            11908-19180         AL353804.22        4059-11331          c
FEATURES             Location/Qualifiers
     source          1..19180
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.2"
     gene            1..19180
                     /gene="XIST"
                     /gene_synonym="DXS1089; DXS399E; LINC00001; NCRNA00001;
                     swd66; SXI1"
                     /note="X inactive specific transcript"
                     /db_xref="GeneID:7503"
                     /db_xref="HGNC:HGNC:12810"
                     /db_xref="MIM:314670"
     ncRNA           1..19180
                     /ncRNA_class="lncRNA"
                     /gene="XIST"
                     /gene_synonym="DXS1089; DXS399E; LINC00001; NCRNA00001;
                     swd66; SXI1"
                     /product="X inactive specific transcript, transcript
                     variant 6"
                     /db_xref="GeneID:7503"
                     /db_xref="HGNC:HGNC:12810"
                     /db_xref="MIM:314670"
     exon            1..11333
                     /gene="XIST"
                     /gene_synonym="DXS1089; DXS399E; LINC00001; NCRNA00001;
                     swd66; SXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            11334..11397
                     /gene="XIST"
                     /gene_synonym="DXS1089; DXS399E; LINC00001; NCRNA00001;
                     swd66; SXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            11398..11534
                     /gene="XIST"
                     /gene_synonym="DXS1089; DXS399E; LINC00001; NCRNA00001;
                     swd66; SXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            11535..11743
                     /gene="XIST"
                     /gene_synonym="DXS1089; DXS399E; LINC00001; NCRNA00001;
                     swd66; SXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            11744..11907
                     /gene="XIST"
                     /gene_synonym="DXS1089; DXS399E; LINC00001; NCRNA00001;
                     swd66; SXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            11908..19180
                     /gene="XIST"
                     /gene_synonym="DXS1089; DXS399E; LINC00001; NCRNA00001;
                     swd66; SXI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      19163..19168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XIST"
                     /gene_synonym="DXS1089; DXS399E; LINC00001; NCRNA00001;
                     swd66; SXI1"
                     /note="hexamer: AATATA"
     polyA_site      19180
                     /gene="XIST"
                     /gene_synonym="DXS1089; DXS399E; LINC00001; NCRNA00001;
                     swd66; SXI1"
                     /note="major polyA site"
ORIGIN      

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