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Previous release (v1)
2024-05-01 06:17:01, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NR_039950 84 bp RNA linear PRI 06-FEB-2022
DEFINITION Homo sapiens microRNA 4787 (MIR4787), microRNA.
ACCESSION NR_039950
VERSION NR_039950.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 84)
AUTHORS Wang L, Wang Z, Zhang R, Huang L, Zhao Z, Yang Y, Cui L and Zhang
S.
TITLE MiR-4787-5p Regulates Vascular Smooth Muscle Cell Apoptosis by
Targeting PKD1 and Inhibiting the PI3K/Akt/FKHR Pathway
JOURNAL J Cardiovasc Pharmacol 78 (2), 288-296 (2021)
PUBMED 33958547
REMARK GeneRIF: MiR-4787-5p Regulates Vascular Smooth Muscle Cell
Apoptosis by Targeting PKD1 and Inhibiting the PI3K/Akt/FKHR
Pathway.
REFERENCE 2 (bases 1 to 84)
AUTHORS Enomoto Y, Takagi R, Naito Y, Kiniwa T, Tanaka Y, Hamada-Tsutsumi
S, Kawano M, Matsushita S, Ochiya T and Miyajima A.
TITLE Identification of the novel 3' UTR sequences of human IL-21 mRNA as
potential targets of miRNAs
JOURNAL Sci Rep 7 (1), 7780 (2017)
PUBMED 28798470
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 84)
AUTHORS Hansen TB, Kjems J and Bramsen JB.
TITLE Enhancing miRNA annotation confidence in miRBase by continuous
cross dataset analysis
JOURNAL RNA Biol 8 (3), 378-383 (2011)
PUBMED 21558790
REFERENCE 4 (bases 1 to 84)
AUTHORS Persson H, Kvist A, Rego N, Staaf J, Vallon-Christersson J, Luts L,
Loman N, Jonsson G, Naya H, Hoglund M, Borg A and Rovira C.
TITLE Identification of new microRNAs in paired normal and tumor breast
tissue suggests a dual role for the ERBB2/Her2 gene
JOURNAL Cancer Res 71 (1), 78-86 (2011)
PUBMED 21199797
REFERENCE 5 (bases 1 to 84)
AUTHORS Kozomara A and Griffiths-Jones S.
TITLE miRBase: integrating microRNA annotation and deep-sequencing data
JOURNAL Nucleic Acids Res 39 (Database issue), D152-D157 (2011)
PUBMED 21037258
REFERENCE 6 (bases 1 to 84)
AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright
AJ.
TITLE miRBase: microRNA sequences, targets and gene nomenclature
JOURNAL Nucleic Acids Res 34 (Database issue), D140-D144 (2006)
PUBMED 16381832
COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation
provided by NCBI staff in collaboration with miRBase. The reference
sequence was derived from AC096920.2.
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
that are involved in post-transcriptional regulation of gene
expression in multicellular organisms by affecting both the
stability and translation of mRNAs. miRNAs are transcribed by RNA
polymerase II as part of capped and polyadenylated primary
transcripts (pri-miRNAs) that can be either protein-coding or
non-coding. The primary transcript is cleaved by the Drosha
ribonuclease III enzyme to produce an approximately 70-nt stem-loop
precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and
antisense miRNA star (miRNA*) products. The mature miRNA is
incorporated into a RNA-induced silencing complex (RISC), which
recognizes target mRNAs through imperfect base pairing with the
miRNA and most commonly results in translational inhibition or
destabilization of the target mRNA. The RefSeq represents the
predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Sequence Note: This record represents a predicted microRNA
stem-loop as defined by miRBase. Some sequence at the 5' and 3'
ends may not be included in the intermediate precursor miRNA
produced by Drosha cleavage.
##Evidence-Data-START##
Transcript is intronless :: LM611422.1 [ECO:0000345]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-84 AC096920.2 38383-38466 c
FEATURES Location/Qualifiers
source 1..84
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.2"
gene 1..84
/gene="MIR4787"
/gene_synonym="mir-4787"
/note="microRNA 4787"
/db_xref="GeneID:100616138"
/db_xref="HGNC:HGNC:41653"
/db_xref="miRBase:MI0017434"
precursor_RNA 1..84
/gene="MIR4787"
/gene_synonym="mir-4787"
/product="microRNA 4787"
/db_xref="GeneID:100616138"
/db_xref="HGNC:HGNC:41653"
/db_xref="miRBase:MI0017434"
exon 1..84
/gene="MIR4787"
/gene_synonym="mir-4787"
/inference="alignment:Splign:2.1.0"
variation 1
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:977038833"
variation 2
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="g"
/db_xref="dbSNP:1344013128"
variation 3
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="g"
/db_xref="dbSNP:922545786"
variation 9
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="c"
/db_xref="dbSNP:2107624484"
variation 10
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:2033834480"
variation 11..26
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="gtggcgg"
/replace="gtggcgggggtggcgg"
/db_xref="dbSNP:2033834746"
variation 11
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="g"
/db_xref="dbSNP:2033834617"
ncRNA 14..35
/ncRNA_class="miRNA"
/gene="MIR4787"
/gene_synonym="mir-4787"
/product="hsa-miR-4787-5p"
/db_xref="miRBase:MIMAT0019956"
/db_xref="GeneID:100616138"
/db_xref="HGNC:HGNC:41653"
/db_xref="miRBase:MI0017434"
variation 15
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:2033834879"
variation 17
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="g"
/db_xref="dbSNP:1419795843"
variation 19..29
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="ggtggcggcgg"
/replace="ggtggcggcggtggcggcgg"
/db_xref="dbSNP:1410283258"
variation 19
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="g"
/replace="t"
/db_xref="dbSNP:1185815330"
variation 21
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="g"
/replace="t"
/db_xref="dbSNP:937341665"
variation 22..30
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="ggcggcggc"
/replace="ggcggcggcggcggcggc"
/db_xref="dbSNP:1205425429"
variation 22
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="g"
/db_xref="dbSNP:2033835627"
variation 23
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="g"
/db_xref="dbSNP:2033835904"
variation 24
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1258476104"
variation 27
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="c"
/db_xref="dbSNP:2033836208"
variation 30
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:1252597605"
variation 32
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:2107624668"
variation 34
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="g"
/db_xref="dbSNP:2033836589"
variation 35
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="g"
/db_xref="dbSNP:1211419587"
variation 36
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="g"
/replace="t"
/db_xref="dbSNP:2033836997"
variation 38
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="g"
/db_xref="dbSNP:867895270"
variation 43
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="g"
/db_xref="dbSNP:985301871"
variation 46
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="g"
/replace="t"
/db_xref="dbSNP:2107624720"
variation 50
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="g"
/replace="t"
/db_xref="dbSNP:2107624727"
ncRNA 51..74
/ncRNA_class="miRNA"
/gene="MIR4787"
/gene_synonym="mir-4787"
/product="hsa-miR-4787-3p"
/db_xref="miRBase:MIMAT0019957"
/db_xref="GeneID:100616138"
/db_xref="HGNC:HGNC:41653"
/db_xref="miRBase:MI0017434"
variation 54..78
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="gcgccgcccactgccccgcgccgcc"
/replace="gcgccgcccactgccccgcgccgcccactgccccgcgccgcc"
/db_xref="dbSNP:1215012450"
variation 55
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="g"
/db_xref="dbSNP:1317404607"
variation 56
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="g"
/db_xref="dbSNP:1285749936"
variation 57
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:2033837868"
variation 58
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:1230862465"
variation 61
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:1354491242"
variation 63
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="t"
/db_xref="dbSNP:1209791713"
variation 65
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:2033838452"
variation 69
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:1417050028"
variation 70
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:1360282676"
variation 71
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace=""
/replace="g"
/db_xref="dbSNP:2033838990"
variation 72
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="c"
/db_xref="dbSNP:868757328"
variation 76
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:2033839282"
variation 77
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:946807134"
variation 81
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="c"
/db_xref="dbSNP:2107624927"
variation 82
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="c"
/replace="t"
/db_xref="dbSNP:1455858573"
variation 83
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="a"
/replace="c"
/db_xref="dbSNP:1347406949"
variation 84
/gene="MIR4787"
/gene_synonym="mir-4787"
/replace="g"
/replace="t"
/db_xref="dbSNP:1162954251"
ORIGIN
cggtccagacgtggcgggggtggcggcggcatcccggacggcctgtgagggatgcgccgcccactgccccgcgccgcctgaccg
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]