LOCUS       NR_039668                 68 bp    RNA     linear   PRI 23-JAN-2022
DEFINITION  Homo sapiens microRNA 3135b (MIR3135B), microRNA.
ACCESSION   NR_039668
VERSION     NR_039668.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 68)
  AUTHORS   Wang F, Li Z, Zhao M, Ye W, Wu H, Liao Q, Bu S and Zhang Y.
  TITLE     Circulating miRNAs miR-574-5p and miR-3135b are potential metabolic
            regulators for serum lipids and blood glucose in gestational
            diabetes mellitus
  JOURNAL   Gynecol Endocrinol 37 (7), 665-671 (2021)
   PUBMED   34126831
  REMARK    GeneRIF: Circulating miRNAs miR-574-5p and miR-3135b are potential
            metabolic regulators for serum lipids and blood glucose in
            gestational diabetes mellitus.
REFERENCE   2  (bases 1 to 68)
  AUTHORS   Shi J, Ren Y, Liu Y, Cheng Y and Liu Y.
  TITLE     Circulating miR-3135b and miR-107 are potential biomarkers for
            severe hypertension
  JOURNAL   J Hum Hypertens 35 (4), 343-350 (2021)
   PUBMED   32327699
  REMARK    GeneRIF: Circulating miR-3135b and miR-107 are potential biomarkers
            for severe hypertension.
REFERENCE   3  (bases 1 to 68)
  AUTHORS   Hu W, Xu B, Zhang J, Kou C, Liu J, Wang Q and Zhang R.
  TITLE     Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages
            reduces endothelial cells permeability and monocyte
            transendothelial migration by targeting JAM-C
  JOURNAL   Exp Cell Res 388 (1), 111823 (2020)
   PUBMED   31926946
REFERENCE   4  (bases 1 to 68)
  AUTHORS   Enomoto Y, Takagi R, Naito Y, Kiniwa T, Tanaka Y, Hamada-Tsutsumi
            S, Kawano M, Matsushita S, Ochiya T and Miyajima A.
  TITLE     Identification of the novel 3' UTR sequences of human IL-21 mRNA as
            potential targets of miRNAs
  JOURNAL   Sci Rep 7 (1), 7780 (2017)
   PUBMED   28798470
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 68)
  AUTHORS   Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY,
            Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP,
            Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI,
            Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI, Liu Q,
            How T, Grubor V, Gao Y, Patel A, Wu H, Zhu J, Blobe GC, Lipsky PE,
            Chadburn A and Dave SS.
  CONSRTM   Hematologic Malignancies Research Consortium
  TITLE     Deep sequencing of the small RNA transcriptome of normal and
            malignant human B cells identifies hundreds of novel microRNAs
  JOURNAL   Blood 116 (23), e118-e127 (2010)
   PUBMED   20733160
REFERENCE   6  (bases 1 to 68)
  AUTHORS   Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright
            AJ.
  TITLE     miRBase: microRNA sequences, targets and gene nomenclature
  JOURNAL   Nucleic Acids Res 34 (Database issue), D140-D144 (2006)
   PUBMED   16381832
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with miRBase. The reference
            sequence was derived from AL672104.4.
            
            Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
            that are involved in post-transcriptional regulation of gene
            expression in multicellular organisms by affecting both the
            stability and translation of mRNAs. miRNAs are transcribed by RNA
            polymerase II as part of capped and polyadenylated primary
            transcripts (pri-miRNAs) that can be either protein-coding or
            non-coding. The primary transcript is cleaved by the Drosha
            ribonuclease III enzyme to produce an approximately 70-nt stem-loop
            precursor miRNA (pre-miRNA), which is further cleaved by the
            cytoplasmic Dicer ribonuclease to generate the mature miRNA and
            antisense miRNA star (miRNA*) products. The mature miRNA is
            incorporated into a RNA-induced silencing complex (RISC), which
            recognizes target mRNAs through imperfect base pairing with the
            miRNA and most commonly results in translational inhibition or
            destabilization of the target mRNA. The RefSeq represents the
            predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
            
            Sequence Note: This record represents a predicted microRNA
            stem-loop as defined by miRBase. Some sequence at the 5' and 3'
            ends may not be included in the intermediate precursor miRNA
            produced by Drosha cleavage.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL672104.4         14255-14322         c
FEATURES             Location/Qualifiers
     source          1..68
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..68
                     /gene="MIR3135B"
                     /note="microRNA 3135b"
                     /db_xref="GeneID:100616218"
                     /db_xref="HGNC:HGNC:41783"
                     /db_xref="miRBase:MI0016809"
     precursor_RNA   1..68
                     /gene="MIR3135B"
                     /product="microRNA 3135b"
                     /db_xref="GeneID:100616218"
                     /db_xref="HGNC:HGNC:41783"
                     /db_xref="miRBase:MI0016809"
     exon            1..68
                     /gene="MIR3135B"
                     /inference="alignment:Splign:2.1.0"
     variation       3
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1315019912"
     variation       4
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:935902905"
     variation       5
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1292500923"
     variation       6
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1763852998"
     ncRNA           7..28
                     /ncRNA_class="miRNA"
                     /gene="MIR3135B"
                     /product="hsa-miR-3135b"
                     /db_xref="miRBase:MIMAT0018985"
                     /db_xref="GeneID:100616218"
                     /db_xref="HGNC:HGNC:41783"
                     /db_xref="miRBase:MI0016809"
     variation       7
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1763852845"
     variation       8
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1437307191"
     variation       9
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1202765326"
     variation       11
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:905889141"
     variation       14
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:922757991"
     variation       15
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1562200624"
     variation       16
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1763851794"
     variation       19
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1763851618"
     variation       20
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1582355093"
     variation       30
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1763851286"
     variation       35
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4351242"
     variation       37
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1333711317"
     variation       42
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1275371288"
     variation       44
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1232188346"
     variation       46
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1368590309"
     variation       47
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1322132038"
     variation       49
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:950049808"
     variation       52
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1763849953"
     variation       55
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4285314"
     variation       56
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1763849458"
     variation       61
                     /gene="MIR3135B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1763849268"
     variation       64
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1387253703"
     variation       67
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:983514346"
     variation       68
                     /gene="MIR3135B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1164940570"
ORIGIN      

tgcccaggctggagcgagtgcagtggtgcagtcagtcctagctcactgcagcctcgaactcctgggct

//