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Previous release (v1)
2024-05-01 15:28:05, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NR_039602 98 bp RNA linear PRI 03-OCT-2021
DEFINITION Homo sapiens microRNA 378d-2 (MIR378D2), microRNA.
ACCESSION NR_039602
VERSION NR_039602.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 98)
AUTHORS Chen Q, Li Z, Xu Z, Chen C, Wang J, Zhu J and Dong Z.
TITLE miR-378d is Involved in the Regulation of Apoptosis and Autophagy
of and E2 Secretion from Cultured Ovarian Granular Cells Treated by
Sodium Fluoride
JOURNAL Biol Trace Elem Res 199 (11), 4119-4128 (2021)
PUBMED 33405077
REMARK GeneRIF: miR-378d is Involved in the Regulation of Apoptosis and
Autophagy of and E2 Secretion from Cultured Ovarian Granular Cells
Treated by Sodium Fluoride.
REFERENCE 2 (bases 1 to 98)
AUTHORS Jia H, Wang X and Sun Z.
TITLE Exploring the molecular pathogenesis and biomarkers of high risk
oral premalignant lesions on the basis of long noncoding RNA
expression profiling by serial analysis of gene expression
JOURNAL Eur J Cancer Prev 27 (4), 370-378 (2018)
PUBMED 28418939
REFERENCE 3 (bases 1 to 98)
AUTHORS Enomoto Y, Takagi R, Naito Y, Kiniwa T, Tanaka Y, Hamada-Tsutsumi
S, Kawano M, Matsushita S, Ochiya T and Miyajima A.
TITLE Identification of the novel 3' UTR sequences of human IL-21 mRNA as
potential targets of miRNAs
JOURNAL Sci Rep 7 (1), 7780 (2017)
PUBMED 28798470
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 98)
AUTHORS Kozomara A and Griffiths-Jones S.
TITLE miRBase: integrating microRNA annotation and deep-sequencing data
JOURNAL Nucleic Acids Res 39 (Database issue), D152-D157 (2011)
PUBMED 21037258
REFERENCE 5 (bases 1 to 98)
AUTHORS Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY,
Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP,
Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI,
Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI, Liu Q,
How T, Grubor V, Gao Y, Patel A, Wu H, Zhu J, Blobe GC, Lipsky PE,
Chadburn A and Dave SS.
CONSRTM Hematologic Malignancies Research Consortium
TITLE Deep sequencing of the small RNA transcriptome of normal and
malignant human B cells identifies hundreds of novel microRNAs
JOURNAL Blood 116 (23), e118-e127 (2010)
PUBMED 20733160
REFERENCE 6 (bases 1 to 98)
AUTHORS Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L,
Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van
Zonneveld AJ, Mano H, Plasterk R and Cuppen E.
TITLE Many novel mammalian microRNA candidates identified by extensive
cloning and RAKE analysis
JOURNAL Genome Res 16 (10), 1289-1298 (2006)
PUBMED 16954537
REFERENCE 7 (bases 1 to 98)
AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright
AJ.
TITLE miRBase: microRNA sequences, targets and gene nomenclature
JOURNAL Nucleic Acids Res 34 (Database issue), D140-D144 (2006)
PUBMED 16381832
COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation
provided by NCBI staff in collaboration with miRBase. The reference
sequence was derived from AC084346.3.
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
that are involved in post-transcriptional regulation of gene
expression in multicellular organisms by affecting both the
stability and translation of mRNAs. miRNAs are transcribed by RNA
polymerase II as part of capped and polyadenylated primary
transcripts (pri-miRNAs) that can be either protein-coding or
non-coding. The primary transcript is cleaved by the Drosha
ribonuclease III enzyme to produce an approximately 70-nt stem-loop
precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and
antisense miRNA star (miRNA*) products. The mature miRNA is
incorporated into a RNA-induced silencing complex (RISC), which
recognizes target mRNAs through imperfect base pairing with the
miRNA and most commonly results in translational inhibition or
destabilization of the target mRNA. The RefSeq represents the
predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Sequence Note: This record represents a predicted microRNA
stem-loop as defined by miRBase. Some sequence at the 5' and 3'
ends may not be included in the intermediate precursor miRNA
produced by Drosha cleavage.
##Evidence-Data-START##
Transcript is intronless :: LM609638.1 [ECO:0000345]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-98 AC084346.3 28339-28436
FEATURES Location/Qualifiers
source 1..98
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q22.1"
gene 1..98
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/note="microRNA 378d-2"
/db_xref="GeneID:100616169"
/db_xref="HGNC:HGNC:41797"
/db_xref="miRBase:MI0003840"
precursor_RNA 1..98
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/product="microRNA 378d-2"
/db_xref="GeneID:100616169"
/db_xref="HGNC:HGNC:41797"
/db_xref="miRBase:MI0003840"
exon 1..98
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/inference="alignment:Splign:2.1.0"
variation 3
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1005831834"
variation 5
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1810043785"
variation 6
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1474739432"
variation 12
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1182185243"
variation 13
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370873660"
ncRNA 22..41
/ncRNA_class="miRNA"
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/product="hsa-miR-378d"
/db_xref="miRBase:MIMAT0018926"
/db_xref="GeneID:100616169"
/db_xref="HGNC:HGNC:41797"
/db_xref="miRBase:MI0003840"
variation 24
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1810043238"
variation 29
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376196852"
variation 34
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1810043130"
variation 36
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1810043086"
variation 37
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1810042866"
variation 39
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="t"
/db_xref="dbSNP:1810042804"
variation 43
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="g"
/db_xref="dbSNP:1047915880"
variation 46
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="g"
/replace="t"
/db_xref="dbSNP:943629262"
variation 47
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1810042633"
variation 49
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1810042586"
variation 51
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1421653858"
variation 52..53
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="aa"
/db_xref="dbSNP:1377832713"
variation 52
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1810042452"
variation 56
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1810042321"
variation 60
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1375034772"
variation 61
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:910689169"
variation 65
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1810042142"
variation 66
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1052380609"
variation 67
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:929099072"
variation 69
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1810041978"
variation 71
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:933735851"
variation 73
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2130851798"
variation 74
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1371631145"
variation 76
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:1223707127"
variation 77
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1810041763"
variation 79
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="g"
/replace="t"
/db_xref="dbSNP:923025793"
variation 87
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:764126042"
variation 88
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="g"
/replace="t"
/db_xref="dbSNP:2130851784"
variation 93
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1218210671"
variation 94
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1277611658"
variation 98
/gene="MIR378D2"
/gene_synonym="mir-378d-2"
/replace="a"
/replace="t"
/db_xref="dbSNP:73692959"
ORIGIN
gaatggttacaaggagagaacactggacttggagtcagaaaactttcatccaagtcattccctgctctaagtcccatttctgttccatgagattgttt
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]