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Previous release (v1)
2024-05-01 18:14:33, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NR_036157 73 bp RNA linear PRI 15-MAY-2022
DEFINITION Homo sapiens microRNA 320e (MIR320E), microRNA.
ACCESSION NR_036157
VERSION NR_036157.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 73)
AUTHORS Xu C, Zhang Z, Liu N, Li L, Zhong H, Wang R, Shi Q, Zhang Z, Wei L,
Hu B, Zhang H, Shen X, Wang Y, Liu Y and Yuan W.
TITLE Small extracellular vesicle-mediated miR-320e transmission promotes
osteogenesis in OPLL by targeting TAK1
JOURNAL Nat Commun 13 (1), 2467 (2022)
PUBMED 35513391
REMARK GeneRIF: Small extracellular vesicle-mediated miR-320e transmission
promotes osteogenesis in OPLL by targeting TAK1.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 73)
AUTHORS Enomoto Y, Takagi R, Naito Y, Kiniwa T, Tanaka Y, Hamada-Tsutsumi
S, Kawano M, Matsushita S, Ochiya T and Miyajima A.
TITLE Identification of the novel 3' UTR sequences of human IL-21 mRNA as
potential targets of miRNAs
JOURNAL Sci Rep 7 (1), 7780 (2017)
PUBMED 28798470
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 73)
AUTHORS Perez-Carbonell L, Sinicrope FA, Alberts SR, Oberg AL, Balaguer F,
Castells A, Boland CR and Goel A.
TITLE MiR-320e is a novel prognostic biomarker in colorectal cancer
JOURNAL Br J Cancer 113 (1), 83-90 (2015)
PUBMED 26035698
REMARK GeneRIF: systematic biomarker discovery and validation approach
identified miR-320e to be a novel prognostic biomarker that is
associated with adverse clinical outcome in stage III CRC patients
treated with 5-FU-based adjuvant chemotherapy
REFERENCE 4 (bases 1 to 73)
AUTHORS Kozomara A and Griffiths-Jones S.
TITLE miRBase: integrating microRNA annotation and deep-sequencing data
JOURNAL Nucleic Acids Res 39 (Database issue), D152-D157 (2011)
PUBMED 21037258
REFERENCE 5 (bases 1 to 73)
AUTHORS Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC,
Parsons PG, Schmidt C, Sturm RA and Hayward NK.
TITLE Characterization of the Melanoma miRNAome by Deep Sequencing
JOURNAL PLoS One 5 (3), e9685 (2010)
PUBMED 20300190
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 73)
AUTHORS Goff LA, Davila J, Swerdel MR, Moore JC, Cohen RI, Wu H, Sun YE and
Hart RP.
TITLE Ago2 immunoprecipitation identifies predicted microRNAs in human
embryonic stem cells and neural precursors
JOURNAL PLoS One 4 (9), e7192 (2009)
PUBMED 19784364
REMARK Publication Status: Online-Only
REFERENCE 7 (bases 1 to 73)
AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright
AJ.
TITLE miRBase: microRNA sequences, targets and gene nomenclature
JOURNAL Nucleic Acids Res 34 (Database issue), D140-D144 (2006)
PUBMED 16381832
COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation
provided by NCBI staff in collaboration with miRBase. The reference
sequence was derived from AC008635.6.
On Apr 17, 2019 this sequence version replaced NR_036157.1.
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
that are involved in post-transcriptional regulation of gene
expression in multicellular organisms by affecting both the
stability and translation of mRNAs. miRNAs are transcribed by RNA
polymerase II as part of capped and polyadenylated primary
transcripts (pri-miRNAs) that can be either protein-coding or
non-coding. The primary transcript is cleaved by the Drosha
ribonuclease III enzyme to produce an approximately 70-nt stem-loop
precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and
antisense miRNA star (miRNA*) products. The mature miRNA is
incorporated into a RNA-induced silencing complex (RISC), which
recognizes target mRNAs through imperfect base pairing with the
miRNA and most commonly results in translational inhibition or
destabilization of the target mRNA. The RefSeq represents the
predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Sequence Note: This record represents a predicted microRNA
stem-loop as defined by miRBase. Some sequence at the 5' and 3'
ends may not be included in the intermediate precursor miRNA
produced by Drosha cleavage.
##Evidence-Data-START##
Transcript is intronless :: SRR7346977.1296413.1,
SRR1163658.394830.1 [ECO:0000345]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-73 AC008635.6 28170-28242
FEATURES Location/Qualifiers
source 1..73
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.32"
gene 1..73
/gene="MIR320E"
/gene_synonym="mir-320e"
/note="microRNA 320e"
/db_xref="GeneID:100422913"
/db_xref="HGNC:HGNC:38230"
/db_xref="miRBase:MI0014234"
precursor_RNA 1..73
/gene="MIR320E"
/gene_synonym="mir-320e"
/product="microRNA 320e"
/db_xref="GeneID:100422913"
/db_xref="HGNC:HGNC:38230"
/db_xref="miRBase:MI0014234"
exon 1..73
/gene="MIR320E"
/gene_synonym="mir-320e"
/inference="alignment:Splign:2.1.0"
variation 1
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:968686216"
variation 2
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:1311796093"
variation 4
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1020606470"
variation 5
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="aa"
/db_xref="dbSNP:1178987677"
variation 6
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1472892015"
variation 7
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="g"
/replace="t"
/db_xref="dbSNP:1599841298"
variation 8
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="g"
/replace="t"
/db_xref="dbSNP:1236568196"
variation 9
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:1362957808"
variation 10
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:550113165"
variation 11
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="c"
/replace="t"
/db_xref="dbSNP:1435578114"
variation 12
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1386803168"
variation 13
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="t"
/db_xref="dbSNP:1300837130"
variation 15
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:779364784"
variation 16
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="c"
/replace="t"
/db_xref="dbSNP:1377833232"
variation 18
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="c"
/replace="t"
/db_xref="dbSNP:1174992094"
variation 19
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:10423365"
variation 20
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="c"
/replace="t"
/db_xref="dbSNP:1388897521"
variation 21
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:561384200"
variation 22
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1448060372"
variation 24
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1445040859"
variation 26
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="g"
/replace="t"
/db_xref="dbSNP:2053767760"
variation 28
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="g"
/replace="t"
/db_xref="dbSNP:956580179"
variation 31
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="c"
/replace="t"
/db_xref="dbSNP:1264344933"
variation 33
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="g"
/replace="t"
/db_xref="dbSNP:1199089169"
variation 34
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="g"
/replace="t"
/db_xref="dbSNP:1483079525"
variation 35
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:1281233315"
variation 36
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:1213113971"
variation 38
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="c"
/replace="t"
/db_xref="dbSNP:1340086399"
variation 39..42
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="ggg"
/replace="gggg"
/db_xref="dbSNP:537624653"
variation 39
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:745895188"
variation 40
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="g"
/replace="t"
/db_xref="dbSNP:1228123200"
variation 42
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:2053767264"
variation 43..46
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="aaa"
/replace="aaaa"
/db_xref="dbSNP:1395183419"
ncRNA 44..61
/ncRNA_class="miRNA"
/gene="MIR320E"
/gene_synonym="mir-320e"
/product="hsa-miR-320e"
/db_xref="miRBase:MIMAT0015072"
/db_xref="GeneID:100422913"
/db_xref="HGNC:HGNC:38230"
/db_xref="miRBase:MI0014234"
variation 44
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:1310391092"
variation 47..51
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="gctgg"
/replace="gctggctgg"
/db_xref="dbSNP:1227217890"
variation 47
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="g"
/replace="t"
/db_xref="dbSNP:2053767137"
variation 48
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="c"
/replace="t"
/db_xref="dbSNP:2053767098"
variation 50
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:2053767050"
variation 52
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:1375683815"
variation 55
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:1314290882"
variation 61
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:774175431"
variation 63
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:2053766822"
variation 65
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:1350612892"
variation 69
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:2122150124"
variation 71
/gene="MIR320E"
/gene_synonym="mir-320e"
/replace="a"
/replace="g"
/db_xref="dbSNP:761487513"
ORIGIN
ctccatggggccttctcttcccagttcttcctggagtcggggaaaagctgggttgagaaggtgaaaagaaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]