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Previous release (v1)
2024-05-03 17:11:47, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001414462 2996 bp mRNA linear PRI 21-FEB-2023
DEFINITION Homo sapiens transmembrane BAX inhibitor motif containing 6
(TMBIM6), transcript variant 3, mRNA.
ACCESSION NM_001414462 XM_047429490
VERSION NM_001414462.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2996)
AUTHORS Zhang X, Chen Q, He Y, Shi Q, Yin C, Xie Y, Yu H, Bao Y, Wang X,
Tang C and Dong Z.
TITLE STRIP2 motivates non-small cell lung cancer progression by
modulating the TMBIM6 stability through IGF2BP3 dependent
JOURNAL J Exp Clin Cancer Res 42 (1), 19 (2023)
PUBMED 36639675
REMARK GeneRIF: STRIP2 motivates non-small cell lung cancer progression by
modulating the TMBIM6 stability through IGF2BP3 dependent.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2996)
AUTHORS Liao Y, Qiu Z and Bai L.
TITLE miR-302d-3p regulates the viability, migration and apoptosis of
breast cancer cells through regulating the TMBIM6-mediated ERK
signaling pathway
JOURNAL Mol Med Rep 24 (6) (2021)
PUBMED 34651659
REMARK GeneRIF: miR302d3p regulates the viability, migration and apoptosis
of breast cancer cells through regulating the TMBIM6mediated ERK
signaling pathway.
REFERENCE 3 (bases 1 to 2996)
AUTHORS Bhattarai KR, Kim HK, Chaudhary M, Ur Rashid MM, Kim J, Kim HR and
Chae HJ.
TITLE TMBIM6 regulates redox-associated posttranslational modifications
of IRE1alpha and ER stress response failure in aging mice and
humans
JOURNAL Redox Biol 47, 102128 (2021)
PUBMED 34562874
REMARK GeneRIF: TMBIM6 regulates redox-associated posttranslational
modifications of IRE1alpha and ER stress response failure in aging
mice and humans.
REFERENCE 4 (bases 1 to 2996)
AUTHORS Chang X, Zhang T, Meng Q, ShiyuanWang, Yan P, Wang X, Luo D, Zhou X
and Ji R.
TITLE Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by
Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum
Stress
JOURNAL Oxid Med Cell Longev 2021, 5529913 (2021)
PUBMED 33859776
REMARK GeneRIF: Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia
by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic
Reticulum Stress.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2996)
AUTHORS Han Q, Wang J, Luo H, Li L, Lu X, Liu A, Deng Y and Jiang Y.
TITLE TMBIM6, a potential virus target protein identified by integrated
multiomics data analysis in SARS-CoV-2-infected host cells
JOURNAL Aging (Albany NY) 13 (7), 9160-9185 (2021)
PUBMED 33744846
REMARK GeneRIF: TMBIM6, a potential virus target protein identified by
integrated multiomics data analysis in SARS-CoV-2-infected host
cells.
REFERENCE 6 (bases 1 to 2996)
AUTHORS Grzmil M, Thelen P, Hemmerlein B, Schweyer S, Voigt S, Mury D and
Burfeind P.
TITLE Bax inhibitor-1 is overexpressed in prostate cancer and its
specific down-regulation by RNA interference leads to cell death in
human prostate carcinoma cells
JOURNAL Am J Pathol 163 (2), 543-552 (2003)
PUBMED 12875974
REMARK GeneRIF: Results indicate that the human Bax inhibitor-1 gene may
serve as a prostate cancer expression marker based on its
overexpression in prostate carcinoma and prostate cancer cell
lines.
REFERENCE 7 (bases 1 to 2996)
AUTHORS Jean JC, Oakes SM and Joyce-Brady M.
TITLE The Bax inhibitor-1 gene is differentially regulated in adult
testis and developing lung by two alternative TATA-less promoters
JOURNAL Genomics 57 (2), 201-208 (1999)
PUBMED 10198159
REFERENCE 8 (bases 1 to 2996)
AUTHORS Cowling RT and Birnboim HC.
TITLE Preliminary characterization of the protein encoded by human
testis-enhanced gene transcript (TEGT)
JOURNAL Mol Membr Biol 15 (4), 177-187 (1998)
PUBMED 10087504
REFERENCE 9 (bases 1 to 2996)
AUTHORS Xu Q and Reed JC.
TITLE Bax inhibitor-1, a mammalian apoptosis suppressor identified by
functional screening in yeast
JOURNAL Mol Cell 1 (3), 337-346 (1998)
PUBMED 9660918
REFERENCE 10 (bases 1 to 2996)
AUTHORS Walter L, Marynen P, Szpirer J, Levan G and Gunther E.
TITLE Identification of a novel conserved human gene, TEGT
JOURNAL Genomics 28 (2), 301-304 (1995)
PUBMED 8530040
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC084037.35 and AC131157.4.
On Feb 21, 2023 this sequence version replaced XM_047429490.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR14038193.1538106.1,
SRR11853567.7018.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-55 AC084037.35 28819-28873
56-214 AC084037.35 29219-29377
215-300 AC084037.35 39726-39811
301-409 AC084037.35 40235-40343
410-530 AC084037.35 42897-43017
531-579 AC084037.35 45489-45537
580-677 AC084037.35 45645-45742
678-757 AC084037.35 45945-46024
758-858 AC084037.35 46483-46583
859-934 AC131157.4 3177-3252
935-2996 AC131157.4 4346-6407
FEATURES Location/Qualifiers
source 1..2996
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13.12"
gene 1..2996
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="transmembrane BAX inhibitor motif containing 6"
/db_xref="GeneID:7009"
/db_xref="HGNC:HGNC:11723"
/db_xref="MIM:600748"
exon 1..55
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
exon 56..214
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
misc_feature 179..181
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="upstream in-frame stop codon"
exon 215..300
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
CDS 245..958
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="isoform 1 is encoded by transcript variant 3; BAX
inhibitor 1; testis-enhanced gene transcript protein;
transmembrane BAX inhibitor motif-containing protein 6;
testis enhanced gene transcript"
/codon_start=1
/product="bax inhibitor 1 isoform 1"
/protein_id="NP_001401391.1"
/db_xref="GeneID:7009"
/db_xref="HGNC:HGNC:11723"
/db_xref="MIM:600748"
/translation="
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMGTAMIFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSLGNVFFGSIWLFQANLYVGLVVMCGFVLFDTQLIIEKAEHGDQDYIWHCIDLFLDFITVFRKLMMILAMNEKDKKKEKK"
misc_feature 290..928
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="BAX inhibitor (BI)-1; Region: BI-1; cd10430"
/db_xref="CDD:198412"
misc_feature 332..394
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="propagated from UniProtKB/Swiss-Prot (P55061.2);
transmembrane region"
misc_feature 401..463
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="propagated from UniProtKB/Swiss-Prot (P55061.2);
transmembrane region"
misc_feature 503..565
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="propagated from UniProtKB/Swiss-Prot (P55061.2);
transmembrane region"
misc_feature 581..643
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="propagated from UniProtKB/Swiss-Prot (P55061.2);
transmembrane region"
misc_feature 662..724
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="propagated from UniProtKB/Swiss-Prot (P55061.2);
transmembrane region"
misc_feature 743..805
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="propagated from UniProtKB/Swiss-Prot (P55061.2);
transmembrane region"
exon 301..409
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
exon 410..530
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
exon 531..579
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
exon 580..677
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
exon 678..757
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
exon 758..858
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
exon 859..934
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
exon 935..2996
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/inference="alignment:Splign:2.1.0"
regulatory 1049..1054
/regulatory_class="polyA_signal_sequence"
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="hexamer: AATGAA"
polyA_site 1067
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="major polyA site"
regulatory 2938..2943
/regulatory_class="polyA_signal_sequence"
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="hexamer: AATATA"
regulatory 2973..2978
/regulatory_class="polyA_signal_sequence"
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="hexamer: AATAAA"
polyA_site 2974
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="major polyA site"
polyA_site 2996
/gene="TMBIM6"
/gene_synonym="BAXI1; BI-1; TEGT"
/note="major polyA site"
ORIGIN
agagcacatccggtgttagaagcgctggtaggccttggagaggcgggttaggaagacgcagggccccttggcctagcttcgatcgttcgaattcagagcacgtccttccgaggtgaaggaacgcgaaactccacccatccgattgctgttcggctgcgggcgggtcctttggtcgggctgaccctgggtgagcggcccggagccaagactcgagagtggagactgctgcacggactctggaaccatgaacatatttgatcgaaagatcaactttgatgcgcttttaaaattttctcatataaccccgtcaacgcagcagcacctgaagaaggtctatgcaagttttgccctttgtatgtttgtggcggctgcaggggcctatgtccatatggtcactcatttcattcaggctggcctgctgtctgccttgggctccctgatattgatgatttggctgatggcaacacctcatagccatgaaactgaacagaaaagactgggacttcttgctggatttgcattccttacaggagttggcctgggccctgccctggagttttgtattgctgtcaaccccagcatccttcccactgctttcatgggcacggcaatgatctttacctgcttcaccctcagtgcactctatgccaggcgccgtagctacctctttctgggaggtatcttgatgtcagccctgagcttgttgcttttgtcttccctggggaatgttttctttggatccatttggcttttccaggcaaacctgtatgtgggactggtggtcatgtgtggcttcgtcctttttgatactcaactcattattgaaaaggccgaacatggagatcaagattatatctggcactgcattgatctcttcttagatttcattactgtcttcagaaaactcatgatgatcctggccatgaatgaaaaggataagaagaaagagaagaaatgaagtgaccatccagcctttcccaattagacttcctctccttccacccctcatttcctttttgcacacattacaggtggtgtgttctgtgataatgaaaagcatcagaaaagcttttgtactttgtggtttcctctattttgaattttttgatcaaaaaactgattagcagaatatagtttggagtttggcttcatcttcctggggttcccctcactcccttttttgtcaaccccatctgtagcctcttcctctactcaggcagtcgacccgccacgatgagaagtgggaccagcagagggcgccaacttcaggagtccgctttcccaccaggcttcattcacccagtggacctgaactgtttggtagagccacccggcccttccttcctcattgttgtttggtatgcgcacagttcctgtgggactgggccgtgagttttccattggaaagaagttcagtggtcccattgttaactcagcctcaaatctcaactgtcaggccctacaaagaaaatggagagcctcttctggtggatgctttgctccctctgagctgcccatgctggtctggcaaacacacctttctgctttgccttcacaaaagtaatgtgttccctttcccaccccttgcctgaccctcagggagtcagcctgcttccatccatgggtgggaagacttcagcacaaaggaaagactaattcttgtcaggcatttttgaaaaggctgattatgtgtatcaaggtacagcatcgtagggttcccctaaacttgccctgtttttgtttttttagtttgttatccccttactgagcggcctctactaggtggctgtgattaaatgtcccaagcaaggatagggaaggggaatggttgagcctctggagatcattgtaaccaatcctgccagacctgtttggggcagtggggagcaaacctagataaggacctgtttggggcagcagggagcaaaatctcctttaacaaccaagcagttcctcattcacatcaacagagcgaggctgtgataacttaggaggcagcaatcctaatagtccttcagtgcattttagtctgtctccaactggacaccagtaggtagtgtcaagccagagattcggggcagtagataaatgttcattttactgatgcactttagtttttggtctgttacctgttttccagaaatttgtggccttttaggcgggagttaggcgaccaaaccagtgagagccccaatccctgcagttttgtggcttcaagtgtgggtggacagtcctaatggggatctccagctccttcctgtgggctgccacagacagctacccccagaagggtcaatgttgggagtggttgtggctctgagctgctctacagagcttcagtgtgagaggatcgagccattgaaagctcattaccagtaggacataatttttggctctccctattcacaaccagtgcacagtttgacacagtggcctcaggttcacagtgcaccatgtcactgtgctatcctacgaaatcatttgtttctaagttgtgtttattcctggagtgacatgccaccccgaatggctcactttcactgaggatgctgtcctctgatttagctgctgcctccagcctctggcttgagaacttactaaaggcacttccttcctgttaaacccctgttaactctccataaatttggtgattctctgctaggcctaagattttgagttaacatctcttgaagccaaactccaccttctgtgctttttgcttgggataatggagtttttctttagaaacagtgccaagaatgacaagatattaaaaaaaaaaaagaaagaaaaaaaaaaaaacacctacttttaaagaaaatacctaacagatttttaatatagttatctctaccactttcttttctagtttcttgattttcagctcaggctgcattctaactcatactgtgaagacaaaggtgtttttgattcagaaatatatgaaatctgcatagtcttaatttgtaaaaaataaagaaaattccttaaccttt
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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