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Previous release (v1)
2025-06-09 01:57:53, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_001413462 3012 bp mRNA linear PRI 07-MAY-2024
DEFINITION Homo sapiens cryptochrome circadian regulator 1 (CRY1), transcript
variant 6, mRNA.
ACCESSION NM_001413462
VERSION NM_001413462.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3012)
AUTHORS Ma,J., Chen,S., Liu,J., Liao,Y., Li,L., Wang,C.C., Song,S.,
Feng,R., Hu,H. and Quan,S.
TITLE Cryptochrome 1 regulates ovarian granulosa cell senescence through
NCOA4-mediated ferritinophagy
JOURNAL Free Radic Biol Med 217, 1-14 (2024)
PUBMED 38522484
REMARK GeneRIF: Cryptochrome 1 regulates ovarian granulosa cell senescence
through NCOA4-mediated ferritinophagy.
REFERENCE 2 (bases 1 to 3012)
AUTHORS Chiou,Y.Y., Lee,C.Y., Yang,H.W., Cheng,W.C. and Ji,K.D.
TITLE Circadian modulation of glucose utilization via CRY1-mediated
repression of Pdk1 expression
JOURNAL J Biol Chem 300 (2), 105637 (2024)
PUBMED 38199564
REMARK GeneRIF: Circadian modulation of glucose utilization via
CRY1-mediated repression of Pdk1 expression.
REFERENCE 3 (bases 1 to 3012)
AUTHORS Liu,D., Xie,Z., Gu,P., Li,X., Zhang,Y., Wang,X., Chen,Z., Deng,S.,
Shu,Y. and Li,J.D.
TITLE Cry1Delta11 mutation induces ADHD-like symptoms through hyperactive
dopamine D1 receptor signaling
JOURNAL JCI Insight 8 (16), e170434 (2023)
PUBMED 37606043
REMARK GeneRIF: Cry1Delta11 mutation induces ADHD-like symptoms through
hyperactive dopamine D1 receptor signaling.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3012)
AUTHORS Sancar,A.
TITLE Regulation of the mammalian circadian clock by cryptochrome
JOURNAL J Biol Chem 279 (33), 34079-34082 (2004)
PUBMED 15123698
REMARK Review article
REFERENCE 5 (bases 1 to 3012)
AUTHORS van der Horst,G.T., Muijtjens,M., Kobayashi,K., Takano,R.,
Kanno,S., Takao,M., de Wit,J., Verkerk,A., Eker,A.P., van
Leenen,D., Buijs,R., Bootsma,D., Hoeijmakers,J.H. and Yasui,A.
TITLE Mammalian Cry1 and Cry2 are essential for maintenance of circadian
rhythms
JOURNAL Nature 398 (6728), 627-630 (1999)
PUBMED 10217146
REFERENCE 6 (bases 1 to 3012)
AUTHORS Kobayashi,K., Kanno,S., Smit,B., van der Horst,G.T., Takao,M. and
Yasui,A.
TITLE Characterization of photolyase/blue-light receptor homologs in
mouse and human cells
JOURNAL Nucleic Acids Res 26 (22), 5086-5092 (1998)
PUBMED 9801304
REFERENCE 7 (bases 1 to 3012)
AUTHORS Zhao,S. and Sancar,A.
TITLE Human blue-light photoreceptor hCRY2 specifically interacts with
protein serine/threonine phosphatase 5 and modulates its activity
JOURNAL Photochem Photobiol 66 (5), 727-731 (1997)
PUBMED 9383998
REFERENCE 8 (bases 1 to 3012)
AUTHORS Hsu,D.S., Zhao,X., Zhao,S., Kazantsev,A., Wang,R.P., Todo,T.,
Wei,Y.F. and Sancar,A.
TITLE Putative human blue-light photoreceptors hCRY1 and hCRY2 are
flavoproteins
JOURNAL Biochemistry 35 (44), 13871-13877 (1996)
PUBMED 8909283
REFERENCE 9 (bases 1 to 3012)
AUTHORS van der Spek,P.J., Kobayashi,K., Bootsma,D., Takao,M., Eker,A.P.
and Yasui,A.
TITLE Cloning, tissue expression, and mapping of a human photolyase
homolog with similarity to plant blue-light receptors
JOURNAL Genomics 37 (2), 177-182 (1996)
PUBMED 8921389
REFERENCE 10 (bases 1 to 3012)
AUTHORS Todo,T., Ryo,H., Yamamoto,K., Toh,H., Inui,T., Ayaki,H., Nomura,T.
and Ikenaga,M.
TITLE Similarity among the Drosophila (6-4)photolyase, a human photolyase
homolog, and the DNA photolyase-blue-light photoreceptor family
JOURNAL Science 272 (5258), 109-112 (1996)
PUBMED 8600518
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC078929.27 and AC007541.9.
Summary: This gene encodes a flavin adenine dinucleotide-binding
protein that is a key component of the circadian core oscillator
complex, which regulates the circadian clock. This gene is
upregulated by CLOCK/ARNTL heterodimers but then represses this
upregulation in a feedback loop using PER/CRY heterodimers to
interact with CLOCK/ARNTL. Polymorphisms in this gene have been
associated with altered sleep patterns. The encoded protein is
widely conserved across plants and animals. Loss of the related
gene in mouse results in a shortened circadian cycle in complete
darkness. [provided by RefSeq, Jan 2014].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR14038192.490822.1,
SRR14038194.1495236.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1968968
[ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-746 AC078929.27 85171-85916
747-855 AC007541.9 50627-50735
856-998 AC007541.9 67571-67713
999-1183 AC007541.9 70871-71055
1184-1272 AC007541.9 71451-71539
1273-1413 AC007541.9 72737-72877
1414-1725 AC007541.9 72957-73268
1726-1877 AC007541.9 74753-74904
1878-2080 AC007541.9 75129-75331
2081-2173 AC007541.9 75433-75525
2174-2245 AC007541.9 79783-79854
2246-2349 AC007541.9 79929-80032
2350-3012 AC007541.9 80793-81455
FEATURES Location/Qualifiers
source 1..3012
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q23.3"
gene 1..3012
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="cryptochrome circadian regulator 1"
/db_xref="GeneID:1407"
/db_xref="HGNC:HGNC:2384"
/db_xref="MIM:601933"
exon 1..746
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
misc_feature 532..534
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="upstream in-frame stop codon"
CDS 589..2349
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="isoform d is encoded by transcript variant 6;
cryptochrome-1; cryptochrome 1 (photolyase-like);
cryptochrome circadian clock 1"
/codon_start=1
/product="cryptochrome-1 isoform d"
/protein_id="NP_001400391.1"
/db_xref="GeneID:1407"
/db_xref="HGNC:HGNC:2384"
/db_xref="MIM:601933"
/translation="
MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKIIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEELGFDTDGLSSAVWPGGETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGLLASVPSNPNGNGGFMGYSAENIPGCSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGTGLSGGKRPSQEEDTQSIGPKVQRQSTN"
misc_feature 601..2049
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="Deoxyribodipyrimidine photolyase [Replication,
recombination and repair]; Region: PhrB; COG0415"
/db_xref="CDD:440184"
misc_feature 736..750
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 1. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 799..801
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="Phosphoserine, by AMPK.
/evidence=ECO:0000250|UniProtKB:P97784; propagated from
UniProtKB/Swiss-Prot (Q16526.1); phosphorylation site"
misc_feature 832..849
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 2. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1039..1056
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 3. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1327..1329
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="Phosphoserine, by MAPK.
/evidence=ECO:0000250|UniProtKB:P97784; propagated from
UniProtKB/Swiss-Prot (Q16526.1); phosphorylation site"
misc_feature 1351..1368
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 4. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1399..1416
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 5. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1426..1428
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="Phosphoserine, by AMPK.
/evidence=ECO:0000250|UniProtKB:P97784; propagated from
UniProtKB/Swiss-Prot (Q16526.1); phosphorylation site"
misc_feature 1441..1458
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 6. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1591..1605
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 7. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1699..1998
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: Required for inhibition of CLOCK-BMAL1-mediated
transcription. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1723..1740
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 8. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1771..1788
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 9. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1819..1836
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 10. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1876..1893
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 11. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 1999..2067
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: Interaction with TIMELESS.
/evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 2044..2061
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 12. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 2062..2079
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: LIR 13. /evidence=ECO:0000250|UniProtKB:P97784"
misc_feature 2242..2346
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="propagated from UniProtKB/Swiss-Prot (Q16526.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2290..2292
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P97784; propagated from
UniProtKB/Swiss-Prot (Q16526.1); phosphorylation site"
exon 747..855
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 856..998
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 999..1183
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 1184..1272
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 1273..1413
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 1414..1725
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 1726..1877
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 1878..2080
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 2081..2173
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 2174..2245
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 2246..2349
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
exon 2350..3012
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/inference="alignment:Splign:2.1.0"
regulatory 2989..2994
/regulatory_class="polyA_signal_sequence"
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="hexamer: ATTAAA"
polyA_site 3012
/gene="CRY1"
/gene_synonym="DSPD; PHLL1"
/note="major polyA site"
ORIGIN
agagtcacccgggcagcctcgggaccggtcaccggccggcaaccgtccagcggcctcgaccaccgcctctagcctccgttcccggtcctttctcccgggccgagagacagcgtcgccgacaggggctcattcccctccggttctcctcggtgactcacctcgggcgggccgttttgtctttaggggccgccttggtggggcgaggtttccgtgacgaatctcctggggccgtccgtgccggctcgggccgtcgtggcggctcgagctcctggaacttgctcaggctccggaggtccgaggccctcgaagttatgcgtcgcctccaggcggttgcggcgggcgcgggctcctaaagggcgtcacacccggactccgccgactaggcaacctccattcatctttccactgcgcctccggcgcccccgccttctccggtcccctcctcggagtcattttttcctgttccccctctgccgccctttcctcacgccccgggtgaggcaattctcttggaagcgaaggtgtcggctatgagccggagcctccttccttgaatttctccgtggaggacccgccgcgccccccggcatgggggtgaacgccgtgcactggttccgaaaggggctccggctccacgacaaccccgccctgaaggagtgcattcagggcgccgacaccatccgctgcgtctacatcctggacccctggttcgccggctcctccaatgtgggcatcaacaggtggcgatttttgcttcagtgtcttgaggatcttgatgccaatctacgaaaattaaactcccgtctgtttgtgattcgtggacaaccagcagatgtgtttcccaggcttttcaaggaatggaacattactaaactttcaattgagtatgattctgagccctttggaaaggaacgagacgcagctattaagaaactggcaactgaagctggagtagaagtcattgtaagaatttcacatacattatatgacctagacaagatcatagaactcaatggtggacaaccgcctctaacttataaaagattccagactctcatcagcaaaatggaaccactagagataccagtagagacaattacttcagaagtgatagaaaagtgcacaactcctctgtctgatgaccatgatgagaaatatggagtcccttcactggaagagctaggttttgatacagatggcttatcctctgcagtgtggccaggtggagaaactgaagcacttactcgtttggaaaggcatttggaaagaaaagcttgggtggcaaattttgaaagacctcgaatgaatgcgaattctctgcttgcaagccctactggacttagtccttatctccgatttggttgtttgtcatgtcgactgttttacttcaaactaacagatctctacaaaaaggtaaagaagaacagttcccctcccctttccctttatgggcaactgttatggcgtgaatttttctatacagcagcaacaaataatccacgctttgataaaatggaaggaaaccctatctgtgttcagattccttgggataaaaatcctgaggctttagccaaatgggcggaaggccggacaggctttccatggattgatgccatcatgacacagcttcgtcaggagggttggattcatcatctagccaggcatgcagttgcttgcttcctgacacgaggggacctgtggattagttgggaagaaggaatgaaggtatttgaagaattattgcttgatgcagattggagcataaatgctggaagttggatgtggctgtcttgtagttccttttttcaacagttttttcactgctattgccctgttggttttggtaggagaacagatcccaatggagactatatcaggcgttatttgcctgtcctaagaggcttccctgcaaaatatatctatgatccctggaatgcaccagaaggtatccaaaaggtagccaaatgtttgataggagttaattatcctaaaccaatggtgaaccatgctgaggcaagccgtttgaatatcgaaaggatgaaacagatctatcagcagctttcacgatatagaggactaggtcttctggcatcagtaccttctaatcctaatgggaatggaggcttcatgggatattctgcagaaaatatcccaggttgtagcagcagtggaagttgctctcaagggagtggtattttacactatgctcatggcgacagtcagcaaactcacctgttgaagcaaggaagaagctccatgggcactggtctcagtggtgggaaacgtcctagtcaggaagaggacacacagagtattggtcctaaagtccagagacagagcactaattagtttttttttcccccttaaatcacagaaaacattcaggaggaatactgttgcagctgaaattggtggggagttcaatacttttcaattaagttatttaaaaatattcttcattgatggaaagcagttacatattgaaatatgttgtttctaatgacatttctgtggtttttaactttttaatgaatttcacagaggacaattggtaatttgtatataaagaacttggcaagagaatttgcttaatgtaaatataaacagtcacaattagtatagacccatcgatatatttttgataatttttcatgtatggtaaagttaaaatgacaaattgatattctgatataaaactcaaagttttgaagtcagtgggaaaaaaggaggtttttagactttcttaaaagacgttaaaattttaggacagaattttcttgatgttgtttgatctaactttgcactctttgataataatgttttagataatgtgcgtaatccaaattggtattgtagcctctgttaacacagacagtatatgttttaaactttgatgtaaacctttttagacccaaacttgtggaagtatcatgtgttaagttctctgtctctgtttctttgttcatttattactaaaatgaacttgttattaaagtatatgcaaatatgaaa
//
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@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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