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Previous release (v1)
2024-05-03 20:27:13, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001410908 7582 bp mRNA linear PRI 01-JAN-2023
DEFINITION Homo sapiens lysine methyltransferase 2E (inactive) (KMT2E),
transcript variant 3, mRNA.
ACCESSION NM_001410908 XM_047420611
VERSION NM_001410908.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7582)
AUTHORS Pereira-Martins DA, Weinhauser I, Coelho-Silva JL, Franca-Neto PL,
Almeida LY, Bianco TM, Silva CL, Franca RF, Traina F, Rego EM,
Schuringa JJ and Lucena-Araujo AR.
TITLE MLL5 improves ATRA driven differentiation and promotes
xenotransplant engraftment in acute promyelocytic leukemia model
JOURNAL Cell Death Dis 12 (4), 371 (2021)
PUBMED 33824267
REMARK GeneRIF: MLL5 improves ATRA driven differentiation and promotes
xenotransplant engraftment in acute promyelocytic leukemia model.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7582)
AUTHORS Sharawat IK, Panda PK and Dawman L.
TITLE Clinical Characteristics and Genotype-Phenotype Correlation in
Children with KMT2E Gene-Related Neurodevelopmental Disorders:
Report of Two New Cases and Review of Published Literature
JOURNAL Neuropediatrics 52 (2), 98-104 (2021)
PUBMED 33111303
REMARK GeneRIF: Clinical Characteristics and Genotype-Phenotype
Correlation in Children with KMT2E Gene-Related Neurodevelopmental
Disorders: Report of Two New Cases and Review of Published
Literature.
Review article
REFERENCE 3 (bases 1 to 7582)
AUTHORS Conforti R, Iovine S, Santangelo G, Capasso R, Cirillo M, Fratta M
and Caranci F.
TITLE ODLURO syndrome: personal experience and review of the literature
JOURNAL Radiol Med 126 (2), 316-322 (2021)
PUBMED 32691224
REMARK GeneRIF: ODLURO syndrome: personal experience and review of the
literature.
Review article
REFERENCE 4 (bases 1 to 7582)
AUTHORS Lee KH, Kim BC, Jeong CW, Ku JH, Kim HH and Kwak C.
TITLE MLL5, a histone modifying enzyme, regulates androgen receptor
activity in prostate cancer cells by recruiting co-regulators, HCF1
and SET1
JOURNAL BMB Rep 53 (12), 634-639 (2020)
PUBMED 33050986
REMARK GeneRIF: MLL5, a histone modifying enzyme, regulates androgen
receptor activity in prostate cancer cells by recruiting
co-regulators, HCF1 and SET1.
REFERENCE 5 (bases 1 to 7582)
AUTHORS O'Donnell-Luria AH, Pais LS, Faundes V, Wood JC, Sveden A, Luria V,
Abou Jamra R, Accogli A, Amburgey K, Anderlid BM, Azzarello-Burri
S, Basinger AA, Bianchini C, Bird LM, Buchert R, Carre W, Ceulemans
S, Charles P, Cox H, Culliton L, Curro A, Demurger F, Dowling JJ,
Duban-Bedu B, Dubourg C, Eiset SE, Escobar LF, Ferrarini A, Haack
TB, Hashim M, Heide S, Helbig KL, Helbig I, Heredia R, Heron D,
Isidor B, Jonasson AR, Joset P, Keren B, Kok F, Kroes HY,
Lavillaureix A, Lu X, Maas SM, Maegawa GHB, Marcelis CLM, Mark PR,
Masruha MR, McLaughlin HM, McWalter K, Melchinger EU,
Mercimek-Andrews S, Nava C, Pendziwiat M, Person R, Ramelli GP,
Ramos LLP, Rauch A, Reavey C, Renieri A, Riess A, Sanchez-Valle A,
Sattar S, Saunders C, Schwarz N, Smol T, Srour M, Steindl K, Syrbe
S, Taylor JC, Telegrafi A, Thiffault I, Trauner DA, van der Linden
H Jr, van Koningsbruggen S, Villard L, Vogel I, Vogt J, Weber YG,
Wentzensen IM, Widjaja E, Zak J, Baxter S, Banka S and Rodan LH.
CONSRTM Deciphering Developmental Disorders (DDD) Study
TITLE Heterozygous Variants in KMT2E Cause a Spectrum of
Neurodevelopmental Disorders and Epilepsy
JOURNAL Am J Hum Genet 104 (6), 1210-1222 (2019)
PUBMED 31079897
REMARK GeneRIF: Heterozygous Variants in KMT2E Cause a Spectrum of
Neurodevelopmental Disorders and Epilepsy.
REFERENCE 6 (bases 1 to 7582)
AUTHORS Sun XJ, Xu PF, Zhou T, Hu M, Fu CT, Zhang Y, Jin Y, Chen Y, Chen
SJ, Huang QH, Liu TX and Chen Z.
TITLE Genome-wide survey and developmental expression mapping of
zebrafish SET domain-containing genes
JOURNAL PLoS One 3 (1), e1499 (2008)
PUBMED 18231586
REMARK GeneRIF: MLL5 protein has been classified into a distinct subfamily
with SETD5, because its SET domain and domain architecture show
high homology with SETD5 rather than the members in MLL subfamily
(i.e. MLL, MLL2, MLL3 and MLL4)
Publication Status: Online-Only
REFERENCE 7 (bases 1 to 7582)
AUTHORS Cheng F, Liu J, Zhou SH, Wang XN, Chew JF and Deng LW.
TITLE RNA interference against mixed lineage leukemia 5 resulted in cell
cycle arrest
JOURNAL Int J Biochem Cell Biol 40 (11), 2472-2481 (2008)
PUBMED 18573682
REMARK GeneRIF: These findings provide evidence that MLL5 might be an
important cell cycle regulator, participating in cell cycle
regulatory network machinery at multiple cell cycle stages.
REFERENCE 8 (bases 1 to 7582)
AUTHORS Deng LW, Chiu I and Strominger JL.
TITLE MLL 5 protein forms intranuclear foci, and overexpression inhibits
cell cycle progression
JOURNAL Proc Natl Acad Sci U S A 101 (3), 757-762 (2004)
PUBMED 14718661
REMARK GeneRIF: MLL5 forms intranuclear protein complexes that may play an
important role in chromatin remodeling and cellular growth
suppression.
REFERENCE 9 (bases 1 to 7582)
AUTHORS Emerling BM, Bonifas J, Kratz CP, Donovan S, Taylor BR, Green ED,
Le Beau MM and Shannon KM.
TITLE MLL5, a homolog of Drosophila trithorax located within a segment of
chromosome band 7q22 implicated in myeloid leukemia
JOURNAL Oncogene 21 (31), 4849-4854 (2002)
PUBMED 12101424
REMARK GeneRIF: MLL5 is a homolog of Drosophila trithorax located within a
segment of chromosome band 7q22 implicated in myeloid leukemia.
REFERENCE 10 (bases 1 to 7582)
AUTHORS Johnson E and Cotter FE.
TITLE Monosomy 7 and 7q--associated with myeloid malignancy
JOURNAL Blood Rev 11 (1), 46-55 (1997)
PUBMED 9218106
REMARK Review article
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC007384.3, AC005065.1 and
AC005070.1.
On Aug 17, 2022 this sequence version replaced XM_047420611.1.
Summary: This gene is a member of the myeloid/lymphoid or
mixed-lineage leukemia (MLL) family and encodes a protein with an
N-terminal PHD zinc finger and a central SET domain. Overexpression
of the protein inhibits cell cycle progression. Alternate
transcriptional splice variants have been characterized. [provided
by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803614.226661.1,
SRR1660809.134811.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1968968
[ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-331 AC007384.3 167714-168044
332-516 AC005065.1 23706-23890
517-631 AC005065.1 45031-45145
632-861 AC005065.1 46218-46447
862-942 AC005065.1 49594-49674
943-1001 AC005065.1 56486-56544
1002-1174 AC005065.1 57510-57682
1175-1213 AC005065.1 58910-58948
1214-1444 AC005065.1 59830-60060
1445-1575 AC005065.1 60170-60300
1576-1693 AC005065.1 61713-61830
1694-1803 AC005065.1 64555-64664
1804-2068 AC005065.1 72876-73140
2069-2167 AC005065.1 74083-74181
2168-2332 AC005070.1 564-728
2333-2641 AC005070.1 1025-1333
2642-2896 AC005070.1 4578-4832
2897-3041 AC005070.1 4998-5142
3042-3292 AC005070.1 5661-5911
3293-3349 AC005070.1 6305-6361
3350-3913 AC005070.1 6501-7064
3914-4200 AC005070.1 8081-8367
4201-4289 AC005070.1 9419-9507
4290-4387 AC005070.1 9910-10007
4388-7582 AC005070.1 10964-14158
FEATURES Location/Qualifiers
source 1..7582
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22.3"
gene 1..7582
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="lysine methyltransferase 2E (inactive)"
/db_xref="GeneID:55904"
/db_xref="HGNC:HGNC:18541"
/db_xref="MIM:608444"
exon 1..331
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 332..516
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
misc_feature 419..421
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="upstream in-frame stop codon"
CDS 446..5896
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/EC_number="2.1.1.354"
/note="isoform b is encoded by transcript variant 3;
histone-lysine N-methyltransferase MLL5; myeloid/lymphoid
or mixed-lineage leukemia protein 5; myeloid/lymphoid or
mixed-lineage leukemia 5 (trithorax homolog, Drosophila);
histone-lysine N-methyltransferase 2E; lysine (K)-specific
methyltransferase 2E; inactive lysine N-methyltransferase
2E; inactive histone-lysine N-methyltransferase 2E"
/codon_start=1
/product="inactive histone-lysine N-methyltransferase 2E
isoform b"
/protein_id="NP_001397837.1"
/db_xref="CCDS:CCDS94170.1"
/db_xref="GeneID:55904"
/db_xref="HGNC:HGNC:18541"
/db_xref="MIM:608444"
/translation="
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRKRENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREAQRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMENINSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNNQEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPALNKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTHTDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPVSDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDNLIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH"
misc_feature 803..934
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="PHD finger found in mixed lineage leukemia 5
(MLL5); Region: PHD_MLL5; cd15550"
/db_xref="CDD:277025"
misc_feature order(827..829,833..847,851..853,866..868,905..919)
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="histone H3 binding site [polypeptide binding];
other site"
/db_xref="CDD:277025"
misc_feature 1412..1798
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="SET domain found in inactive histone-lysine
N-methyltransferase 2E (KMT2E) and similar proteins;
Region: SET_KMT2E; cd19182"
/db_xref="CDD:380959"
misc_feature order(1463..1468,1517..1519,1547..1549,1577..1600,
1658..1672,1694..1696,1742..1744,1775..1795)
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="putative active site [active]"
/db_xref="CDD:380959"
misc_feature order(1463..1468,1577..1588,1658..1672,1781..1783)
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="putative SAM binding site; other site"
/db_xref="CDD:380959"
misc_feature <2126..>2452
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="Trichohyalin-plectin-homology domain; Region: TPH;
pfam13868"
/db_xref="CDD:433539"
misc_feature <4199..>4825
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="104 kDa microneme/rhoptry antigen; Provisional;
Region: PTZ00449"
/db_xref="CDD:185628"
misc_feature <4706..>5806
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="ARC105 or Med15 subunit of Mediator complex
non-fungal; Region: Med15; pfam09606"
/db_xref="CDD:312941"
misc_feature 5501..5737
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="AAA family ATPase Pro-rich N-terminal domain;
Region: Pro-rich_NTERM; NF040555"
/db_xref="CDD:439756"
exon 517..631
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 632..861
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 862..942
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 943..1001
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 1002..1174
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 1175..1213
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 1214..1444
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 1445..1575
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 1576..1693
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 1694..1803
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 1804..2068
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 2069..2167
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 2168..2332
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 2333..2641
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 2642..2896
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 2897..3041
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 3042..3292
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 3293..3349
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 3350..3913
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 3914..4200
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 4201..4289
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 4290..4387
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
exon 4388..7582
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/inference="alignment:Splign:2.1.0"
regulatory 6623..6628
/regulatory_class="polyA_signal_sequence"
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="hexamer: AATAAA"
polyA_site 6648
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="major polyA site"
regulatory 7561..7566
/regulatory_class="polyA_signal_sequence"
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
/note="hexamer: AATAAA"
polyA_site 7582
/gene="KMT2E"
/gene_synonym="HDCMC04P; MLL5; NKp44L; ODLURO; SETD5B"
ORIGIN
agagcgagaggcagtgacactgagcgggcgcagggggccgagtcggagaccgtgccggagttcgggagcggcaacagagtgggcatagacactccgagcagcctcgccgtcgtctctgcgttcctgttgactgcctggctgccccctcccctactcctcggttcctggtgaagaggctgcgcgctgctgtttggggagggggtgtgtggagccgggtcctgtgtccgcagtggctgctgtcggggggtcgcctgttcgcggaggtgcggagagactccttgggggtcgagcacataacggggttcgggtgtctcgtgtgtgaacatcacagggtttgtggatgcacttagatgtttgcaatgagcactgtggctggcatgccccagtgttttggataccaatgcataggactccatagtaatcgaatttaccagaggcgaacgtcatgagcatagtgatcccattgggggttgatacagcagagacgtcatacttggaaatggctgcaggttcagaaccagaatccgtagaagctagccctgtggtagttgagaaatccaacagttatccccaccagttatataccagcagctcacatcattcacacagttacattggtttgccctatgcggaccataattatggtgctcgtcctcctccgacacctccggcttcccctcctccatcagtccttattagcaaaaatgaagtaggcatatttaccactcctaattttgatgaaacttccagtgctactacaatcagcacatctgaggatggaagttatggtactgatgtaaccaggtgcatatgtggttttacacatgatgatggatacatgatctgttgtgacaaatgcagcgtttggcaacatattgactgcatggggattgataggcagcatattcctgatacatatctatgtgaacgttgtcagcctaggaatttggataaagagagggcagtgctactacaacgccggaaaagggaaaatatgtcagatggtgataccagtgcaactgagagtggtgatgaggttcctgtggaattatatactgcatttcagcatactccaacatcaattactttaactgcttcaagagtttccaaagttaatgataaaagaaggaaaaaaagcggggagaaagaacaacacatttcaaaatgtaaaaaggcatttcgtgaaggatctaggaagtcatcaagagttaagggttcagctccagagattgatccttcatctgatggttcaaattttggatgggagacaaagatcaaagcatggatggatcgatatgaagaagcaaataacaaccagtacagtgagggtgttcagagggaggcacaaagaatagctctgagattaggcaatggaaatgacaaaaaagagatgaataaatccgatttgaataccaacaatttgctcttcaaacctcctgtagagagccatatacaaaagaataagaaaattcttaaatctgcaaaagatttgcctcctgatgcacttatcattgaatacagagggaagtttatgctgagagaacagtttgaagcaaatgggtatttctttaaaagaccatacccttttgtgttattctactctaaatttcatgggctagaaatgtgtgttgatgcaaggacttttgggaatgaggctcgattcatcaggcggtcttgtacacccaatgcagaggtgaggcatgaaattcaagatggaaccatacatctttatatttattctatacacagtattccaaagggaactgaaattactattgcctttgattttgactatggaaattgtaagtacaaggtggactgtgcatgcctcaaagaaaacccagagtgccctgttctaaaacgtagttctgaatccatggaaaatatcaatagtggttatgagaccagacggaaaaaaggaaaaaaagacaaagatatttcaaaagaaaaagatacacaaaatcagaatattactttggattgtgaaggaacgaccaacaaaatgaagagcccagaaactaaacaaagaaagctttctccactgagactatcagtatcaaataatcaggaaccagattttattgatgatatagaagaaaaaactcctattagtaatgaagtagaaatggaatcagaggagcagattgcagaaaggaaaaggaagatgacaagagaagaaagaaaaatggaagcaattttgcaagcttttgccagacttgaaaagagagagaaaagaagagaacaagctttggaaaggatcagcacagccaaaactgaagttaaaactgaatgtaaagatacacagattgtcagtgatgctgaagttattcaggaacaagcaaaagaagaaaatgctagcaagccaacccctgccaaagtaaatagaactaaacagagaaaaagtttttctcggagtaggactcacattggacagcagcgtcggagacacagaactgtcagcatgtgttcagatatccagccatcttctcctgatatagaagttacttcacaacaaaatgatattgaaaatactgtacttacaatagaaccagaaactgaaactgcactagcagaaataattactgaaactgaagttccagcacttaataaatgtcctaccaagtaccccaaaacaaagaagcacttggttaatgaatggttaagtgagaagaatgagaagacaggaaaaccttcagatggcctttcagaaaggcctctacgcataactacagatcctgaagtgttagctacacaactcaattctttaccaggtctcacttacagcccccatgtatactccactcctaagcattatattagatttacttcaccattcctttcagaaaaaaggagaagaaaagaacctactgaaaacatttctggttcatgcaagaagcgatggttgaaacaagctctggaagaagaaaattcagcaattttacatagatttaattcaccctgtcaagaaagatccagaagtcctgcagtcaatggtgaaaataaaagtccactactattaaatgacagctgttcccttccagatttaactacaccactaaaaaaacgaagattttatcagttgctagattcggtttactcagaaacctccacacctactccttccccgtatgctacaccaactcacaccgatattactcctatggacccatcttttgccacgcctccacggataaaatcagatgatgaaacttgtagaaatggttataaacccatatattcaccagttaccccagtaactcctggtacaccaggaaataccatgcactttgagaatatttcttccccagaaagttctccagaaataaagagacgcacttatagtcaagagggatatgacagatcttcaaccatgttaacattggggccttttagaaattctaatttaactgaactgggtctgcaagaaataaagactattggttatacgagccctaggagtaggactgaagtcaacaggcagtgtcctggagaaaaggaacctgtgtcagaccttcagctaggactcgatgcagttgagccaactgccctacataaaaccctggaaacgcctgcacatgacagggctgagcccaacagccaactggactcgactcactctggacggggcacaatgtattcttcctgggtaaagagccctgacagaacaggagttaacttctcagtgaactccaacttgagggacctgacaccctcgcatcagttggaggttggaggaggcttccgaataagtgagtcaaagtgcctgatgcaggatgatactagaggcatgtttatggaaacaactgtgttttgtacttccgaagatgggcttgtatctggtttcggacggactgttaatgacaatttgatcgacgggaattgcacaccccagaatccaccacaaaagaaaaaggtttctctattagaataccgtaagagacaacgtgaagctaggaaaagtggctctaagacagagaactttccactcattagtgtatcaccccatgcaagtggaagcttgagcaacaatggtgatggctgtgccagcagtaatgacaatggggagcaggtggaccacactgctagcctacctttaccaacaccagctacagtttataatgccacttctgaagaaactagcaataactgccctgttaaggatgctactgctagtgagaagaatgaaccagaagttcaatggactgcctcaacttcagtggaacaagtcagagaaaggagttatcagagagctttacttctcagtgatcaccgaaaagataaagatagtgaccctgatcctgaaaatccagaacccacaactacgaatgaatgtccatccccagatacttctcaaaatacttgtaaaagtcctccaaaaatgagcaagcctggttcacctggatctgtaattcctgctcaagcacacgggaaaatattcacaaaaccagatccccaatgggactccacagttagtgcatccgaagctgaaaatggtgttcacctaaaaacagagctccaacaaaaacagctatcaaataacaaccaagcactttcaaagaatcatcctcctcagacacacgttcgtaattcatctgagcaactttcacaaaagctgccttctgtgccaacaaagttgcactgtcctccatcacctcacctagaaaatcctccaaagtcatccacgcctcacacacctgtacagcatggttatctttcaccaaagcctccttcacagcagttaggatctccctacaggcctcatcattcacagtcacctcaagttggaacacctcagcgagagcctcaaagaaacttttatccagcagcacagaaccttccagccaatactcagcaggcaacttctggaacattatttacacagacaccctcaggacaatcttcagcaacatacagtcagtttaaccaacaaagtctgaacagcacggcaccaccccctccacctcctccacctccttcttcgtcttactatcaaaaccagcagccctctgcaaactttcagaattataatcagctcaaaggtagtctttctcaacaaactgtgtttacatcaggaccaaatcaagcacttcctggcaccacaagccagcaaacagttccaggacaccacgtgactccagggcattttttgccctctcagaaccctaccattcaccatcaaactgctgctgccgtagtcccccctcctcctccaccaccacctgctccaggaccgcaccttgtacaacagccgaattcccatcagcaacactctgtagcacatgtagtagggcctgttcatgcggtcacccctgggtcgcatattcattctcaaactgctggacaccacttacccccacccccaccccctcctggtcctgcccctcatcaccatccaccaccccatccatccacaggactccaaggtctacaagcacaacaccagcatgttgtaaattcagcacccccaccaccccctccgccgccaccttccagtgttttggcttctgggcatcataccacatcagctcaagccttacaccacccacctcatcaaggacctccactttttccttcgagtgctcatccaactgtaccaccgtatccctcacaagctacacatcataccactttgggaccgggaccccagcaccagccttctggaacagggccacattgtccattacctgtcacaggtcctcatctccagccccaaggaccaaacagtattccaacacctactgcttcagggttctgtcctcatcctggctctgtggccctgccacatggggttcaaggacctcagcaggcatctccagtgcctggacagattccaattcacagagcacaggtgccaccaacatttcaaaacaattaccatgggtcagggtggcattaaaatggactccaaaaacatttttttaaatgttctgtaagataaactgtatatttcatatgtacctgttaaggtactttttaaagcttgtacatgaacctttgtataaaaaacaccagtgctctttcgttgtatttttctcatttttgctttttaaaattcctttaaaaaatgtgctgttaagccagtattaggtatctttattttgtaagtgaacattccagctgtttttttctggcagatctgatgctgatttgatgctgtatgatcttttttttttttttagttaaattcatttagtgaatgttctattattttatacatacacattaagtactcagctaagtaatggcactatgaggattttttttttctttcctgtcagcagcagttctgtgaatgcatcttaggtataaaaatgcaatacagatttttatattttggtgtggacatggctcattttgttttaccagttatttgcaagcaaaatgtaatttaatgtatagatgatttctaatgtctcctgacaaactgtaaatactgcatttcttttgcgtatataattgcttacagcttttctcatttgatatatagcattgtacatatgacaagtcttttgcaaaactgtgtgatctttgtgaaagtagtacagtatatgacctttaatttcttttttattttaaatatactgtcacactgaagcactggttgggcattttaattcatgttaataaatcacaattatgtcagttttaccagattgtcctgtacaacttctaagatcgggatctgtgtgtttctacagaagttctagttttcaaatatagattgtaaggagccttcaattttctttagcgactactacctcagcaacaggaggcagcaaggggctgttcctgtggtggtttctgtttgcatttttgcaggagccataggaaactactgaaatgattgtgctgggtaaattaaggatctggcatcatacaaaatgaagccagaccactaatgcattacagtagttcttgaatacaaggtacaacaactgtttgaaaatatgggtagtttgcccaaaacaggaaaatttgtcttgggtgtaaaaactaaagaaaaaaggcattattcctagatctctcagtgaaatgaaaatggcctcttaagtgaacgtttttattgctaaaatataaaatgctagttagttattaattattaatcttcaaaaaattaaaaatttcccagcctttgtcttctacctctgaggattcagtaagtacatccaataataatgatactgttttatcaatcaacatatttttcatcatccaattacctgacataatttggcacaggatacaaattctgtgcatcagagaaagtaaacactaaaatgactgcgtgacctcattcagtcatgtttttacactttgaacctctatttatttccttttgaaaattagctaatgatggtacattaacgcagctcacttagggctcaatcctaatcacagcttcaaattttagaagaacatataggccaagtttgccatcctcaatttgtccaacaaaattctatttatggtatttagtaaagaaacatttgtctgagaagaaatggttttacatcatctatcctgatagtttcaaacagaataaaggtaactagcatgtgaaataaaaatattcttcttaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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