LOCUS       XM_046941796           10773 bp    mRNA    linear   VRT 01-MAR-2022
DEFINITION  PREDICTED: Gallus gallus dicer 1, ribonuclease III (DICER1),
            transcript variant X2, mRNA.
ACCESSION   XM_046941796
VERSION     XM_046941796.1
DBLINK      BioProject: PRJNA698609
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_052536.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Gallus gallus Annotation Release 106
            Annotation Version          :: 106
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 9.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10773
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /isolate="bGalGal1"
                     /db_xref="taxon:9031"
                     /chromosome="5"
                     /sex="female"
                     /tissue_type="blood"
                     /country="USA: Fayetteville"
                     /lat_lon="36.0822 N 94.1719 W"
                     /collection_date="20-May-2019"
                     /collected_by="Nick Anthony"
     gene            1..10773
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 5
                     mRNAs, 11 ESTs, 876 long SRA reads, 16 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments"
                     /db_xref="CGNC:8359"
                     /db_xref="GeneID:423437"
     misc_feature    1
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /experiment="COORDINATES: cap analysis [ECO:0007248]"
                     /note="transcription start site"
     CDS             399..6164
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X1"
                     /protein_id="XP_046797752.1"
                     /db_xref="GeneID:423437"
                     /db_xref="CGNC:8359"
                     /translation="

MKSPALQSLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFNKNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSSLEVTESWTKEKWSQEFSKHQVLVMTCHVALTVLRNEYLSLSNINLLVFDECHLAIQDHPYREIMKICEDYPSCPRILGLTASILNGKCDPAELEEKIKKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPYTDKSGLYGRLLRELDEALHFLNDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTSETETEPIVDDDDVFPPYVLRTDENSPRVTINTAIGHINRYCARLPSDPFTHLAPKCKTRELPDHTFYSTLYLPINSPLRASIVGPPMSCARLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSLQMLELITRLHQYIFSHILRLEKPALEFKPTEADSAYCVLPLNIVDDSSTLDIDFKFMEDIEKSEARTGIPSTQYTKEMPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTATDAGVGVKSLPADFRYPNLDFGWKKSIDSKSFISIPSSSLVENENYCKHSTIVVPENAAHQGANRTSSAEKHDQMSVSYRTLLDESPSKLQIDVSAELAAINGVSYNKNLANGNCDLVNRDFCQGNQLNYCRQEIPVQPTTSYPIQNLYSSENQPKPSNECTLLSNKYLDGNANRSTSDGCPKMTLTTSTSTALNLSKDKVDSEKNTSSGYSSKTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYIVNQDKSNTDKWEKDETTKENLLANGKLDYDDDDEEDEDLMWRLPKEETDFEDDFLEYDQEHIKFIDSMLMGSGAFVKKISLSHFSTTDSNYEWKAPKKSSLGNVPFSSDFDDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDAGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKKTDWESTLCATGENCNSEQKNLSPNSVSACIVNSEPSLYKDLEYGCLKIPPRCMFDHPDAEKTLNHLISGFENFEKKINYSFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQMEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEMVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS"

     misc_feature    522..1115
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(522..533,540..542,591..614,735..737,924..926,
                     1017..1019)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(699..704,771..776,849..851,855..860,867..869,
                     942..950)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1209..1493
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1224..1229,1236..1238,1242..1247,1422..1427,
                     1434..1439,1446..1448,1455..1460,1467..1469)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1512..2090
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1743..1751,1959..1961,2016..2018,2022..2024)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1971..1973,1977..1979,2052..2054,2058..2060)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2286..2552
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:427264"
     misc_feature    3054..3422
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
                     involved in cleaving dsRNA in the RNA interference
                     pathway. It generates dsRNAs which are approximately 20 bp
                     long (siRNAs), which in turn target hydrolysis of
                     homologous RNAs. PAZ domains are named...; Region:
                     PAZ_dicer_like; cd02843"
                     /db_xref="CDD:239209"
     misc_feature    order(3243..3245,3282..3284,3300..3302,3312..3314,
                     3366..3368,3390..3392,3396..3398)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239209"
     misc_feature    4287..>4562
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="Ribonuclease III family; Region: RIBOc; smart00535"
                     /db_xref="CDD:197778"
     misc_feature    order(4338..4343,4350..4355,4362..4364,4371..4376,
                     4383..4388,4392..4400,4428..4430)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    5391..6149
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="dsRNA-specific ribonuclease [Transcription];
                     Region: Rnc; COG0571"
                     /db_xref="CDD:223644"
     polyA_site      10773
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

gaggaaggagcggatgagaacgggaggccgcgagcctcgccatgctttggaggggaaggcgcacacacgtctcgccgccaatcgtttggttcctttcatgtcgcggggacgcgaagcgtaagctgcgcagggtggaattctcggagcgggcttgcgtcgcaggcgctgggcggcctccgttggttacctagggtgaaacaaaattacaggcttggaaactctggaaaagctcagcatcagtatttgagagccgaagcctgcaaattatgtgattaacctacaagctgatatcatgatgtcaaaatgcagtttggaaagcataagcacagaggctgcagagattaaaacgtaggctgtgctggaacaaaaacgcaatgacagaaacactggatgaatgaatgaaaagccctgctttgcaatccctcagcatggcgggactgcagctcatgacccctgcttcctccccaatgggtccattttttggactaccgtggcaacaagaagcaattcatgataacatttatacgccaagaaaatatcaggttgaactgcttgaagcagctttggatcataatacaatagtctgtttaaacactggctcagggaagacttttattgcagtactactcactaaagagctgtcctatcagatcaggggggatttcaacaaaaatggaaaaagaactgtgttcttggtcaactcagcaaatcaagttgctcagcaagtgtcagctgtcaggacacattcagatcttaaagtgggagagtattcaagtttagaggtaactgaatcatggacaaaagagaaatggagtcaggaattctctaagcatcaggttctggttatgacatgtcatgttgctttgactgttttgagaaatgagtatttatccctgtcaaatattaatctactggtgtttgatgagtgccatcttgcaatccaggaccatccataccgtgaaattatgaagatctgtgaggattacccatcttgccctcgaatcttgggattaactgcttccattttaaatgggaagtgtgatcctgctgagttagaagaaaagataaagaaactggagaaaatactaaagagcaatgctgaaactgcaactgatttggtggtcttagatagatatacttctcagccatgtgagattgttgtagactgtggaccatatactgacaaaagtggattgtacggaagactattaagggaattagatgaagcacttcattttctaaatgactgcaacatatctgtacattcaaaggaaagagattctacgttaatttctaaacagatattgtcagactgtcgagctgtgttggttgttctgggaccctggtgtgcagataaggtagctgggatgatggtgagagagctacagaagtatatcaaacatgagcaagaggagctgcacaggaaatttttattgtttacagacactttccttaggaaaatacatgcactctgtgaagagcatttctcacctgcctcacttgacctgaaatttgtaactccaaaagtaataaagctgcttgaaatcttgcgcaaatacaaaccatatgaacggcagcagttcgaaagtgttgaatggtataacaatagaaatcaggataattatgtatcatggagtgattctgaagatgatgatgaagatgaagagattgaggagaaagagaagccagagactaatttcccatctccttttacgaatattttatgtggaattatttttgtggaaagaagatacacagcagttgttctaaataggttgataaaagaagctggcaaacaggatccagaactggcttacatcagtagcaatttcataactggacatggcattggcaagaatcagcctcgtaacaagcagatggaagtagaattcagaaagcaggaagaggttcttagaaaatttcgagcacacgagaccaatcttcttattgctaccagtattgtagaagagggtgttgacataccaaaatgcaatttggtggtgcgttttgatttgcccacagaataccgttcctatgtgcagtcaaaaggaagagctagagcaccaatttccaattatataatgttagcagatacagacaaaattaaaagttttgaggaagatcttaagacatataaagcaattgagaagatcctgagaaataaatgctcaaaatctgttgataccagcgaaactgaaactgaacccattgttgatgatgatgatgtgtttccaccctatgtgctgagaacagatgagaacagtccaagagttactatcaacactgcaattggacacataaataggtactgcgctagattaccaagtgatccatttacacacctagctcccaagtgtaaaacccgagaactacctgatcatacattctactctactctctacctgccaatcaactcacctcttcgagcatcaattgttggtcctccaatgagttgtgcaagattggctgagagagttgtagctcttatttgctgtgaaaaactgcacaaaatcggtgaactggatgaccatttgatgccagttggaaaagaaacggttaaatatgaggaagagcttgatttacatgatgaagaagaaaccagtgtgccaggaagaccaggctctacaaaaagacgacagtgctaccctaaagctattccagaatgtttgagggatagttatcccaaacctgatcagccctgttacctgtatgtaataggaatggtgttaactactccattgcctgatgagctcaactttaggagacgaaagctatatcctcctgaggatacgacgagatgttttggcatattgacagccaaacctatacctcagattcctcactttcctgtgtatactcgctctggagaggttacaatatctattgagcttaagaaatctggttttactttgtctttgcaaatgcttgagctgataacacgactccaccagtacattttctcacatattcttcgtcttgagaaacctgcactagagttcaaacccacagaagctgattcagcctattgtgttctacctcttaacattgttgatgactccagcactttggacattgactttaagtttatggaagacattgaaaagtctgaagcgcgtacaggcattcccagtacacagtatacaaaagaaatgccttttattttcaagttagaagactaccaggatgcagttatcattccacggtatcgaaattttgatcagcctcatcgattctatgtagctgatgtatacactgatcttactccactcagtaaattcccttcccctgaatatgaaacttttgctgaatattataaaacaaaatataatcttgacctgaccaatctcaaccagccgctgctggatgtggaccacacatcttcaagacttaatcttttgactcctcgccatttgaatcagaaggggaaagcacttccactaagcagtgctgagaagaggaaggcaaaatgggaaagtctgcagaataagcagatactggttcctgagctatgtgctatacatcctattccagcatcgttgtggagaaaagcagtttgcctccccagcatactttatcgcctgcactgccttttgacagcagaggaactaagagctcaaacagccactgatgctggcgtaggggttaaatcacttcctgcagatttcagatatcctaacctggacttcggatggaaaaaatctattgacagcaaatctttcatctccatacctagctcctctttggtagagaatgaaaattactgtaagcacagcacaattgtagtccctgaaaatgctgcacatcaaggtgctaatagaacctcttctgcagaaaaacatgaccaaatgtctgtgagttacagaacactgcttgatgagtcacccagtaaactccaaattgatgtctcagcagaacttgcagcaattaatggtgtttcttataataaaaatcttgccaatggcaattgtgatttagttaacagagacttttgccaaggaaatcagctgaattactgcaggcaggaaatacctgtacaaccaactacctcatatcccattcagaatttatacagcagtgagaaccagcccaagcccagcaatgaatgtactctactgagtaataaataccttgatggaaatgctaacagatctacctcagatggatgccccaaaatgacattgaccaccagtacttcaacagctcttaatctttcaaaagacaaagtggattctgaaaagaacacttccagtgggtactcctcaaaaactcttggtcctaatcctggtctcattcttcaggctttgactctttcaaatgctagtgatggatttaatttggagcggctagaaatgcttggtgattcatttttaaagcatgccatcactacatacttgttttgcacttaccctgatgcgcacgagggacggctgtcatacatgagaagtaaaaaagtcagcaactgtaacttgtatcgccttggaaaaaagaaaggactgcctagtcgaatggtggtatcgatttttgatccccctgtcaattggcttcctcccggttacatagtaaaccaggacaagagcaacactgataaatgggagaaagacgaaacgacaaaggagaatttgttggctaatggtaaacttgattatgatgatgacgacgaagaggatgaagacctaatgtggaggttgcccaaggaagaaacagactttgaagatgattttttggagtatgatcaagagcatatcaaattcatagatagtatgttaatgggatcgggggcttttgtgaagaaaatttctctctctcacttttcaaccactgattcaaactatgaatggaaagcacccaaaaagtcatccctgggtaacgttccgttttcatcagattttgatgattttgactacagctcttgggatgctatgtgctatctggatcctagcaaggctgttgaagaggatgattttgtagtgggtttctggaatccatcagaagaaaactgt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