LOCUS       XM_046932028            6715 bp    mRNA    linear   VRT 01-MAR-2022
DEFINITION  PREDICTED: Gallus gallus argonaute 1, RISC catalytic component
            (AGO1), transcript variant X1, mRNA.
ACCESSION   XM_046932028
VERSION     XM_046932028.1
DBLINK      BioProject: PRJNA698614
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_052595.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Gallus gallus Annotation Release 106
            Annotation Version          :: 106
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 9.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6715
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /isolate="bGalGal1"
                     /db_xref="taxon:9031"
                     /chromosome="23"
                     /sex="female"
                     /tissue_type="blood"
                     /country="USA: Fayetteville"
                     /lat_lon="36.0822 N 94.1719 W"
                     /collection_date="20-May-2019"
                     /collected_by="Nick Anthony"
     gene            1..6715
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="argonaute 1, RISC catalytic component; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 15 mRNAs, 1 EST, 343 long SRA reads, 6 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 63 samples with support for all
                     annotated introns"
                     /db_xref="CGNC:1607"
                     /db_xref="GeneID:428222"
     misc_feature    1
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /experiment="COORDINATES: cap analysis [ECO:0007248]"
                     /note="transcription start site"
     CDS             309..2699
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /codon_start=1
                     /product="protein argonaute-1 isoform X1"
                     /protein_id="XP_046787984.1"
                     /db_xref="GeneID:428222"
                     /db_xref="CGNC:1607"
                     /translation="

MPTQSQQVREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWMAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA"

     misc_feature    393..617
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    645..797
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    798..1160
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(954..956,999..1001,1041..1043,1053..1055,1107..1109,
                     1128..1130,1134..1136)
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1293..2570
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1704..1706,1716..1718,1752..1763,1770..1772,
                     1794..1796,1803..1805,1815..1817,1827..1829)
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1908..1910,1914..1916,2124..2126,2538..2540)
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      6715
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

ggcgcgtgcgcgctggggcgcagcgtgaggcggctgcggcggtgcggcaccggccccggccccgcgccccggccctgccctgcccgcggcccggcgaggagcggcgcccgcgtggatgggatggaagcgggaccttcgggagcagctgcaggcgcatacctgccacccttgcagcaggtatttcaagcgccgcgtcggcccgggataggaactgttgggaagcccatcaagctcttagccaactactttgaagtggacattcccaagatcgatgtatatcattatgaagtggatatcaagcccgacaaatgcccacgcagagtcaacaggtaagggaagtcgtggagtacatggtacagcacttcaaacctcagatctttggcgaccggaagccagtctacgatgggaagaaaaacatttacactgttacagccttacccattggaaatgagagggttgactttgaggtgacaatcccaggagaaggcaaggacaggatatttaaggtctctatcaagtggatggccattgtgagctggcgcatgctccacgaagccctggtgagcgggcagatccctgtccctttggagtctgtccaggcactggatgtggccatgaggcacctggcttccatgaggtacacccctgttggccgctccttcttctccccaccagaaggctattaccaccccctgggaggtggcagggaggtctggttcggtttccaccagtctgtcaggcctgccatgtggaagatgatgctcaacattgatgtttctgcaacggccttctacaaagcccagcctgtaattgagttcatgtgtgaggtgctggatatccggaacatcgatgaacaaccgaagccactgacggactcacagagagtgcgtttcaccaaggagatcaaaggtttgaaagtagaggttacccactgtgggcagatgaagaggaaataccgtgtgtgtaacgttacccggcggccggccagccaccagacgtttcccctgcagctggagagcggtcagacagtggagtgcacagtggctcagtacttcaagcagaaatacaacctgcagctgaaataccctcacctcccgtgtctccaggttggccaagagcagaagcacacatacctgcccttggaggtgtgtaacatcgtggcaggccagcggtgcatcaagaagctcacagacaatcaaacatcaaccatgataaaagcaacggccaggtctgccccagacaggcaggaggagatcagccgcctgatgaagaatgccagctacaacctggatccgtacattcaggagtttgggatcaaggtgaaggatgacatgacggaggtgacggggagggtcctgccagcacctattctgcagtacggaggcaggaaccgagccattgcaactcccaaccagggcgtgtgggacatgcgagggaagcagttctacaacggcattgagatcaaagtctgggcgattgcttgctttgccccgcagaagcagtgtcgagaagaggtgctgaagaactttacagaccagctgcgcaagatctccaaggacgcagggatgccgatccaaggccagccctgtttctgtaaatacgcccagggtgcagacagtgtggagcccatgtttcggcacctcaagaacacctattcagggcttcagctcatcattgtcatcctgccaggaaaaacaccggtgtacgccgaggtgaagcgtgttggggacactctcctgggaatggccacgcagtgcgtccaggtcaagaatgtggtgaaaacctccccgcagaccctttccaacctctgcctcaagatcaacgtcaagcttggcgggatcaacaacatcctagtgcctcaccagcgctctgctgtctttcagcagccagtgatattcctcggggctgatgtcactcacccacctgctggagatgggaagaaaccctctataacagctgttgtgggcagcatggacgcccaccccagccggtactgtgccacggtgcgtgtgcagcgtcctcgccaggagatcattgaggatttgtcctacatggtaagggagctcctcatccagttctacaaatccacgcgcttcaaacccaccaggatcatattctaccgtgacggtgttcccgaggggcagctcccacagatccttcactacgagctcctagcaatccgagatgcctgcatcaaactggaaaaggattaccagcctggcatcacttatatcgttgtccagaaaaggcatcacacccgtctcttctgcgcagacaagaatgagaggattgggaagagcgggaacatcccagcaggaacaacagtggatacaaacatcactcaccctttcgagtttgacttctacttgtgcagtcatgcaggcattcagggtacgagccggccctcccattactacgtgctctgggatgacaaccggttcaccgcagatgagctgcagatcctcacgtaccagctgtgccatacctacgtgcgctgcacccgctcggtctccatcccagccccggcttactacgcccggctggtggcattcagagcgcggtaccacctcgtggacaaggagcatgacagtggcgagggcagccatatatctggacagagcaacggcagagacccccaggccttggcaaaggctgtgcaggttcatcaggacactttacgtaccatgtactttgcttgaaagcctaacttttgttacctcactcaagaaagctttcagatttgtaggagccatacaaaaaaggaagcattgggacaccttgtttttttttttccaatgagaaatcactgcagggcaggcagcgtcggttcgaggcaggagaccagcaccaccggacaggaagatccaacaccttcgtaggattggaagagactgattatttttttagttttttctggctttgcaaaattttgacctgaccaaacacatgaaggcattcaaggaagggataaaagtcccaggaggcggaagcaggttgtcatgtttaagatgcaatactatagactcctgactgtgaaaggcggatttggtcctccgttgcccaccaggcgctggtaggtattttttgtgggggttggggggaggggatttttagagccttaaaacagaagactagatttataaaactaatattttagaatatgagatgctttaatgggttaaggggaaaaaacaactagtttatagataactctaacactaacagttccccgcccccgagcgattccccccatataacgtaaggcaccctagcacttagctcagaactgaaaactgtcttccttgtgttaaaagctagttagctgctgccatttgaagcaacagtcacagacttttccatgggtgagtgccttactacgatgctgcaaaatttcaatgtttttaatcttgtaaggaaaatagtaatcttgtcttgatggtggtccatatttccatcggaaggagttaatttctatggtcctgagttgcagtttgtgttagatcacaacctcgtggtggttaaactccgttgaaagatgtgcactttcatataggacacgtttaatggctgctgacccatttttgtttccaatgtactacttgttatttaaaactgtttctgacaaatgggggcactgccatcccatgaggacagaaatcgctatcaatttcttttttttcttttttctttttttttttttcctgaatttctatgatggacaccgggatttttttactgagcattatttttatacgatactgagtctgttgccaaaacacacgagtcattcacatcctcagagtttacatcgccgcgctcgcaccagaggttcccaacgtttcctgtgtgtgttacacagtgtggccgtgcagctcggggcctctccactgttgtgctgctaccttgtgctgctctttgtgtcaccctattgctgatttcgtgcacggggtttttattctgaaagcacaccagagacgttccttagtcagaatgatcaaatccttgttaccgtcgtggggaagctcctcctgatctgtttttaacaggggaaaaaaaaaaaaagccttttttgtttgtttgtttccaacagtaacatggtggctgcttttcagactcattttgctgcacagaatgaccattatgcacagcagggcagtagtaacaactcattaccaatatcacgtgggcagattgggtttttttctatatgaaaggtgtgcacaacgcttccttgaagagagaaactgtgtgcactcctgctgagctctcaggagaagagctctgttatcattttactgccaaaagtgaacgtgttttcagagcagatctgtcaccagcactgccccttgtcagtgcgcggatagaagcacacctttttgttttgtactttctgatgtttaaactcgccttgccttcatgaaatccatactagtcatgctggcccattgatctgtcctaatactgggaattcactctgcctgttttctttttgggcaacgtgtttgtgaacaatgaagacatcaatatgctatgcaaactaagtgctgagcccgctgatgtcacctttggtgaagatcctacatttagcacagttgtctttttcctcgagactgcagtatttggttcacattctcctttgcaccttgtgtcaaacaccactgctgtctgtctgcagggtggtggggaggagaccaggagctcttcgtggtcagtagggtaggaagtcttaggaaagcttttagagagcagggaatgcatcaacactaagcgtcaacgtgagaagcctacattcctatacacaagtgcctgcatagtgacacaaatccagcacctctccatttcatcctcagacctctggcttgtgttcattgaaagcaaaacgatctcagaggggctgtacctgctcacctcgtattagaaagcccctcgttaagaatcaaaccggggttaaggtcaaggttctctctgtaagtgggtttgttcaccagcattacaatggaaagcacctggctgctggcagcagcgaggggcaaaggtattttggttcctagtttttctttcttttagtgttttagttgggtctagaattctggaatgtcttttagtagccgtggcatagcacgtgccatttttaaccatttgaaaagagatagtgtgggcatttacagaaacagcttgttgctctgtaatgttttttttttttttaaccttgagacttgaaatgtaaaatggacctttaagatttgcactcatttgtaaggtggctgttcatagagaactatgaatgaagacttgctgatgtagcacctacttttaacagcaattttaactacacaaaagcttcacagcttctgaaacgctcagctggtgacttgcagatcgcgttctgcccttatttcaccctctgcattgggttttcatggttttgattcaataaaaaagccaaactcaatagctgctgtgccctttaagccgtatttccactttgaagatgttataaggggtttgagttacccgcatgttttctataacagactatgcactgtaccttctgcgcagctccagcattcaatatttctaccgttttcttgtccaagatgcaaacgaataagtgcatgtcgaggtgctgtgcattttgctacccgtagcagatagctgttaagccagagacatatcaggatctgtagttagccacaaaccccacgtggacatcccgaatggctcccgagtctctctgccttctcagtgcgcacgcgttccttctgcaactggaaacatcgccaagtgcatgcaagccttgtgggaagaggaataacttccatttgtctgtcggttgttggatgctgtgtgtttcccttgtctcatacctggacgtgacgggggcagtgggggtgtcccagtactcgcaagcctctgacctgatgcctcgtgtcacaaagcccgagcgttcagcgttgcctcgtggaaggttttcttcttggaaaatgagtgtgaaaataaagaaaagaatgtcattcttttaggaagggaagccagacagcaggacagcaataaacacatgaaattcatatcttgcctgagtgatttgcacttcgatagtcgtgaaagaaaattgatggggactccagtgcttttgtgttcagttctagcccctttcgtacctcctttatacagcaggtgttggactgtacatggggtgtttacaaacactctctttgggttgttatttttcttgcggttattttttttttgctttagcttgaactctctatggtccatttgttaaatagatgtgaacggttgatgtacagtacttactaaacaagcagcagcacaaaacttattttattaagaaaatatggcatatattttaaaggttgggtatcaacttttctttttttttctttttgtatgcgtggaattaagactggtgaagagtaacaaaacccttggattacatttggattaggccaaaagatgatactgtaagatcgtaaccacctctttattaaagaaagcggtatgattaaagagctccagaacattgtatttatatttgatttgattgctttggtggattttttttttttaatttcaattttttttttttttttgccttaatcctgatttttgcttgcaactttgacttcgcagtcccaagtgtctgttatcctgtaagtgttggcagaagacctaaataaaagcaatgtgaata

//