LOCUS       NM_205358               2051 bp    mRNA    linear   VRT 07-AUG-2024
DEFINITION  Gallus gallus LIM homeobox transcription factor 1 beta (LMX1B),
            mRNA.
ACCESSION   NM_205358
VERSION     NM_205358.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Tang,H., Finn,R.D. and Thomas,P.D.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
            Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2051)
  AUTHORS   Schweizer,H., Johnson,R.L. and Brand-Saberi,B.
  TITLE     Characterization of migration behavior of myogenic precursor cells
            in the limb bud with respect to Lmx1b expression
  JOURNAL   Anat Embryol (Berl) 208 (1), 7-18 (2004)
   PUBMED   15007643
  REMARK    GeneRIF: Myogenic precursors in limb bud were devoid of Lmx1b
            expression. Lmx1b is not only expressed at early stages of limb
            development but maintains its pattern, at least until after birth.
            New details of Lmx1b expression on cellular basis within limb.
REFERENCE   4  (bases 1 to 2051)
  AUTHORS   Holmes,G., Crooijmans,R., Groenen,M. and Niswander,L.
  TITLE     ALC (adjacent to LMX1 in chick) is a novel dorsal limb mesenchyme
            marker
  JOURNAL   Gene Expr Patterns 3 (6), 735-741 (2003)
   PUBMED   14643681
REFERENCE   5  (bases 1 to 2051)
  AUTHORS   Mauch,T.J., Yang,G., Wright,M., Smith,D. and Schoenwolf,G.C.
  TITLE     Signals from trunk paraxial mesoderm induce pronephros formation in
            chick intermediate mesoderm
  JOURNAL   Dev Biol 220 (1), 62-75 (2000)
   PUBMED   10720431
REFERENCE   6  (bases 1 to 2051)
  AUTHORS   Vogel,A., Rodriguez,C., Warnken,W. and Izpisua Belmonte,J.C.
  TITLE     Dorsal cell fate specified by chick Lmx1 during vertebrate limb
            development
  JOURNAL   Nature 378 (6558), 716-720 (1995)
   PUBMED   7501017
  REMARK    Erratum:[Nature 1996 Feb 29;379(6568):848]
REFERENCE   7  (bases 1 to 2051)
  AUTHORS   Riddle,R.D., Ensini,M., Nelson,C., Tsuchida,T., Jessell,T.M. and
            Tabin,C.
  TITLE     Induction of the LIM homeobox gene Lmx1 by WNT7a establishes
            dorsoventral pattern in the vertebrate limb
  JOURNAL   Cell 83 (4), 631-640 (1995)
   PUBMED   7585966
REFERENCE   8  (bases 1 to 2051)
  AUTHORS   Tsuchida,T., Ensini,M., Morton,S.B., Baldassare,M., Edlund,T.,
            Jessell,T.M. and Pfaff,S.L.
  TITLE     Topographic organization of embryonic motor neurons defined by
            expression of LIM homeobox genes
  JOURNAL   Cell 79 (6), 957-970 (1994)
   PUBMED   7528105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000308.1.
            
            On Nov 24, 2021 this sequence version replaced NM_205358.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L39880.1, U41823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992323, SAMEA103992393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               JAENSK010000308.1  9846417-9846924
            509-695             JAENSK010000308.1  9847142-9847328
            696-928             JAENSK010000308.1  9932454-9932686
            929-1107            JAENSK010000308.1  9935624-9935802
            1108-1185           JAENSK010000308.1  9936707-9936784
            1186-1252           JAENSK010000308.1  9937187-9937253
            1253-1414           JAENSK010000308.1  9938162-9938323
            1415-2051           JAENSK010000308.1  9940066-9940702
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="17"
                     /map="17"
     gene            1..2051
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /note="LIM homeobox transcription factor 1 beta"
                     /db_xref="CGNC:621"
                     /db_xref="GeneID:396312"
     exon            1..508
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    121..123
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /note="upstream in-frame stop codon"
     CDS             370..1572
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /note="homeodomain protein (lmx); LIM homeobox protein;
                     LIM/homeobox protein 1; homeobox protein LMX-1"
                     /codon_start=1
                     /product="LIM/homeobox protein LMX-1.2"
                     /protein_id="NP_990689.2"
                     /db_xref="CGNC:621"
                     /db_xref="GeneID:396312"
                     /translation="

MDIASGPESLERCFPRGPTDCAKMLDGIKMEDHPLRSGPATLGVLLGSECPHQAVCEGCQRPISDRFLMRVNESSWHEECLQCAVCQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLSCFCCCVCERQLRKGDEFVLKEGQLLCKSDYEKEKDLLSSVSPDDSDSVKSDDEDGDVKPTKGQVTQGKGSDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVMSNRMEGMMTSYTPLAPPQQQIVAMDQSSYGTDPFQQGLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFLASSEVNSMQARVGNPIDRLYSMQSSYFAS"

     misc_feature    535..693
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /note="The first LIM domain of Lmx1b; Region: LIM1_Lmx1b;
                     cd09371"
                     /db_xref="CDD:188757"
     misc_feature    order(535..537,544..546,598..600,607..609,616..618,
                     625..627,676..678,685..687)
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188757"
     misc_feature    712..876
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /note="The second LIM domain of Lmx1a and Lmx1b; Region:
                     LIM2_Lmx1a_Lmx1b; cd09378"
                     /db_xref="CDD:188764"
     misc_feature    order(712..714,721..723,778..780,787..789,796..798,
                     805..807,862..864,871..873)
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188764"
     misc_feature    895..1047
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /note="propagated from UniProtKB/Swiss-Prot (P53413.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1024..1194
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            509..695
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..928
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1107
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1185
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1252
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1414
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..2051
                     /gene="LMX1B"
                     /gene_synonym="LMX; LMX1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atggcacaggggctgcggagcgccgggaagccccgccgccgcccggccccaccgctccgcccggcccggccccgggagggccctcctgcgggcgtggggctcggcgctgccgggagcaggtgacaccgcgaccgccccgcgccgtgtgcgcggcaatgtgcgcgcccgtgtagcgcggccgccccatgggcacggcgccggctcgttcctctgccccccgtctctggaagcgccggcaggaagcgcgcctcatgtctcccagataaaagtaaaagcgctccctcctcctggcagcgcagcgccccgcgctcggcccgacgcggggtgcgcggccccgccatccccggctcccccgtgccgccgccccatatggacatcgcctcgggccccgagtccttggagaggtgcttcccgcgcggcccgacggactgcgccaagatgctggacggcatcaagatggaagatcacccgctgcgctcgggtccggccacgctcggagtgttactggggtcggagtgcccgcaccaggccgtgtgcgaaggctgccagaggcccatctcggatcgctttctgatgagggtgaacgagtcctcctggcacgaggagtgtttgcagtgcgcggtgtgtcagcaagccctcaccaccagctgctacttccgggaccgaaagctctactgcaaacaggactaccaacagctttttgctgccaagtgcagtggctgcatggaaaaaattgccccaacagaatttgtgatgagagccctggagtgtgtttaccacttaagctgcttctgttgctgtgtttgtgagcgacagctgagaaaaggggatgagtttgttcttaaggaagggcagttgctctgtaaaagtgactatgagaaagagaaggacctgttgagctccgtcagcccagacgattccgactcagttaaaagcgatgatgaagatggagatgttaagcccaccaaaggacaagtaacacaaggaaaaggaagtgatgatgggaaggacccaaggagacctaaacgaccaaggacaatactcactacgcagcagagacgagcattcaaagcatcctttgaagtgtcttccaagccctgtaggaaggtcagagaaactctagcagctgaaacaggactcagtgtgcgagttgtccaggtttggtttcaaaaccaaagagcaaagatgaaaaaactagcacgaaggcaccagcagcagcaggagcaacaaaattctcagcgactagggcaagaagtaatgtctaaccgaatggaaggaatgatgacatcttacacaccacttgcaccaccgcagcagcagattgtagcaatggatcaaagcagttatggcacagacccatttcagcagggtctgacccctccacaaatgccaggcgaccacatgaacccttatggaaacgactccatttttcatgatatcgacagtgatacctctttaactagcttgagcgactgttttcttgcctcttctgaagttaactccatgcaggctagggtaggaaaccccattgacaggctgtactctatgcagagctcctatttcgcctcatgaaaataaacgaaaacaaacagccggcgtgtatttagccagtgactttttccgtgcagcctctacagccatatgttgcccagctcttccttcacagtgactcctgctgcctctggactgcaaagagcatttttaggaagactttatttgtgtgcatatatgtatgtatgtacgtgcatatatcagtacctacctacctacatacatacatatataaacaaaacacatccaccagtcacatacccttgattcccagcttgcaccagaccaagagagaagcgtgaaaggaacagaagactctgctcttcagcagcctttgttttggtttggtttgagctcttcgttgtaaaggaaatggattttgtggaaagctagaccttttcctcctttctctcttcctttcttttggatgtttaaattttttttaagccactgatactgacatcagtcaaccatatgacaaataaatcaaagaaactgga

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