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Previous release (v1)
2026-01-17 20:56:23, GGRNA.v2 : RefSeq release 232 (Sep, 2025)
LOCUS NM_205303 3381 bp mRNA linear VRT 28-APR-2025
DEFINITION Gallus gallus calpain 11 (CAPN11), mRNA.
ACCESSION NM_205303
VERSION NM_205303.1
KEYWORDS RefSeq.
SOURCE Gallus gallus (chicken)
ORGANISM Gallus gallus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
REFERENCE 1 (bases 1 to 3381)
AUTHORS Tang,H., Finn,R.D. and Thomas,P.D.
TITLE TreeGrafter: phylogenetic tree-based annotation of proteins with
Gene Ontology terms and other annotations
JOURNAL Bioinformatics 35 (3), 518-520 (2019)
PUBMED 30032202
REFERENCE 2 (bases 1 to 3381)
AUTHORS Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
TITLE Manual GO annotation of predictive protein signatures: the InterPro
approach to GO curation
JOURNAL Database (Oxford) 2012, bar068 (2012)
PUBMED 22301074
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 3381)
AUTHORS Macqueen,D.J., Delbridge,M.L., Manthri,S. and Johnston,I.A.
TITLE A newly classified vertebrate calpain protease, directly ancestral
to CAPN1 and 2, episodically evolved a restricted physiological
function in placental mammals
JOURNAL Mol Biol Evol 27 (8), 1886-1902 (2010)
PUBMED 20223856
REFERENCE 4 (bases 1 to 3381)
AUTHORS Zhang,Z.R., Liu,Y.P., Jiang,X., Du,H.R. and Zhu,Q.
TITLE Study on association of single nucleotide polymorphism of CAPN1
gene with muscle fibre and carcass traits in quality chicken
populations
JOURNAL J Anim Breed Genet 125 (4), 258-264 (2008)
PUBMED 18727211
REMARK GeneRIF: The CAPN1 gene has been associated with meat quality
traits in chicken.
REFERENCE 5 (bases 1 to 3381)
AUTHORS Zhang,Z.R., Zhu,Q., Jiang,X.S. and Du,H.R.
TITLE [Study on correlation between single nucleotide polymorphism of
CAPN1 gene and muscle tenderness and carcass traits in chicken]
JOURNAL Yi Chuan 29 (8), 982-988 (2007)
PUBMED 17681928
REMARK GeneRIF: Results showed that CAPN1 gene may be the major gene
affecting the tenderness traits of chicken or it links with the
major gene, and the the polymorphic site may be used as molecular
markers for meat tenderness and chicken quality.
REFERENCE 6 (bases 1 to 3381)
AUTHORS Sorimachi,H., Tsukahara,T., Okada-Ban,M., Sugita,H., Ishiura,S. and
Suzuki,K.
TITLE Identification of a third ubiquitous calpain species--chicken
muscle expresses four distinct calpains
JOURNAL Biochim Biophys Acta 1261 (3), 381-393 (1995)
PUBMED 7742367
REFERENCE 7 (bases 1 to 3381)
AUTHORS Minami,Y., Emori,Y., Kawasaki,H. and Suzuki,K.
TITLE E-F hand structure-domain of calcium-activated neutral protease
(CANP) can bind Ca2+ ions
JOURNAL J Biochem 101 (4), 889-895 (1987)
PUBMED 3038855
REFERENCE 8 (bases 1 to 3381)
AUTHORS Emori,Y., Ohno,S., Tobita,M. and Suzuki,K.
TITLE Gene structure of calcium-dependent protease retains the ancestral
organization of the calcium-binding protein gene
JOURNAL FEBS Lett 194 (2), 249-252 (1986)
PUBMED 3000828
REFERENCE 9 (bases 1 to 3381)
AUTHORS Ohno,S., Emori,Y., Imajoh,S., Kawasaki,H., Kisaragi,M. and
Suzuki,K.
TITLE Evolutionary origin of a calcium-dependent protease by fusion of
genes for a thiol protease and a calcium-binding protein?
JOURNAL Nature 312 (5994), 566-570 (1984)
PUBMED 6095110
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from X01415.1.
##Evidence-Data-START##
Transcript exon combination :: X01415.1, EF507731.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA103992290,
SAMEA103992323 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..3381
/organism="Gallus gallus"
/mol_type="mRNA"
/db_xref="taxon:9031"
/chromosome="3"
/map="3"
gene 1..3381
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="calpain 11"
/db_xref="CGNC:54348"
/db_xref="GeneID:396240"
exon 1..283
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
misc_feature 17..19
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="upstream in-frame stop codon"
CDS 38..2155
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/EC_number="3.4.22.52"
/note="mu/M-type; calpain-1 large subunit;
calcium-activated neutral proteinase"
/codon_start=1
/product="calpain-1 catalytic subunit"
/protein_id="NP_990634.1"
/db_xref="CGNC:54348"
/db_xref="GeneID:396240"
/translation="
MMPFGGIAARLQRDRLRAEGVGEHNNAVKYLNQDYEALKQECIESGTLFRDPQFPAGPTALGFKELGPYSSKTRGVEWKRPSELVDDPQFIVGGATRTDICQGALGDCWLLAAIGSLTLNEELLHRVVPHGQSFQEDYAGIFHFQIWQFGEWVDVVVDDLLPTKDGELLFVHSAECTEFWSALLEKAYAKLNGCYESLSGGSTTEGFEDFTGGVAEMYDLKRAPRNMGHIIRKALERGSLLGCSIDITSAFDMEAVTFKKLVKGHAYSVTAFKDVNYRGQQEQLIRIRNPWGQVEWTGAWSDGSSEWDNIDPSDREELQLKMEDGEFWMSFRDFMREFSRLEICNLTPDALTKDELSRWHTQVFEGTWRRGSTAGGCRNNPATFWINPQFKIKLLEEDDDPGDDEVACSFLVALMQKHRRRERRVGGDMHTIGFAVYEVPEEAQGSQNVHLKKDFFLRNQSRARSETFINLREVSNQIRLPPGEYIVVPSTFEPHKEADFILRVFTEKQSDTAELDEEISADLADEEEITEDDIEDGFKNMFQQLAGEDMEISVFELKTILNRVIARHKDLKTDGFSLDSCRNMVNLMDKDGSARLGLVEFQILWNKIRSWLTIFRQYDLDKSGTMSSYEMRMALESAGFKLNNKLHQVVVARYADAETGVDFDNFVCCLVKLETMFRFFHSMDRDGTGTAVMNLAEWLLLTMCG"
misc_feature 182..1072
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="Calpain family cysteine protease; Region:
Peptidase_C2; pfam00648"
/db_xref="CDD:459889"
misc_feature 1079..1588
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="propagated from UniProtKB/Swiss-Prot (P00789.2);
Region: Domain III"
misc_feature 1109..1582
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="Calpain, subdomain III. Calpains are
calcium-activated cytoplasmic cysteine proteinases,
participate in cytoskeletal remodeling processes, cell
differentiation, apoptosis and signal transduction.
Catalytic domain and the two calmodulin-like domains
are...; Region: Calpain_III; cd00214"
/db_xref="CDD:238132"
misc_feature order(1220..1228,1259..1261)
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="acidic loop; other site"
/db_xref="CDD:238132"
misc_feature 1589..1636
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="propagated from UniProtKB/Swiss-Prot (P00789.2);
Region: Linker"
misc_feature 1637..2149
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="propagated from UniProtKB/Swiss-Prot (P00789.2);
Region: Domain IV"
misc_feature 1646..2152
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="Penta-EF hand, calcium binding motifs, found in
mu-type calpain (CAPN1); Region: EFh_PEF_CAPN1; cd16198"
/db_xref="CDD:320073"
misc_feature 1646..1732
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="EF-hand motif [structural motif]; Region: EF-hand
motif"
/db_xref="CDD:320073"
misc_feature order(1682..1690,1703..1705,1757..1759,1802..1804,
1808..1810,1814..1816,1835..1837,1892..1894,1898..1900,
1904..1906,1925..1927,2021..2023,2027..2032)
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="Ca binding site [ion binding]; other site"
/db_xref="CDD:320073"
misc_feature 1775..1864
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="EF-hand motif [structural motif]; Region: EF-hand
motif"
/db_xref="CDD:320073"
misc_feature 1865..1957
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="EF-hand motif [structural motif]; Region: EF-hand
motif"
/db_xref="CDD:320073"
misc_feature 1973..2059
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="EF-hand motif [structural motif]; Region: EF-hand
motif"
/db_xref="CDD:320073"
misc_feature 2063..2152
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="EF-hand motif [structural motif]; Region: EF-hand
motif"
/db_xref="CDD:320073"
exon 284..353
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 354..472
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 473..606
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 607..775
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 776..859
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 860..945
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 946..1020
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1021..1181
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1182..1351
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1352..1363
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1364..1575
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1576..1615
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1616..1681
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1682..1739
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1740..1804
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1805..1873
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1874..1952
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 1953..2069
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 2070..2128
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
exon 2129..3381
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/inference="alignment:Splign:2.1.0"
polyA_site 3380
/gene="CAPN11"
/gene_synonym="CANP; mu/m-CAPN; mu/mCAPN"
/note="polyA site"
ORIGIN
gacacagaggtggaggtagcggtgccagtacgcagctatgatgccctttggggggatcgctgcccggctgcagagggaccgcctgagagccgagggggtcggcgagcacaacaacgctgtcaagtacctcaaccaggactatgaagccctcaagcaagagtgcatcgagagtggcaccctcttcagggacccccagttcccagctggccccactgccctcggcttcaaggagctggggccatactccagcaagacacggggcgtggagtggaagcgtccatcggaattagtggatgaccctcagttcatcgttggtggtgcaacccggacagatatctgccaaggagctctgggtgactgctggctgctggctgccatcggctccctcactctcaacgaggaactcctgcaccgtgtggtgccccacgggcagagcttccaggaggactacgctggcatcttccacttccagatctggcagtttggtgaatgggtggatgtggtggtggacgacctgctgcccaccaaggacggggagctcctgtttgtgcattcagcagagtgcacagagttctggagtgctctgctggagaaggcttacgccaagctgaacggctgctacgagtcgctctcagggggcagcaccactgagggctttgaggatttcaccggcggcgtagcggagatgtatgacctcaagcgggcaccgcgcaacatgggccacatcatccgcaaggcactggagagggggtccctgctgggctgctccatcgacatcacaagtgcctttgatatggaagcagtgaccttcaagaagctggtgaaaggccatgcctattctgtcaccgccttcaaagatgtgaactaccggggtcagcaggaacagctcatccgtatcagaaacccctggggtcaggtggagtggactggagcctggagcgatggttcttccgagtgggacaacattgaccccagcgacagagaagagctgcaactgaagatggaggatggagagttttggatgtctttccgggacttcatgagggagttctccaggctggagatctgcaacctaacccccgatgccctcaccaaagatgagctcagcaggtggcacacacaggtgttcgagggcacatggcgccgagggagcactgctgggggctgcaggaacaacccagccacattctggatcaatccccagtttaagatcaagctgctggaagaggatgatgaccctggggatgacgaggtggcttgcagcttcttggtggccctgatgcagaagcaccgtaggagggagcggcgagtagggggcgacatgcataccatcggcttcgctgtctacgaggttcctgaggaggcccagggaagccagaatgtgcacttgaagaaggacttcttcctgcgaaaccagtcgcgggcacgctctgagaccttcatcaacttgagggaagtgagcaaccagatccggctgccccctggcgagtacatcgttgtgccctccacctttgagccacacaaggaggccgacttcatactgcgggtcttcaccgagaagcagtcagacacagcggagctggatgaggagatctcggcagacctggcagatgaggaagaaataaccgaggacgacattgaggatggtttcaagaacatgttccagcagctggcaggggaggacatggaaatcagcgtcttcgagctcaagacgattctgaacagagtgatcgccagacacaaagatctgaagacggatggcttcagtctggactcctgccgcaacatggtcaacctgatggataaagatggcagtgcccgcctggggctggtggagttccagatcctatggaacaagatccgcagctggctgacaatcttccgccagtatgacctggataaatcaggcaccatgagctcatacgagatgcgcatggctctagagtcagctggtttcaagctgaataacaagctgcatcaggtggtggttgcccgttacgcagatgctgagacgggcgtggacttcgacaactttgtctgctgcctggtgaagctggagacaatgttcaggttcttccacagcatggatcgtgatggcactggaaccgctgtcatgaatctcgctgagtggctgctgctgacaatgtgcggctaggagccaggacagatgcgctgtgactaggacgctccagcaggccaggccacctccaagtgcctcgcttcaggtccatggacacaggataatctccctcctcttgctccatcctatgctgagccaccagccctgcctgtcagcacgcctcgctccactctcacccatggagcattttgcagggggcaaggcaggcaggggctgccctttctccttttctgggctgggcttgctttccacccttctcctcctcttgtcccaccccagaagagaaggagggcaagcagcacggggagtctgtagttcactgcacctagctttggggcagctgcttagaggccagtgcaggagcagactgggggctatccacccggcagggagaggtgggagctgtgggggggaagaggaggaggacttgttttgcttgctccagtgctgtctcatcccctgtggcatgtgctacctgtcccagggagcatcagcagatgctgcctcgcttaggcagggcagttggttcatggggaaccagggtgagaagttacacgctcttaatgccattgccttgcactcatcagcactaaacatgaccaaagcacggagctgcagctggtcaggacactggtgttcaatacctcctgctgcaacctctttctgcgtggccttcaagctctccctcacaccccttactctctgcccccctctgtcccaccatagggccaaagcctatcatttaagcactcccctgccacgtgccactataacacagcccatcgtgctcctctcatcctatgcacgcacagcagtaccactacaccctttccccagggctgtcctggcctcccctcctgctgccacggtggagttgggccaaggaggactggtgatggctgggaggcatttctccagtacacagttgtctgttttcctctttccgccctcatttcaccctgttatgatccctaaagccctcgggctccttcactcagcacagatatgctcctgtgccaatgtatttgcacttctccacactcctcacccccctctgttcctgtggatgatggggtggctccagcatggcagtgggcaaaggcccagccaaggcaggcaggcccttagccgctcccaggcctacggctccggaggccgtgcttgcagcaataaccactcctgcccacctggcaggcccgcttcctctttgtgctcggggcaataaacctagctctgttgga
//
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@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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