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Previous release (v1)
2025-02-22 13:12:20, GGRNA.v2 : RefSeq release 228 (Jan, 2025)
LOCUS NM_205273 8918 bp mRNA linear VRT 05-OCT-2024
DEFINITION Gallus gallus nuclear factor I A (NFIA), mRNA.
ACCESSION NM_205273
VERSION NM_205273.2
KEYWORDS RefSeq.
SOURCE Gallus gallus (chicken)
ORGANISM Gallus gallus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
REFERENCE 1 (bases 1 to 8918)
AUTHORS Tang,H., Finn,R.D. and Thomas,P.D.
TITLE TreeGrafter: phylogenetic tree-based annotation of proteins with
Gene Ontology terms and other annotations
JOURNAL Bioinformatics 35 (3), 518-520 (2019)
PUBMED 30032202
REFERENCE 2 (bases 1 to 8918)
AUTHORS Singh,P.N.P., Yadav,U.S., Azad,K., Goswami,P., Kinare,V. and
Bandyopadhyay,A.
TITLE NFIA and GATA3 are crucial regulators of embryonic articular
cartilage differentiation
JOURNAL Development 145 (2) (2018)
PUBMED 29247144
REMARK GeneRIF: Characterized the regulatory roles of two transcription
factors, NFIA and GATA3, in articular cartilage differentiation,
maintenance and the coordinated differentiation of articular and
transient cartilage. Both NFIA and GATA3 block hypertrophic
differentiation. Our results suggest that NFIA is not sufficient
but necessary for articular cartilage differentiation.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 8918)
AUTHORS Glasgow,S.M., Laug,D., Brawley,V.S., Zhang,Z., Corder,A., Yin,Z.,
Wong,S.T., Li,X.N., Foster,A.E., Ahmed,N. and Deneen,B.
TITLE The miR-223/nuclear factor I-A axis regulates glial precursor
proliferation and tumorigenesis in the CNS
JOURNAL J Neurosci 33 (33), 13560-13568 (2013)
PUBMED 23946414
REMARK GeneRIF: we found that miR-223 can suppress glial precursor
proliferation via repression of NFIA during chick spinal cord
development
REFERENCE 4 (bases 1 to 8918)
AUTHORS Kang,P., Lee,H.K., Glasgow,S.M., Finley,M., Donti,T., Gaber,Z.B.,
Graham,B.H., Foster,A.E., Novitch,B.G., Gronostajski,R.M. and
Deneen,B.
TITLE Sox9 and NFIA coordinate a transcriptional regulatory cascade
during the initiation of gliogenesis
JOURNAL Neuron 74 (1), 79-94 (2012)
PUBMED 22500632
REMARK GeneRIF: NFIA is a transcription factor that plays a crucial role
in the onset of gliogenesis; we found that its induction is
regulated by the transcription factor Sox9 and that this
relationship mediates the initiation of gliogenesis
REFERENCE 5 (bases 1 to 8918)
AUTHORS Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
TITLE Manual GO annotation of predictive protein signatures: the InterPro
approach to GO curation
JOURNAL Database (Oxford) 2012, bar068 (2012)
PUBMED 22301074
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 8918)
AUTHORS Kruse,U. and Sippel,A.E.
TITLE Transcription factor nuclear factor I proteins form stable homo-
and heterodimers
JOURNAL FEBS Lett 348 (1), 46-50 (1994)
PUBMED 8026582
REFERENCE 7 (bases 1 to 8918)
AUTHORS Kruse,U. and Sippel,A.E.
TITLE The genes for transcription factor nuclear factor I give rise to
corresponding splice variants between vertebrate species
JOURNAL J Mol Biol 238 (5), 860-865 (1994)
PUBMED 8182757
REFERENCE 8 (bases 1 to 8918)
AUTHORS Rupp,R.A., Kruse,U., Multhaup,G., Gobel,U., Beyreuther,K. and
Sippel,A.E.
TITLE Chicken NFI/TGGCA proteins are encoded by at least three
independent genes: NFI-A, NFI-B and NFI-C with homologues in
mammalian genomes
JOURNAL Nucleic Acids Res 18 (9), 2607-2616 (1990)
PUBMED 2339052
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAENSK010000239.1.
On Oct 6, 2021 this sequence version replaced NM_205273.1.
##Evidence-Data-START##
Transcript exon combination :: X68152.1, SRR13267658.12618.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA103992290, SAMEA103992323
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-336 JAENSK010000239.1 15988016-15988351
337-868 JAENSK010000239.1 15992976-15993507
869-934 JAENSK010000239.1 16114458-16114523
935-1009 JAENSK010000239.1 16138671-16138745
1010-1127 JAENSK010000239.1 16147267-16147384
1128-1255 JAENSK010000239.1 16149892-16150019
1256-1384 JAENSK010000239.1 16175412-16175540
1385-1563 JAENSK010000239.1 16187501-16187679
1564-1729 JAENSK010000239.1 16190204-16190369
1730-1821 JAENSK010000239.1 16197451-16197542
1822-8918 JAENSK010000239.1 16219481-16226577
FEATURES Location/Qualifiers
source 1..8918
/organism="Gallus gallus"
/mol_type="mRNA"
/db_xref="taxon:9031"
/chromosome="8"
/map="8"
gene 1..8918
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/note="nuclear factor I A"
/db_xref="CGNC:49704"
/db_xref="GeneID:396210"
exon 1..336
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
misc_feature 79..81
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/note="upstream in-frame stop codon"
CDS 310..1839
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/note="CTF; NF1-A; NFI-A; NF-I/A; nuclear factor 1/A;
TGGCA-binding protein; CCAAT-box-binding transcription
factor"
/codon_start=1
/product="nuclear factor 1 A-type"
/protein_id="NP_990604.1"
/db_xref="CGNC:49704"
/db_xref="GeneID:396210"
/translation="
MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEFREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSEADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRIKSVEDEMDSPGEEPFYTSQGRSPGSGSQSSGWHEVEPGMPSPTALKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGATSPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG"
misc_feature 334..447
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/note="Nuclear factor I protein pre-N-terminus; Region:
NfI_DNAbd_pre-N; pfam10524"
/db_xref="CDD:463134"
misc_feature 511..825
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/note="MH1 domain; Region: MH1; pfam03165"
/db_xref="CDD:460833"
misc_feature 949..1812
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/note="CTF/NF-I family transcription modulation region;
Region: CTF_NFI; pfam00859"
/db_xref="CDD:459967"
exon 337..868
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
exon 869..934
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
exon 935..1009
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
exon 1010..1127
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
exon 1128..1255
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
exon 1256..1384
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
exon 1385..1563
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
exon 1564..1729
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
exon 1730..1821
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
exon 1822..8918
/gene="NFIA"
/gene_synonym="CNFI-A; cNFI-A3"
/inference="alignment:Splign:2.1.0"
ORIGIN
gcgcggcgcagcgcggcgcagcgcggcgcggcgggcgctatgcctttaacagagcgcggggcaggcatgccgagcgcgtagtgcgggaaagtcgaggcggggttaaagttcagctcatggagcggctccgcgctggctgcagtttggcagagttggaaatgtgaaagcaagaagcaggctcggggctccccctcctctcctctctctctctctttttttttcctctctctccctctctccccccctctccccctctctctcctctctcccgcacacgcacacctccgcccgcagccccccgcagcagtcatgtattctccgctctgtctcacgcaggatgaatttcatcccttcatcgaagcacttctgcctcacgtccgagcgtttgcgtacacgtggttcaacctgcaagcccgaaagagaaaatacttcaaaaaacatgagaaacgcatgtcaaaagaggaagagagggccgtgaaggacgaactcttaagtgaaaaacccgaggtaaagcagaaatgggcgtccagacttctggcaaagcttcggaaagatatcaggcctgaatttcgggaggattttgttctcacagtcacaggaaaaaagcctccgtgttgcgtcctttccaatccagaccagaagggcaagatgagaagaattgactgccttcgccaggcagataaggtctggaggttggacctcgttatggtgattttatttaaaggtattccgctcgaaagtactgatggcgagcgccttgtaaagtccccacagtgctctaaccccgggctgtgcgtacagccccaccatataggagtttctgttaaggaactcgatttatatttggcatactttgtgcacgccgcagattcaagtcaatctgaaagtcccagccagccaagtgaagctgatattaaggaccagccagaaaatggacatttgggcttccaggacagttttgtcacatcaggtgttttcagtgtgaccgagctagtaagagtctcacaaacaccaatagctgcaggaacaggccctaatttctccctctcagatttggaaagttcttcgtactacagcatgagcccaggagcaatgaggaggtctttacctagcacatcctctaccagctctacaaaacgtatcaaatctgtggaggatgagatggacagtcctggtgaggagccgttctatacaagccaagggcgctctccaggaagtggcagccagtcaagtggatggcatgaagtggaaccaggaatgccatcgccaactgcattaaagaagtcagagaagtctggtttcagcagtccctcgccttcgcagacctcctcccttggaacggctttcacacagcaccatcgacctgtcattacaggacccagagcaagtccacatgcaacaccatcgactcttcattttccaacatcacccattatccaacagcctgggccatacttctcacacccagcaatccgctatcatcctcaggagactctgaaagagtttgtccaacttgtctgccccgacgctggtcagcaggctggacaggtggggttcctaaatcccaatggtagcagccaaggcaaggtgcacaatccattccttcctaccccaatgttgccaccaccacctccgccaccaatggctaggcctgtgcctctgccagtgccagacacaaaacctccaactacatcaacagaaggaggggccacctctcccacttctccaacctactcgacacccagcacctcccccgcaaaccgattcgtcagtgttggaccacgggatccaagctttgtaaatatccctcaacagactcagtcctggtacctgggataaaagtctccgcttcccaccacgcaccggacagaccacctgaccccttcccacctctgtaacacggaagcagcagcatcgcagcgcagcgacttcacatcggcggaaggggaggcgagcagacaccgacagcaaactcgtacatggaaatggcaaacgttatggttgaatggcaaaggccgtaactttttcgagattttttttttttaaacaacttaggactgttgtaatttctcctatggtgctggaaatggttgggcttcataacttttgaagtgtttcattggtagtgtaagcgttaggtgacactgagtagaactagcctctgctgctgcttaccaactcgctgttgtaacacactttccatatggagcctaactgtttgacagtatcctcatcgatttttcccatacaggtgtgagacttcttgagaaatcatgaaacacacttaaactataacttttgtagtagctgaattctgcaatatataacttaccggacagacatagagcatgttttcctgtaacatatcggaaaaaaaatgcaggtttttttttttgttttgttcttgttgttgttgttgttgttggggtttttttttttttggttttttttttttacagtcggcacttagatacgtaacacgaaccataagagcattgtcaacaattattttccactcaattgcagagcgatttaaaacatcgaactactactattcacttaaaaaagaaaaaaaaagaaaaaaaaagtttgaaatgctgcacttacattgaaaaaaaaaaacatttttcaacaattttcaacaattacacaaaaattcacgcagaaatggggaagttggtctgttttgacagaaactgacaggaatcaatcaaaacaatcgaattttgaattgagtaaagtgcaatttcattggatagctaaatatctttgtaagatagagattgttgaaaattctatttttgttttccaagtccttccaccccgggactctaaattattggggtaaaaaacagccttgcaagaaaaaggggagctatttttgctttttatgttttttattgttgaacttgtatccctttaaaactgaaggaaaattaaaaaaaaaaaaaaaaaacaaatctaatggtgcttttaccacaatatgttaactacattaaatgctaattaatcattttctgttatcaaagcacataactaaaattaaatcataatatctgttaattttataagctaaaagtcactataatggattatgccaattctgacaaattttacgtgtttccggcaatatagggtttatcagttctcaaacacctttgggaataatagagaacggtccagaaattaaaacaccttcgtgtccctgaactggtacattttctggactgcaaggaaaacaatacagaaacgaatgctgatcgtacaacttctgccagttcaaagtgagggcacttgctgaagaagaagagaaaaagaaaaaaaaaaaaaaaaagtttggaccccaaacgtcctgtatcttatgtacaaaaaaaaggaaaaaaaaagaaaaaaaaaaaagagtgcaagtgattttttctatcagacagcggagcacccctttgcttcacatgcaactttaagaaggtttcctatactatacatatatatacgttctggttggcaagtccagctaatcagagaaagtctctgcatgttctagtgttagtaactaatttttatatagttaatgtagggtaaagtagagtgcattaagacacaatattgtaatccctattccaggcacttgcctttaaactatgtttgttcgacccttcagaagggtttctactactgtcctatacaatcaagtaactgaaattcttgggaagacactttgctcctcatcttttccctgaaacaatgttttgttttgttttcttaatttgcacgaaacaaacaaacaaaaaaaattccatatcaatgtgccttgccctggatagcgattatttgtggaattgttgcacatgttcctatattgaaaggggtttttccctagtcaagcatttggagacactttttgtaaatgtgacttttatgtcagccattgtcagtttcaacatctagaattaaataggatgttagttgttccgcagataggagtagtgtttattgtcctgtatggtcagtggcagtgctattctgagatctgtagatgctagattatcagtatttttggatgttgctgcattttacattttatttggagtcttcctttcgttttgttttggttttttttttcgttttgtttttttttttttcccagatatatgaaaatatgcaatacctgcttatatcatgtagaaaagcttagcgattattaatttttcttttcattttttttttatttgaccaaagttggtgctgcacttgacgcagtgtgttttaggtgtttgtctttgtacttttgtgattttgaatgcacatgcaggaagggctcttcttagagaagcagtcaaactgtgaagcactaagctgaaccctgcttcaagcaatttttgttttacaactgttcctttcacaagcaagccttaaaaaagaaaaaaaaacttcctttttcttcagatcccacacccatttttattagcagactgcaatcaatccacattcaataaaagtatataatgcccatttttatatgcacgtttttaaacttccaagttctgaaaattgtttactggttattctctatttaaggaaaaaaaaaataaaatgttttggattttcatatgtgtctgataagtggttgagtagtcattttgctctattgtattgtgtgattgttagtatatggtatcacatcctctagccagcatcctttgccttccctatagcacttagctgggcattactttattaagacatatgtgcactaaaaaaaaaatagcagctttcagtgcttcacagtgaagggaaaaaaagcctagacaaacattttgtcagaaccttgctatgagacaaggtattaccagtaaattggttgtacatacaataaaattgcacccttttttaaacaaaacaaactaagcaatagtttgggcagttagttgtttttagtgagcatgttgtagtcatggctgcaaagagagagaattaaactgcccactcagaagatatgtaatttgtatgttgtatagttttattgattacactgatttattctaccctattttataatgcaggacttttgtaatgttgtttaaatgaggaaaaatttctgtcaaattagcttagtggaatttctgattgttcgttataaaggcagcgttcatagaattgctttttttttttttttttttttttcctttgggaactggatttaagttaaaaactttcccgtttcctttttttgtatgtatttaaatacagttatttttcttctctcaatggtatagcatattcctatgcttgagaagtataggctactgaagaaccattgtaaatggacattacaggtatgctgtatttttgaaggtattttgtcatattaagtttgatgacgctaaagttagggaattctgagcagaatggcgagaaaaaagaaaaacagaaatgttttaaaggctttaaaacatgagcgaggcggtcagggccgtcggcccgccggggttggagagcaatccccgcgcagtcccctttttgctcagcccgctgcagagccgccatgcaggtgcagaggccgtgtgcgggcggcccctcggccccggggggtccatccgtgggctctgggacacgcgaacaactttttcccccccacactccccccctcccagccccaccccctctcccgtctccttctctgcagaagttgtcagacgcacaaatcctctgccctgcattcatccacccacccacccatccaaattgaaagacctagaaattgcttagcgcgaattgactttgccagttaattcctttcttttttttcctctttttgaactagggcacttgcttttatcatgccgcacaccccagcgatgccattatttattcctcttcctttcttaatgaaaccttacgggcttcaagttaggcagccatggtacactttgtctctgctgtgatccccctaaatagggtcgcaggggaaggaaccaccaagttctctgactccgcagtattcagtcagcccacaggaatatgcaaaatccctctaacgttgttttttttttcttctttctctatttctctttgttccatatatttgcagctttgtagtaacagtgttataaaatacttactgtacaaaaatacgagaaaacccagatacatagcctaaaacaggttttttttttttccttgtggtgaattattattattttttttttttttaagaatgtcagtttaatatcgtacttcttcgcattgtgtctctggaaatatctttttttttttttttttttttttttttttttttttttttttttggtagaaggcctccatcgaacaaaattaaaaccataaccggcatgacaatgtaaggagagcttcaatggcacctaaacaatatccaaacaacaaaaccaacctcatgaggtctgtcagaggcaggtcttgtgaagttaacactgcctgctaggcaggattttcattaaatcaagcttacaatgccaattttgtcttgaagtcaatgcatgtattactgtttgacagtaaacccagctatgccatcatcaagtccaaggctgcgcaatagtctaattagtatcgagtacattttccttttattttttccaataaaaaagcagtgggatgaaaattgctttgatatatagcaggtaacattgaagctattccatagcacttaactgtagtgaatactgtgtcaccaattctgaaatcaatttaatgtttaatgcaaatccattacatggtgctattacaggctggcaaaatgatttacaaaaatgtgacaacttgggctcaattcactctgctttccaacaatgtaaatgcatagcagtgtttatctgcatgaaaactatgcactaatctatctgaaaaaaaaaaaaaaaagaaaagaatatatcgactttggtatctactttccgtttacttcgatccttgcctttttggtcattgttataatgccagctttaggacagaaagaattataagaaaaccagcataatacctgatatattaaaatgtagtgcctgtgaaatctgtattatattgctcttctgaagtaagatttttctacaccggtagccttcgctgtctgtcagaaccttctgatataggtgatgtaaaataaccgtacaatattaatgcatgctattccataatgcttagtagctgtatgaatattactcaaagttatgttagtctttttttctgacttggttcttgtcagataggtttaaagatatttcactgagaacgcaaattctgtcttttcttgatttggggtgttttcagtattttggaggtatacatttacttaaattcagtattacttgtgttttggttttttttttcttttttttttttctttttttttctttttttttttccttttttttttttttttttttccctagagggcaggacatggtgtttgagaccagaaatccgtgcctggtaagattttcgtctcgaaaagctaccctaagaattgcagagcttgctctgaagaacatcccttaaagttcaaattgaagggacggtcctttaaccccacagacgagatggagctcatctcgcgggagatttcttaatgggcagcggttaaccaggtacccatgcttgacccttcttcacaccagacttcctcatatagaagaaaaaccctttaaaaaaaaaaaaaaaagaaaagaaaaaaaaagaaaaaaaaaaaaaaaacctcatgtggttgtttagtttcatgcacagttgcaatatttttcttcaaacaaactctgtacaaactttgggcccgattcataaaagctcagttgctattaacacgggactctggtgggcttttctcgtccaaattggggctccctctctccctagtgcactctggccgggcctccccccgcagccctcgctcctctccctccccttcccctctccacctcccaaactctgaacaaaatccatgcgagtggatgtggagacggagccgagagcggcggggccccgaagccgcgctccagccctggcagggttccgtcacttcgtggtacaatgctatttgatggcaagggacattttgtctgtaccagaaaaatacgctagattgctacctctgagctctagagaaaaccttcgtaaaggacaacacttgtatacagtgtgaacttttgtactttgtacgcttttttttagggaagactgttttccacttagttaatcttctatgctcgagcatgaacaaaaacaattgtgtcagtgaaattcccccttttatctgcatccacaaattaatatgaggggaaaaaacgaagatgagtttctagatggagcatggtaggaagcgtccccagcttagcacctgcctcgccactgcgggcggcccttggggaaaggctgcaggattcctggctttgggaatgccaccaggagcggtccccacgttgggtggctccgcggtttcccccatggccgagctcagccccagccccagccgctttctgagcctggtccagccgagtccctcggtgtcacttttcaatccggggcactaaaatttccactggccgcgggaaagatctgctgcaaattcacttgacacccgtgttaataccatgtcgtgttcatttttttatgagtcaggcccctcgtgcctctagtatacttgtattgactctcatagttaccattttagttttactgtgttctgtgaaaaaaattgtaattggttgagaatcactgtgggcatccattcttattcaactaagtctccgcaggttttttgagctggtgtggattagtttaactcttgtattcaaccattagtgctaccaccttctcacattacaatacaattactggaagcaagtactgcatttcctatgcaacaaaaaaggaaaataaaaaattgctaatgctac
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]