LOCUS       NM_001398451            3037 bp    mRNA    linear   VRT 30-APR-2025
DEFINITION  Gallus gallus prolyl 3-hydroxylase 2 (P3H2), transcript variant 2,
            mRNA.
ACCESSION   NM_001398451 XM_015291385
VERSION     NM_001398451.1
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 3037)
  AUTHORS   Tang,H., Finn,R.D. and Thomas,P.D.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 3037)
  AUTHORS   Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
            Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3037)
  AUTHORS   Fernandes,R.J., Farnand,A.W., Traeger,G.R., Weis,M.A. and Eyre,D.R.
  TITLE     A role for prolyl 3-hydroxylase 2 in post-translational
            modification of fibril-forming collagens
  JOURNAL   J Biol Chem 286 (35), 30662-30669 (2011)
   PUBMED   21757687
REFERENCE   4  (bases 1 to 3037)
  AUTHORS   Hubbard,S.J., Grafham,D.V., Beattie,K.J., Overton,I.M.,
            McLaren,S.R., Croning,M.D., Boardman,P.E., Bonfield,J.K.,
            Burnside,J., Davies,R.M., Farrell,E.R., Francis,M.D.,
            Griffiths-Jones,S., Humphray,S.J., Hyland,C., Scott,C.E., Tang,H.,
            Taylor,R.G., Tickle,C., Brown,W.R., Birney,E., Rogers,J. and
            Wilson,S.A.
  TITLE     Transcriptome analysis for the chicken based on 19,626 finished
            cDNA sequences and 485,337 expressed sequence tags
  JOURNAL   Genome Res 15 (1), 174-183 (2005)
   PUBMED   15590942
REFERENCE   5  (bases 1 to 3037)
  AUTHORS   Vranka,J.A., Sakai,L.Y. and Bachinger,H.P.
  TITLE     Prolyl 3-hydroxylase 1, enzyme characterization and identification
            of a novel family of enzymes
  JOURNAL   J Biol Chem 279 (22), 23615-23621 (2004)
   PUBMED   15044469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000240.1.
            
            On Dec 16, 2021 this sequence version replaced XM_015291385.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HAEL01009592.1, SRR13267652.23657.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992393, SAMEA103992470
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAENSK010000240.1  13680379-13680602
            225-371             JAENSK010000240.1  13722668-13722814
            372-561             JAENSK010000240.1  13723666-13723855
            562-693             JAENSK010000240.1  13726305-13726436
            694-836             JAENSK010000240.1  13726978-13727120
            837-926             JAENSK010000240.1  13728316-13728405
            927-967             JAENSK010000240.1  13728633-13728673
            968-1062            JAENSK010000240.1  13729067-13729161
            1063-1190           JAENSK010000240.1  13731344-13731471
            1191-1286           JAENSK010000240.1  13731818-13731913
            1287-1437           JAENSK010000240.1  13731998-13732148
            1438-1555           JAENSK010000240.1  13732595-13732712
            1556-1631           JAENSK010000240.1  13733103-13733178
            1632-1772           JAENSK010000240.1  13733370-13733510
            1773-3037           JAENSK010000240.1  13734283-13735547
FEATURES             Location/Qualifiers
     source          1..3037
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="9"
                     /map="9"
     gene            1..3037
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="prolyl 3-hydroxylase 2"
                     /db_xref="CGNC:49910"
                     /db_xref="GeneID:414143"
     exon            1..224
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    192..194
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="upstream in-frame stop codon"
     exon            225..371
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1865
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /EC_number="1.14.11.7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     leprecan-like protein 1; leprecan-like 1"
                     /codon_start=1
                     /product="prolyl 3-hydroxylase 2 isoform 2"
                     /protein_id="NP_001385380.1"
                     /db_xref="CGNC:49910"
                     /db_xref="GeneID:414143"
                     /translation="

MANPEHMEIQQDIENYKTTAGKVSLIDLEAKPHMEDYSAGVRHYDKEEYGLAITFLERALEGYYAEDEDCQIMCEGPQRFEEHEYLEYKAGLYEAIADHYMQVLACKHDCIRELATRSGRISPIENFLPLHYDYLQFAYYRVGDYVKALECARSYLLFHPDDEDVLENAAYYEGLLEGTVDPATIKPRKEAKALLHRHKLESHLLRVAAVGLGFTYTEPNYWKRYGARQDEHSVPSSISSEPEDGPRLSLTKKPTPKPDRELKEGGPLLYSDVKFVYNSQQLNGTQRVLLDNVISEEQCRELHRVASGIMLAGDGYRGKTSPHTPNERFEGATVLKALKYGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHLVCRTALSGQQERRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNADFEGGEFIFTEMDAKTVTASIKPKCGRMVSFSSGGENPHGVKAVTKGQRCAVALWFTLDPLYRELERIQADEVIAMLDQEHVGRSEMNINPKDEL"

     misc_feature    1152..1748
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="Prolyl 4-hydroxylase alpha subunit homologues;
                     Region: P4Hc; smart00702"
                     /db_xref="CDD:214780"
     exon            372..561
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..693
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..836
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..926
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..967
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1062
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1190
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1286
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1437
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1555
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1631
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1772
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..3037
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggaggaagtgagacgtacgcgcagctgggagctgaaagggctgcagcagcctctcgctgtgagcatccccaatgatttatctgcagaattcccagcggcaggaggctgtcggggcaagagggctcagggtggagactccagcgagaaacggctccaagcagaagcctcgcagaagggcatcctgcaagcagtgatggtgggatgtaggagagggggcaagaacgctgaacaagctggaggaggcagcaaacgcagctcacaccttcttcatggcaaaccctgagcacatggagatacagcaggacattgagaactacaaaaccacagcagggaaagtcagcttgatcgacctggaggccaagccgcacatggaggattacagtgctggtgtcaggcactatgacaaggaggagtacgggttggccatcaccttcttggagcgtgcactggaagggtactatgctgaggatgaggattgccagatcatgtgcgaaggaccacagaggtttgaggaacacgaatacctggaatataaggctggcctctacgaagctattgcagatcactacatgcaagtcctggcctgcaaacacgactgcatccgagagctcgccacgcgctcgggccgcatctcacccatcgaaaacttccttcccctccactacgattacctgcagtttgcctattacagagtcggtgactacgtgaaagccctggagtgtgccaggtcctacctcctcttccacccggatgatgaagatgtcttggagaatgcagcttattatgagggcctcttggaaggtaccgtggatccggccactatcaagcccagaaaggaagcaaaagcattgctgcatcggcacaagctggagtcccacctcctgcgggtggctgcggttggcctggggttcacctacacggagccaaactactggaagaggtatggtgcccgccaagatgagcatagtgtcccatcgagtattagcagtgagccagaggatgggccccggctgtcactaacaaagaaacccacaccaaaaccagatcgagagctgaaggaggggggtccacttctctacagcgacgtgaagtttgtctacaactcacagcagctgaacggcacccagcgagtgctgctggacaacgtcatctcagaggagcagtgtcgggagcttcacagagtggccagtgggatcatgttggctggagatggctataggggcaaaacctctccccatactccaaatgagagatttgaaggagccacggtcctcaaagccctcaagtatggctatgagggccgtgtcccactgaagagcgcccggctcttctacgacatcagcgagaaggcccgcaggatcgtcgagtcctacttcatgctcaactccacactctacttctcctacactcacctggtgtgccgcaccgctctctctggccagcaggagaggaggaatgacctgagccaccccatccatgccgacaactgcctcctggaccccgaggccaatgagtgctggaaggagcctcctgcctacacctttcgggactacagtgccctcctctacatgaatgcagatttcgaaggcggcgaattcattttcactgagatggatgccaaaacagtgacggcatccatcaagcccaagtgtggacggatggtcagcttctcatccggtggtgagaacccacatggagtgaaggcggttaccaaagggcagcggtgcgctgtggctctatggtttaccttggacccactttacagagaactggagcgaatccaggcagatgaagtgatcgccatgttggaccaggagcacgtaggacgcagtgaaatgaacatcaacccaaaggatgagctatgaactaggccaaagacttttttttttttctattaaatatttatttaatattgttaatcttattagaacctttctatttttgtacagagatgctgtataaattaacaggttaatatgattgtggagttttcaggagtgcctcttctgtgtttagcacagctcttgctgggacccctcctccctgtgccagcatctcctgctgggcccgtctttgctgctggggttccctgtccttcttgagcgctgctgtaccccctccaaggaccctttttattttcctcagccagaagtagctgcttctctttagcctctgctagagaaatgtctcaggtgtgctgatggatctctctccctctccctcctgccaagctgtggctgcagacctagtgctgttgccctagaaagcacagccaggcccttggttggagcttaccttcctcaggagctttatttttgcttcctgctgcttcatctcagtgccttttcagtgcctttctgctaccctcagccagccctgccattatttctaggacttaaaactggcagtgggcgttgggctttgctcttcattgttgcagcttgtacccccacccatgtacccatgtacccatgggtactgctggttgacctcaggagcaagacagggaaccaagggcttagcatcattgcatggcttaagttgaaagggaccctaaagctctgtgccctctcgatgaacagttgcccaggctccggaggagatgccattaccccaggaagagtgagggaaggttgatttgctccacctcttcaactactgcacctgcaggggagaacactgtgagtgcctctgagccactggcatgccttggttcctggacgtcacctcccttgcctacaggccattcaagtgcttcagcaggttggcttcccaagaaaacactcctggtaattgcttacccaccctctgtttaacacagctgcaagagaagctggggagaagggggtggcagctggagagcagaaccaggggctctgttatcccctctgtgccccaccaaaactcagccagggcttggctcctgcactgcacccttggccctggtctgtgctgctcccaggggctgctttgctgctgtggtgataactggagctgtgtgttaatccaggggaaataaaacaagtgagacaccaca

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