LOCUS       NM_001396480            3461 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus argonaute 4, RISC catalytic component (AGO4),
            transcript variant 1, mRNA.
ACCESSION   NM_001396480
VERSION     NM_001396480.1
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 3461)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3461)
  AUTHORS   Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P,
            Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci
            P, Hayashizaki Y and Buerstedde JM.
  TITLE     Full-length cDNAs from chicken bursal lymphocytes to facilitate
            gene function analysis
  JOURNAL   Genome Biol 6 (1), R6 (2005)
   PUBMED   15642098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000339.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13267659.92860.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA103992290,
                                           SAMEA103992323 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAENSK010000339.1  4254019-4254070     c
            53-218              JAENSK010000339.1  4250705-4250870     c
            219-339             JAENSK010000339.1  4250117-4250237     c
            340-521             JAENSK010000339.1  4249749-4249930     c
            522-658             JAENSK010000339.1  4249238-4249374     c
            659-793             JAENSK010000339.1  4249020-4249154     c
            794-881             JAENSK010000339.1  4248755-4248842     c
            882-1029            JAENSK010000339.1  4248226-4248373     c
            1030-1149           JAENSK010000339.1  4248028-4248147     c
            1150-1278           JAENSK010000339.1  4247677-4247805     c
            1279-1412           JAENSK010000339.1  4247384-4247517     c
            1413-1597           JAENSK010000339.1  4246792-4246976     c
            1598-1757           JAENSK010000339.1  4246005-4246164     c
            1758-2073           JAENSK010000339.1  4245244-4245559     c
            2074-2208           JAENSK010000339.1  4244916-4245050     c
            2209-2310           JAENSK010000339.1  4244014-4244115     c
            2311-2510           JAENSK010000339.1  4243583-4243782     c
            2511-3461           JAENSK010000339.1  4242534-4243484     c
FEATURES             Location/Qualifiers
     source          1..3461
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="23"
                     /map="23"
     gene            1..3461
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="argonaute 4, RISC catalytic component"
                     /db_xref="CGNC:66346"
                     /db_xref="GeneID:419629"
     exon            1..52
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..2619
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein argonaute-4; argonaute RISC catalytic component 4;
                     eukaryotic translation initiation factor 2C, 4"
                     /codon_start=1
                     /product="protein argonaute-4 isoform 1"
                     /protein_id="NP_001383409.1"
                     /db_xref="CGNC:66346"
                     /db_xref="GeneID:419629"
                     /translation="

MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSIQWVSVVSLQLLLEALAGHLNEVPEDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKLTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQETSQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA"

     misc_feature    109..498
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    529..681
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    682..1044
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(838..840,883..885,925..927,937..939,991..993,
                     1012..1014,1018..1020)
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1183..2490
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1594..1596,1606..1608,1642..1653,1660..1662,
                     1684..1686,1693..1695,1705..1707,1717..1719)
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1798..1800,1804..1806,2044..2046,2458..2460)
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="active site"
                     /db_xref="CDD:240015"
     exon            53..218
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            219..339
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            340..521
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            522..658
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            659..793
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            794..881
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1029
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1149
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1278
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1412
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1597
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1757
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..2073
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2208
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2310
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2510
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..3461
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gggggggaccgcagcgaggccgccgccgccgccatggaagcgctgggacccgggcccccagcaagccttttccagcccccccgtcgcccaggcctgggaactgttgggaaacccatccgcctcctagccaaccactttcaggttcagatccccaagattgatgtttatcactatgatgtggatatcaaaccagaaaaacgaccccgaagagtgaacagagaagtggtggatactatggtgagacacttcaagatgcagatatttggtgaccggcagcctggatacgatgggaagcggaacatgtacactgcacacccattacccattggcagggacagagtggatatggaggtgacacttccaggagaggggaaggaccagactttcaaagtgtccattcagtgggtgtcagttgtcagccttcagttgctgttggaagctctggcagggcatttgaatgaagttcctgaagattctgtacaagcacttgatgtaattacacggcaccttccgtccatgaggtatactcctgtgggtcgctcctttttttccccccctgaaggctattaccaccctctgggtggtggcagggaggtctggtttggtttccaccagtctgtcaggcctgccatgtggaacatgatgctcaacattgatgtatcagcaactgctttctatcgtgctcagcctatcattgagttcatgtgtgaggtcttggacattcagaacatcaatgaacaaaccaagcctctgacagactcccaacgtgtcaagtttaccaaagaaatcagaggtctaaaagtagaggttactcactgtggccagatgaagagaaagtatcgagtttgcaatgttactcgtcgaccagccagccatcagacgtttcctctgcagttggaaaatgggcaggctatggagtgtacagtagctcagtattttaagcagaagtacagtctgcagctaaaatatcctcatcttccctgtctccaagtaggacaggagcagaaacacacatacttaccgcttgaggtgtgtaacatagtggcaggccagaggtgtatcaagaagttaacagacaatcagacatcaactatgataaaagcgactgcaagatctgcacccgaccgacaggaagaaatcagcagacttgtgaaaagtaacagtatggttggtggacctgatccatatctgaaggagtttggtattgttgtccataatgaaatgacagagttgacaggcagagttttgccagcgccaatgctgcaatatggaggcaggaacaagactgtggccacaccaaaccaaggtgtgtgggacatgagagggaaacagttctatgctggcattgagattaaagtttgggctgttgcctgttttgctcctcaaaaacaatgcagggaagacttactaaagagttttacagaccagctgcgcaagatctccaaggacgcagggatgccgatccaaggccagccctgtttctgtaaatacgcccagggtgcagacagtgtggagcccatgttcaaacatttaaaactgacttatgttggtctgcagctgattgtggtgattctacctggaaagacacccgtgtatgctgaagtaaagcgagttggcgacactcttcttggcatggccactcagtgtgttcaggtaaagaatgtggtgaaaacctcaccacaaacactgtccaacctgtgtctgaaaataaatgcaaagcttggaggaatcaacaacgtgctcgtacctcatcaaaggccctcggtgttccagcagccagtgatctttttgggagcagatgtcactcaccctcctgctggggatggaaagaagccttccatagctgctgtggtcggcagcatggatggccatcctagccgttactgtgccacagtgcgagtgcagacctcccgtcaggagacctcccaggaactgctgtacagccaggaggtgatacaggacctgacaaacatggtgcgagaactgctgatacagttttacaaatccacacgtttcaagcctacaagaatcatttactacagaggaggagtatcagaagggcagatgaagcaggtagcttggccagaacttatagcaatcagaaaggcctgtattagtttggaagaagactacagaccaggaataacctacatcgttgtgcagaaaagacaccacaccaggctgttctgtgccgacaaaactgaaagggtgggtaagagtggcaacgtaccagcgggcactactgtggacagcacgatcacgcacccttctgaatttgacttttacctctgtagccacgcaggaattcagggaaccagccggccctcccactatcaggtcctgtgggatgacaactgtttcactgcagatgagctacagctgctgacctatcagctgtgtcacacgtatgtgcgctgtacgcgatcagtctctattccagcacctgcatactatgccagactggtagcatttagggctagataccatcttgtggacaaggatcacgacagtgctgaaggcagccacgtgtcaggacagagcaatggccgtgatcctcaggctctggcaaaggcagtgcagatccaccatgatactcaacatacaatgtattttgcttgagagcatctgggaagatgaggcaaagccaacaactcgttcagtcctgacatgttttcaatgcctactgctatagctagggcccggtttctttcagactgcccactaccagcagctctgaacagtcgcactgaatctgtacttcaaacaatgtctgatgcaccgacacaattgagccattcgtttcgttattttacgtcatagaaattcatagactgtcttttctgatgcattggactaaatttttacctcaaagcgcaaaaggccgatcatcccgacgtttttaaaggacttggcacgaaaggtttctattgaatactttgctagctctggtctttaggttcccttctcatcccattagctgatggtgacgactgattctccgtcctcacgcgctgcttagtgagtatgcgtagtatggcgaagttctcctccagttcaatgtaatcgttctcttgtgtggggccatagatttttttaatggagattttagacttcactactgtaaatgccttttaacagacgtaactttcacaggtcttgcagtttttgtcggttttactaatgacctttttaacctgcagactcgggctgcaaagcaattgcactattctgcgagttcagatcggtggttcctgttgtgaatgtgtgacgtgcccaggtggtggtgcctggcagtagctttcaattgtaacgcctacagataatgctgccatggcgtcgtgacaaacactgaaccatcgttttcccccctctaaaaaaacaaaacaaaaaaaaaaacgaaaaaaaaaaaaacaaaaaaaggatttaaaaaaaaaatagaaaaaaaaatacaaaaaaaaaaa

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