LOCUS       NM_001317212            6707 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus argonaute 1, RISC catalytic component (AGO1), mRNA.
ACCESSION   NM_001317212 XM_425781
VERSION     NM_001317212.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 6707)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6707)
  AUTHORS   Ender C and Meister G.
  TITLE     Argonaute proteins at a glance
  JOURNAL   J Cell Sci 123 (Pt 11), 1819-1823 (2010)
   PUBMED   20484662
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000339.1.
            
            On Sep 23, 2021 this sequence version replaced NM_001317212.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA103992290,
                              SAMEA103992323 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAENSK010000339.1  4237575-4237719     c
            146-329             JAENSK010000339.1  4231795-4231978     c
            330-450             JAENSK010000339.1  4230755-4230875     c
            451-632             JAENSK010000339.1  4230446-4230627     c
            633-769             JAENSK010000339.1  4230214-4230350     c
            770-904             JAENSK010000339.1  4229776-4229910     c
            905-992             JAENSK010000339.1  4229384-4229471     c
            993-1140            JAENSK010000339.1  4228282-4228429     c
            1141-1260           JAENSK010000339.1  4227848-4227967     c
            1261-1383           JAENSK010000339.1  4227403-4227525     c
            1384-1517           JAENSK010000339.1  4226668-4226801     c
            1518-1702           JAENSK010000339.1  4225129-4225313     c
            1703-1862           JAENSK010000339.1  4224806-4224965     c
            1863-1953           JAENSK010000339.1  4224422-4224512     c
            1954-2148           JAENSK010000339.1  4222106-4222300     c
            2149-2283           JAENSK010000339.1  4221472-4221606     c
            2284-2385           JAENSK010000339.1  4220498-4220599     c
            2386-2585           JAENSK010000339.1  4219472-4219671     c
            2586-6707           JAENSK010000339.1  4214938-4219059     c
FEATURES             Location/Qualifiers
     source          1..6707
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="23"
                     /map="23"
     gene            1..6707
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="argonaute 1, RISC catalytic component"
                     /db_xref="CGNC:1607"
                     /db_xref="GeneID:428222"
     exon            1..145
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2694
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="eukaryotic translation initiation factor 2C, 1;
                     argonaute RISC catalytic component 1"
                     /codon_start=1
                     /product="protein argonaute-1"
                     /protein_id="NP_001304141.1"
                     /db_xref="CGNC:1607"
                     /db_xref="GeneID:428222"
                     /translation="

MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWMAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA"

     misc_feature    220..612
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    640..792
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    793..1155
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(949..951,994..996,1036..1038,1048..1050,1102..1104,
                     1123..1125,1129..1131)
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1288..2565
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1699..1701,1711..1713,1747..1758,1765..1767,
                     1789..1791,1798..1800,1810..1812,1822..1824)
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1903..1905,1909..1911,2119..2121,2533..2535)
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /note="active site"
                     /db_xref="CDD:240015"
     exon            146..329
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..450
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..632
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..769
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..904
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..992
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1140
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1260
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1383
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1517
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1702
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1862
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1953
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2148
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2283
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2385
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2585
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..6707
                     /gene="AGO1"
                     /gene_synonym="EIF2C1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggcgcgtgcgcgctggggcgcagcgtgaggcggctgcggcggtgcggcaccggccccggccccgcgccccggccctgccctgcccgcggcccggcgaggagcggcgcccgcgtggatgggatggaagcgggaccttcgggagcagctgcaggcgcatacctgccacccttgcagcaggtatttcaagcgccgcgtcggcccgggataggaactgttgggaagcccatcaagctcttagccaactactttgaagtggacattcccaagatcgatgtatatcattatgaagtggatatcaagcccgacaaatgcccacgcagagtcaacagggaagtcgtggagtacatggtacagcacttcaaacctcagatctttggcgaccggaagccagtctacgatgggaagaaaaacatttacactgttacagccttacccattggaaatgagagggttgactttgaggtgacaatcccaggagaaggcaaggacaggatatttaaggtctctatcaagtggatggccattgtgagctggcgcatgctccacgaagccctggtgagcgggcagatccctgtccctttggagtctgtccaggcactggatgtggccatgaggcacctggcttccatgaggtacacccctgttggccgctccttcttctccccaccagaaggctattaccaccccctgggaggtggcagggaggtctggttcggtttccaccagtctgtcaggcctgccatgtggaagatgatgctcaacattgatgtttctgcaacggccttctacaaagcccagcctgtaattgagttcatgtgtgaggtgctggatatccggaacatcgatgaacaaccgaagccactgacggactcacagagagtgcgtttcaccaaggagatcaaaggtttgaaagtagaggttacccactgtgggcagatgaagaggaaataccgtgtgtgtaacgttacccggcggccggccagccaccagacgtttcccctgcagctggagagcggtcagacagtggagtgcacagtggctcagtacttcaagcagaaatacaacctgcagctgaaataccctcacctcccgtgtctccaggttggccaagagcagaagcacacatacctgcccttggaggtgtgtaacatcgtggcaggccagcggtgcatcaagaagctcacagacaatcaaacatcaaccatgataaaagcaacggccaggtctgccccagacaggcaggaggagatcagccgcctgatgaagaatgccagctacaacctggatccgtacattcaggagtttgggatcaaggtgaaggatgacatgacggaggtgacggggagggtcctgccagcacctattctgcagtacggaggcaggaaccgagccattgcaactcccaaccagggcgtgtgggacatgcgagggaagcagttctacaacggcattgagatcaaagtctgggcgattgcttgctttgccccgcagaagcagtgtcgagaagaggtgctgaagaactttacagaccagctgcgcaagatctccaaggacgcagggatgccgatccaaggccagccctgtttctgtaaatacgcccagggtgcagacagtgtggagcccatgtttcggcacctcaagaacacctattcagggcttcagctcatcattgtcatcctgccaggaaaaacaccggtgtacgccgaggtgaagcgtgttggggacactctcctgggaatggccacgcagtgcgtccaggtcaagaatgtggtgaaaacctccccgcagaccctttccaacctctgcctcaagatcaacgtcaagcttggcgggatcaacaacatcctagtgcctcaccagcgctctgctgtctttcagcagccagtgatattcctcggggctgatgtcactcatccacctgctggagatgggaagaaaccctctataacagctgttgtgggcagcatggacgcccaccccagccggtactgtgccacagtgcgtgtgcagcgtcctcgccaggagatcattgaggatttgtcctacatggtaagggagctcctcatccagttctacaaatccacgcgcttcaaacccaccaggatcatattctaccgtgacggtgttcccgaggggcagctcccacagatccttcactacgagctcctagcaatccgagatgcctgcatcaaactggaaaaggattaccagcctggcatcacttatatcgttgtccagaaaaggcatcacacccgtctcttctgcgcagacaagaatgagaggattgggaagagcgggaacatcccagcaggaacaacagtggatacaaacatcactcaccctttcgagtttgacttctacttgtgcagtcatgcaggcattcagggtacgagccggccctcccattactacgtgctctgggatgacaaccggttcaccgcagatgagctgcagatcctcacgtaccagctgtgccatacctacgtgcgctgcacccgctcggtctccatcccagccccggcttactacgcccggctggtggcattcagagcgcggtaccacctcgtggacaaggagcacgacagtggcgagggcagccatatatctggacagagcaacggcagagacccccaggccttggcaaaggctgtgcaggttcatcaggacactttacgtaccatgtactttgcttgaaagcctaacttttgttacctcactcaagaaagctttcagatttgtaggagccatacaaaaaaggaagcattgggacaccttgtttttttttttccaatgagaaatcactgcagggcaggcagcgtcggttcgaggcaggagaccagcaccaccggacaggaagatccaacaccttcgtaggattggaagagactgattatttttttagttttttctggctttgcaaaattttgacctgaccaaacacatgaaggcattcaaggaagggataaaagtcccaggaggcggaagcaggttgtcatgtttaagatgcaatactatagactcctgactgtgaaaggcggatttggtcctccgttgcccaccaggcgctggtaggtattttttgtgggggttggggggaggggatttttagagccttaaaacagaagactagatttataaaactaatattttagaatatgagatgctttaatgggttaaggggaaaaaacaactagtttatagataactctaacactaacagttccccgcccccgagcgattccccccatataacgtaaggcaccctagcacttagctcagaactgaaaactgtcttccttgtgttaaaagctagttagctgctgccatttgaagcaacagtcacagacttttccatgggtgagtgccttactacgatgctgcaaaatttcaatgtttttaatcttgtaaggaaaatagtaatcttgtcttgatggtggtccatatttccatcggaaggagttaatttctatggtcctgagttgcagtttgtgttagatcacaacctcgtggtggttaaactccgttgaaagatgtgcactttcatataggacacgtttaatggctgctgacccatttttgtttccaatgtactacttgttatttaaaactgtttctgacaaatgggggcactgccatcccatgaggacagaaatcgctatcaatttcttttttttcttttttcttttttttttttcctgaatttctatgatggacaccgggatttttttactgagcattatttttatacgatactgagtctgttgccaaaacacacgagtcattcacatcctcagagtttacatcgccgcgctcgcaccagaggttcccaacgcttcctgtgtgtgttacacagtgtggccgtgcagctcggggcctctccactgttgtgctgctaccttgtgctgctctttgtgtcaccctattgctgatttcgtgcacggggtttttattctgaaagcacaccagagacgttccttagtcagaatgatcaaatccttgttaccgtcgtggggaagctcctcctgatctgtttttaacaggggaaaaaaaaaaaaaagccttttttgtttgtttgtttccaacagtaacatggtggctgcttttcagactcattttgctgcacagaatgaccattatgcacagcagggcagtagtaacaactcattaccaatatcacgtgggcagattgggtttttttctatatgaaaggtgtgcacaacgcttccttgaagagagaaactgtgtgcactcctgctgagctctcaggagaagagctctgttatcattttactgccaaaagtgaacgtgttttcagagcagatctgtcaccagcactgccccttgtcagtgcgcggatagaagcacacctttttgttttgtactttctgatgtttaaactcgccttgccttcatgaaatccatactagtcatgctggcccattgatctgtcctaatactgggaattcactctgcctgttttctttttgggcaacgtgtttgtgaacaatgaagacatcaatatgctatgcaaactaagtgctgagcccgctgatgtcacctttggtgaagatcctacatttagcacagttgtctttttcctcgagactgcagtatttggttcacattctcctttgcaccttgtgtcaaacaccactgctgtctgtctgcagggtggtggggaggagaccaggagctcttcgtggtcagtagggtaggaagtcttaggaaagcttttagagagcagggaatgcatcaacactaagcgtcaacgtgagaagcctacattcctatacacaagtgcctgcatagtgacacaaatccagcacctctccatttcatcctcagacctctggcttgtgttcattgaaagcaaaacgatctcagaggggctgtacctgctcacctcgtattagaaagcccctcgttaagaatcaaaccggggttaaggtcaaggttctctctgtaagtgggtttgttcaccagcattacaatggaaagcacctggctgctggcagcagcgaggggcaaaggtattttggttcctagtttttctttcttttagtgttttagttgggtctagaattctggaatgtcttttagtagccgtggcatagcacgtgccatttttaaccatttgaaaagagatagtgtgggcatttacagaaacagcttgttgctctgtaatgtttttttttttttaaccttgagacttgaaatgtaaaatggacctttaagatttgcactcatttgtaaggtggctgttcatagagaactatgaatgaagacttgctgatgtagcacctacttttaacagcaattttaactacacaaaagcttcacagcttctgaaacgctcagctggtgacttgcagatcgcgttctgcccttatttcaccctctgcattgggttttcatggttttgattcaataaaaaagccaaactcaatagctgctgtgccctttaagccgtatttccactttgaagatgttataaggggtttgagttacccgcatgttttctataacagactatgcactgtaccttctgcgcagctccagcattcaatatttctaccgttttcttgtccaagatgcaaacgaataagtgcatgtcaaggtgctgtgcattttgctacccgtagcagatagctgttaagccagagacatatcaggatctgtagttagccacaaaccccacgtggacatcccgaatggctcccgagtctctctgccttctcagtgcgcacgcgttccttctgcaactggaaacatcgccaagtgcatgcaagccttgtgggaagaggaataacttccatttgtctgtcggttgttggatgctgtgtgtttcccttgtctcatacctggacgtgacgggggcagtgggggtgtcccagtactcgcaagcctctgacctgatgcctcgtgtcacaaagcccgagcgttcagcgttgcctcgtggaaggttttcttcttggaaaatgagtgtgaaaataaagaaaagaatgtcattcttttaggaagggaagccagacagcaggacagcaataaacacatgaaattcatatcttgcctgagtgatttgcacttcgatagtcgtgaaagaaaattgatggggactccagtgcttttgtgttcagttctagcccctttcgtacctcctttatacaacaggtgttggactgtacatggggtgtttacaaacactctctttgggttgttatttttcttgcggttattttttttttgctttagcttgaactctctatggtccatttgttaaatagatgtgaacggttgatgtacagtacttactaaacaagcagcagcacaaaacttattttattaagaaaatatggcatatattttaaaggttgggtatcaacttttctttttttttctttttgtatgcgtggaattaagactggtgaagagtaacaaaacccttggattacatttggattaggccaaaagatgatactgtaagatcgtaaccacctctttattaaagaaaacggtatgattaaagagctccagaacattgtatttatatttgatttgattgctttggtggatttttttttttttaatttcaatttttttttttttgccttaatcctgatttttgcttgcaactttgacttcgcagtcccaagtgtctgttatcctgtaagtgttggcagaagacctaaataaaagcaatgtgaata

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