LOCUS       NM_001293230            1588 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus reticulocalbin 2 (RCN2), transcript variant 2, mRNA.
ACCESSION   NM_001293230 XM_413734
VERSION     NM_001293230.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 1588)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 1588)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1588)
  AUTHORS   Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong
            WT, Tickle C, Brown WR, Wilson SA and Hubbard SJ.
  TITLE     A comprehensive collection of chicken cDNAs
  JOURNAL   Curr Biol 12 (22), 1965-1969 (2002)
   PUBMED   12445392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000245.1.
            
            On Sep 23, 2021 this sequence version replaced NM_001293230.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HAEK01016974.1, CO772753.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992432, SAMEA103992528
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAENSK010000245.1  2766944-2767069     c
            127-232             JAENSK010000245.1  2766755-2766860     c
            233-429             JAENSK010000245.1  2764799-2764995     c
            430-531             JAENSK010000245.1  2762547-2762648     c
            532-628             JAENSK010000245.1  2761269-2761365     c
            629-771             JAENSK010000245.1  2759277-2759419     c
            772-1588            JAENSK010000245.1  2755622-2756438     c
FEATURES             Location/Qualifiers
     source          1..1588
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="10"
                     /map="10"
     gene            1..1588
                     /gene="RCN2"
                     /note="reticulocalbin 2"
                     /db_xref="CGNC:2050"
                     /db_xref="GeneID:415350"
     exon            1..126
                     /gene="RCN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..924
                     /gene="RCN2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; reticulocalbin 2, EF-hand calcium binding
                     domain"
                     /codon_start=1
                     /product="reticulocalbin-2 isoform 2 precursor"
                     /protein_id="NP_001280159.2"
                     /db_xref="CGNC:2050"
                     /db_xref="GeneID:415350"
                     /translation="

MRRRPRLALGLALVLAALGSAYGQHRADYDREALLGGQEEAEEYARLSPEEQQRRLKAIVRRIDADNDGLLSKDELSSWIQQSFKHYVTQEAKQHFHDYDKNGDGLVSWKEYNLQMYDRVIDFDENTVLEDQEEESFRQEKKRFEKANRDDDPDLNVDEFIAFEHPEEVEYMTDFVIEEALEEHDKDGDGFVSLEEFLGDYRRDPTAKEDPEWILVEKDRFVNDYDKDNDGKLNPQELLSWIVPNNQGIAQEEALHLIEEMDLNDDKKLSEAEVLKNQDLFLNSEATDYGRQLHDERFYHEEL"

     sig_peptide     13..81
                     /gene="RCN2"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    79..858
                     /gene="RCN2"
                     /note="EF-hand, calcium binding motif, found in CREC-EF
                     hand family; Region: EFh_CREC; cl25354"
                     /db_xref="CDD:330175"
     misc_feature    79..156
                     /gene="RCN2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320021"
     misc_feature    175..264
                     /gene="RCN2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320021"
     misc_feature    283..372
                     /gene="RCN2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320021"
     misc_feature    430..516
                     /gene="RCN2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320021"
     misc_feature    538..627
                     /gene="RCN2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320021"
     misc_feature    661..750
                     /gene="RCN2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320021"
     misc_feature    769..858
                     /gene="RCN2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320021"
     exon            127..232
                     /gene="RCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            233..429
                     /gene="RCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            430..531
                     /gene="RCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..628
                     /gene="RCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..771
                     /gene="RCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1588
                     /gene="RCN2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctcggcggcgcgatgcggcggcggccgcggctggcgctgggcctggccctggtcctggcggcgctgggctcggcgtacgggcagcaccgcgccgattatgaccgggaggcgctgctcggagggcaggaggaggcggaggagtacgcgcggctcagcccggaagagcagcagcggcggctgaaggccatcgtgcggaggatcgacgcggacaacgacggcctcctcagcaaggatgagctgagctcctggatacagcagtcattcaaacactatgttacacaagaagctaagcagcacttccacgactatgacaaaaatggtgatggattggtgtcttggaaggagtacaacttacaaatgtacgatcgtgtaattgattttgatgagaacactgtcctggaggatcaagaagaagaatcatttcggcaggagaagaagcgttttgaaaaagctaatagggatgatgatcctgatctaaatgtggatgaatttattgcctttgaacatcccgaagaagtggagtatatgacggactttgtcattgaggaggctttagaagaacatgataaagatggtgatggatttgtgagcctggaagaattccttggtgattacagaagagacccaactgccaaggaagatccagaatggatacttgttgagaaggatcgatttgtgaatgactatgacaaggataatgatgggaaactcaaccctcaagagctgttgtcctggatagtacctaataaccagggtattgcacaagaggaggctcttcacctgattgaagagatggatctgaatgatgataaaaagctttctgaggcagaagttcttaagaaccaggatttgtttcttaacagcgaagccacggattatggcaggcagcttcacgatgaacgtttctaccacgaagaactttagattatttattttgtaatctgtttttcttcccttcctttcattgggagcctttgttaaatgcactcacttttcagctttgttgcaagttttacgctgtaattacaatagaataacgtttgtgtaaatacttggcattcaaaattaaattgccctcctgcagacttccttaggcctcttctcgccttccaaattaatcttaaatacctactccaaaattacatagcaatgggaaaggaattagttaaggtacagtactgtattgtgcagggctgtgtgactgtacttcaaataaatggataatctaaacggttgtgaaggaattcaaaacagaaaatgagactactattttttctaatcagtttaattagggaggagagcggaggagatggagggaaggtgtttagagtgagtatcaactgtgttttatttaatacgtttggagaaacacttaggttaaatgcctcaattgtttaagaggtttctacttaatgttaaatggttcctataatgtgttttactgtattacggaaagaaaaacctgctatttttacatctacagacaataattgtttttatgtacaattctacaacactggcagtacgatggtattttacattgtcaagaccttcttcatttgttggattaaaaccaaaataaattcca

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