LOCUS       NM_001244738            1673 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus E2F transcription factor 6 (E2F6), transcript variant
            1, mRNA.
ACCESSION   NM_001244738
VERSION     NM_001244738.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 1673)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 1673)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1673)
  AUTHORS   Shin JH, Kim H, Lim D, Jeon M, Han BK, Park TS, Kim JK, Lillehoj
            HS, Cho BW and Han JY.
  TITLE     Analysis of chicken embryonic gonad expressed sequenced tags
  JOURNAL   Anim Genet 37 (1), 85-86 (2006)
   PUBMED   16441308
REFERENCE   4  (bases 1 to 1673)
  AUTHORS   Savolainen P, Fitzsimmons C, Arvestad L, Andersson L and Lundeberg
            J.
  TITLE     ESTs from brain and testis of White Leghorn and red junglefowl:
            annotation, bioinformatic classification of unknown transcripts and
            analysis of expression levels
  JOURNAL   Cytogenet Genome Res 111 (1), 79-87 (2005)
   PUBMED   16093725
REFERENCE   5  (bases 1 to 1673)
  AUTHORS   Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P,
            Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci
            P, Hayashizaki Y and Buerstedde JM.
  TITLE     Full-length cDNAs from chicken bursal lymphocytes to facilitate
            gene function analysis
  JOURNAL   Genome Biol 6 (1), R6 (2005)
   PUBMED   15642098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000066.1.
            
            On Sep 23, 2021 this sequence version replaced NM_001244738.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein-coding.
            
            Sequence Note: This RefSeq record was created from transcripts from
            multiple strains because no single transcript from the same strain
            was available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments and orthologous
            data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HAEK01013050.1, CV860592.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA103992290,
                                           SAMEA103992323 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               JAENSK010000066.1  2015269-2015557     c
            290-338             JAENSK010000066.1  2010835-2010883     c
            339-555             JAENSK010000066.1  2009873-2010089     c
            556-714             JAENSK010000066.1  2009398-2009556     c
            715-829             JAENSK010000066.1  2008118-2008232     c
            830-977             JAENSK010000066.1  2006582-2006729     c
            978-1673            JAENSK010000066.1  2005148-2005843     c
FEATURES             Location/Qualifiers
     source          1..1673
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="3"
                     /map="3"
     gene            1..1673
                     /gene="E2F6"
                     /note="E2F transcription factor 6"
                     /db_xref="CGNC:51570"
                     /db_xref="GeneID:421943"
     exon            1..289
                     /gene="E2F6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    197..199
                     /gene="E2F6"
                     /note="upstream in-frame stop codon"
     CDS             224..982
                     /gene="E2F6"
                     /codon_start=1
                     /product="transcription factor E2F6"
                     /protein_id="NP_001231667.1"
                     /db_xref="CGNC:51570"
                     /db_xref="GeneID:421943"
                     /translation="

MAAASKWERLRPLRPDTLRLSATPMLDLNLDDDVPVVKKTLKVKRPRFDASLVYLTRKFMDLVKRAPDGVLDLNDVATALGVQKRRVYDITSVLDGIDLIQKRSKNHIQWVGSNLDQVVEMAAQRQNLKDELSDLSAMEEALDELIKDCAHQLFDLTDDKENAKLAYVTYQDIRSIQAFQKQIVIAIKAPEETRLEIPIPKEDCIKVHVKSTKGPIDVYLCEVEQDKPADKNSEDKEAVTSETEPSVPPDEE"

     misc_feature    365..559
                     /gene="E2F6"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:426717"
     misc_feature    590..895
                     /gene="E2F6"
                     /note="Dimerization domain of E2F transcription factors;
                     Region: E2F_DD; cd14660"
                     /db_xref="CDD:271137"
     misc_feature    590..697
                     /gene="E2F6"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271137"
     misc_feature    order(593..598,605..610,614..619,626..631,635..640,
                     647..652,656..661,665..673,677..682,689..691,713..730,
                     737..742,749..751,761..787,833..856,860..871,875..877,
                     893..895)
                     /gene="E2F6"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271137"
     misc_feature    order(791..820,824..829,836..838)
                     /gene="E2F6"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271137"
     exon            290..338
                     /gene="E2F6"
                     /inference="alignment:Splign:2.1.0"
     exon            339..555
                     /gene="E2F6"
                     /inference="alignment:Splign:2.1.0"
     exon            556..714
                     /gene="E2F6"
                     /inference="alignment:Splign:2.1.0"
     exon            715..829
                     /gene="E2F6"
                     /inference="alignment:Splign:2.1.0"
     exon            830..977
                     /gene="E2F6"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1673
                     /gene="E2F6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atccgccgcccagccacccgcaggtgggggagggtaggagtggccgcagcgcctcgcggcgagccaaggcggccccggcaccccctccgcccggaggtggggcggggatggaggcgccttcttcccgcacggtcccgcagcctcatcgggtaggcctctgagtgccctgccgcccctccgaaggccgccgccggcgtgaggtaggaggaggggccgcgcgaacatggccgccgcctccaagtgggagcgcctgaggccgctacggccggacacgctgcgtctgagcgcgacaccaatgcttgacttgaatttggatgatgacgtaccagttgtaaaaaaaactctgaaggtcaaaaggcctcgatttgatgcatccttggtttatttgactcgaaaattcatggatcttgttaaaagagctccagatggtgtccttgatttaaacgacgtagcaacagctcttggagtacaaaaacgaagagtatatgacatcaccagtgtgttggatgggatcgacttaattcagaaaagatcaaagaatcacatccagtgggtaggttctaatcttgaccaagttgttgaaatggcagcacagcggcaaaaccttaaagatgaactttctgacttgtcagccatggaagaagctctggatgaattaatcaaggattgtgctcatcagttatttgatctaacagatgacaaagaaaatgcaaaactagcttatgtgacgtaccaagatatccgtagcattcaggcatttcaaaaacagattgtgattgcaatcaaagctccagaagaaaccagactggaaataccgattcctaaagaggattgcatcaaagtacatgtaaagagcacaaaaggacccattgacgtgtatctgtgtgaggtggaacaagataagccagcagacaaaaattctgaagataaggaagctgtcacttctgaaactgagccatcagttcctcctgatgaagagtgagaggaactacaactgaatctaacaccaaatgtaaatatctgtgttgtagagctcttccaaagctgtttggaactgtaaacttgccaacctgaaatgctccagagtattttgtatttaaaacagcaacggattgagtgcttgcacaggaacgtttaatattcccaagtcagaagacagtggctcctagatttgatattaggagctttgattttataattgcatgtgatctacagagctttgggaaaatggtggttttagtttatgaaataattttaattgatggaaaacgcattcagtaaatggatttgaaaaatgaaggtttgagaactgtttctggaactatttgtaaaccttctgaaaatgtatataataaagaaaatgcacttttcagttctgaggctgcactactatggagaaggattattaaatacagatgaagaaagaactgatgtatcagaagcctttgttatgaggaacaagatgtaaatagtatgagaattatgccttccactgtgtagatactgtttgcattatttgcatccagttctgcattaaatatggtatcaacactgaagttaaataatggctttttgtatatctgtaccatgtccgagtagttactgatgtaggtttattgagatggtttacatttctgcctctgtacagcaaagaaataaactttataaaagca

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