LOCUS       NM_001198662            3250 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus ectonucleotide pyrophosphatase/phosphodiesterase 2
            (ENPP2), mRNA.
ACCESSION   NM_001198662 XM_418466
VERSION     NM_001198662.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 3250)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3250)
  AUTHORS   Ohuchi H, Fukui H, Matsuyo A, Tomonari S, Tanaka M, Arai H, Noji S
            and Aoki J.
  TITLE     Autotaxin controls caudal diencephalon-mesencephalon development in
            the chick
  JOURNAL   Dev Dyn 239 (10), 2647-2658 (2010)
   PUBMED   20737506
  REMARK    GeneRIF: ATX RNA interference altered the expression pattern of
            Pax6-regualted genes, Tcf4, Lim1, and En1, implying that ATX is
            required for the maintenance of the regional identity of the caudal
            diencephalon and the diencephalon-mesencephalon boundary (DMB).
REFERENCE   4  (bases 1 to 3250)
  AUTHORS   Ahanda ML, Ruby T, Wittzell H, Bed'Hom B, Chausse AM, Morin V,
            Oudin A, Chevalier C, Young JR and Zoorob R.
  TITLE     Non-coding RNAs revealed during identification of genes involved in
            chicken immune responses
  JOURNAL   Immunogenetics 61 (1), 55-70 (2009)
   PUBMED   19009289
REFERENCE   5  (bases 1 to 3250)
  AUTHORS   Ohuchi H, Hayashibara Y, Matsuda H, Onoi M, Mitsumori M, Tanaka M,
            Aoki J, Arai H and Noji S.
  TITLE     Diversified expression patterns of autotaxin, a gene for
            phospholipid-generating enzyme during mouse and chicken development
  JOURNAL   Dev Dyn 236 (4), 1134-1143 (2007)
   PUBMED   17366625
  REMARK    GeneRIF: Non-conserved roles for ATX during neural development and
            organogenesis.
            Erratum:[Dev Dyn. 2007 May;236(5):1376. Hayashibaral, Yasunori
            [corrected to Hayashibara, Yasunori]]
REFERENCE   6  (bases 1 to 3250)
  AUTHORS   Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong
            WT, Tickle C, Brown WR, Wilson SA and Hubbard SJ.
  TITLE     A comprehensive collection of chicken cDNAs
  JOURNAL   Curr Biol 12 (22), 1965-1969 (2002)
   PUBMED   12445392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000044.1.
            
            On Sep 23, 2021 this sequence version replaced NM_001198662.1.
            
            Sequence Note: This RefSeq record was created from transcript
            sequence data from multiple strains. The extent of this transcript
            is supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB285185.1, SRR13267658.5612.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA103992290,
                                           SAMEA103992323 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAENSK010000044.1  15401163-15401424   c
            263-365             JAENSK010000044.1  15400763-15400865   c
            366-521             JAENSK010000044.1  15395680-15395835   c
            522-647             JAENSK010000044.1  15393474-15393599   c
            648-708             JAENSK010000044.1  15391419-15391479   c
            709-806             JAENSK010000044.1  15390051-15390148   c
            807-886             JAENSK010000044.1  15388985-15389064   c
            887-1006            JAENSK010000044.1  15387693-15387812   c
            1007-1062           JAENSK010000044.1  15378410-15378465   c
            1063-1128           JAENSK010000044.1  15376174-15376239   c
            1129-1201           JAENSK010000044.1  15375424-15375496   c
            1202-1313           JAENSK010000044.1  15366990-15367101   c
            1314-1439           JAENSK010000044.1  15365462-15365587   c
            1440-1471           JAENSK010000044.1  15363297-15363328   c
            1472-1599           JAENSK010000044.1  15362395-15362522   c
            1600-1687           JAENSK010000044.1  15360780-15360867   c
            1688-1775           JAENSK010000044.1  15360522-15360609   c
            1776-1948           JAENSK010000044.1  15359513-15359685   c
            1949-1997           JAENSK010000044.1  15359186-15359234   c
            1998-2134           JAENSK010000044.1  15356742-15356878   c
            2135-2270           JAENSK010000044.1  15356187-15356322   c
            2271-2348           JAENSK010000044.1  15354993-15355070   c
            2349-2481           JAENSK010000044.1  15352493-15352625   c
            2482-2638           JAENSK010000044.1  15351721-15351877   c
            2639-3250           JAENSK010000044.1  15345932-15346543   c
FEATURES             Location/Qualifiers
     source          1..3250
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="2"
                     /map="2"
     gene            1..3250
                     /gene="ENPP2"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 2"
                     /db_xref="CGNC:12299"
                     /db_xref="GeneID:420361"
     exon            1..262
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    182..184
                     /gene="ENPP2"
                     /note="upstream in-frame stop codon"
     CDS             230..2809
                     /gene="ENPP2"
                     /EC_number="3.1.4.39"
                     /note="autotaxin"
                     /codon_start=1
                     /product="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 2"
                     /protein_id="NP_001185591.1"
                     /db_xref="CGNC:12299"
                     /db_xref="GeneID:420361"
                     /translation="

MAKKGCFYFHQVISLFAFAFGVNVCMGFTTNRFRRSEEWDEGPISVLSDSPWISTSGSCKNRCFELQEAEPPGCRCDNLCKSYNSCCFDFDELCLKTARGWECTKDRCGETRNDDNACHCSEDCLSRGDCCTNYQVVCKGETHWVDDDCEEIKTPECPAGFVRPPLIIFSVDGFRASYMKKGNKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFSLRGREKFNHRWWGGQPIWITAAKQGVKAGTFFWSVVIPHERRILTILQWLTLPDNERPYVYAFYSEQPDAAGHRYGPFNSEMMVNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDTTCERTEFLSNYLTNVEDIILLPGSLGRIRPRSSNNLKYDPKVIVANLTCRKPDQHFKPYLKHHLPKRLHYAYNRRIEDVHLLVERKWHVARKAVDVYKKPTGKCFFHGDHGYDNKINSMQTVFIGYGPTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRANVYKPTVPDEVAKPLYPVALPSASDFDIGCTCDDKNKLDELNKRFHVKGTEEKHLLYGRPAVLYRTKYNILHHHDFESGYSETFLMPLWTSYTISKQAEVSGVPEHLASCVRPDLRISPGNSQSCSAYRGDKQLSYSFLFPPQLSSSAEAKYDAFLITNIIPMYPAFKKVWNYFQRVLVKRYATERNGVNVISGPIFDYDYDGLHDTPEKIKQFVEGSAIPVPTHYYAIITSCLDFTQPADKCDGPLSVLSYILPHRPDNDESCNSMEDESKWVEDLLKMHTARVRDIEQLTSLDFFRKTSRSYTEILSLKTYLHTFESEI"

     misc_feature    398..520
                     /gene="ENPP2"
                     /note="Somatomedin B domain; Region: Somatomedin_B;
                     pfam01033"
                     /db_xref="CDD:426004"
     misc_feature    524..655
                     /gene="ENPP2"
                     /note="Somatomedin B -like domains; Region: SO;
                     smart00201"
                     /db_xref="CDD:197571"
     misc_feature    725..1666
                     /gene="ENPP2"
                     /note="Type I phosphodiesterase / nucleotide
                     pyrophosphatase; Region: Phosphodiest; pfam01663"
                     /db_xref="CDD:396300"
     misc_feature    order(743..745,854..859,920..922,1163..1165,1175..1177,
                     1307..1312,1655..1657)
                     /gene="ENPP2"
                     /note="active site"
                     /db_xref="CDD:293742"
     misc_feature    order(743..745,854..859,920..922,1163..1165,1175..1177,
                     1310..1312,1655..1657)
                     /gene="ENPP2"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:293742"
     misc_feature    1730..1738
                     /gene="ENPP2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293742"
     misc_feature    2060..2752
                     /gene="ENPP2"
                     /note="DNA/RNA non-specific endonuclease; Region: NUC;
                     smart00477"
                     /db_xref="CDD:214683"
     misc_feature    order(2246..2251,2255..2257,2366..2368,2378..2380)
                     /gene="ENPP2"
                     /note="active site"
                     /db_xref="CDD:238043"
     misc_feature    order(2246..2251,2378..2380)
                     /gene="ENPP2"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238043"
     exon            263..365
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..521
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..647
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..708
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..806
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..886
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1006
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1062
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1128
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1201
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1313
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1439
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1471
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1599
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1687
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1775
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1948
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..1997
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2134
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2270
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2348
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2481
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2638
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..3250
                     /gene="ENPP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gggggagggcgcagcgagggatgatgcctggagcttcttgcactcggagctgcgatttgtgagtgaaacatgatgaaatcaccccctggacaaatcacacgagcctgtcaacctcaccaggtgggattacttgtagctaatagcccgaactcccagagcaaacagagctctgcgctcactataaagcaaaagggacggtaccgcacgggcttttcaagaatcctctagtatggctaagaagggctgcttctacttccaccaggtcatatctttatttgcttttgcctttggagtaaatgtctgcatgggatttacaacaaatcgctttaggagatctgaagaatgggatgagggcccaatctcagtcctgtcagattccccctggatcagtacctctggctcctgcaaaaacagatgctttgaacttcaagaggcagagcctcctggctgccgctgtgacaacctgtgcaagagctacaacagctgctgcttcgactttgatgagctgtgcttaaagacagctcgaggctgggaatgtaccaaagaccgctgtggagaaaccaggaatgatgacaatgcttgtcactgctctgaagactgcttaagtagaggagactgttgcactaattaccaggtcgtttgcaaaggagaaacccactgggtcgatgatgactgtgaagagataaaaactcctgaatgtccagcaggctttgttcgtcctcctttgatcatcttctctgttgatggtttccgtgcatcatatatgaagaaagggaacaaggtcatgcccaatattgaaaagctgagatcttgtggaacacattctccttacatgaggccggtctatcctacaaaaaccttccccaacttgtacacccttgctactggactctatcctgaatcacatggaatcgttggcaattcaatgtatgacccagtgtttgatgccagcttcagtcttcgagggcgagagaaattcaatcacagatggtggggaggtcaaccaatttggattactgcagccaagcaaggggtgaaagctggcacattcttctggtctgttgtcatcccccacgagcgtagaatactaacaatactgcagtggctgacccttccggataacgaaaggccttatgtttatgctttctactctgagcaaccagatgctgctggccacagatatggtcctttcaactcagagatgatggtaaatcccctgagagagattgacaagacagtaggacaactaatggatggactgaaacagctgaaactgcatcgatgtgtcaatgtcatatttgttggtgatcatgggatggaagacactacttgtgaaagaactgaatttttgagcaactacctgaccaacgtggaagatatcattctgctgcctggatctttagggagaattcgccctaggtctagcaataacctgaaatatgaccccaaagtgattgttgccaaccttacatgcaggaagccagaccagcactttaagccatacttgaagcatcaccttcctaaacgcttgcactatgcttacaataggcgaattgaggatgtccatttactggtcgagcgcaagtggcatgtagcaaggaaagctgtggatgtttacaagaaaccaacaggaaagtgtttcttccatggagaccatggctatgacaacaagataaacagcatgcagactgtcttcataggttatggacctacattcaaatacaagaccaaagtaccgccttttgaaaacattgaactttacaatgtcatgtgtgatctgcttggattaaagcctgctcccaataatggtacccacggaagtttgaatcacctgctaagagccaatgtttataaaccaactgtgccagatgaagttgctaagccactttatcctgtagctctaccttctgcatcagattttgatataggatgtacatgtgatgataagaacaagttggatgaactcaacaagcgctttcatgtcaagggaacggaagagaagcatcttctgtacgggcgccctgcagtgctgtaccgcacgaagtacaatatcttgcaccaccatgactttgaaagtggctacagtgaaacattcctgatgcctctctggacatcctacactatttccaaacaggcagaggtatccggtgtcccagaacacctggccagctgcgtcaggcccgatctccgcatatctccaggaaacagccagagctgctcagcctacagaggtgacaagcagctctcctacagcttcctcttccctcctcaactaagttcctctgcagaagcaaagtatgatgcttttctaataacaaatatcattccaatgtatcctgctttcaaaaaggtatggaactatttccaaagggttttagtgaagagatatgccactgaacgaaatggagtcaatgttataagtggaccaatctttgactatgactatgatggtttacatgacacacctgaaaaaatcaaacagtttgtggaaggcagtgccatccctgttcctactcattactatgccatcataaccagctgtttagatttcactcagccagccgacaagtgtgatggaccactctctgttctctcgtacatccttccccaccggcctgacaacgatgagagctgcaatagcatggaagatgaatcaaagtgggttgaagatcttcttaagatgcacactgcacgggtgcgggacattgagcagctcacaagcttggacttcttccgaaagacgagtcgcagctacacagaaatcctctccctaaagacatacctgcatacatttgaaagtgaaatttagctttctaaccttgctcagtgcattcttttatcaactggtgtatatttttatattgtttttatatttattaatttgaaaccaggacattaaaaatattagtattttaatcttgtatcaaatcttaaatattaaacccttgtgtcatttgttttgtttctctaatgtttaatataggtatgtctcttggtttatttagtagcgcttgtaatactgcagcttaagtccttactccaagcttttatctggtgctgcagaatttgatacgtgattcgaggaaatattaatttcccatgctcctttaccacacttttagtcctgtactgtgtatcaaaatactgaacatgtaaaattacattcatttactgttgactatgtgacagacatatttaaaccctatagacaaatagcatcttaaatataataaaccacacattcagtttt

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