LOCUS       NM_001044695            1906 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus SIX homeobox 2 (SIX2), mRNA.
ACCESSION   NM_001044695
VERSION     NM_001044695.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Garcez RC, Le Douarin NM and Creuzet SE.
  TITLE     Combinatorial activity of Six1-2-4 genes in cephalic neural crest
            cells controls craniofacial and brain development
  JOURNAL   Cell Mol Life Sci 71 (11), 2149-2164 (2014)
   PUBMED   24061537
  REMARK    GeneRIF: Combinatorial activity of Six1, Six2, and Six4 genes in
            cephalic neural crest cells controls craniofacial and brain
            development.
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Yamamoto-Shiraishi Y and Kuroiwa A.
  TITLE     Wnt and BMP signaling cooperate with Hox in the control of Six2
            expression in limb tendon precursor
  JOURNAL   Dev Biol 377 (2), 363-374 (2013)
   PUBMED   23499659
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAENSK010000063.1.
            
            On Sep 23, 2021 this sequence version replaced NM_001044695.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB199732.1, BU131501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992393, SAMEA103992415
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-826               JAENSK010000063.1  2493149-2493974     c
            827-1906            JAENSK010000063.1  2489944-2491023     c
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="3"
                     /map="3"
     gene            1..1906
                     /gene="SIX2"
                     /note="SIX homeobox 2"
                     /db_xref="CGNC:54367"
                     /db_xref="GeneID:724086"
     exon            1..826
                     /gene="SIX2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    153..155
                     /gene="SIX2"
                     /note="upstream in-frame stop codon"
     CDS             267..1130
                     /gene="SIX2"
                     /note="sine oculis-related homeobox 2; sine oculis
                     homeobox homolog 2"
                     /codon_start=1
                     /product="homeobox protein SIX2"
                     /protein_id="NP_001038160.1"
                     /db_xref="CGNC:54367"
                     /db_xref="GeneID:724086"
                     /translation="

MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSAHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENNENSNSNSHNPLSASMNGNKTVLGSSEDEKTPSGTPDHTSSSPALLLGSNPGLQPLHGLGHPQGPSAIPVPSTDPMHHHSLQDSILNPMSSNLVDLGS"

     misc_feature    291..620
                     /gene="SIX2"
                     /note="Transcriptional regulator, SIX1, N-terminal SD
                     domain; Region: SIX1_SD; pfam16878"
                     /db_xref="CDD:465293"
     misc_feature    651..806
                     /gene="SIX2"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(654..656,774..776,783..788,795..797)
                     /gene="SIX2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            827..1906
                     /gene="SIX2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

actctcgcaactcggacttacaaaaaggaggcggccggggaaaagccttccgcgctcgggctccgcgactccggcaccgctcctcagcagctccccgcgccccgctccggcgccgggctccgccgatggccgcggtcccccgcgccgggccgtgagtcccgccgggccccgccgggcgccaccgccccggggccggccccgcatgcgggccgctgcccgccgccccaccgagcggccgtagggtgcgcggcggggcagggctcaccatgtcgatgctcccgacttttggcttcacccaagagcaagtggcttgcgtctgcgaggtgctccagcaaggcggcaacatcgagcggctggggcggttcctctggtccctccctgcgtgcgagcacctccacaaaaacgagagcgtcctgaaggccaaggccgtggtggccttccatcggggcaacttccgagagctctacaagatcctggagagccaccagttctcggcgcacaaccaccccaagctgcagcagctctggctcaaggcgcactacatcgaggcggagaagctgcgggggcgacccctaggggcggtgggcaagtaccgggtgcgccgcaagttcccgctgccccgctccatctgggacggcgaggagaccagctactgcttcaaggagaagagccgcagcgtcctccgcgagtggtacgcgcacaatccctacccgtccccccgtgagaagcgggagctggccgaggccaccggcctcaccaccacgcaggtcagcaactggttcaagaaccgccggcagcgggaccgagcggccgaggccaaggaaagggaaaacaacgagaattccaactccaacagccacaacccgctctcggcgtcaatgaacgggaataagacagttctggggagctcggaggacgagaagacgccgtcagggaccccggaccacacctcctccagccccgctctgctgctcggctccaacccggggctgcagcccctgcacggcctgggccacccgcagggccccagcgccatccccgtgcccagcaccgaccccatgcaccaccacagcttgcaggactccatcctcaatcccatgtcatccaacctggtcgatctgggctcttaaaaccgcttacacgctccctccttcgcacctcctttactccctctttttctctctccttttttttttttttttctttttttctttttttcctcctttatttttccctctcaatcttaccagagactgtaagcgatgacaaagccctcagcggccgcgccgtgccgcaccccccctgctgctgtccgggccgtgggcagcagcaccgtgagaagccccggggaaggctcggggcggtgggacaggaccggggctgtcccctcgggccgcaccgcagctcctcgcgaccctctcggtgctgtcatccgccagcgtgctccgtgcgcgtaaaggagcgcggtgattttggggtggggggtggggggggtgggaaggaatcccgattggaatcccgcatcgctcccgttatcctattgtagctatgtatccgcggcaggtgtacgatgtacaatcgcaactaagaatacagaagttgtagtcaagttatagcagcaacacgcactaggcagactctgtaaccttcttgtagctgacgctatgcagaaagacggctgcttcggcctcagccgtgtggtgctttcgccgtttgcggggtgggaaggaggagaggcccggcccggttcgggcagggaagaaggattgctgctcaagtttagacctaaccgacagtatcaaccgcaagtcactcgaccttagttttgtttattgtttatattatgtgaatacattctttggaagatatttctgcttttattttataataaaatttagaaatctaa

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