LOCUS       NM_001039453            2558 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus aquaporin 1 (AQP1), mRNA.
ACCESSION   NM_001039453 XM_418489
VERSION     NM_001039453.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 2558)
  AUTHORS   McLennan R, McKinney MC, Teddy JM, Morrison JA, Kasemeier-Kulesa
            JC, Ridenour DA, Manthe CA, Giniunaite R, Robinson M, Baker RE,
            Maini PK and Kulesa PM.
  TITLE     Neural crest cells bulldoze through the microenvironment using
            Aquaporin 1 to stabilize filopodia
  JOURNAL   Development 147 (1) (2020)
   PUBMED   31826865
  REMARK    GeneRIF: the expression and function of AQP-1 during chick cranial
            neural crest cell migration
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2558)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   3  (bases 1 to 2558)
  AUTHORS   Jha KA, Nag TC, Kumar V, Kumar P, Kumar B, Wadhwa S and Roy TS.
  TITLE     Differential Expression of AQP1 and AQP4 in Avascular Chick Retina
            Exposed to Moderate Light of Variable Photoperiods
  JOURNAL   Neurochem Res 40 (11), 2153-2166 (2015)
   PUBMED   26285902
  REMARK    GeneRIF: In normal photoperiod, AQP1 was expressed in ganglion cell
            layer, outer part of inner nuclear layer and photoreceptor inner
            segments
REFERENCE   4  (bases 1 to 2558)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2558)
  AUTHORS   Camerino GM, Nicchia GP, Dinardo MM, Ribatti D, Svelto M and
            Frigeri A.
  TITLE     In vivo silencing of aquaporin-1 by RNA interference inhibits
            angiogenesis in the chick embryo chorioallantoic membrane assay
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 52 (7), 51-56 (2006)
   PUBMED   17543222
  REMARK    GeneRIF: AQP1 could have a key role in physiological and
            pathological angiogenesis.
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAENSK010000035.1.
            
            On Sep 23, 2021 this sequence version replaced NM_001039453.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HAEK01035277.1, BX933585.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992290, SAMEA103992323
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               JAENSK010000035.1  1136073-1136540
            469-633             JAENSK010000035.1  1151326-1151490
            634-714             JAENSK010000035.1  1151703-1151783
            715-2558            JAENSK010000035.1  1153148-1154991
FEATURES             Location/Qualifiers
     source          1..2558
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="2"
                     /map="2"
     gene            1..2558
                     /gene="AQP1"
                     /note="aquaporin 1"
                     /db_xref="CGNC:3878"
                     /db_xref="GeneID:420384"
     exon            1..468
                     /gene="AQP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..894
                     /gene="AQP1"
                     /EC_number="2.7.1.21"
                     /note="aquaporin 1 (channel-forming integral protein,
                     28kDa); aquaporin 1 (channel-forming integral protein,
                     28kDa, CO blood group); aquaporin 1 (Colton blood group)"
                     /codon_start=1
                     /product="aquaporin-1"
                     /protein_id="NP_001034542.1"
                     /db_xref="CGNC:3878"
                     /db_xref="GeneID:420384"
                     /translation="

MASEFKKKMFWRAVVAEFLAMILFIFISIGSALGFNFPVSVNGTSATQDNVKVSLAFGLSIATMAQSVGHISGAHLNPAVTLGLLLSCQISIFKALMYILAQCLGAVVATAILSGVTSSLPYNSLGLNALAKGINAGQGLGIEIIATLQLVLCVLATTDRRRNDVSGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSALIANNFENHWIFWVGPIIGGAGAALIYDFILAPRSSDLTDRVKVWTSGQVEEYDLEGDDMNSRVEMKPK"

     misc_feature    91..765
                     /gene="AQP1"
                     /note="Major intrinsic protein; Region: MIP; pfam00230"
                     /db_xref="CDD:395174"
     misc_feature    order(250..252,304..312,646..651,658..660,667..669)
                     /gene="AQP1"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(310..318,658..666)
                     /gene="AQP1"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     exon            469..633
                     /gene="AQP1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..714
                     /gene="AQP1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..2558
                     /gene="AQP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agctttctcttcagacctcgaagggaaaatatcaggcaggggaaagaaacagaagagaaagagggcagagaaagaggagagatggccagtgaattcaaaaagaaaatgttctggagggcggtggtggctgagttcctcgccatgatcctctttatttttatcagcattggctcggctctgggttttaatttcccagtgtcagtcaacgggacatcagcaactcaggacaacgtgaaggtttcgctggcttttgggttatccatcgcgaccatggcgcagagcgtgggccacatcagcggtgcccacctgaacccggcggtgaccctgggcctcctgctgagctgccagatcagcatcttcaaggcgctgatgtacatcctcgcccagtgcctgggggcagtggtggccaccgccatcctgtccggagtcacctcctctctgccctacaactccctggggctcaatgcgcttgcaaaaggaatcaatgcaggccaaggactaggaattgaaatcattgctactctccagctggttttgtgcgttcttgccaccacagaccggagaaggaatgatgtctcaggatcagcacctctggccattggtctctctgttgccttgggacatctccttgcaattgattacaccggttgtggaattaacccagccagatcttttggctcagcactgattgccaacaactttgaaaatcattggatcttctgggttggcccaatcattggaggagcaggtgctgccctcatctatgacttcatcctggctcccagaagcagtgacctgactgatcgcgtgaaggtgtggaccagcggccaagtagaagagtatgatctggaaggagatgatatgaactccagagttgaaatgaagccaaaataaagaaggacaagggggaggggaaacgcattggtttttgaagattttatcagtgttatagactctttgtaaaccagcaagaagtactttgttttgtaattcaatatggttttccatttttttgcacccaatctaaatagctattttatatctggggtctttcaattacaatgtcttcaggccaagaattcattagaatgatctaaataaattgggttgttatttaacccttctctcactactatgaaatttgctggtgtgttcagtgtggctggctctcccagcacatcatgcagtagtgatgagtagctttctgaaagaatagatacttaggataaaactccatctgtaccattaataggggtttataccagaaaaaaagtatttatacagaaataaatacaaggctgacatttaatgtcagcagtgcatgtgaaaaaaattctttaagcatttctcagaaataccttttggaagcaaaggctgctaaaaatcatttgttatatagaaagaaccataattttctaaattgttgatgacctccaagaaagaggaccagaaatactgttgagcagaacaagaagctccagatttccgagatctatttgcattttccagtgtttcgtcctctctgaacctgcatccagttgtgaagggataacctaaaaatgtgtagatatatgaattcctgggaagtagtaactagaagtgagattgaagagcagtagttacaacagcaacaagaacaacatggtgctgatatgtaaacaggatctgattgttcctgtggctgttctacttttgcttctcttatgtaaattaactgtatatttgaaaagaaaccaggaaaaaaaaaataaagactcctttcttcctgaccccattttaagagcaagtgctatgacattcagggacaattaatagatatacacacagtatattttctaatgagggacaagtaaatacccgtgtgtaagtccattttgagggtcatttctttggtttttatatatatatatataaatataaatgtttatatatgtgttttatacagaaagcctagtatactgttttgtaagaaaataagagcagaaaacaagtggaaagaatttcataagagcttagcaaaataaatgacactggaaacatgaagaaaactaacactctaaacaaaatggaagacgattttctgtttttgtgtgcgtgctacctttgatttcctgaataacccataacagtagctggtctcacatactaactatagactatagctgaagcagataggtgctgatatacttgttctgcactaaaccgttttacgtaaggaatgaggcccagagaaacctacataaaaaatgacacagttaacccttcagacaagcaccccggaggtaatatgaatgacagatgtctcctggtggacagacagcatggacagtgaaaatgaaagagggttgacataggaatccatatagattggatcatttcatctagttgagaagatgtgcaagataaaaagaaaaaaaaaaaaaagaaatgccagcagactaaaccagaatctttcttgcctacttttggtgtgttatcctgtgtattgtcagtgtacatgcagcatgattggattttggggtggtttaaaaataaacaaaaccatttgtgctaacaca

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