LOCUS       NM_001039276            3579 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus argonaute 4, RISC catalytic component (AGO4),
            transcript variant 2, mRNA.
ACCESSION   NM_001039276 XM_417776
VERSION     NM_001039276.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3579)
  AUTHORS   Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P,
            Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci
            P, Hayashizaki Y and Buerstedde JM.
  TITLE     Full-length cDNAs from chicken bursal lymphocytes to facilitate
            gene function analysis
  JOURNAL   Genome Biol 6 (1), R6 (2005)
   PUBMED   15642098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000339.1.
            
            On Oct 18, 2021 this sequence version replaced NM_001039276.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13267659.315315.1,
                                           SRR13267654.245557.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA103992290,
                                           SAMEA103992323 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAENSK010000339.1  4255001-4255170     c
            171-336             JAENSK010000339.1  4250705-4250870     c
            337-457             JAENSK010000339.1  4250117-4250237     c
            458-639             JAENSK010000339.1  4249749-4249930     c
            640-776             JAENSK010000339.1  4249238-4249374     c
            777-911             JAENSK010000339.1  4249020-4249154     c
            912-999             JAENSK010000339.1  4248755-4248842     c
            1000-1147           JAENSK010000339.1  4248226-4248373     c
            1148-1267           JAENSK010000339.1  4248028-4248147     c
            1268-1396           JAENSK010000339.1  4247677-4247805     c
            1397-1530           JAENSK010000339.1  4247384-4247517     c
            1531-1715           JAENSK010000339.1  4246792-4246976     c
            1716-1875           JAENSK010000339.1  4246005-4246164     c
            1876-2191           JAENSK010000339.1  4245244-4245559     c
            2192-2326           JAENSK010000339.1  4244916-4245050     c
            2327-2428           JAENSK010000339.1  4244014-4244115     c
            2429-2628           JAENSK010000339.1  4243583-4243782     c
            2629-3579           JAENSK010000339.1  4242534-4243484     c
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="23"
                     /map="23"
     gene            1..3579
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="argonaute 4, RISC catalytic component"
                     /db_xref="CGNC:66346"
                     /db_xref="GeneID:419629"
     exon            1..170
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            171..336
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            337..457
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..2737
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein argonaute-4; argonaute RISC catalytic component 4;
                     eukaryotic translation initiation factor 2C, 4"
                     /codon_start=1
                     /product="protein argonaute-4 isoform 2"
                     /protein_id="NP_001034365.1"
                     /db_xref="CGNC:66346"
                     /db_xref="GeneID:419629"
                     /translation="

MVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSIQWVSVVSLQLLLEALAGHLNEVPEDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKLTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQETSQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA"

     misc_feature    362..616
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    647..799
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    800..1162
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(956..958,1001..1003,1043..1045,1055..1057,
                     1109..1111,1130..1132,1136..1138)
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1301..2608
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1712..1714,1724..1726,1760..1771,1778..1780,
                     1802..1804,1811..1813,1823..1825,1835..1837)
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1916..1918,1922..1924,2162..2164,2576..2578)
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="active site"
                     /db_xref="CDD:240015"
     misc_feature    2624..2689
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5ZMW0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            458..639
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            640..776
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            777..911
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            912..999
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1147
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1267
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1396
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1530
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1715
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1875
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2191
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2326
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2428
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2628
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..3579
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cccggtcagggcggagcgaggcgcccggtgcgcgggcggcgcggagctgcgcgaggtacttcgggtcccctcagccggggcgcgtgagggggccccggtgctgggtttgcggaggccgcagccacaccataacccgaacccgcacggtgtgggatccggctcacgtatagggcccccagcaagccttttccagcccccccgtcgcccaggcctgggaactgttgggaaacccatccgcctcctagccaaccactttcaggttcagatccccaagattgatgtttatcactatgatgtggatatcaaaccagaaaaacgaccccgaagagtgaacagagaagtggtggatactatggtgagacacttcaagatgcagatatttggtgaccggcagcctggatacgatgggaagcggaacatgtacactgcacacccattacccattggcagggacagagtggatatggaggtgacacttccaggagaggggaaggaccagactttcaaagtgtccattcagtgggtgtcagttgtcagccttcagttgctgttggaagctctggcagggcatttgaatgaagttcctgaagattctgtacaagcacttgatgtaattacacggcaccttccgtccatgaggtatactcctgtgggtcgctcctttttttccccccctgaaggctattaccaccctctgggtggtggcagggaggtctggtttggtttccaccagtctgtcaggcctgccatgtggaacatgatgctcaacattgatgtatcagcaactgctttctatcgtgctcagcctatcattgagttcatgtgtgaggtcttggacattcagaacatcaatgaacaaaccaagcctctgacagactcccaacgtgtcaagtttaccaaagaaatcagaggtctaaaagtagaggttactcactgtggccagatgaagagaaagtatcgagtttgcaatgttactcgtcgaccagccagccatcagacgtttcctctgcagttggaaaatgggcaggctatggagtgtacagtagctcagtattttaagcagaagtacagtctgcagctaaaatatcctcatcttccctgtctccaagtaggacaggagcagaaacacacatacttaccgcttgaggtgtgtaacatagtggcaggccagaggtgtatcaagaagttaacagacaatcagacatcaactatgataaaagcgactgcaagatctgcacccgaccgacaggaagaaatcagcagacttgtgaaaagtaacagtatggttggtggacctgatccatatctgaaggagtttggtattgttgtccataatgaaatgacagagttgacaggcagagttttgccagcgccaatgctgcaatatggaggcaggaacaagactgtggccacaccaaaccaaggtgtgtgggacatgagagggaaacagttctatgctggcattgagattaaagtttgggctgttgcctgttttgctcctcaaaaacaatgcagggaagacttactaaagagttttacagaccagctgcgcaagatctccaaggacgcagggatgccgatccaaggccagccctgtttctgtaaatacgcccagggtgcagacagtgtggagcccatgttcaaacatttaaaactgacttatgttggtctgcagctgattgtggtgattctacctggaaagacacccgtgtatgctgaagtaaagcgagttggcgacactcttcttggcatggccactcagtgtgttcaggtaaagaatgtggtgaaaacctcaccacaaacactgtccaacctgtgtctgaaaataaatgcaaagcttggaggaatcaacaacgtgctcgtacctcatcaaaggccctcggtgttccagcagccagtgatctttttgggagcagatgtcactcaccctcctgctggggatggaaagaagccttccatagctgctgtggtcggcagcatggatggccatcctagccgttactgtgccacagtgcgagtgcagacctcccgtcaggagacctcccaggaactgctgtacagccaggaggtgatacaggacctgacaaacatggtgcgagaactgctgatacagttttacaaatccacacgtttcaagcctacaagaatcatttactacagaggaggagtatcagaagggcagatgaagcaggtagcttggccagaacttatagcaatcagaaaggcctgtattagtttggaagaagactacagaccaggaataacctacatcgttgtgcagaaaagacaccacaccaggctgttctgtgccgacaaaactgaaagggtgggtaagagtggcaacgtaccagcgggcactactgtggacagcacgatcacgcacccttctgaatttgacttttacctctgtagccacgcaggaattcagggaaccagccggccctcccactatcaggtcctgtgggatgacaactgtttcactgcagatgagctacagctgctgacctatcagctgtgtcacacgtatgtgcgctgtacgcgatcagtctctattccagcacctgcatactatgccagactggtagcatttagggctagataccatcttgtggacaaggatcacgacagtgctgaaggcagccacgtgtcaggacagagcaatggccgtgatcctcaggctctggcaaaggcagtgcagatccaccatgatactcaacatacaatgtattttgcttgagagcatctgggaagatgaggcaaagccaacaactcgttcagtcctgacatgttttcaatgcctactgctatagctagggcccggtttctttcagactgcccactaccagcagctctgaacagtcgcactgaatctgtacttcaaacaatgtctgatgcaccgacacaattgagccattcgtttcgttattttacgtcatagaaattcatagactgtcttttctgatgcattggactaaatttttacctcaaagcgcaaaaggccgatcatcccgacgtttttaaaggacttggcacgaaaggtttctattgaatactttgctagctctggtctttaggttcccttctcatcccattagctgatggtgacgactgattctccgtcctcacgcgctgcttagtgagtatgcgtagtatggcgaagttctcctccagttcaatgtaatcgttctcttgtgtggggccatagatttttttaatggagattttagacttcactactgtaaatgccttttaacagacgtaactttcacaggtcttgcagtttttgtcggttttactaatgacctttttaacctgcagactcgggctgcaaagcaattgcactattctgcgagttcagatcggtggttcctgttgtgaatgtgtgacgtgcccaggtggtggtgcctggcagtagctttcaattgtaacgcctacagataatgctgccatggcgtcgtgacaaacactgaaccatcgttttcccccctctaaaaaaacaaaacaaaaaaaaaaacgaaaaaaaaaaaaacaaaaaaaggatttaaaaaaaaaatagaaaaaaaaatacaaaaaaaaaaa

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