LOCUS       NM_001031560            1675 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus N-acetylneuraminate pyruvate lyase (NPL), mRNA.
ACCESSION   NM_001031560 XM_426630
VERSION     NM_001031560.3
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 1675)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 1675)
  AUTHORS   Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P,
            Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci
            P, Hayashizaki Y and Buerstedde JM.
  TITLE     Full-length cDNAs from chicken bursal lymphocytes to facilitate
            gene function analysis
  JOURNAL   Genome Biol 6 (1), R6 (2005)
   PUBMED   15642098
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAENSK010000237.1.
            
            On Sep 23, 2021 this sequence version replaced NM_001031560.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HAEK01007295.1, AJ720150.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992290, SAMEA103992323
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAENSK010000237.1  7432545-7432596
            53-121              JAENSK010000237.1  7432822-7432890
            122-195             JAENSK010000237.1  7434317-7434390
            196-283             JAENSK010000237.1  7435491-7435578
            284-341             JAENSK010000237.1  7436003-7436060
            342-417             JAENSK010000237.1  7436152-7436227
            418-510             JAENSK010000237.1  7436785-7436877
            511-659             JAENSK010000237.1  7437682-7437830
            660-706             JAENSK010000237.1  7438193-7438239
            707-791             JAENSK010000237.1  7439025-7439109
            792-831             JAENSK010000237.1  7440247-7440286
            832-1675            JAENSK010000237.1  7441396-7442239
FEATURES             Location/Qualifiers
     source          1..1675
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="8"
                     /map="8"
     gene            1..1675
                     /gene="NPL"
                     /note="N-acetylneuraminate pyruvate lyase"
                     /db_xref="CGNC:3411"
                     /db_xref="GeneID:429074"
     exon            1..52
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     exon            53..121
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..983
                     /gene="NPL"
                     /EC_number="4.1.3.3"
                     /note="NALase; sialate lyase; sialic acid lyase; sialic
                     acid aldolase; sialate-pyruvate lyase; N-acetylneuraminic
                     acid aldolase; N-acetylneuraminate pyruvate lyase
                     (dihydrodipicolinate synthase)"
                     /codon_start=1
                     /product="N-acetylneuraminate lyase"
                     /protein_id="NP_001026731.2"
                     /db_xref="CGNC:3411"
                     /db_xref="GeneID:429074"
                     /translation="

MTPRKKLEGLVAATVTPMTPDGRINLSVIHQYVDYLVSEQNVKNIFVNGTTGEGLSLSIQERKQLAEEWMCQGKDKLDHVIIHVGALSLLESQELARHAAAIGASGIAVIAPSFFKPTNKDELLGFLQKVASEAPTVPFYYYHIPAMTGVKIRVEELLDGIREQIPTFQGVKFSDTDLLDLAQCINKKEREQFVFLYGVDEQLLSALAIGANGAVGSTYNYLGRKTNLMLQAFAKPDLALARKYQFLTGEFLSFVIKLGFGVAQTKAVMTSVSGIPMGPPRLPLVGASEEFIAKAKAKLESIVWPDGD"

     misc_feature    75..947
                     /gene="NPL"
                     /note="TIM-like beta/alpha barrel domains; Region: TIM;
                     cl21457"
                     /db_xref="CDD:451249"
     misc_feature    480..482
                     /gene="NPL"
                     /note="Involved in proton transfer during cleavage.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q5ZKD4.1); other site"
     misc_feature    570..572
                     /gene="NPL"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:188634"
     exon            122..195
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     exon            196..283
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     exon            284..341
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     exon            342..417
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     exon            418..510
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     exon            511..659
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     exon            660..706
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     exon            707..791
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     exon            792..831
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1675
                     /gene="NPL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gccccacagccgctccggagccggcggggcgcttcgggcgcgggttgtggagctcgatgacacccagaaagaagctggagggtctggtcgctgccacagtcaccccgatgactcctgacggacgaatcaacctttcagtgattcaccagtatgtggattacctggtaagcgagcagaatgtgaagaacatctttgtgaatggcaccacaggagaaggcctgtcccttagcatccaggagaggaagcagttggctgaagaatggatgtgccaagggaaagacaagctggatcatgtgataattcacgtgggagctttaagtctattggagtcccaagaactggccagacatgcagcagccataggtgctagtggcattgcagtaatagctccctccttcttcaaacccacaaacaaagatgaactccttggtttcttacagaaagttgcatctgaagcccctacagttccattttattactaccacattccagctatgacgggtgtaaagattcgtgttgaggagttgctggatggaataagagagcagatccccaccttccagggtgtgaagttcagcgacacggacctcttggaccttgcacagtgcataaacaagaaggagagagaacagttcgtgtttctctatggggtagatgagcaactgttgagtgcactggcaataggggcaaatggagcagttggaagtacctacaactacttaggtaggaaaaccaacctgatgttgcaggcttttgcaaagccagaccttgcattagcacggaaataccagtttctcacgggggaatttctcagctttgtcatcaaactaggttttggtgttgcacagacaaaagctgtaatgacttccgtttctggcatccccatgggacctccacggcttccacttgttggtgcctctgaggaattcatcgccaaggccaaagccaagctggagagcattgtgtggcctgatggtgactgacttcactcccacgtcagtgtgcaggggctccttttctgggattcactgtctcttggcatgctcctcatgtaatgggctggtttggctgtgatctccttcaggaaaatgaaagtaatcggcgtggaagggctggcacacgtgtagccagccacctgttctttaacttcactctgctcctctggagctctgcactgcccagcactggctgctgtcattaaacaaacacacaaagacaaaacaaaactggtttgctccagcagagggatcctgaccttcttttgtctagaaaggaaggtctgcctgcgctgccccaaactggaggggaataaacttttgacaagggtagacagtgattggacaagggggaatggttttaagctcaaggagggaaggtttagattacatgtcggaggaagttcttcacggagagagtgatgaggtgctggaacagcctgcccagagaggctgtgaatgctccatccctggaggtggtcaggaccaggttggatgggcagcatctggtctggtaccagatctggaggttggtggacctgcctgtgtcagggggttggaatttggtgatccttgggggtcctttccagcccaagccattctgtgattctatgttttgtcctctccctgagcatcactagcactagggtgtcactgctgtaatacaacctgtctgctca

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