LOCUS       NM_001024734            1342 bp    mRNA    linear   VRT 19-SEP-2023
DEFINITION  Gallus gallus selenoprotein S (SELENOS), mRNA.
ACCESSION   NM_001024734 XM_413890
VERSION     NM_001024734.3
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 1342)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 1342)
  AUTHORS   Gladyshev VN, Arner ES, Berry MJ, Brigelius-Flohe R, Bruford EA,
            Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland
            PR, Diamond AM, Driscoll DM, Ferreiro A, Flohe L, Green FR, Guigo
            R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A,
            Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Kohrle J, Krol A,
            Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV,
            Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP,
            Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U,
            Simonovic M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD
            and Zhang Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   3  (bases 1 to 1342)
  AUTHORS   Bubenik JL, Miniard AC and Driscoll DM.
  TITLE     Alternative transcripts and 3'UTR elements govern the incorporation
            of selenocysteine into selenoprotein S
  JOURNAL   PLoS One 8 (4), e62102 (2013)
   PUBMED   23614019
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1342)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1342)
  AUTHORS   Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R,
            Hatfield DL and Gladyshev VN.
  TITLE     Composition and evolution of the vertebrate and mammalian
            selenoproteomes
  JOURNAL   PLoS One 7 (3), e33066 (2012)
   PUBMED   22479358
REFERENCE   6  (bases 1 to 1342)
  AUTHORS   Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P,
            Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci
            P, Hayashizaki Y and Buerstedde JM.
  TITLE     Full-length cDNAs from chicken bursal lymphocytes to facilitate
            gene function analysis
  JOURNAL   Genome Biol 6 (1), R6 (2005)
   PUBMED   15642098
REFERENCE   7  (bases 1 to 1342)
  AUTHORS   Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong
            WT, Tickle C, Brown WR, Wilson SA and Hubbard SJ.
  TITLE     A comprehensive collection of chicken cDNAs
  JOURNAL   Curr Biol 12 (22), 1965-1969 (2002)
   PUBMED   12445392
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL588177.1, BX934085.2,
            BX931291.2 and AJ731176.1.
            
            On Jan 23, 2017 this sequence version replaced NM_001024734.2.
            
            Summary: This gene encodes a transmembrane protein that is
            localized in the endoplasmic reticulum (ER). It is involved in the
            degradation process of misfolded proteins in the ER, and may also
            have a role in inflammation control. This protein is a
            selenoprotein, containing the rare amino acid selenocysteine (Sec).
            Sec is encoded by the UGA codon, which normally signals translation
            termination. The 3' UTRs of selenoprotein mRNAs contain a conserved
            stem-loop structure, designated the Sec insertion sequence (SECIS)
            element, that is necessary for the recognition of UGA as a Sec
            codon, rather than as a stop signal. Two additional stem-loop
            structures in the 3' UTR of this mRNA have been shown to function
            as modulators of Sec insertion (PMID:23614019). [provided by
            RefSeq, Jul 2017].
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA103992290,
                              SAMEA103992323 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: inferred from conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AL588177.1         2-93
            93-547              BX934085.2         81-535
            548-1320            BX931291.2         511-1283
            1321-1342           AJ731176.1         17-38               c
FEATURES             Location/Qualifiers
     source          1..1342
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="10"
                     /map="10"
     gene            1..1342
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /note="selenoprotein S"
                     /db_xref="CGNC:50005"
                     /db_xref="GeneID:415522"
     exon            1..123
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    18..20
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /note="upstream in-frame stop codon"
     CDS             36..620
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /note="UGA stop codon recoded as selenocysteine;
                     VCP-interacting membrane protein; VCP interacting membrane
                     selenoprotein"
                     /codon_start=1
                     /transl_except=(pos:612..614,aa:Sec)
                     /product="selenoprotein S"
                     /protein_id="NP_001019905.1"
                     /db_xref="CGNC:50005"
                     /db_xref="GeneID:415522"
                     /translation="

MELGDRGGAGPGPGKPALEREGLELLQHTVGALLSSYGWYILLACVAIYLIVQKISPYLRMRPSSQQGATGAAVEPDMVVRRQEALLASRLRMQEELNAQAERYKEKQRQLEEQKRRQKIEMWESMQEGKSYKGNLKLSQQEAESGASTSSAVPKSKPNKKPLRGGGYNPLSGEGGGTCSWRPGRRGPSAGGUG"

     misc_feature    87..611
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /note="Selenoprotein S (SelS); Region: Selenoprotein_S;
                     pfam06936"
                     /db_xref="CDD:429198"
     misc_feature    612..614
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /note="Selenocysteine; other site"
     exon            124..258
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            259..365
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            366..455
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            456..534
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            535..1325
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1160..1236
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      1297..1302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
     polyA_site      1325
                     /gene="SELENOS"
                     /gene_synonym="SELS; VIMP"
ORIGIN      

ggggcggctcccggacgtgaggcggcagcggggccatggagctcggggaccgcggcggggccgggcccggccccgggaaaccggccctggaacgagagggcctcgagctgctgcagcacacggtgggcgccctgctgtcgagctatggctggtacatcctcctggcctgcgtcgccatctatctcatcgtccagaagatatccccatacttgaggatgaggcccagcagccagcaaggagcaactggcgcagctgtcgagcccgacatggtggtaagaagacaagaagctttgttggcgtctcgcctgaggatgcaagaggagttgaatgcacaagcagaaagatacaaagaaaaacaaagacagcttgaagaacagaagcgaaggcagaagatagaaatgtgggaaagcatgcaagaaggaaaaagttataaaggaaacctgaaactgagtcagcaagaagcagaatctggtgcctccacctcatcagcagtcccgaaatctaaaccaaacaagaagcccttgcgaggaggtggctataaccccctgtctggagaaggaggtggaacttgttcctggagaccgggccgcaggggtccctctgcgggtggatgaggctaacctgcctggggtcccttcagcatacccactgtctgcctgcctacagtttgcatgtcacactgactcctttgggatttgtttgagcgtgggtgttaacacagatttacaccatttctgagtattaacagcagcggatgctacacggggaaaaatatctgatcctcttagagaggatgaaggaagaaacaatgtcagtatagttagtcactttattttctccttagtgaggaagcagttttcagccaggatgatcgcttgtggttgtgaaagctgggttctatggctggccgtgcagtagtctggcctcaaacaaatcaatgtctagacctctgtttacctgcttaaaatgaggggattcaccaaccttagacgtgtaatgggatttacagtttgtctggaaggtatatataggagggaaggatattctcattggcagacaggttcaattttagaaggagggactttaaggaaacctggatgaactgacaggtgtgttgggtttgcaccagaagctcgttactgcgggagagtctctgtgacaagctgctctgtatgatgttttccttataaatggtaaacaaaccaatgaggattactgatgctagacagcagatgggggtttcttgctattctttttttttattttcaactgctttgtaaaaacgatacaattaatattaaatataattgcaaacaaatcataaaaaaaaaaaaaaaaaaaa

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