LOCUS       NM_001001460            4472 bp    mRNA    linear   VRT 24-SEP-2023
DEFINITION  Gallus gallus peroxisome proliferator-activated receptor gamma
            (PPARG), transcript variant 1, mRNA.
ACCESSION   NM_001001460 XM_015292931 XM_414308
VERSION     NM_001001460.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 4472)
  AUTHORS   Seo Y, Kubota T, Sudo M, Toda N, Ogawa Y and Miyaguchi Y.
  TITLE     Effects of dried natto diet on the transcript levels of the
            peroxisome proliferator-activated receptor-gamma,
            coactivator-1alpha and -1beta, and nuclear receptor corepressor 1
            genes in laying hens
  JOURNAL   Anim Sci J 92 (1), e13522 (2021)
   PUBMED   33624372
  REMARK    GeneRIF: Effects of dried natto diet on the transcript levels of
            the peroxisome proliferator-activated receptor-gamma,
            coactivator-1alpha and -1beta, and nuclear receptor corepressor 1
            genes in laying hens.
REFERENCE   2  (bases 1 to 4472)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   3  (bases 1 to 4472)
  AUTHORS   Duan K, Sun Y, Zhang X, Zhang T, Zhang W, Zhang J, Wang G, Wang S,
            Leng L, Li H and Wang N.
  TITLE     Identification and characterization of transcript variants of
            chicken peroxisome proliferator-activated receptor gamma
  JOURNAL   Poult Sci 94 (10), 2516-2527 (2015)
   PUBMED   26286997
  REMARK    GeneRIF: Open reading frame analysis showed that five cPPARgamma
            transcript variants (cPPARgamma1 to 5) could encode two cPPARgamma
            protein isoforms (cPPARgamma1 and cPPARgamma2), which differ only
            in their N-terminal region. cPPARgamma1 was highly expressed in
            various chicken tissues.
REFERENCE   4  (bases 1 to 4472)
  AUTHORS   Huang JB, Zhang Y, Zhou YB, Wan XC and Zhang JS.
  TITLE     Effects of epigallocatechin gallate on lipid metabolism and its
            underlying molecular mechanism in broiler chickens
  JOURNAL   J Anim Physiol Anim Nutr (Berl) 99 (4), 719-727 (2015)
   PUBMED   25521589
REFERENCE   5  (bases 1 to 4472)
  AUTHORS   Navidshad B and Royan M.
  TITLE     Ligands and Regulatory Modes of Peroxisome Proliferator-Activated
            Receptor Gamma (PPARgamma) in Avians
  JOURNAL   Crit Rev Eukaryot Gene Expr 25 (4), 287-292 (2015)
   PUBMED   26559088
  REMARK    GeneRIF: The most important metabolic effect of PPARgamma in
            chicken is its task in adipogenesis. Reviewing the ligands of
            chicken PPARgamma gene can be useful to a better understanding of
            PPARgamma regulatory functions. [Review]
            Review article
REFERENCE   6  (bases 1 to 4472)
  AUTHORS   Wang JT, Li S, Li JL, Zhang JW and Xu SW.
  TITLE     Effects of cold stress on the messenger ribonucleic acid levels of
            peroxisome proliferator-activated receptor-{gamma} in spleen,
            thymus, and bursa of Fabricius of chickens
  JOURNAL   Poult Sci 88 (12), 2549-2554 (2009)
   PUBMED   19903953
  REMARK    GeneRIF: The results indicate that the PPAR-gamma gene is expressed
            in all 3 immune organs and has different expression traits. The
            magnitude and direction of change in PPAR-gamma gene expression
            differs with the type of cold stress and the tissue.
REFERENCE   7  (bases 1 to 4472)
  AUTHORS   Sato K, Matsushita K, Matsubara Y, Kamada T and Akiba Y.
  TITLE     Adipose tissue fat accumulation is reduced by a single
            intraperitoneal injection of peroxisome proliferator-activated
            receptor gamma agonist when given to newly hatched chicks
  JOURNAL   Poult Sci 87 (11), 2281-2286 (2008)
   PUBMED   18931179
  REMARK    GeneRIF: Levels of PPARgamma mRNA in the abdominal fat pad of
            7-d-old broiler chicks given a single dose of troglitazone at 1 d
            old were significantly greater than those in control chickens.
REFERENCE   8  (bases 1 to 4472)
  AUTHORS   Wang Y, Mu Y, Li H, Ding N, Wang Q, Wang Y, Wang S and Wang N.
  TITLE     Peroxisome proliferator-activated receptor-gamma gene: a key
            regulator of adipocyte differentiation in chickens
  JOURNAL   Poult Sci 87 (2), 226-232 (2008)
   PUBMED   18212364
  REMARK    GeneRIF: This was designed to investigate the function and
            regulatory mechanism of PPARgamma in chicken adipogenesis by RNA
            interference.
REFERENCE   9  (bases 1 to 4472)
  AUTHORS   Sato K, Fukao K, Seki Y and Akiba Y.
  TITLE     Expression of the chicken peroxisome proliferator-activated
            receptor-gamma gene is influenced by aging, nutrition, and agonist
            administration
  JOURNAL   Poult Sci 83 (8), 1342-1347 (2004)
   PUBMED   15339009
  REMARK    GeneRIF: findings suggest that peroxisome proliferatior-activated
            receptor-gamma plays an important role in the regulation of fat
            deposition and egg production in chickens
REFERENCE   10 (bases 1 to 4472)
  AUTHORS   Takada I, Yu RT, Xu HE, Lambert MH, Montana VG, Kliewer SA, Evans
            RM and Umesono K.
  TITLE     Alteration of a single amino acid in peroxisome
            proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR
            delta phenotype
  JOURNAL   Mol Endocrinol 14 (5), 733-740 (2000)
   PUBMED   10809235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000252.1.
            
            On or before Nov 24, 2021 this sequence version replaced
            XM_015292931.3, NM_001001460.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13267653.16437.1,
                                           SRR13267654.198789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992290, SAMEA103992323
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAENSK010000252.1  1985183-1985215
            34-261              JAENSK010000252.1  2015439-2015666
            262-431             JAENSK010000252.1  2017277-2017446
            432-570             JAENSK010000252.1  2018903-2019041
            571-770             JAENSK010000252.1  2024661-2024860
            771-1221            JAENSK010000252.1  2028970-2029420
            1222-4472           JAENSK010000252.1  2036486-2039736
FEATURES             Location/Qualifiers
     source          1..4472
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="12"
                     /map="12"
     gene            1..4472
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="peroxisome proliferator-activated receptor gamma"
                     /db_xref="CGNC:3698"
                     /db_xref="GeneID:373928"
     exon            1..33
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    15..17
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="upstream in-frame stop codon"
     exon            34..261
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1469
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="peroxisome proliferative activated receptor, gamma"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor
                     gamma"
                     /protein_id="NP_001001460.1"
                     /db_xref="CGNC:3698"
                     /db_xref="GeneID:373928"
                     /translation="

MVDTEMPFWPVNFGISPVDLSAMDDHMHSFDIKPFTTVDFSSISSPHYEDIPLGRADQTSIDYKYDIKLQDCQSAIKMEPPSPPYFSEKVQLYNKPHEESSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLRMGEDQIKCKHASPLQEQNKEVAIRIFQRCQFRSVEAVQEITEFAKNIPGFVNLDLNDQVTLLKYGVHEIIYTLLASLMNKDGVLISDGQGFMTREFLKSLRKPFCDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQIIKKTETDMSLHPLLQEIYKDLY"

     misc_feature    42..275
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="PPAR gamma N-terminal region; Region: PPARgamma_N;
                     pfam12577"
                     /db_xref="CDD:432648"
     misc_feature    363..614
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="DNA-binding domain of peroxisome
                     proliferator-activated receptors (PPAR) is composed of two
                     C4-type zinc fingers; Region: NR_DBD_Ppar; cd06965"
                     /db_xref="CDD:143523"
     misc_feature    order(366..368,375..377,417..419,426..428,474..476,
                     489..491,519..521,528..530)
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="zinc binding site [ion binding]; other site"
                     /db_xref="CDD:143523"
     misc_feature    order(390..404,420..425,429..431,435..437,441..446,
                     453..455,510..515,522..524,531..533,564..566,573..587,
                     591..593)
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143523"
     misc_feature    order(504..509,513..518)
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:143523"
     misc_feature    660..1463
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="The ligand binding domain of peroxisome
                     proliferator-activated receptors; Region: NR_LBD_PPAR;
                     cd06932"
                     /db_xref="CDD:132730"
     misc_feature    order(885..890,900..902,1002..1004,1014..1016,1023..1025,
                     1050..1052,1056..1058,1125..1127,1380..1382)
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:132730"
     misc_feature    order(915..917,924..926,936..938,951..953,966..971,
                     975..980,987..992)
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="coactivator recognition site [polypeptide binding];
                     other site"
                     /db_xref="CDD:132730"
     misc_feature    order(1152..1154,1218..1220,1227..1229,1254..1256,
                     1323..1325,1335..1337,1344..1346,1350..1355,1362..1367,
                     1386..1388)
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:132730"
     exon            262..431
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..570
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..770
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1221
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..4472
                     /gene="PPARG"
                     /gene_synonym="PPARgamma; PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

acagtttctccggctgagacttgacagcgccagagattacaatggttgacacagaaatgccgttttggcccgttaattttggaattagcccagtggatctgtctgcgatggatgatcatatgcattcctttgacataaagccatttaccactgttgatttttcaagcatttcttcaccacactatgaagatatacctcttggaagagctgatcaaacaagcattgattataaatatgatatcaagctccaggattgccaaagtgcaatcaaaatggagcctccttctcctccctatttttctgaaaaagtgcagttatacaataaacctcatgaggagtcttccaactcacttatggctattgaatgtcgtgtgtgtggggacaaggcctctggatttcattatggagtgcatgcatgtgaaggttgtaagggcttttttcgaagaacaatcagattaaagcttatttatgataggtgtgaccttaattgtcgcatccataagaaaagcagaaataagtgtcaatactgcagatttcagaaatgtcttgcagttggaatgtcacataatgccatcaggtttgggcgaatgccacaagcggagaaggagaagctcttggcagagatttccagcgacatcgaccagttaaatcctgaatctgctgatctgcgagcgcttgccaagcatttgtatgactcatacataaagtccttccctctgaccaaagccaaggcaagggcgatcttgacaggaaagacgacagacaaatcaccatttgttatttatgacatgaactctttaaggatgggagaagatcagatcaagtgtaagcatgcatcaccactgcaggaacagaacaaagaagtagcaattcgcattttccagcgatgtcagtttcgctctgtggaggcagtgcaggagattacagaatttgcgaagaacattccaggttttgtgaatcttgacctgaatgatcaggtaactctcctgaaatatggtgtccatgagatcatatatactctcctggcttctctcatgaataaagatggagttcttatatctgatggacaaggattcatgacacgggagtttctgaagagtctgagaaaacctttttgtgactttatggagcccaagtttgagtttgctgtgaagttcaatgcactggaattagatgacagtgacctggcaatatttatagctgtcattatactaagtggagatcgcccaggtttgttaaatgtgaagcccattgaagatatacaagataatctgttgcaagctttggagctccagctaaagctgaatcatccagagtcatcacagctgtttgcaaaattgcttcagaaaatgacggacctcagacaaattgtaacggaacacgtgcagctgttgcaaataataaagaaaacggaaacagatatgagtcttcatccactcctacaagaaatctataaagacttatattaatggcgatagtagttcttatcctctgacataatgtatgttcttcagattgcactatttctttgagagaaaactttgcatacttaagaaattactgtgaaacagcatttaaagaagagagagcttagtatagtagatctattttatgcatattgtttataaagacacatttacaatttacttttaatattaaaaatatctatatcatgaaattgttggcagtattttcagaattaatttttttaactatcttatttcctaaaattgcttgtccagtatgattgatgcttgcttcactgaggttggttaagcatgcagttaaattttcaacttaaaaataaaaatctttctccttaaacatttctagggaaacattttaagtattatgtttgattctgtgctcccaaggcagcggcaaaataacaatgaagttgaatcatggattagcacaacttcacacaaggactcaaaaggtaaaagttagacatgtcaggtctagtagttgttcctaccataataaattttcaaactgatagagttctgtaatgaggactttgtatacgtatgaattaggcccatcatttatgggcactcaaaaacttgactccatttcaagcattaattgaggaatatacactgctcatcactttcttagagattcttaggaagcagccttttcacttgctctgctcatacagttccaagactggagaagcagtctgcatggagatgcagtgcagctgcctctctgccattatctgcaatgcacatgccacaccagctagtgctaatgcagccttcagctactctgggaagtctgttgctggaatgggttcacatcataccaaagttatttgatgaactctcattgaaaaatatactcagtcaaaatgctgtggaaaattggaataggatgacacctcttaaataaaagcaagatttgaattcattcttgaaaacataaacctgtaatggaaaccctagtatattaatttgacttgagatgtcattatttatcactgggaatgagaatgcttttgagaggttcgatgctttaaggctgctaattttattttatacattgctctatagtgtcaaacaagatttccacagggagcaaagtataggagaatgcgtaaattttttagaagtaaatttagttacactatcttcttttggtattctcagtccaattgtgagattcccttagattcacatgtattgtggccacatttactgtttgtgaatgtgtttcagaaactaaagcaagtatgatccacagtgatgtgctcaagaatggaattttggaaagaaaaaagaaagccactaattgtaacacatactattgaagcaaggagtggtccttaattgaatacgtggcaagaagtgtgccttaaacttagacacatttactgatgatatgtaagcagaccaaaagggagtagaattgggaataggtgatcaggctcaattttcagtgagtctaaatccgccttcctaccaatgtggcccttggaaatcttagttggtacaaaaagaggctgtcagaattaaatattaaaataaatccttaagcttatgccttacatacctgaaaatatttcctactacttatttcagacaaactctgggcctatggtcagtagtgagcattatgcctaccaggaagtgattggagaattggatcattcagcctcaaggtttaaaatccacagatgagatttcagtgagatgaagtcagtgtgaggctaaacagctttgatcttcactaagtttcaggtaacttaggaaaattgccctacaacaaatggcgtgttgtttgttaatgctcaaattgcatgttttcctgcactttagatttaggtacgttgtgtgaactgagcattagattctgacagggattacatgcacggtattttgtggctgttaccattcaaaagaagtttttctcacgaatttgttttccactgggcactggccatttgaagttttgccatctatcacttagtggagaacctctgtttaatcgcagagttcatcccctcctgtaggaggacatatcaaagactaactggtaccaagatagaccacagttccaacaccaaattcctataatagtaacacactgtcaaaaatattaatctgagactgcatttcccatacaatccaatttcacattggtatcactagaaataagataccagaattagttttaaataaagaggaatgctgaggcatattcttacataagttattattaaacgttatttgaaaaggacagtggaaaaggtgctttgaaaatgaaattaaattagtgactttgttacagtaagaatttctgtgtaactaagaagcacattaactcagagaccatcgttctacttcattccaagtggtagtacttctagaagtatcagtttagcagttgcactgcttgaggatttcagcctaacgcagacatatgcaattcatatattttgagagtggtaatgtaatggcagtcataatgctctaaggatagaagagaagacagatttgcaggaacaggtgttgtcctttataattatggggggactgaatgcccaaatagcctatacttttaattcaactgtataagctgctttaataaaatatatcgttctccctacatcctggcttctcttacattttgataatttttcatcatgttttcctcaagccatggaaaatgttaatttttatgtgaattactaatcacagaaatgttctaattctaaacggttacatcatggttaggaagttttgcctaaaatacttttctacaagaataggtcttaagggaaaaatgttcatttaatggacaattgctgtgtactaatttagaacaaatgactgttatgaggatatgaaaacattttctcaaaaaacagtgttttctcttgtgaattatgttcagaattttgatctaattgtaaatacttcttgtttctatgggattttatttattaaaaaacaaacaaaaaaaaa

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