LOCUS       NM_001106846            3052 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus claudin 2 (Cldn2), mRNA.
ACCESSION   NM_001106846 XM_001054180 XM_236535
VERSION     NM_001106846.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3052)
  AUTHORS   Rosas-Martinez,L., Rodriguez-Munoz,R., Namorado-Tonix,M.D.C.,
            Missirlis,F., Del Valle-Mondragon,L., Sanchez-Mendoza,A.,
            Reyes-Sanchez,J.L. and Cervantes-Perez,L.G.
  TITLE     Hyperglycemic levels in early stage of diabetic nephropathy affect
            differentially renal expression of claudins-2 and -5 by oxidative
            stress
  JOURNAL   Life Sci 268, 119003 (2021)
   PUBMED   33417957
  REMARK    GeneRIF: Hyperglycemic levels in early stage of diabetic
            nephropathy affect differentially renal expression of claudins-2
            and -5 by oxidative stress.
REFERENCE   2  (bases 1 to 3052)
  AUTHORS   Montalbetti,N., Rued,A.C., Clayton,D.R., Ruiz,W.G., Bastacky,S.I.,
            Prakasam,H.S., Eaton,A.F., Kullmann,F.A., Apodaca,G. and
            Carattino,M.D.
  TITLE     Increased urothelial paracellular transport promotes cystitis
  JOURNAL   Am J Physiol Renal Physiol 309 (12), F1070-F1081 (2015)
   PUBMED   26423859
  REMARK    GeneRIF: While the integrity of the urothelial barrier was
            preserved in the rats transduced with CLDN-2, we found that the
            expression of this protein in the umbrella cells initiated an
            inflammatory process
REFERENCE   3  (bases 1 to 3052)
  AUTHORS   Molina-Jijon,E., Rodriguez-Munoz,R., Namorado Mdel,C.,
            Pedraza-Chaverri,J. and Reyes,J.L.
  TITLE     Oxidative stress induces claudin-2 nitration in experimental type 1
            diabetic nephropathy
  JOURNAL   Free Radic Biol Med 72, 162-175 (2014)
   PUBMED   24726862
  REMARK    GeneRIF: We suggest that loss of claudin-2 is associated with
            increased natriuresis in experimental type 1 diabetic nephropathy
REFERENCE   4  (bases 1 to 3052)
  AUTHORS   Yatabe,M.S., Yatabe,J., Takano,K., Murakami,Y., Sakuta,R., Abe,S.,
            Sanada,H., Kimura,J. and Watanabe,T.
  TITLE     Effects of a high-sodium diet on renal tubule Ca2+ transporter and
            claudin expression in Wistar-Kyoto rats
  JOURNAL   BMC Nephrol 13, 160 (2012)
   PUBMED   23199000
  REMARK    GeneRIF: Chronic high-salt diet for 8 weeks in Wistar-Kyoto rats
            decreases claudin-2 protein expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3052)
  AUTHORS   Westmoreland,J.J., Drosos,Y., Kelly,J., Ye,J., Means,A.L.,
            Washington,M.K. and Sosa-Pineda,B.
  TITLE     Dynamic distribution of claudin proteins in pancreatic epithelia
            undergoing morphogenesis or neoplastic transformation
  JOURNAL   Dev Dyn 241 (3), 583-594 (2012)
   PUBMED   22275141
REFERENCE   6  (bases 1 to 3052)
  AUTHORS   Imamura,M., Kojima,T., Lan,M., Son,S., Murata,M., Osanai,M.,
            Chiba,H., Hirata,K. and Sawada,N.
  TITLE     Oncostatin M induces upregulation of claudin-2 in rodent
            hepatocytes coinciding with changes in morphology and function of
            tight junctions
  JOURNAL   Exp Cell Res 313 (9), 1951-1962 (2007)
   PUBMED   17434483
  REMARK    GeneRIF: These results suggest that expression of claudin-2 in
            rodent hepatocytes may play a specific role as controlling the size
            of paracellular permeability in the barrier to keep bile in bile
            canaculi.
REFERENCE   7  (bases 1 to 3052)
  AUTHORS   Ohta,H., Adachi,H. and Inaba,M.
  TITLE     Developmental changes in the expression of tight junction protein
            claudins in murine metanephroi and embryonic kidneys
  JOURNAL   J Vet Med Sci 68 (2), 149-155 (2006)
   PUBMED   16520537
REFERENCE   8  (bases 1 to 3052)
  AUTHORS   Furuse,M., Sasaki,H. and Tsukita,S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J Cell Biol 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   9  (bases 1 to 3052)
  AUTHORS   Kubota,K., Furuse,M., Sasaki,H., Sonoda,N., Fujita,K., Nagafuchi,A.
            and Tsukita,S.
  TITLE     Ca(2+)-independent cell-adhesion activity of claudins, a family of
            integral membrane proteins localized at tight junctions
  JOURNAL   Curr Biol 9 (18), 1035-1038 (1999)
   PUBMED   10508613
REFERENCE   10 (bases 1 to 3052)
  AUTHORS   Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J Cell Biol 141 (7), 1539-1550 (1998)
   PUBMED   9647647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1, CB696787.1, CB790981.1, CV120097.1, CO392895.1,
            CB808365.1, CB806944.1 and BM392116.1.
            
            On Mar 4, 2008 this sequence version replaced NM_001106846.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1686209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000021.1  108248513-108248563
            52-156              CB696787.1         53-157
            157-166             JAXUCZ010000021.1  108248669-108248678
            167-174             JAXUCZ010000021.1  108255979-108255986
            175-281             CB696787.1         176-282
            282-659             CB790981.1         59-436
            660-1256            CV120097.1         113-709
            1257-1713           CO392895.1         103-559
            1714-1715           JAXUCZ010000021.1  108257526-108257527
            1716-1885           CO392895.1         562-731
            1886-2025           CB808365.1         82-221
            2026-2243           JAXUCZ010000021.1  108257838-108258055
            2244-2511           CB806944.1         20-287
            2512-3052           BM392116.1         1-541               c
FEATURES             Location/Qualifiers
     source          1..3052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..3052
                     /gene="Cldn2"
                     /gene_synonym="RGD1560247"
                     /note="claudin 2"
                     /db_xref="GeneID:300920"
                     /db_xref="RGD:1560247"
     exon            1..166
                     /gene="Cldn2"
                     /gene_synonym="RGD1560247"
                     /inference="alignment:Splign:2.1.0"
     exon            167..3035
                     /gene="Cldn2"
                     /gene_synonym="RGD1560247"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    265..267
                     /gene="Cldn2"
                     /gene_synonym="RGD1560247"
                     /note="upstream in-frame stop codon"
     CDS             349..1041
                     /gene="Cldn2"
                     /gene_synonym="RGD1560247"
                     /codon_start=1
                     /product="claudin-2"
                     /protein_id="NP_001100316.1"
                     /db_xref="GeneID:300920"
                     /db_xref="RGD:1560247"
                     /translation="

MASLGVQLVGYILGLLGLLGTSIAMLLPNWRTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAMSSLACIISVVGMRCTVFCQESRAKDRVAVVGGVFFILGGILGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISALFSLVAGVILCFSCSPQGNRTNYYDGYQAQPLATRSSPRSAQQPKAKSEFNSYSLTGYV"

     misc_feature    361..891
                     /gene="Cldn2"
                     /gene_synonym="RGD1560247"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
ORIGIN      

agaaggctcagatttacaggtggattttacaaagctgtggctaataattagaaatcccttatcaccacagcccgtggccccttggacccagttcacctttccctggacctagtcctcttttccgctggagcatctctcccagagcccttcgagaaagaacagctccgttttctagatgccttcttgagcctgcttgtggccacccacagatacttgtaaggaggaaagaagtcagcttgccagagacactgtgaaatgagggattagaggccgggatccaagaaacaagagccgcagccaaaagacaagcgaacaggttccgaagatacttctactgagaggtctgccatggcctcccttggcgtccaactggtgggctacatcctaggccttttggggctattaggcacatcgattgccatgctgctccccaactggcgaacaagttcttatgttggtgccagcattgtgacggcggttggcttttccaagggcctctggatggagtgtgcgacccacagcactggcatcacccagtgtgatatctacagtactcttttaggacttcctgctgacatccaggctgcccaggccatgatggtgacatccagtgcaatgtcctcgctggcctgcattatctctgtggtgggcatgagatgcacagtgttctgccaggaatctcgagctaaggacagagtggctgtagtgggtggagtctttttcatccttggtggtatcctgggttttatcccagttgcttggaatcttcacggcattctccgggacttctactcaccactggtccctgacagcatgaaatttgagattggagaagctctgtacttgggaatcatttcagcgctgttttccttggtagctggagtcatcctctgcttttcctgctcacctcagggaaatcgtaccaactactatgatggctaccaggcccagcctcttgccactaggagctctccaagatctgctcaacagcccaaagccaagagtgagttcaactcatacagcctgactgggtatgtgtgaagaaccaggggccagagctgggggtggggtggggtggtggctgggactataaaaatagtagtggacaatgcccccagggttacaggcaaaggacattgccattgaatcatgtgtaaggtgctgctgagggtagaatgactttggccattggatgaagtaaaggcagagatgagaacaggggtgacagcatgtacatcgaattgccaaggacacttatcaagcgagcttttctatttcttttctcactaaggcaccttctgtgccctgaatgctcaacccaaaagtctaaatcccattgctgccactttttgctatgcccagaggctctcttctgccctttggtttacttggagatctgttccccaaccaatcatattccattgactaaccatctgtgatcaaaagaccttctccctctggctgaaattggctcttgactcaaatactaggggacagagagaagaaagaggggtggcttctgcgagaatgtttctagctcccttctcacatctccagccaaagaaatggattggtcagttataggccctgaagcctctcttccagttttgctatgagtgcaatatgtccagactggtttgggaaggaactgaaggaaagctatctcatggcatcccacagaaagcagctgagtataggatgggaggcaacctgggctccaaagaaacaaaaacaaacaacaaagcccaccagaatcacttctcagatcatctcctctaattgccacccatttgtgggtcaggaatggaagcactgctacaggaagacagtagaggcatacagaaagctgaaggctgcagccccctcactccaccgaggactggccaagaagctgaagtgaactaccgctcaaagtgctgtctcccactgaggtgtctgacccagcttcctgataaaccacaagacttggagccctagacaagggtttccttagggacaataaagcagtttttctagaactgccctttgacatgggagcagcagagggctaaaaggactctttagccctggccaaaaacgaatggggactttggtatggaagaactgctgggcagagatgcatggtaggtgtgtgtgctcctactgttttggagaggcaaccctaccagatactttagacttgttgggaaaaacaacctatctgggtctttactcagcactacagagcctctgaaaggccacagcatcagagaggtcctttgtcacttttaatattcgagtcatcgcccatcagaagatattcttacaggtatgcaaagtcttcagtgtggaacatcttttgaccaaggtgttgtgttcatgacctgagtgattggtgaacttctgcctgggattgtgattgaggtgggaggacagagactggttctcagtgcaacactccatggtcttaaaatgctccgttttcctctgtggtagatgggggtcagaatctagagacattaaccccaacagcctaatagcaccaacttcagaagattcccagcacacctcatcaaaacttcagcagcggcaagagaggcccatatgtgaggtttcctttaacacgcctttcctatttccaccatattacttgggttcaagctgttatgctgacctggaagccatttcatccccatgcttggagaacttgctcaccgtcatccccttcattgagccttctctaatcactccttcctgcccttcccctcctccaattcccaatatataaattgcttaatccttatcattcataattttgattaacagtttatagttcttgtatgcgcatttgtatgtgtgtgtgtgtgtgtgtgtttgtgtgtgtgtgtgtgtgtgtgtgtgtgtctatccgtctacctgtctatctgtgtgatctcaaaagttcactgtaagtacttggagggcaattgccatatcttagacctgtctatatgtatactcaagactgtaacagtgctgagcacacacaaggtgatcaataaatggatgttgattgaaaaaaaaaaaaaaaaaa

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