LOCUS       NM_001100224            2145 bp    mRNA    linear   VRT 06-JUL-2023
DEFINITION  Xenopus tropicalis SHOX homeobox 2 (shox2), mRNA.
ACCESSION   NM_001100224
VERSION     NM_001100224.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Puskaric S, Schmitteckert S, Mori AD, Glaser A, Schneider KU,
            Bruneau BG, Blaschke RJ, Steinbeisser H and Rappold G.
  TITLE     Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker
            region of the developing heart
  JOURNAL   Hum Mol Genet 19 (23), 4625-4633 (2010)
   PUBMED   20858598
  REMARK    GeneRIF: work establishes a link between Tbx5, Shox2 and Bmp4 in
            the pacemaker region of the developing heart
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW and
            Richardson P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ675518.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ675518.1, DR894820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00028294, SAMD00028298
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="5"
                     /map="5"
     gene            1..2145
                     /gene="shox2"
                     /gene_synonym="og12; og12x; ogi2x; shot"
                     /note="SHOX homeobox 2"
                     /db_xref="GeneID:100101703"
                     /db_xref="Xenbase:XB-GENE-480993"
     exon            1..435
                     /gene="shox2"
                     /gene_synonym="og12; og12x; ogi2x; shot"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    9..11
                     /gene="shox2"
                     /gene_synonym="og12; og12x; ogi2x; shot"
                     /note="upstream in-frame stop codon"
     CDS             156..1091
                     /gene="shox2"
                     /gene_synonym="og12; og12x; ogi2x; shot"
                     /note="short stature homeobox 2"
                     /codon_start=1
                     /product="short stature homeobox protein 2"
                     /protein_id="NP_001093694.1"
                     /db_xref="GeneID:100101703"
                     /db_xref="Xenbase:XB-GENE-480993"
                     /translation="

MEELTAFVSKSFDQKIKEKKEMITYREVLESGPARGKEPGCGEGAREDGLAGNRCIGGGGGGGGGGGGARSPVLELDLSVERIRESGSPKLTEVSPEIKERKEELKQQALEEEGQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAGSQFEACRVAPYVNVGALRMPFQQDSHCNVPSLSFQVQAQLQLDSAVAHAHHHLHPHLTAHAPYMMFPAPPFGLPLATLAAETATAASVVAAAAAAKTSSKNSSIADLRLKAKKHAAALGL"

     misc_feature    516..686
                     /gene="shox2"
                     /gene_synonym="og12; og12x; ogi2x; shot"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1029..1076
                     /gene="shox2"
                     /gene_synonym="og12; og12x; ogi2x; shot"
                     /note="OAR motif; Region: OAR; pfam03826"
                     /db_xref="CDD:461067"
     exon            436..650
                     /gene="shox2"
                     /gene_synonym="og12; og12x; ogi2x; shot"
                     /inference="alignment:Splign:2.1.0"
     exon            651..708
                     /gene="shox2"
                     /gene_synonym="og12; og12x; ogi2x; shot"
                     /inference="alignment:Splign:2.1.0"
     exon            709..797
                     /gene="shox2"
                     /gene_synonym="og12; og12x; ogi2x; shot"
                     /inference="alignment:Splign:2.1.0"
     exon            798..2145
                     /gene="shox2"
                     /gene_synonym="og12; og12x; ogi2x; shot"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

caaactcttagcgggcaggagggacacagatctctaacgaggggcactgggaaggggcaaactctcccgccgcctcttcatgtttcattgctgagctttcagggaccctgccagccagagccgccggcttattattattattgttagcgcaggctatggaagaacttactgcttttgtgtccaagtcatttgatcagaagatcaaggagaagaaggagatgatcacttaccgggaggtgttggaaagcggcccagctcggggcaaggagcctggctgcggagaaggggcccgggaggacggactagcggggaaccggtgtataggagggggtggcggcggtggaggaggtggtggaggggccagatccccggtcttggagctcgatctgtccgtggagaggatcagggagagtggaagcccgaagctcactgaggtatccccagagataaaggaacggaaggaggagctgaagcagcaggcactggaggaagagggacagactaagatcaagcagagaaggagtcggactaacttcaccctggagcagctgaatgagctggagagattgtttgatgagacccactacccagatgccttcatgagggaggagttgagccagcgccttggcctgtcagaggccagagttcaggtctggtttcaaaacagaagggcaaaatgcagaaaacaagaaaatcagctccataaaggggtcctgataggagcagggagccagtttgaagcgtgtagagtcgcaccttatgtcaatgtgggagccctgaggatgccattccagcaggatagtcattgcaacgtgccatccttgtccttccaggttcaggcacagttgcagctggacagcgccgtggcccacgcccaccaccacctccatcctcacctgacggcgcatgcgccctacatgatgttcccggccccgcccttcggactcccgctggcgacactggctgcggagacggcgacggcagcgtctgtagttgcggcagctgcggctgctaaaacctctagcaagaactcgagcattgcagatcttagacttaaagccaaaaaacacgcagcagctctaggactgtgactagcactgcatgggccctttaccggcagggcccaacagactacgtctcaaaacccttatttatgagctggagcctctcagccaaacccttcattgtgcaggaagtagaagggccaaggtcatgtgacagaggggcctttccgtgcagcagattgtactggccaggtgatgctgagcctctcagcggtcccactacctgcaagtaccttacactttgtggggccagtccagccatcaaaccacaggaagagaccgctacttctgtttcttaaatattagggatatttttatgctaatgtgtgaacagtggggatgctgggagcacacaatttctttctgctgtggaacttgaaagggaagaaaaaaaaaaaatctgtaaaaccctgggacacagaaagcaccagggaaagataagatggtgggaagttcacaggttttgacactgacccttttgtgncaagttcactttaatacaaggaatctgaacagtgaggcgggcctccttatgtctcatcttctggatgcgcaggcaagtctggaagaataattatagaaaaaataatgaaagacgctttctcttcgaatttctattggggaaatgtatagcagactctctagcaaatttctggtttgcatgttctttgccatatcattgatgctgttttttgactcactttgcacttcatcctcaattgaagtagagggacattacaaaggaaatgaagatgatgccaaaatactgtattccttatagaacaaagcatttaaatgggaaacggggaaacatatatgcccactatctattgaaaggtaagggatggccctccagcttttgttaagatacagttctgtttcctaagggatgctgggaattgtaaatcaacaacagctggagggagaaaggttggaaatccctgtctggagaaaatccattaggttctggggccaaagttacagaagagggagcccctgcaatttcagcaattgcagtgttacccataatttatttttgtccatgtgtggaatactgatcttgtgcactataatttgtata

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