LOCUS       NM_001001216            1909 bp    mRNA    linear   VRT 04-FEB-2024
DEFINITION  Xenopus tropicalis iroquois homeobox 3 (irx3), mRNA.
ACCESSION   NM_001001216
VERSION     NM_001001216.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 1909)
  AUTHORS   Rodriguez-Seguel,E., Alarcon,P. and Gomez-Skarmeta,J.L.
  TITLE     The Xenopus Irx genes are essential for neural patterning and
            define the border between prethalamus and thalamus through mutual
            antagonism with the anterior repressors Fezf and Arx
  JOURNAL   Dev Biol 329 (2), 258-268 (2009)
   PUBMED   19268445
REFERENCE   2  (bases 1 to 1909)
  AUTHORS   Klein,S.L., Strausberg,R.L., Wagner,L., Pontius,J., Clifton,S.W.
            and Richardson,P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC067972.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067972.1, CR760274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00028291, SAMN00861986
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1909
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="4"
                     /map="4"
     gene            1..1909
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /note="iroquois homeobox 3"
                     /db_xref="GeneID:407888"
                     /db_xref="Xenbase:XB-GENE-480486"
     exon            1..485
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    231..233
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /note="upstream in-frame stop codon"
     CDS             264..1610
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein irx-3"
                     /protein_id="NP_001001216.1"
                     /db_xref="GeneID:407888"
                     /db_xref="Xenbase:XB-GENE-480486"
                     /translation="

MSFPQLGYQYIRPLYPSDRQNVGGTRSGTELSPAGTLSNVLSSVYGTPYAAAAAAQAYGAFLPYSAELPIFPQLGSQYEMKDSPGVQHAAFSHPHAAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSDHEEDKHEDDEEIDLENIDTEDIESKEDLDDPDTDIHSDSKTDARSDSEASDGFEDLNAPEDRLLKSVVGQRQVLNEEPQDKCALSSDAKASQPACEQIKLDRIPSSPPLENNIPAAHKPKIWSLAETATTPDNPRRSPNTGGSVNTQNLIAQHRLIASPGSRFQGWTGRAFSAQQLSLLNSAHFLQGLSVSHTALGSGTASFPKAAEPKHSTDSLTDRSSTVDIEKKIPVLNTAFQPVQRRSQNQLDAAMILSALSSS"

     misc_feature    642..758
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    774..1013
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NVN3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1173..1226
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /note="Motif in Iroquois-class homeodomain proteins
                     (only). Unknown function; Region: IRO; smart00548"
                     /db_xref="CDD:214716"
     misc_feature    1422..1493
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NVN3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            486..1482
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1555
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1885
                     /gene="irx3"
                     /gene_synonym="irx-1; irx3b; xiro-3; xiro3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtgagactagaggacttgggaggagcttacgctgggcttgaaatgtcaatcacagtgtgagtgccaatgatctgaagcaatctgctaggaactgacctggtccacgcagatcaatagcaccagagggagaggacagagccaccgagatccctgctggaaccctagaagcccggttccccccttcctgggtcgcttgatgtgtagggagacgggcaagcaaactcaggtcatagaaggggattccctgcgcctccggctgcaccatgtccttcccacagctgggctaccagtacatcagacctctatacccctcggacaggcagaacgtggggggcaccaggagcggaactgaactctctccggccgggactctttctaatgttctctcctcggtgtacggaactccctacgctgcagccgccgcggcacaagcctatggagccttcctgccctacagcgcggagctgcccatcttcccccagttgggctcacagtatgaaatgaaggacagtccgggggtccagcatgccgccttctcccacccccacgcagccttttatccctacggacagtaccagtttggagatccgtcaaggcccaaaaacgctaccagagagagcacaagtacccttaaggcctggctcaacgaacacagaaagaacccatatccgaccaagggcgagaagatcatgcttgccatcatcactaaaatgaccctcacacaggtgtccacctggtttgctaacgcaaggaggagacttaaaaaggagaacaaaatgacttgggcccccaggagccgaactgatgaggaaggtaacgcttacggcagcgaccatgaagaagacaagcatgaggacgacgaggagattgacctggagaacatcgacactgaggacattgagagtaaggaagacttggatgacccagacactgatatacactcggactctaaaactgatgccaggagtgactcggaagcctcggatgggtttgaggacctgaatgcccctgaggacagacttctcaagtcagtggttggtcaaaggcaggtgttaaatgaggagccccaggacaagtgtgcactttcttctgatgctaaagcttcccagcctgcgtgtgagcagatcaaactggacagaatcccctctagtcctcctctggagaacaacattcccgcggcccacaaacccaaaatctggtcactggcagagacagcaacaaccccagataacccacgcaggtcccccaacacgggtggctcagtgaacactcaaaacctgattgcacaacacagacttatcgcctccccagggagcaggttccagggttggactggaagagcattctctgctcagcagttgtctttactaaactctgctcattttctgcaaggactgagcgtctctcacacagccctgggctctggcactgcaagtttccctaaggccgccgagcccaagcacagcacagactctctaacagatcgatccagtacagtggacatagagaaaaaaatacctgtattaaatacagctttccaaccagtgcaacgaaggtcacaaaatcagctggacgctgccatgatcctttccgctctatcctcatcctaacagtgtattttatatttatattttcttcttttttaactattcgaatgactgtaaaatatttctatgctgggtagtaacgccttgtaagcatgtctgtggataaaatggaacaaaaattgtttctattctcttatgcagaccagagttcgtatggtttgtcttgtgctaattaaacgtcggtcatttttgtatatatagtacaaatgtaaatatgtgtttaaaccaaattgtacaaataagtatatatttttggttaataaattcttcacaatttaaaaaaaaaaaaaaaaaaaaaaaaa

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