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Previous release (v1)
2024-11-23 10:38:01, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_138845 17544 bp mRNA linear ROD 24-JUN-2024
DEFINITION Rattus norvegicus trinucleotide repeat containing adaptor 6B
(Tnrc6b), mRNA.
ACCESSION NM_138845 XM_001077084 XM_576311
VERSION NM_138845.5
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 17544)
AUTHORS Edwards,T.L., Hartmann,K.E. and Velez Edwards,D.R.
TITLE Variants in BET1L and TNRC6B associate with increasing fibroid
volume and fibroid type among European Americans
JOURNAL Hum Genet 132 (12), 1361-1369 (2013)
PUBMED 23892540
REFERENCE 2 (bases 1 to 17544)
AUTHORS Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
Krijgsveld,J. and Hentze,M.W.
TITLE Insights into RNA biology from an atlas of mammalian mRNA-binding
proteins
JOURNAL Cell 149 (6), 1393-1406 (2012)
PUBMED 22658674
REFERENCE 3 (bases 1 to 17544)
AUTHORS Ender,C. and Meister,G.
TITLE Argonaute proteins at a glance
JOURNAL J Cell Sci 123 (Pt 11), 1819-1823 (2010)
PUBMED 20484662
REMARK Review article
REFERENCE 4 (bases 1 to 17544)
AUTHORS Fabian,M.R., Mathonnet,G., Sundermeier,T., Mathys,H.,
Zipprich,J.T., Svitkin,Y.V., Rivas,F., Jinek,M., Wohlschlegel,J.,
Doudna,J.A., Chen,C.Y., Shyu,A.B., Yates,J.R. 3rd, Hannon,G.J.,
Filipowicz,W., Duchaine,T.F. and Sonenberg,N.
TITLE Mammalian miRNA RISC recruits CAF1 and PABP to affect
PABP-dependent deadenylation
JOURNAL Mol Cell 35 (6), 868-880 (2009)
PUBMED 19716330
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000007.1.
On Apr 3, 2024 this sequence version replaced NM_138845.4.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: SRR26643429.28118.1,
SRR26643287.18807.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760383, SAMEA5760386
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on expression
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-200 JAXUCZ010000007.1 114132574-114132773
201-269 JAXUCZ010000007.1 114173236-114173304
270-360 JAXUCZ010000007.1 114186322-114186412
361-428 JAXUCZ010000007.1 114207038-114207105
429-516 JAXUCZ010000007.1 114276624-114276711
517-538 JAXUCZ010000007.1 114282578-114282599
539-880 JAXUCZ010000007.1 114290738-114291079
881-3223 JAXUCZ010000007.1 114293092-114295434
3224-3382 JAXUCZ010000007.1 114297157-114297315
3383-3558 JAXUCZ010000007.1 114298450-114298625
3559-3630 JAXUCZ010000007.1 114301188-114301259
3631-3676 JAXUCZ010000007.1 114302099-114302144
3677-3813 JAXUCZ010000007.1 114303396-114303532
3814-3939 JAXUCZ010000007.1 114308599-114308724
3940-4071 JAXUCZ010000007.1 114315802-114315933
4072-4167 JAXUCZ010000007.1 114316197-114316292
4168-4390 JAXUCZ010000007.1 114316425-114316647
4391-4528 JAXUCZ010000007.1 114322078-114322215
4529-4705 JAXUCZ010000007.1 114325207-114325383
4706-4852 JAXUCZ010000007.1 114326555-114326701
4853-4948 JAXUCZ010000007.1 114326949-114327044
4949-5173 JAXUCZ010000007.1 114333015-114333239
5174-5244 JAXUCZ010000007.1 114333653-114333723
5245-5384 JAXUCZ010000007.1 114336500-114336639
5385-17544 JAXUCZ010000007.1 114337851-114350010
FEATURES Location/Qualifiers
source 1..17544
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="7"
/map="7q34"
gene 1..17544
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="trinucleotide repeat containing adaptor 6B"
/db_xref="GeneID:192178"
/db_xref="RGD:621428"
exon 1..200
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 201..269
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
misc_feature 226..228
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="upstream in-frame stop codon"
exon 270..360
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
CDS 316..5772
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="androgen receptor-related apoptosis-associated
protein CBL27; trinucleotide repeat containing 6B"
/codon_start=1
/product="trinucleotide repeat-containing gene 6B protein"
/protein_id="NP_620200.2"
/db_xref="GeneID:192178"
/db_xref="RGD:621428"
/translation="
MHTNEGEVEEESSSQVEQEDFVMEGHGKTPPPGEESKQEKEQEREEQLMEDKKRKKEDKKKKEATQKVTEQKTKVPEVTKPSLSQPTAASPIGSSPSPPVNGGNNAKRVAVPNGQPPSAARYMPREVPPRFRCQQDHKVLLKRGQPPPPSCMLLGGGAGPPPCTAPGANPNNAQVTGALLQSESGTAPESTLGGAAASNYANSTWGPGASSNNGASPNPIHIWDKVIVDGSDMEEWPCIASKDTESSSENTTDNNSASNPGSEKSALPGSTTSNKGKGSQCQSASSGNECNLGVWKSDPKAKSVQSPNSTSDSNNGLGTWRSTSGQDRIGPGSGFSNFNPNSNPSAWPALVQEGTCRKGVLEAEGSSSSAQVSTVGQASREQQSKMENAGVNFVVSGREQAQIHNTDGPKNGNTNSLNLSSPNPMENKGMPFGMGLGNTSRSTDAPSQSTGDRKTGSVGSWGAARGPSGADTVSGQSNSGNNGNNGKDREDSWKGASVPKPTGSQSDSWDNNNRSTGGSWNFGPQDSNDNKWGEGNKMTSGVSQGEWKQPTGSDELKIGEWSGPNQPNSSTGAWDNQKGHPLPENQGNAQAPCWGRSSSSAGSEVGGQSTGSNHKAGSSDSHNSGRRSYRPAHPDCQAVLQTLLSRTDLDPRVLSNTGWGQTQIKQDTVWDIEEVPRPEGKSDKGTEGWESAATQTKNSGGWGDAPSQSNQMKSGWGELSASTEWKDPKSTGGWNDYKNNNSSNWGGGRADEKTPSSWNESSCKDQGWGGGRQPNQGWTSGKNGWGEEVDQVKNNNWESSANKPVSGWGEGGQSEIGTWGNGGNTNLASKGGWEDCKRSPAWNETGRQPNSWNKQHQQQQQQPPPPQPEASGSWGGPPPPPQGNVRPSNSNWSSGPQPATPKDDEPSGWEEPSPQSISRKMDIDDGTSAWGDPNSYNYKNVNLWDKNSQGGPAPREPNLPTPMTGKSASVWSKSTPPAPDNGTSAWGEPNESSPGWGEMDDAGASATGWGNTPASAPNAMKPNSKSMQDGWGESDGPVTGARHPSWEEEDDGGVWNTAGSQGSTSSHNSASWGQGGKKQMKCSIKGNNDSWMNPLAKQFSNMGLLSQTEDNPSSKMDLSVDKKFDVDKRTMNLGDFNDIMRKDRPGFRPPNSKDLGTTDSGPYFEKGGSHGLFGNSTAQSRGLHTPVQPLSSSPGLRAQVPPQFISPQVSASMLKQFPNSGLNPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQQQQQQQQQQQQQQRQPSMKHSPSHPVGPKPHLDNMVPNTLNVGLPDLPTKGPIPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEATMHKNGAIVAPGKTRGGSPYNQFDIIPGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGTATSPIVDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGLTNPKPASPWSSTAPRSVRGWGTQDSRIASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFATEDEVSRFLAQAQPPTPAATPSAPATGWQSLETSQNQADPVGPALNLFGGSTGLGQWSSSAGGSSGADLAGTSLWGPPNYSSSLWGVPTVEDPHRMGSPAPLLPGDLLGGGSDSI"
misc_feature <1399..>2193
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="serine-rich protein; Region: ser_rich_anae_1;
NF033849"
/db_xref="CDD:468206"
misc_feature 3250..3585
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="Argonaute hook; Region: Ago_hook; pfam10427"
/db_xref="CDD:463088"
misc_feature 4369..5205
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="TNRC6-PABC binding domain; Region: TNRC6-PABC_bdg;
pfam16608"
/db_xref="CDD:465195"
misc_feature 5209..5457
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="RNA recognition motif (RRM) found in vertebrate
trinucleotide repeat-containing gene 6B protein (TNRC6B);
Region: RRM_TNRC6B; cd12712"
/db_xref="CDD:410111"
exon 361..428
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 429..516
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 517..538
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 539..880
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 881..3223
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3224..3382
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3383..3558
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3559..3630
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3631..3676
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3677..3813
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3814..3939
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3940..4071
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4072..4167
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4168..4390
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4391..4528
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4529..4705
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4706..4852
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4853..4948
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4949..5173
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 5174..5244
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 5245..5384
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 5385..17544
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
ORIGIN
cggaggggaaagtttgtttattttgtttttagtttctggggtccccgagcttcgggaaggtgaagcgagcgacagtgacccccctagcctctcagcctccccgcgacgtcgcctctacagcttgcggagaagcggagaccgcggtcaccgctgggctccacagcggaacgacgcgctctcggagccggcgcggctcagcgggtcttgggttttttgcactgaatgtaacctagactgatcgtctcagttgccccaggatactgtcagaggcagtgtctgtgtgtgtctgcagagctttgcacagaatctgttcccatgcacaccaatgagggagaagtagaggaagagagcagctcccaggtggaacaggaggattttgtaatggaagggcatggcaagactccacctcctggagaagaaagcaaacaagagaaggagcaagaaagggaagaacagttaatggaagacaagaaaaggaagaaagaggataaaaagaaaaaagaagccacccagaaggtcacggaacaaaaaaccaaagtgcccgaagtgacgaaaccaagtttaagccaaccaacggccgccagcccaattggcagctctccatcgccaccagtcaatggtggcaacaatgccaaaagggtggcagtgccgaacggacaaccgccaagcgccgcccgctacatgcctcgggaggtgccaccgcgattccgttgccagcaggaccacaaagtgttactaaaacgtgggcagccccctccaccgtcctgcatgctcctagggggtggggcggggcctcctccctgcacagcacctggagcaaaccccaacaacgcacaagtgacaggagcgctgctgcagagcgagagtgggacggcaccagagtcaacccttggaggtgctgctgcttcaaattatgcaaattccacttggggcccgggagcctcctccaacaacggcgcctcccccaacccaattcacatctgggacaaggtgattgtagacgggtctgacatggaagagtggccttgtattgccagcaaagacactgaatcttcttccgaaaacaccaccgataacaacagtgcctcgaaccctggctctgagaagagcgctctgccaggaagcaccactagtaacaaaggcaaagggagccagtgccagtctgcaagttctgggaatgaatgtaatcttggggtctggaaatctgaccctaaggctaaatctgttcagtctcccaactctacttcagatagcaacaatggactaggaacctggaggagtaccagtggtcaagatagaattggacctggctctggcttcagcaactttaacccaaatagcaacccatctgcctggccagcattggtccaagaaggaacttgtaggaaaggggtgttggaggcagaaggtagcagttccagtgcacaagtcagcacagtaggtcaggcatccagggaacagcagtcaaagatggagaatgcgggtgttaattttgttgtctctggcagagaacaggctcagattcataacactgatggaccaaaaaacggaaacactaactccttgaacttaagttcaccaaaccccatggaaaataagggaatgccctttggaatgggcttggggaacacctccaggagcactgatgccccttcacaaagcactggagatcgaaagactgggagtgttgggtcttggggcgcagctagggggccttctggagctgacacagtctctggacaaagcaattctggaaacaatgggaacaatggaaaagacagagaggactcctggaaaggagcttccgttccaaaaccaactgggtcacaaagtgactcttgggacaacaataacaggtctacgggtgggtcctggaattttggccctcaggactctaatgacaacaaatggggtgaagggaacaaaatgacatctggggtctctcagggagaatggaaacagccgactgggtctgatgagttgaaaattggagaatggagtggtccaaaccaaccaaattctagcactggagcatgggacaatcaaaagggccaccccctcccagaaaaccaaggcaatgcccaggctccctgttggggaagatcttccagctccgcaggaagtgaagttggaggtcaaagcactggaagcaaccacaaagcaggaagtagcgacagtcataattctggtcgtcggtcatacaggcccgcacatcctgattgccaggctgtcttgcagactcttttgagccggactgatttggaccctagggtgctctcaaacactggctggggccaaactcaaattaagcaggacacagtgtgggatattgaagaggtgccaaggcctgaggggaaatctgacaaaggaactgaggggtgggagagcgctgccacacagaccaagaactcagggggctggggagatgcacccagccaaagcaatcaaatgaagtctggatggggggagctctcagcctcaacagagtggaaagaccccaagagtacaggaggctggaatgactacaagaacaacaactcttctaactggggaggaggacgagcggatgaaaagacaccttcctcttggaatgagagttcttgtaaggatcaggggtggggaggtgggcgccagcccaaccaaggatggacttctgggaagaatggttggggcgaggaggttgatcaagtgaaaaataacaattgggaaagttctgccaataagcctgtgtctgggtggggtgaaggagggcagagtgaaattggaacttggggcaatggtgggaatacaaacctcgcttcaaaaggtgggtgggaagattgcaaaagatcccctgcatggaatgagactggcagacagcctaattcctggaataaacaacaccaacagcagcagcagcagccaccgccaccacagccagaggcttctggttcatggggaggcccacccccaccacctcaaggcaatgttcgaccttctaattccaactggagcagtgggccccaacctgcaacccctaaggatgatgaacccagtggttgggaggagccatccccacagtcaattagtcgaaaaatggacatcgatgatggcacttcagcttggggagaccctaacagttataactacaagaatgtgaacctttgggataagaattctcaagggggcccagcacctcgagaaccaaacctgcctaccccgatgaccggaaaatcagcatcagtctggagcaaaagcacaccacctgctccagataatgggacttcagcctggggtgagccaaatgaaagcagtcctgggtggggtgagatggatgatgcaggagcatcagccacaggctggggaaacacacctgccagcgctcccaatgccatgaaacccaattccaaatctatgcaagacggctggggggagagtgatggcccagtcacaggagctcgccatcctagctgggaagaggaagatgatggaggagtctggaacaccgccggctctcagggaagcacttcctcccacaactcagcaagctggggacaaggaggaaagaaacaaatgaagtgctcgataaaaggaaacaatgattcgtggatgaatcctcttgccaaacagttttcaaatatgggattgctgagtcaaactgaggataacccaagcagcaaaatggatttgtctgtagataagaaatttgatgtggacaagagaacaatgaatctcggggattttaatgatatcatgaggaaggatcgacctgggttccgtccacctaattccaaagacttgggaaccacagacagtgggccttattttgagaagggcggcagtcatggtttgtttggaaacagcacagcacagtcaagaggcctgcacactccagtgcagccactgagttcttctcctggtctccgggcgcaagtgcctccccagtttatctccccccaggtttctgcctcaatgctcaagcagttccccaacagtggcctgaatccaggtctctttaatgtggggccccagttatctcctcaacaaattgccatgctgagccagcttccacagattccccagtttcagttggcttgtcagcttcttctgcagcagcagcagcagcagcagttgctacagaaccagagaaagatctctcaagcagtgcgccagcagcaagagcagcagctggcaagaatggtgagtgctctccagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagaggcaacctagcatgaagcattcaccttctcatcctgttgggcctaagccacatttggacaacatggtacccaacacgctgaatgtggggctcccagaccttccgaccaaaggaccaatccctggatatggttctggctttagctctggtggaatggactatggtatggttggtggcaaggaggctggaactgagtctcgcttcaaacagtggacctccatgatggaagggctgccatctgtggccacacaagaagctaccatgcacaaaaacggcgctatagtggcccctggtaagacccgaggagggtcaccatacaaccagtttgatataatcccaggtgacacactgggtggccatacgggtcctgctggtgatagctggttacctgccaaatctccaccgactaataaaatcggaagtaaatccagcaatgccagttggcctccagaattccaaccaggagtgccatggaaaggtatccaaaatatcgaccctgaatctgacccctatgtcaccccaggaagtgtgctggggggcacagccacatcgcccattgtagatactgaccaccaactgctgcgggataacaccacagggtctaattcttccctcaacacctcgctgccttcacctggtgcctggccctacagtgcctctgacaactcctttaccaacgttcatagcacttcagcaaagttccctgattacaaatccacgtggtccccagatcccataggacacaa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//
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@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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