LOCUS       NM_001439063            5111 bp    mRNA    linear   ROD 23-SEP-2025
DEFINITION  Rattus norvegicus POU class 6 homeobox 1 (Pou6f1), mRNA.
ACCESSION   NM_001439063 XM_039078246
VERSION     NM_001439063.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5111)
  AUTHORS   Li,W.Y., Li,Z.G., Fu,X.M., Wang,X.Y., Lv,Z.X., Sun,P., Zhu,X.F. and
            Wang,Y.
  TITLE     Transgenic Schwann cells overexpressing POU6F1 promote sciatic
            nerve regeneration within acellular nerve allografts
  JOURNAL   J Neural Eng 19 (6) (2022)
   PUBMED   36317259
  REMARK    GeneRIF: Transgenic Schwann cells overexpressing POU6F1 promote
            sciatic nerve regeneration within acellular nerve allografts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5111)
  AUTHORS   Xiao,W., Geng,W., Zhou,M., Xu,J., Wang,S., Huang,Q., Sun,Y., Li,Y.,
            Yang,G. and Jin,Y.
  TITLE     POU6F1 cooperates with RORA to suppress the proliferation of lung
            adenocarcinoma by downregulation HIF1A signaling pathway
  JOURNAL   Cell Death Dis 13 (5), 427 (2022)
   PUBMED   35504868
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5111)
  AUTHORS   Toda,K., Yamamoto,D., Fumoto,M., Ikeshita,N., Herningtyas,E.H.,
            Iida,K., Takahashi,Y., Kaji,H., Chihara,K. and Okimura,Y.
  TITLE     Involvement of mPOU (Brn-5), a class VI POU protein, in the gene
            expression of Pit-1 as well as PRL
  JOURNAL   Mol Cell Endocrinol 280 (1-2), 20-29 (2008)
   PUBMED   17933456
  REMARK    GeneRIF: Brn-5 enhances prolactin gene expression directly in
            association with Pit-1 and CREB-binding protein, and indirectly via
            the activation of Pit-1 gene expression.
REFERENCE   4  (bases 1 to 5111)
  AUTHORS   Molinari,S., Relaix,F., Lemonnier,M., Kirschbaum,B., Schafer,B. and
            Buckingham,M.
  TITLE     A novel complex regulates cardiac actin gene expression through
            interaction of Emb, a class VI POU domain protein, MEF2D, and the
            histone transacetylase p300
  JOURNAL   Mol Cell Biol 24 (7), 2944-2957 (2004)
   PUBMED   15024082
REFERENCE   5  (bases 1 to 5111)
  AUTHORS   Cui,H. and Bulleit,R.F.
  TITLE     Expression of the POU transcription factor Brn-5 is an early event
            in the terminal differentiation of CNS neurons
  JOURNAL   J Neurosci Res 52 (6), 625-632 (1998)
   PUBMED   9669311
REFERENCE   6  (bases 1 to 5111)
  AUTHORS   Wey,E. and Schafer,B.W.
  TITLE     Identification of novel DNA binding sites recognized by the
            transcription factor mPOU (POU6F1)
  JOURNAL   Biochem Biophys Res Commun 220 (2), 274-279 (1996)
   PUBMED   8645295
REFERENCE   7  (bases 1 to 5111)
  AUTHORS   Wey,E., Lyons,G.E. and Schafer,B.W.
  TITLE     A human POU domain gene, mPOU, is expressed in developing brain and
            specific adult tissues
  JOURNAL   Eur J Biochem 220 (3), 753-762 (1994)
   PUBMED   7908264
REFERENCE   8  (bases 1 to 5111)
  AUTHORS   Andersen,B., Schonemann,M.D., Pearse,R.V. 2nd, Jenne,K.,
            Sugarman,J. and Rosenfeld,M.G.
  TITLE     Brn-5 is a divergent POU domain factor highly expressed in layer IV
            of the neocortex
  JOURNAL   J Biol Chem 268 (31), 23390-23398 (1993)
   PUBMED   7901208
REFERENCE   9  (bases 1 to 5111)
  AUTHORS   Okamoto,K., Wakamiya,M., Noji,S., Koyama,E., Taniguchi,S.,
            Takemura,R., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Muramatsu,M. et al.
  TITLE     A novel class of murine POU gene predominantly expressed in central
            nervous system
  JOURNAL   J Biol Chem 268 (10), 7449-7457 (1993)
   PUBMED   8463278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 25, 2025 this sequence version replaced XM_039078246.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               JAXUCZ010000007.1  133579518-133579800 c
            284-376             JAXUCZ010000007.1  133573842-133573934 c
            377-572             JAXUCZ010000007.1  133571375-133571570 c
            573-694             JAXUCZ010000007.1  133568231-133568352 c
            695-920             JAXUCZ010000007.1  133566790-133567015 c
            921-1174            JAXUCZ010000007.1  133566013-133566266 c
            1175-1303           JAXUCZ010000007.1  133564786-133564914 c
            1304-1507           JAXUCZ010000007.1  133564014-133564217 c
            1508-1649           JAXUCZ010000007.1  133561693-133561834 c
            1650-1818           JAXUCZ010000007.1  133560490-133560658 c
            1819-5111           JAXUCZ010000007.1  133556506-133559798 c
FEATURES             Location/Qualifiers
     source          1..5111
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..5111
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /note="POU class 6 homeobox 1"
                     /db_xref="GeneID:116545"
                     /db_xref="RGD:620615"
     exon            1..283
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            284..376
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..2164
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /note="brain-5; brn-5 protein; brain-specific homeobox/POU
                     domain protein 5"
                     /codon_start=1
                     /product="POU domain, class 6, transcription factor 1"
                     /protein_id="NP_001425992.1"
                     /db_xref="GeneID:116545"
                     /db_xref="RGD:620615"
                     /translation="

MDAGAGSDSSLTVNEQVIVMSGHETIRVLEVGVDAQLPAEEESKGLESVAADGSQSGGPAEARGPAGEAGSCDPDHSAEATVKSLPGIPPSPAPAIATLSQAPSQPQASQTLTPLAVQAAPQVLTQESLATVLTGVMVPAGAVTQPLLIPIGITGQVAGQQGLAVWTIPTATVAALPGLTAASPTGGAFKPPLAGLQAAAVLNTALPTPVQAAPPVQASSPAQPRPPAQPQTLFQTQQLLQTTPAILPQPTVATVAAPTPKPVDAAPQITVQPAGFAFSPGIISAASLGGQTQILGSLTTAPVITNTIPSMPGISSPILTNAQGQVIGALPWVVNSASVATPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPSTPESPAKSEVQPIQPTQAVPPPAVILTSPAPALKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP"

     misc_feature    <449..1606
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    1673..1897
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /note="Found in Pit-Oct-Unc transcription factors; Region:
                     POU; smart00352"
                     /db_xref="CDD:197673"
     misc_feature    1961..2131
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            377..572
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            573..694
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            695..920
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1174
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1303
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1507
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1649
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1818
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..5111
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gggggcgaggaggggactgcacctggccgcccccgcccccggcgtcccggcccgcgcgtggcccgcaacccacggccgctccgctctgccaaccccggcggggggctcagggggcggcgggtcccgagtggctccgggccgagcgagccgggccgagccgctccggcttctttgtctgcgggcggccgcccgggccgcggccccctggcatgggccgggggatgagtgtctagtccgtggccgctgggcagccggggagcgggaggctgggcttcgggctccggatgcactaggtgtgggctggagccccccccccccttcggtgaccatggatgctggagctggatctgactcatctctgactgtcaatgagcaggtcatcgtgatgtcaggccacgagaccatccgcgtgttggaagttggagtggatgcccagctcccagctgaggaggagagcaaaggactggagagtgtggcagctgatggctcccagagtgggggccctgctgaagccaggggccctgctggggaagctgggtcatgtgacccagaccattctgcagaagcaacagtgaagtcactgcccggaatccctccgagtcctgccccagccatcgctaccctcagccaagccccaagccagcctcaggcatcacagaccctgacaccactggccgttcaagctgccccccaggtcttgactcaggaaagcttagccacagttctgacaggagttatggtgccagcaggggctgttactcaacctcttcttatccccatcggtattacaggtcaagtggctgggcagcaggggctggccgtgtggaccatccctacagcaactgtggctgccctcccaggactgactgcggcctctcccacggggggagctttcaagccacctttagctggtctccaagcagctgccgtgctgaacaccgccctcccgacacctgtacaagctgccccaccagtccaggcctcctcgcccgcccagccccggccaccagctcagccccagacgctgttccagacccagcagctgctacagaccacgccggccatactcccacagcctactgttgccaccgttgctgcccccacccccaagccagtggatgctgccccacagatcaccgtccagcctgcaggcttcgcttttagcccagggatcatcagtgccgcgtcccttgggggacagacgcaaatcctgggctccctcactacagctccagttattaccaacaccattcccagcatgcccgggatcagcagtccgatcctcaccaatgctcagggacaggttattggagcacttccatgggtagtgaactcagccagtgtggccacaccagcaccagcacagagcctgcaggtccaagctgtgactccccagctcttgttgaatgcccagggccaggtgatcgcaacactagccagcagccccctgcctcaacctgtggctgtccggaagccaagcacaccggagtcccctgcaaagagtgaggtgcaacccatccagccgacacaagccgtgcccccacctgctgtaatcctcaccagcccagctccagcactcaagccatcagcctcagctcccatcccaatcacctgctcagagacacctacagtcagtcagttggtatcaaaaccgcacactccgagtctggatgaggacgggatcaacttagaagagatccgggagtttgccaagaattttaagatccggaggctctccctgggtctgacacagacccaggtgggccaggctctgaccgcaacagaggggccagcctacagccaatcagccatctgcaggttcgagaagttagacatcacacccaagagtgcccagaagctgaagccggttttggaaaagtggttgaacgaggcagagctccggaaccaggaaggccagcagaatctgatggagtttgtgggcggcgagccctccaagaaacgcaagcggcgtacttccttcacaccacaggccatagaggctctcaatgcctactttgagaaaaaccccctgcccaccggccaggagatcaccgagatcgctaaggagctcaactatgaccgtgaggtggtgagggtctggttctgtaatcgacgccagacactcaagaacaccagcaagctgaatgtctttcagatcccctagggctcggggtcagcgtgttccttgtgcgaatccctcagcagtcagctgaagtcactgagtggcagtactgtgggcagctgtgcttgccctcggtcatgagactccacctgtgcatgtgtgtcaatgcctgcctcttctgcccacatatgtcacaccctggggaggcccgaggggctgcatgagagccctaggctctgggctgggcatgtggaaggagggggttggtggggtccttagaaaagcactttgccgaggtggtttctgaagggtgaattctggttgagaaccaggaaggctctgtctttggggcagggccgtagcaactcttggggacaactgtgtagtggctcttggttttggtgacgtcctttcccccttcccctcactcctctgtggctgtgccggtgtgacaacacaccgggtggaactgcagcctcacactgcctcccttcctctgaatatgggcacactgaaccccctgaaaggactgaggaatccagagagtcgtggtgtgctgctcagacccactgtctgccttgatctcgagggatgaaggttcccaaactgaagccagggggttggaaaccctaggttaggagctgtgaggcctctccctgggtcccagtggtggtgatattatgctaagtcgagtcaaaccaagttgaaaggaagctagagtgaactctccagccctggagagtgttaggtctgcggcaggtctggaatttataaagtaaataaggccacccacccagattttcatctaattttcgtttgcagctgtcttccgacacaggggtatgcgaaagggcttgggaaactaacgcatacagcggcagaggatatagattctgactttctccctctcttgtgccctgacccatctcagtccactactgagacgtcttcaaaggagcaaactgatcgataaaccagacggtgaggagctggcgtagggaggaagacagtatccagatggatgatgattcgggaggtctcttgttgaggctgacttataactctagttttgtttgtaacttttacgtcttggaggtctccaaagaccacactttgtccagttgtagaccaagtctgtgtgtgagcaatgccccacccctccacctccccactcccgtgctcctctgagccaacagtgcccaggtcaggcttccctcactcagtaggtgatggcaatcgggggactggcaacacatggaaaccagcttccagccacagagaggctagccagatgttttacttcagtgcattgcccgggaatgtagctcactgggagggaacttagcaagtacaaggctctagagtcagtctgtagcaccgaggggaaagggattcccccagtatttgatttcaagaagtcgggaaagagctaagacgttcgctcagataacccccccaacaagtggcaggtgtcgactatcttgcactactggggttggtttgttgggtttttgttttgttttgtctgagataggatcacacttagctcaggctaacctcgaacttgtagttgaagatgacctgatcctcctgtctccacctcccaagtgctgggattgcagtcacgttctgctgtgcctggctcttctcactccatagccttacggagcccactctctggctgatgtcgacatcacatgatctaccctgaggaaacgactctcaaacaaggacaccatgcagtctccgctggtcccggtgcagagacactaggacccggcttcctctagtgttctctttcctgatgactgttagtccctcttgggtcctgcagtgccagtgtggaggacctcttggtaactctgacatggagaggagggcagttgtgtgttgattcaccacaccaacacacacacacacacacacactgctgcattccgactaaggaaacctgctgaagtctgtcaggaataggagacaagtacgcagcttccctgaccctggctcccaagaaggaatatgttcccagagcaatgctaggtcatgtgattaccaaccagcctccatgagatgggaagttagcttagagtcccgaaacttagcaaggtgatgccctcgagaaaatcaaatgcagcttttcttgctcaaaaccggcactcaggaggttatacacagtgcagccatgctgtggacgccggagagggtaccatctgttctgtgcgtgggggtggggaatctcgaaccactggtctaaattaagcctggccatgcggcgttctcaaaccatccttcatctaaatctgtcttcccaaggctgggctagaatgaaccattttctcctgtgttggaaagacgcacgggtctttcaggagaacagtagcagagcccacatgtttactggctggactactcaagtaaggggtgcaagtgtataaagcgttcccaaagtggggtccgctttggcctttgacctctgcccctgtcccccaacctaagccactgatctacatacagtctttgttattttgggtagcattagactctaaaaacgttagcagttttattttgaaagcaccttctcagacttaagctcgagctccatggctctctcgccttggaaaggggagagtgggaggaagtggttcaactgtatggttggtttgttttaagcaatgggaaaccaaactctctgtggccccgctgagtcagctgcgcccttcgaccctgcactatggcacttcactcaagcaaagttcacagaagaaactggtcacatgaaccgtgaacgcacgtgagtttggcatgagaacacctgatgtgtctgtgttcttggaaatccagtcaacttcctatacccaggactcctttcccgcctggtgggccgcctcccacagtctcccggcacggggggcaccgcccacgaaagctggagaggaggatgggggagtactgccgtagcgtgtgaataaacagtattttttctttcgta

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