LOCUS       NM_001399668            5138 bp    mRNA    linear   ROD 30-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 39, member 9 (Slc39a9),
            transcript variant 4, mRNA.
ACCESSION   NM_001399668
VERSION     NM_001399668.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5138)
  AUTHORS   Kabbesh,H., Bulldan,A., Konrad,L. and Scheiner-Bobis,G.
  TITLE     The Role of ZIP9 and Androgen Receptor in the Establishment of
            Tight Junctions between Adult Rat Sertoli Cells
  JOURNAL   Biology (Basel) 11 (5), 668 (2022)
   PUBMED   35625396
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5138)
  AUTHORS   Bulldan,A., Dietze,R., Shihan,M. and Scheiner-Bobis,G.
  TITLE     Non-classical testosterone signaling mediated through ZIP9
            stimulates claudin expression and tight junction formation in
            Sertoli cells
  JOURNAL   Cell Signal 28 (8), 1075-1085 (2016)
   PUBMED   27164415
  REMARK    GeneRIF: in Sertoli cells, testosterone acts through the receptor
            ZIP9 to trigger the non-classical signaling cascade, resulting in
            increased claudin expression and tight junction formation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-776               JAXUCZ010000006.1  106022858-106023633
            777-885             JAXUCZ010000006.1  106041636-106041744
            886-1086            JAXUCZ010000006.1  106045341-106045541
            1087-1155           JAXUCZ010000006.1  106052009-106052077
            1156-1241           JAXUCZ010000006.1  106054231-106054316
            1242-1371           JAXUCZ010000006.1  106055335-106055464
            1372-5138           JAXUCZ010000006.1  106057968-106061734
FEATURES             Location/Qualifiers
     source          1..5138
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..5138
                     /gene="Slc39a9"
                     /note="solute carrier family 39, member 9"
                     /db_xref="GeneID:314275"
                     /db_xref="RGD:1311236"
     exon            1..776
                     /gene="Slc39a9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    663..665
                     /gene="Slc39a9"
                     /note="upstream in-frame stop codon"
     CDS             681..1583
                     /gene="Slc39a9"
                     /note="isoform 3 is encoded by transcript variant 4; zinc
                     transporter ZIP9; ZIP-9; zrt- and Irt-like protein 9;
                     solute carrier family 39 (zinc transporter), member 9"
                     /codon_start=1
                     /product="zinc transporter ZIP9 isoform 3"
                     /protein_id="NP_001386597.1"
                     /db_xref="GeneID:314275"
                     /db_xref="RGD:1311236"
                     /translation="

MDDFLSISLLSLAMLVGCYVAGIIPLAVNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEEVLEGKHHQASEAKQNVIASDKAAEISVVHEHEHSHDHTQLHAYIGVSLVLGFVFMLLVDQIGSSHVHSTDDPESARPSSSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPAMSMLTYLGLIKKPFQRSMPLEWPCFSLPGHFFTLPPSMSSLRWVEWGTATDLTPLEGEASAALRWQPWFWVASYHSSSQ"

     misc_feature    690..752
                     /gene="Slc39a9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KR82.1);
                     transmembrane region"
     misc_feature    705..>1343
                     /gene="Slc39a9"
                     /note="ZIP Zinc transporter; Region: Zip; cl00437"
                     /db_xref="CDD:444905"
     misc_feature    765..767
                     /gene="Slc39a9"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3KR82.1); glycosylation site"
     misc_feature    783..845
                     /gene="Slc39a9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KR82.1);
                     transmembrane region"
     misc_feature    999..1061
                     /gene="Slc39a9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KR82.1);
                     transmembrane region"
     misc_feature    1119..1181
                     /gene="Slc39a9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KR82.1);
                     transmembrane region"
     misc_feature    1209..1271
                     /gene="Slc39a9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KR82.1);
                     transmembrane region"
     misc_feature    1311..1373
                     /gene="Slc39a9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KR82.1);
                     transmembrane region"
     exon            777..885
                     /gene="Slc39a9"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1086
                     /gene="Slc39a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1155
                     /gene="Slc39a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1241
                     /gene="Slc39a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1371
                     /gene="Slc39a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..5138
                     /gene="Slc39a9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gagacaatccggaagtgggagtaatgaagaggtgccacttggcggccatggcagctgtagtattggcggctcagggtcagggcctggctgagggaagtaccatgggtagcaccgggtgtaggacagagacagcgtcgtatcgactttgctgttgaatcctccagcccattgttagagacttgcaggacatcttgcccgactctagactcgaaaggtactttgctggcactggtgggctggtcccttccctgggggcgtatcacctgcggtgccacccctgggaactggtaccgcgtgtggagaagacacttgggtttacctttttttttcctgctgctaccagggacgttgtcttggggagcgggtcgtcgtgtcaccctcattctgacgattaaggagatctctttttgcacaatttctccatctgttacctaccggaatcccagtgactggcaaccaagtacctaagactgcgcaaagttttctctggtgctagtatcagcaaaaggagcttgcttcttaagagagcggcgggcttcatgaactcaccggccggtggcaaggctgaaagaagtgaggaaattcccgttttcttggaagaccacacgtttaaacagcccaagcgccgtttgaaactggaattttaaagcctggtggaggggtgactacaggagggcagaatggatgactttctctccattagtctgctgtctttggcaatgttggtgggatgttacgtggctggaatcattcctttggctgttaatttctcagaggaacggctgaagctggtgactgtgttgggtgctggccttctctgtggaactgcactggcagtcatcgtgccggaaggggtgcatgcactttatgaggaggtcctggagggaaaacaccaccaagccagtgaagcgaagcagaatgtgattgcatcagacaaagcagcagaaatatcagttgtccatgagcatgagcacagccacgaccacacacagctgcatgcctacattggtgtgtccctggtactgggcttcgttttcatgttgctcgtggaccagattggcagctcccatgtgcattccactgacgatccagaatcagcaaggcccagcagttccaaaatcaccaccacactggggctggttgtccatgctgcagctgatggtgtagctttgggagcagcagcctctacttcacagaccagtgtccagttaattgtgttcgtggcaataatgctacataaggctccagcagcatttgggctggtttccttcctgatgcatgctggcctggagcggaatcgaatcagaaagcacttgctggtctttgcactggcagcaccagccatgtccatgctgacgtacttaggattaataaagaagccctttcagaggtcaatgccactggagtggccatgcttttctctgccgggacatttctttacgttgccaccgtccatgtcctccctgaggtgggtggaatggggcacagccacagacctgacaccactggagggagaggcctcagccgccttgaggtggcagccctggttctgggttgcctcataccactcatcctctcaataggacaccagcactaaccagtcaggttccagcctcagtccacggccattgccatcggggaagaactagcgtgtgacgctcctcacttcctcagtgtcttgtctcaccttgcccatctccacccctgttcctagagtccaagggagatgagagtcaatcgtggaaagtgggacagcatatagcaggaacatcagaattagacagactttgtgttgtcttttaaagggactttgatgtattgagttttgatgtttctcttaaccctattctcagggaagatggaatttagttttaaagaaaagtggagaacttcatacaatgaaatagtaattatgaaacttcagtgttctgtaattaagctaaagttttttcccttagtatagaggctctgccactttacccattggttttaacatggttctcaccatgtaagactggtgctttagcatctgtgccacagccttgagagaaggcgggaacacccatcccttagatgctaaagatgatggcaactaatttgaggttagaataaggaaaataagagcaggagaaaaaagctgaactgaacccaaaagaaacatccactgaaaggggtgtctagagtcatcaacagctcctttgcacgtgcctccctaaatagagcctgcccttccttccagtagagcaatggaggtgggactggcttttgaagaggggtctgttatcatatagcatttttttaaaaagtatcttttgcagaatacttgtctgtagcacactcttagtagccagattctgttcaggcacaggatttctgtcaagaacagtctgatcacagtgaaattaagggatgttaaattttccaggaatttggatagttactgatatcttgtagtaacctttttaaaaagtaacactattacaaagtatgttgtccttttcttccagtcagtggttctcaaccctctgaacactgcaatcctttaatacagttcctcatgttgtggtgccctcccaaccataaaattattttgttgctacttcataactgtaattttactactgttatgatctgtaatgtaaatgtctgatacaggctatctgatatgccacctttgtgggcatcgagacttacaggttgagaagcgctgttctaagtatttcttttagcagcctctgtccctctggctgagcccttgcccagagtggagagtgtttctgtccactccgtagctcttgagcagaaggcggtggggctgtatcagaagggagtatctgctgctggcctcagtctccttgaaatcatgtctgcatcccactcttcccgtgctcttcccctccccagcctacccccactgtgtactactactgctggtgatgtcagtccttgtgtgaggtgaattctcaccacttctttaaccatgaagacagcactgtttcttcttcatttccttcacctaagttacctttgtgcccaatacaacttttttacaccctcaaaaatgtcacctcctcatgagagttgacacagtcactagtactctgataatttaagaaattgagacagcaaaagtattcaacaaaggtaattcttccatgtttgccaaaatctgaataaatcctagtcagataaatgtataatactgtattaatttacattttctgtaccatttcagaaacactttacataaacagggagccaaggctagttttttcagagcagtgagtgcagtcattgtgttttctgtgacatctgtgccagcatgcctgtagattttctctcctgaattgtcactaggtcagccggcagctgtggggttaaacttgtgcgccctctgctggctgtagtggagaaagcagcagaaatgagacgcagctctgtgtggaggctggtacccattgcatcccgagctaaagtgttaatgtgtgcagtgtgggagttgggggtgactctcgtaataggtgactaggaaaggtttgggctcatctagtccttccaaagtacagatgtcttgatctctctagaggctcactttgtcggggtggtccgggtagaagcagcttctgtcaccttgctccgtgcagtggtcagacacttgttgtgctggccagagcctcttgttcagcagtgccttgccaactcactcgaagttgggctagaatatcatgttgggtagggccttggactctggcaaggagtgaaccatcaaacgtccaaatctgccttcctctctgggcctcagtagtagtgagctttccatgcctggagctgctgcctggggactgagtcccttccctgctctgcaggctcagatagccatatgactcttaatagggctcagatgcaggagaggcagcaggaaccagcagagcctccatctagtgggggagaggtcgctcatgcagcaggcagtgccccgaaagcagccaccttgatcgcttcacaacacgtttcagttctgttttcttcctcctaactccctctggaggtgtggatgccttaatgtgcaaacacacttgaacacattggtgatacttgagctgctgccacgattacaagtggaattatgggctaccaaagaagcaattgatgaaaaagcatgggctatccttcctcatgaccaaagcaatcttatttgggattagagttcctttcccccagaatctagatgcatcccccctccccagttcccagtgttgtcagtctccgagtcagcagggcagtgatgtccgtttgattccgctttcctgtgtgtgctattgccagcttggttcttacaggcagactttctggcctgaaaatgccaacggttggaatggcactacccactgagccaagtcaacctgttctggggatctgggtcattagaagaaagggagggtctgttcttttagaaaggggaaaatagatttgtttaaatcagtctgtcaccactggctggttttatttttcaagaattagagctaggaggaacatagcagtgacagagcgtgttaagccttgaccctcatgctagtgaggttctgaacatgggactgtatgtcaatagcacaagcctctaaaacacccttaccttttgggccagagccccagactactggggctcacacagtcatcgggcaagagtcctggaggcagacttgtgttcagtgcagagtgggacgcacccctgaagagcactggctgagatactacacaactcagcctttttaactcgagacatcgaagttcagctcgggagagctgagggtgggggctggtgggaaaggactggcagacagtaggacttccttacatgtgctcagccctcacagagccaagcacagagactggctttgctctgtctgccgtgtcttcccgaaaactgggactctaatggtaacaccatgattcccctggtttggtggcctaaacggtgattttaaatgtctccttttctggattctttgtatacataaactcattccatggatggctgccttataattttgtgtctttccactttaattgtgaatggtttaaaaattgctgtttccgatttgttttatgatattaaatttttattagtgcatacctta

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