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Previous release (v1)
2025-04-20 13:48:27, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_001393810 3574 bp mRNA linear ROD 01-APR-2024
DEFINITION Rattus norvegicus Mov10 RNA helicase (Mov10), transcript variant 2,
mRNA.
ACCESSION NM_001393810 XM_006233085
VERSION NM_001393810.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3574)
AUTHORS Kute,P.M., Ramakrishna,S., Neelagandan,N., Chattarji,S. and
Muddashetty,R.S.
TITLE NMDAR mediated translation at the synapse is regulated by MOV10 and
FMRP
JOURNAL Mol Brain 12 (1), 65 (2019)
PUBMED 31291981
REMARK GeneRIF: FMRP and MOV10 have an important regulatory role in NMDAR
mediated translation at the synapse.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3574)
AUTHORS Warkocki,Z., Krawczyk,P.S., Adamska,D., Bijata,K.,
Garcia-Perez,J.L. and Dziembowski,A.
TITLE Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s
JOURNAL Cell 174 (6), 1537-1548 (2018)
PUBMED 30122351
REFERENCE 3 (bases 1 to 3574)
AUTHORS Skariah,G., Seimetz,J., Norsworthy,M., Lannom,M.C., Kenny,P.J.,
Elrakhawy,M., Forsthoefel,C., Drnevich,J., Kalsotra,A. and Ceman,S.
TITLE Mov10 suppresses retroelements and regulates neuronal development
and function in the developing brain
JOURNAL BMC Biol 15 (1), 54 (2017)
PUBMED 28662698
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3574)
AUTHORS Balinsky,C.A., Schmeisser,H., Wells,A.I., Ganesan,S., Jin,T.,
Singh,K. and Zoon,K.C.
TITLE IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral
Activity against Dengue Virus, Interacts with MOV10
JOURNAL J Virol 91 (5), e01606-16 (2017)
PUBMED 27974568
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3574)
AUTHORS Gregersen,L.H., Schueler,M., Munschauer,M., Mastrobuoni,G.,
Chen,W., Kempa,S., Dieterich,C. and Landthaler,M.
TITLE MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target
degradation by translocation along 3' UTRs
JOURNAL Mol Cell 54 (4), 573-585 (2014)
PUBMED 24726324
REFERENCE 6 (bases 1 to 3574)
AUTHORS Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
TITLE Comparison of tear protein levels in breast cancer patients and
healthy controls using a de novo proteomic approach
JOURNAL Oncol Rep 28 (2), 429-438 (2012)
PUBMED 22664934
REFERENCE 7 (bases 1 to 3574)
AUTHORS Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
Landthaler,M.
TITLE The mRNA-bound proteome and its global occupancy profile on
protein-coding transcripts
JOURNAL Mol Cell 46 (5), 674-690 (2012)
PUBMED 22681889
REFERENCE 8 (bases 1 to 3574)
AUTHORS Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
Krijgsveld,J. and Hentze,M.W.
TITLE Insights into RNA biology from an atlas of mammalian mRNA-binding
proteins
JOURNAL Cell 149 (6), 1393-1406 (2012)
PUBMED 22658674
REFERENCE 9 (bases 1 to 3574)
AUTHORS Chendrimada,T.P., Finn,K.J., Ji,X., Baillat,D., Gregory,R.I.,
Liebhaber,S.A., Pasquinelli,A.E. and Shiekhattar,R.
TITLE MicroRNA silencing through RISC recruitment of eIF6
JOURNAL Nature 447 (7146), 823-828 (2007)
PUBMED 17507929
REFERENCE 10 (bases 1 to 3574)
AUTHORS Meister,G., Landthaler,M., Peters,L., Chen,P.Y., Urlaub,H.,
Luhrmann,R. and Tuschl,T.
TITLE Identification of novel argonaute-associated proteins
JOURNAL Curr Biol 15 (23), 2149-2155 (2005)
PUBMED 16289642
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000002.1.
On Mar 16, 2021 this sequence version replaced XM_006233085.3.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR26360186.1123257.1,
SRR26643290.9493.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760386 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-190 JAXUCZ010000002.1 195003253-195003442 c
191-372 JAXUCZ010000002.1 195002847-195003028 c
373-576 JAXUCZ010000002.1 194991657-194991860 c
577-812 JAXUCZ010000002.1 194991167-194991402 c
813-1074 JAXUCZ010000002.1 194990791-194991052 c
1075-1209 JAXUCZ010000002.1 194989639-194989773 c
1210-1378 JAXUCZ010000002.1 194989237-194989405 c
1379-1533 JAXUCZ010000002.1 194988276-194988430 c
1534-1710 JAXUCZ010000002.1 194987848-194988024 c
1711-1858 JAXUCZ010000002.1 194987579-194987726 c
1859-2017 JAXUCZ010000002.1 194987134-194987292 c
2018-2121 JAXUCZ010000002.1 194986845-194986948 c
2122-2219 JAXUCZ010000002.1 194986583-194986680 c
2220-2436 JAXUCZ010000002.1 194986278-194986494 c
2437-2554 JAXUCZ010000002.1 194984509-194984626 c
2555-2746 JAXUCZ010000002.1 194984165-194984356 c
2747-2821 JAXUCZ010000002.1 194983960-194984034 c
2822-2947 JAXUCZ010000002.1 194983037-194983162 c
2948-3036 JAXUCZ010000002.1 194982871-194982959 c
3037-3158 JAXUCZ010000002.1 194982509-194982630 c
3159-3574 JAXUCZ010000002.1 194982014-194982429 c
FEATURES Location/Qualifiers
source 1..3574
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="2"
/map="2q34"
gene 1..3574
/gene="Mov10"
/gene_synonym="Capza1"
/note="Mov10 RNA helicase"
/db_xref="GeneID:310756"
/db_xref="RGD:1598327"
exon 1..190
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
misc_feature 128..130
/gene="Mov10"
/gene_synonym="Capza1"
/note="upstream in-frame stop codon"
exon 191..372
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
CDS 236..3250
/gene="Mov10"
/gene_synonym="Capza1"
/EC_number="3.6.4.13"
/note="capping protein (actin filament) muscle Z-line,
alpha 1; Mov10, Moloney leukemia virus 10; putative
helicase MOV-10; Mov10 RISC complex RNA helicase"
/codon_start=1
/product="helicase MOV-10"
/protein_id="NP_001380739.1"
/db_xref="GeneID:310756"
/db_xref="RGD:1598327"
/translation="
MPSKFSCRKLRETGQGFESFLAERGLDLETDRERLRAIYNRDFKPSYGTPAPGFSSMLYGMKIANLAFVTKTRVRFFKLDRWADVQLPEKRRIKPGSSISKQHRSLLARIFHDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTKPVTLTHLFPLCWTPQFVFYHGEQDLPCPLGPGESYELHVYCKTSIVGYFPATVLWELLGPGESGAEGAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNPVSTNRIEEGERPDRAKGYELELSLALGTYYPPIRLRQLLPTLLQGPSIFTSPKEVAEIKAQLETTLKSRNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSEIQQEDPVTYKGFVHKVELDRVKLSFSPSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWVLWPTLFPVASRGVSLLPSDVKFKLYDRSLESNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKTCCNWDPKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERLLTYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLRQLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPSTSGPRRHQRLPQEREGEEGLPLQVEPEWRNEL"
misc_feature 1730..2437
/gene="Mov10"
/gene_synonym="Capza1"
/note="DEXXQ/H-box helicase domain of Helz-like helicase;
Region: DEXXQc_Helz-like; cd18038"
/db_xref="CDD:350796"
misc_feature order(1745..1747,1817..1834,2285..2287,2432..2437)
/gene="Mov10"
/gene_synonym="Capza1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:350796"
misc_feature 2438..3055
/gene="Mov10"
/gene_synonym="Capza1"
/note="C-terminal helicase domain of Upf1-like family
helicases; Region: SF1_C_Upf1; cd18808"
/db_xref="CDD:350195"
misc_feature order(2732..2740,2828..2830,2834..2839,2882..2884)
/gene="Mov10"
/gene_synonym="Capza1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:350195"
misc_feature order(2846..2848,2852..2854,2969..2971)
/gene="Mov10"
/gene_synonym="Capza1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:350195"
exon 373..576
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 577..812
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 813..1074
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 1075..1209
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 1210..1378
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 1379..1533
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 1534..1710
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 1711..1858
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 1859..2017
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 2018..2121
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 2122..2219
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 2220..2436
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 2437..2554
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 2555..2746
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 2747..2821
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 2822..2947
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 2948..3036
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 3037..3158
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
exon 3159..3574
/gene="Mov10"
/gene_synonym="Capza1"
/inference="alignment:Splign:2.1.0"
ORIGIN
agtccagctgcagccgacccatgtcctgggccctgccctttgctctgcagcttttctaagtcccgaggctctggagagtgggcgtgggagtagccctagctgaggctccaaggtcctcccggctgtttagggggccccaggcgatagccacgttcggatcctggctcgcagccaggggagggagcttgggtttcatttcccggaccctcctgcctgggccgcagccgccgccgcgatgcccagcaagttcagctgccgaaagctccgggagaccggccaggggttcgagagtttcctggccgaacggggactggacctggagacagatcgcgagcggctgcgggcgatttacaaccgcgacttcaagcccagctatgggacccccgcccctggcttctcctccatgctgtacggaatgaagatcgctaatctggccttcgtcaccaagactcgggtcaggttcttcaaactggaccgctgggctgatgtgcaactaccagaaaagcggcggataaagccagggtcgagcatcagcaaacagcacagatccctgctggccagaatcttccatgacagggctgagtatcttcatggaaagcatggggtggatgtggaggtccaggggccccatgaagcccgggatgggcagctccttatccgcctggatttgaaccgcaaggaggtcctaaccctacggctgcggaacggagggaccaagcctgtcaccctcactcatctgttcccactgtgctggacaccccagtttgtcttctaccatggggaacaggacctgccctgcccactgggcccaggtgaaagctatgaacttcatgtctactgtaagacaagcattgtgggttacttcccagccactgtcctctgggaacttctgggaccaggggagtcgggagcagaaggagcagaaaccttctacattgcccgcttcctggctgctgtcgcccacagccccctggctgcacagttgaaacccacaactcccttcaaacgcccccctcggctcactagaaaccctgtctcaaccaaccggatagaggaaggagagaggccggaccgagccaagggttatgaactagagctaagtttggccctggggacctattacccacccatccgcctccgacaactgctccctacccttcttcagggaccaagtatcttcacgtccccaaaggaagttgctgagatcaaggcccagttggagacaaccctgaaatccaggaactatgaggtgaagctccgactgctgctgcacctggaggagctgcaaatggagcatgacatccggcactatgacctggagtcggtacccatgacctgggaccctgtggaccagaatcccaggctgctcacactggaggttcctggtgtgacagagagccgtccctcagtgctacggggtgaccacctttttgccctgttgtcctctgagatccaacaggaggaccctgtcacctacaagggtttcgtgcacaaggtggagctggaccgtgtcaagctgagcttttctccaagcctcctgagccgattcgtggatgggctgaccttcaaggtgaactttaccttcaaccgccagccccttcgggtccagcaccgtgccctagagttgacggggcgctgggtgctatggcccacgctttttcctgtggcctcccgtggggtctcgctgctgccctcagatgtgaagttcaagctgtatgatcggagtctggagtcaaacccagagcagctgcaggccatgaagcacattgtgaggggcaccacccggcccgccccctacatcatctttgggcctccaggtaccggcaagactgtcacattagtggaggccatcaagcaggtagtgaagcacttgcccaaagcccacatcctggcctgcactccatccaactcaggggctgacctcctgtgtcagcggctccgggtccacctgcccagctccatctatcgcctcctggcccccagcagggacatccgaatggtaccggaggacattaagacctgctgtaactgggatcctaagaagggagagtatgtgtatcctgccaagaagcatctgcagcagtatcgggtcttgattaccaccctcatcactgccagcaggttggtgtcagcccagtttcccatcgatcacttcacacacatcttcatcgatgaggctggccactgcatggagcctgagagtctggtggccatagcaggactgatggatgtcaaggaaacaggcaatcctggagggcagctggtgctggcaggagaccctcggcagctggggcctgtgcttcggtcaccgctagcccagaagcatggactcggctactctctgctagagcgcctgctcacctacaactccttgtataagaagggtcccaatggctatgacccccagttcatcaccaaactgctccgtaactacaggtctcatcccaccatcctggacatccctaaccagctgtactatgatggagagctacaggcctgcgcagatgtggtggatcgagaacggttctgccgttgggaggggctacctcaacagggcttccccatcatcttccatggtgtaatgggcaaagatgagagagagggcaatagcccatccttcttcaaccctgaagaggctgctacagtgacgtcatacctcagacagctcctcgccccttcctccaagaagggtaaagcccgcctgagcccccgaagtgtgggcgtcatctccccgtaccggaagcaggtagaaaaaatccgttactgcatcacaaaacttgaccgagaacttcgaggactggatgacatcaaagacttgaaggtgggctctgtggaagaattccaagggcaagaacgcagtgtcatcctcatctctaccgtccgaagcagccagagttttgtacagctggatctagattttaacctcggtttcctcaagaaccccaagaggttcaatgttgctgtgacccgggccaaggctctgctcattgtagtgggcaaccccctcctcctaggccacgacccggactggaaaacattcctggagttctgtaaagaaaatgggggttacaccggatgcccctttcctgccaaactggacctgcagcagggacaggacttgctccaaggtctgagcaaactcagcccctctacctcagggccccgccgtcaccagcgtctcccccaggagcgggagggtgaagagggcctgcccttacaagtagagccagagtggagaaatgagctctgaggacacagccgccggcccacccgcttgccttctcacaccagccaagccttattgctgcctacccctgacccagaacccagctcacctgtccccgcaagagacgggaaggccgggaagtttacagcccagactctgctagggaaaataaccaaccccttcctctgctagggaaaataacccaagctgctaaaacttggaggaagggggttggaagaaagcttttttaaccctgtcctttgcggtactggggattgaacccagagcctcaaatacgctaggcaagcactctactgctttaagaaaaacatgctgttctatgcaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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