LOCUS       NM_001106265            1890 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus p53 apoptosis effector related to PMP22 (Perp),
            mRNA.
ACCESSION   NM_001106265 XM_001072627 XM_214953
VERSION     NM_001106265.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1890)
  AUTHORS   Fouillade C, Baron-Menguy C, Domenga-Denier V, Thibault C, Takamiya
            K, Huganir R and Joutel A.
  TITLE     Transcriptome analysis for Notch3 target genes identifies Grip2 as
            a novel regulator of myogenic response in the cerebrovasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (1), 76-86 (2013)
   PUBMED   23117660
REFERENCE   2  (bases 1 to 1890)
  AUTHORS   Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T,
            Attardi LD and Klein OD.
  TITLE     PERP regulates enamel formation via effects on cell-cell adhesion
            and gene expression
  JOURNAL   J Cell Sci 124 (Pt 5), 745-754 (2011)
   PUBMED   21285247
REFERENCE   3  (bases 1 to 1890)
  AUTHORS   Ketteler R, Sun Z, Kovacs KF, He WW and Seed B.
  TITLE     A pathway sensor for genome-wide screens of intracellular
            proteolytic cleavage
  JOURNAL   Genome Biol 9 (4), R64 (2008)
   PUBMED   18387192
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1890)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1890)
  AUTHORS   Attardi LD, Reczek EE, Cosmas C, Demicco EG, McCurrach ME, Lowe SW
            and Jacks T.
  TITLE     PERP, an apoptosis-associated target of p53, is a novel member of
            the PMP-22/gas3 family
  JOURNAL   Genes Dev 14 (6), 704-718 (2000)
   PUBMED   10733530
  REMARK    Erratum:[Genes Dev 2000 Jul 15;14(14):1835]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166608.1.
            
            On Apr 29, 2008 this sequence version replaced NM_001106265.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166608.1, DN934252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1890
                     /gene="Perp"
                     /note="p53 apoptosis effector related to PMP22"
                     /db_xref="GeneID:292949"
                     /db_xref="RGD:1310294"
     exon            1..318
                     /gene="Perp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    21..23
                     /gene="Perp"
                     /note="upstream in-frame stop codon"
     CDS             105..686
                     /gene="Perp"
                     /note="PERP, TP53 apoptosis effector"
                     /codon_start=1
                     /product="p53 apoptosis effector related to PMP-22"
                     /protein_id="NP_001099735.1"
                     /db_xref="GeneID:292949"
                     /db_xref="RGD:1310294"
                     /translation="

MLRCGLACERCRWILPLLLLSAIAFDIIALSGRGWLQSSNHIQTSSLWWRCFDEGGGSGSYDDGCQSLMEYAWGRAAAATLFCGFIILVICFILSFFALCGPQMLVFLRVIGGLLALAAVFQIISLVIYPVKYTQTFRLHDNPAVNYIYNWAYGFGWAATIILIGCSFFFCCLPNYEDDLLGNAKPRYFYTSA"

     misc_feature    207..596
                     /gene="Perp"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     exon            319..459
                     /gene="Perp"
                     /inference="alignment:Splign:2.1.0"
     exon            460..1872
                     /gene="Perp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcgggagccgcctcttcctttagtggcggtgtcggcgctcgcaggaccactctcggccgctgctccagccccgcgttcctccgctccgcgccgccaccgacgacatgctgcgctgcggcctggcctgcgagcgctgcaggtggatcctgcccctgctgctgctcagtgccatcgccttcgacatcatcgcgctgtccggccgcggctggctgcagtctagcaaccacatccagacgtcctcgctttggtggaggtgtttcgacgagggcggtggcagcggctcctacgacgatggctgccagagcctcatggaatacgcctggggccgagcagctgctgccactctcttctgtggattcatcatcctggtcatctgcttcatcctctcgttcttcgccctgtgtggaccccagatgcttgttttcctgagagtgattggaggccttctcgcactggctgctgtattccagatcatctccctggttatctatcccgtgaagtacacacaaaccttcaggcttcatgataatcccgctgttaattacatctacaactgggcctatggcttcggatgggcagccacgatcatcttgattggttgctctttcttcttctgctgcctccccaactacgaggatgaccttctgggcaatgcaaagcccaggtacttctatacatctgcctaatgtggagggagatcctgagaaaagcctgctgcaagatgcatgtgaggaggaaagtgttctccaaggagcaaagaacctatgtttgggcagtgttcatatgagtggaaatgctagaataaatgctaaagaaaattcttcataaatagtgttaagtttcatgtccctgtgtatgtcttgcggagttaaaagagacttgtttctgtttgctcagtatatgctgacttctccttgcaccaattctgtatcatttaaacttcatttgttaaagagcatgcccgggaaacttgctaagtaagaaatgctatggcttctcatttaataatctgatgaagcttttgtttttccagagagaatgggttgtttctacagggaatgggttggctacagagcaggaaagctactggcaaattccagtgaccaaatattctgaaattaatgtttttcttaaacacacacacacacacacacacacacacacacacacacacacacacacgccctttttgagttttcagttacataaagaagcagagtggtgtcctacgtgagcatcgatgttttgaacagttattgtttcgctcagctttgtgttgattttctccgatatgcggggaaagtgaaacatggccgttgtcactactgaatgctaaggtgaattttactcttttgacgtagattagaggggtgggtgtgggaagaagccatattaacaaatctgtacagtgttgcgtgtatgtttagaaccagcgtagactagatgggagggtggactaggccttattcctcccgaccgatggatgtgatgaggtcgggtaggaaggcctatgagggttaccattcagacatcccgggagaagacatatcaatgcccctctcagccttaactgagctctactgacagacagctagaatagatttgaactgtaacagaaacctaaatgtaattacaaacctggtcttcctcggtaaacagacttaacatatctgtataatacatacaagggggaaatttgggaatgagtttctctgaatacatattggaagggctgttattattttttcttaccatttatactcactgaatggaaactagcttattttaaatatcagaacactattttgtaagttgcagccaagacaattgcagttttcatgaccagcttccccaataaaccagatgttcaaaaaaaaaaaaaaaaaaaaa

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