LOCUS       NM_001106058            1331 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus claudin 10 (Cldn10), mRNA.
ACCESSION   NM_001106058 XM_001074876 XM_214250
VERSION     NM_001106058.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1331)
  AUTHORS   Hadj-Rabia,S., Brideau,G., Al-Sarraj,Y., Maroun,R.C.,
            Figueres,M.L., Leclerc-Mercier,S., Olinger,E., Baron,S.,
            Chaussain,C., Nochy,D., Taha,R.Z., Knebelmann,B., Joshi,V.,
            Curmi,P.A., Kambouris,M., Vargas-Poussou,R., Bodemer,C.,
            Devuyst,O., Houillier,P. and El-Shanti,H.
  TITLE     Multiplex epithelium dysfunction due to CLDN10 mutation: the HELIX
            syndrome
  JOURNAL   Genet Med 20 (2), 190-201 (2018)
   PUBMED   28771254
REFERENCE   2  (bases 1 to 1331)
  AUTHORS   Klar,J., Piontek,J., Milatz,S., Tariq,M., Jameel,M.,
            Breiderhoff,T., Schuster,J., Fatima,A., Asif,M., Sher,M.,
            Mabert,K., Fromm,A., Baig,S.M., Gunzel,D. and Dahl,N.
  TITLE     Altered paracellular cation permeability due to a rare CLDN10B
            variant causes anhidrosis and kidney damage
  JOURNAL   PLoS Genet 13 (7), e1006897 (2017)
   PUBMED   28686597
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1331)
  AUTHORS   Zemke,A.C., Snyder,J.C., Brockway,B.L., Drake,J.A., Reynolds,S.D.,
            Kaminski,N. and Stripp,B.R.
  TITLE     Molecular staging of epithelial maturation using secretory
            cell-specific genes as markers
  JOURNAL   Am J Respir Cell Mol Biol 40 (3), 340-348 (2009)
   PUBMED   18757308
REFERENCE   4  (bases 1 to 1331)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   5  (bases 1 to 1331)
  AUTHORS   Ohta,H., Adachi,H. and Inaba,M.
  TITLE     Developmental changes in the expression of tight junction protein
            claudins in murine metanephroi and embryonic kidneys
  JOURNAL   J Vet Med Sci 68 (2), 149-155 (2006)
   PUBMED   16520537
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473951.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214250.4, XM_001074876.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1331
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24"
     gene            1..1331
                     /gene="Cldn10"
                     /note="claudin 10"
                     /db_xref="GeneID:290485"
                     /db_xref="RGD:1308027"
     exon            1..406
                     /gene="Cldn10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    226..228
                     /gene="Cldn10"
                     /note="upstream in-frame stop codon"
     CDS             250..1110
                     /gene="Cldn10"
                     /codon_start=1
                     /product="claudin-10"
                     /protein_id="NP_001099528.1"
                     /db_xref="GeneID:290485"
                     /db_xref="RGD:1308027"
                     /translation="

MSRAQISALVCGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAAGSMASTALEIIAFVVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYFANLWKMCVTDSTGVANCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGVVFILSGLCSMTGCSLYANKITTEFFDPLFMEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRMGYTYNGPTSVMSSRTKYQGGEGDFKTTGPSKQFDKNAYV"

     misc_feature    424..951
                     /gene="Cldn10"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     exon            407..634
                     /gene="Cldn10"
                     /inference="alignment:Splign:2.1.0"
     exon            635..796
                     /gene="Cldn10"
                     /inference="alignment:Splign:2.1.0"
     exon            797..878
                     /gene="Cldn10"
                     /inference="alignment:Splign:2.1.0"
     exon            879..986
                     /gene="Cldn10"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1331
                     /gene="Cldn10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

caaaattcctctacaaagttttggtatctcagtagggaattagaaagattatttaggctatcgctaagatgcccttacttcactatacttaatcctaaattcccatacttggagccatcaaagtatgaagaattgtcacccaccctcatgggcgggctgtaacatttgtgggagtcctgtccagtggctgcatgcctaggccaccaaagcattcagtgtggactgtgacagcaggcaaggctgagcaacatgtccagggcgcagatctcagctctggtgtgtggcgttggagggtttggtgctcttgtcgctgccaccacatccaatgaatggaaagtgaccacccgagcatcgtccgtgataaccgccacctgggtttaccagggtctgtggatgaactgcgcagccggcagcatggctagcacggccttggaaatcatcgccttcgtcgtctccatctcgggctgggtgctggtgtcttccacactacccaccgactactggaaggtctccaccatcgatggcactgtcatcaccaccgccacttattttgccaacctgtggaagatgtgcgttaccgattccaccggtgtcgccaactgcaaggacttcccctccatgctggcgctggatggttacatccaggcgtgtagaggactaatgattgccgcggtcagcctgggcttcttcggttccatttttgcactctttggaatgaagtgtaccaaagtcggaggctcggataaagccaaagctaagattgcttgcttggctggggttgtattcatattgtcaggtctgtgttccatgacgggctgttccctgtacgcgaacaaaatcacaacggaattctttgatcccctctttatggagcaaaagtatgaattgggggctgccctcttcatcggatgggcaggagcttctctctgcatcattggcggtgtcatattttgcttttcaatatccgacaacaacaaaacacccagaatgggctacacgtacaatggacccacgtcagtcatgtcttcccggaccaagtatcaaggcggagaaggagattttaaaaccacaggcccttcaaaacagtttgataaaaatgcctatgtctaaagagctctggcaagccgcgtctcgagtttgttgcgcaagagaactgttctcacaatggtccttccaaggctcccctgtaattatcacttaagctgtttttttttttttaaaatatgaatttgaagaatgttgattggatgtaaatgttcttatagttatatactaatcatttttttctgttgtgcctttctataagggaaataaacaggttatttacagga

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