LOCUS       NM_001004282            1668 bp    mRNA    linear   ROD 27-APR-2025
DEFINITION  Rattus norvegicus transmembrane protein 178A (Tmem178a), mRNA.
ACCESSION   NM_001004282 XM_343007
VERSION     NM_001004282.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1668)
  AUTHORS   Decker,C.E., Yang,Z., Rimer,R., Park-Min,K.H., Macaubas,C.,
            Mellins,E.D., Novack,D.V. and Faccio,R.
  TITLE     Tmem178 acts in a novel negative feedback loop targeting NFATc1 to
            regulate bone mass
  JOURNAL   Proc Natl Acad Sci U S A 112 (51), 15654-15659 (2015)
   PUBMED   26644563
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079338.1.
            
            On Sep 10, 2004 this sequence version replaced XM_343007.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            30 bp suspected to be vector contamination from the 5' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079338.1, CK366007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1668              BC079338.1         31-1698
FEATURES             Location/Qualifiers
     source          1..1668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1668
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /note="transmembrane protein 178A"
                     /db_xref="GeneID:362691"
                     /db_xref="RGD:1303057"
     exon            1..408
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..902
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /note="transmembrane protein 178"
                     /codon_start=1
                     /product="transmembrane protein 178A precursor"
                     /protein_id="NP_001004282.1"
                     /db_xref="GeneID:362691"
                     /db_xref="RGD:1303057"
                     /translation="

MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCERSRAGADPPDQKNRLMPLSHLPLRDSPPLGRRLLPGGPGRSDPESWRSLLGLGGLDAECGRPLFATYSGLWRKCYFLGIDRDIDTLILKGIAQRCTAVKYHFSQPIRLRNIPFNLTKIIQQDEWHLLHLRRITAGFLGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTGIFCTISLCTYAASVSYDLNRVPKLIYSLPHDVEHGYSWSIFCAWCSLGFIVAAGGLCIAYPFISRTKIAHLKSGRDSTV"

     sig_peptide     9..83
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q68FV0.1)"
     mat_peptide     84..899
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /product="Transmembrane protein 178A. /id=PRO_0000287282"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FV0.1)"
     misc_feature    129..266
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FV0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    324..830
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    480..482
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q68FV0.1); glycosylation site"
     misc_feature    546..608
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FV0.1);
                     transmembrane region"
     misc_feature    633..695
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FV0.1);
                     transmembrane region"
     misc_feature    780..842
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FV0.1);
                     transmembrane region"
     exon            409..522
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /inference="alignment:Splign:2.1.0"
     exon            523..660
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /inference="alignment:Splign:2.1.0"
     exon            661..1642
                     /gene="Tmem178a"
                     /gene_synonym="Tmem178"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gggaagccatggagccacgggcgctcgtcacggcgctaagcctcggcctcagcctttgctccctggggctgctcgtcacggccatcttcaccgatcactggtacgagaccgacccccggcgccacaaggagagctgcgagcgcagccgcgcgggcgccgaccccccggatcagaagaaccgcctgatgccgctgtcgcacctgccgctgcgggactcgcctcccttggggcgccggctgctccccggcggccctgggcgctctgacccggagtcctggcgctcgctgctggggctcggtgggttggacgccgagtgtggccggccgctgttcgccacctactccggcctctggaggaagtgctacttcctgggcatcgaccgggacatcgacaccctcatcctgaaaggtattgcacagcgatgcactgcggtcaagtaccacttctctcagccaatccgcttacggaacattcctttcaatttaaccaagataatccagcaagatgaatggcacctgcttcatctaagaagaataacagctggattcctgggcatggcggtggctgtcctgctgtgtggctgcatcgtggccacggtcagcttcttctgggaggaaagcctgacccagcacgtggctggactcctattcctcatgacagggatattttgcaccatctcactctgcacgtacgctgccagcgtctcctatgatttgaaccgggtcccaaagctaatttacagcctgcctcatgatgtggaacatggctacagctggtctatcttctgcgcctggtgcagtttaggctttattgtggcagctggaggtctctgcatcgcttatccgtttattagccggaccaagattgcacatctaaagtctggcagggactccacggtatgactgcctgcatcgaagaaggcccagctacagagcggagcgggtctgagttccattaggagcagtactgagttcacatcagggttccaagcacaaagaggtcttttacattccaacctgttgcctgcagccctttccggatgactgactggaaaccttgcagaacttcccaacctttccaaggataagacaactgtgggttcaagtgctttaatgactatttatgctttggttgagcgaagtgagcaacgggctggaggacatttgtaggcatcagagaagaggggcggcggtggaaaaatttgtacgatttccacttatttcagaaagtttgtatataacgattacgggagagtcgtttctatttgtgaaaggattcatgacaaaaacgagcataattttcttgtcactgtgccaggcttgttggactttaatgcagcatcttcagaacttgtcctggtggcgtcctgttgtgtcagcacctgatatttatgcattacttgtgaatgttccttgtcacaagaggattctccttctgttgccttattattacttttaatgaattgaagtcccctctctgtctttgtactggagttcaaatgcataagaataacagaccaactgtgtaagagctgatccgtaacactatgcagcatcctttgaggtcttctccgttccttggcttgtgtctctttatgttaactggatttctgcattaaatgactgccccccttgttaatttaaaaaaaaaaaaaaaaaaaaaaaaaaa

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