LOCUS       NM_139064               1966 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus TNFAIP3 interacting protein 2 (Tnip2), mRNA.
ACCESSION   NM_139064
VERSION     NM_139064.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Nanda,S.K., Nagamori,T., Windheim,M., Amu,S., Aviello,G.,
            Patterson-Kane,J., Arthur,J.S.C., Ley,S.C., Fallon,P. and Cohen,P.
  TITLE     ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a
            Tpl2-Independent Mechanism
  JOURNAL   J Immunol 201 (11), 3373-3382 (2018)
   PUBMED   30355787
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Ventura,S., Cano,F., Kannan,Y., Breyer,F., Pattison,M.J.,
            Wilson,M.S. and Ley,S.C.
  TITLE     A20-binding inhibitor of NF-kappaB (ABIN) 2 negatively regulates
            allergic airway inflammation
  JOURNAL   J Exp Med 215 (11), 2737-2747 (2018)
   PUBMED   30337469
  REMARK    GeneRIF: These results identify ABIN-2 as a novel negative
            regulator of allergic airway responses and importantly indicate
            that TPL-2 inhibitors would not have unwanted allergic
            comorbidities.
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Xie,H., Yang,M., Zhang,B., Liu,M. and Han,S.
  TITLE     Protective Role of TNIP2 in Myocardial Injury Induced by Acute
            Pancreatitis and Its Mechanism
  JOURNAL   Med Sci Monit 23, 5650-5656 (2017)
   PUBMED   29176547
  REMARK    GeneRIF: Authors found that TNIP2 was correlated with the
            activation of NF-kappaB in cerulein-stimulated AR42J cells, and
            TNIP2 over-expression inhibited the inflammatory response caused by
            cerulein. Moreover, results suggest that TNIP2 over-expression
            relieved the cerulein-triggered inflammatory response and
            AP-induced myocardial injury in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Sriskantharajah,S., Guckel,E., Tsakiri,N., Kierdorf,K., Brender,C.,
            Ben-Addi,A., Veldhoen,M., Tsichlis,P.N., Stockinger,B., O'Garra,A.,
            Prinz,M., Kollias,G. and Ley,S.C.
  TITLE     Regulation of experimental autoimmune encephalomyelitis by TPL-2
            kinase
  JOURNAL   J Immunol 192 (8), 3518-3529 (2014)
   PUBMED   24639351
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Leotoing,L., Chereau,F., Baron,S., Hube,F., Valencia,H.J.,
            Bordereaux,D., Demmers,J.A., Strouboulis,J. and Baud,V.
  TITLE     A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2
            (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase
            alpha (IKKalpha)-mediated NF-kappaB transcriptional activity
  JOURNAL   J Biol Chem 286 (37), 32277-32288 (2011)
   PUBMED   21784860
  REMARK    GeneRIF: ABIN-2 acts as a positive regulator of NF-kappaB-dependent
            transcription by activating IKKalpha.
REFERENCE   6  (bases 1 to 1966)
  AUTHORS   Gu,H., Cui,M., Bai,Y., Chen,F., Ma,K., Zhou,C. and Guo,L.
  TITLE     Angiopoietin-1/Tie2 signaling pathway inhibits
            lipopolysaccharide-induced activation of RAW264.7 macrophage cells
  JOURNAL   Biochem Biophys Res Commun 392 (2), 178-182 (2010)
   PUBMED   20060382
REFERENCE   7  (bases 1 to 1966)
  AUTHORS   Papoutsopoulou,S., Symons,A., Tharmalingham,T., Belich,M.P.,
            Kaiser,F., Kioussis,D., O'Garra,A., Tybulewicz,V. and Ley,S.C.
  TITLE     ABIN-2 is required for optimal activation of Erk MAP kinase in
            innate immune responses
  JOURNAL   Nat Immunol 7 (6), 606-615 (2006)
   PUBMED   16633345
  REMARK    GeneRIF: ABIN-2 acts to positively regulate the Erk signaling
            potential by stabilizing TPL-2.
REFERENCE   8  (bases 1 to 1966)
  AUTHORS   Li,C.C., Chou,C.K., Wang,M.H. and Tsai,T.F.
  TITLE     Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays
            liver regeneration in the ABIN-2 transgenic mice
  JOURNAL   Biochem Biophys Res Commun 342 (1), 300-309 (2006)
   PUBMED   16480954
  REMARK    GeneRIF: ABIN-2 may function as a negative regulator that
            downregulates NF-kappaB activation during liver regeneration
REFERENCE   9  (bases 1 to 1966)
  AUTHORS   Lang,V., Symons,A., Watton,S.J., Janzen,J., Soneji,Y., Beinke,S.,
            Howell,S. and Ley,S.C.
  TITLE     ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and
            is essential for TPL-2 protein stability
  JOURNAL   Mol Cell Biol 24 (12), 5235-5248 (2004)
   PUBMED   15169888
  REMARK    GeneRIF: optimal TPL-2 stability in vivo requires interaction with
            ABIN-2 as well as p105
REFERENCE   10 (bases 1 to 1966)
  AUTHORS   Van Huffel,S., Delaei,F., Heyninck,K., De Valck,D. and Beyaert,R.
  TITLE     Identification of a novel A20-binding inhibitor of nuclear
            factor-kappa B activation termed ABIN-2
  JOURNAL   J Biol Chem 276 (32), 30216-30223 (2001)
   PUBMED   11390377
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC102620.11.
            
            On Mar 21, 2007 this sequence version replaced NM_139064.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ304865.1, AK160165.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               AC102620.11        2442-2802
            362-652             AC102620.11        12594-12884
            653-742             AC102620.11        15424-15513
            743-991             AC102620.11        16685-16933
            992-1111            AC102620.11        17122-17241
            1112-1966           AC102620.11        19471-20325
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.89 cM"
     gene            1..1966
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /note="TNFAIP3 interacting protein 2"
                     /db_xref="GeneID:231130"
                     /db_xref="MGI:MGI:2386643"
     exon            1..361
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1375
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /note="A20-binding inhibitor of NF-kappa-B activation 2;
                     A20 binding inhibitor of NF-kappaB activation-2"
                     /codon_start=1
                     /product="TNFAIP3-interacting protein 2"
                     /protein_id="NP_620703.1"
                     /db_xref="CCDS:CCDS19214.1"
                     /db_xref="GeneID:231130"
                     /db_xref="MGI:MGI:2386643"
                     /translation="

MSSGDPRSGRQDGAPRAAAALCGLYHEAGQQLQRLKDQLAARDALIASLRTRLAALEGHTAPSLVDALLDQVERFREQLRRQEEGASETQLRQEVERLTERLEEKEREMQQLMSQPQHEQEKEVVLLRRSVAEKEKARAASDVLCRSLADETHQLRRTLAATAHMCQHLAKCLDERQCAQGDAGEKSPAELEQTSSDASGQSVIKKLQEENRLLKQKVTHVEDLNAKWQRYDASRDEYVKGLHAQLKRRQVPLEPELMKKEISRLNRQLEEKISDCAEANQELTAMRMSRDTALERVQMLEQQILAYKDDFKSERADRERAHSRIQELEEKIMSLMYQVSQRQDSREPGPCRIHTGNKTAKYLEMDALEHVTPGGWRPESRSQQMEPSAEGGHVCTAQRGQGDLQCPHCLRCFSDEQGEAFLRHLSECCQ"

     misc_feature    104..106
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NFZ5; propagated from
                     UniProtKB/Swiss-Prot (Q99JG7.1); phosphorylation site"
     misc_feature    <137..1087
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    629..688
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JG7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    725..826
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /note="TSG101 and ALIX binding domain of CEP55; Region:
                     EABR; pfam12180"
                     /db_xref="CDD:463486"
     misc_feature    950..1126
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JG7.1);
                     Region: Ubiquitin-binding domain (UBD)"
     misc_feature    1199..1264
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JG7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            362..652
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..742
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..991
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1111
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1966
                     /gene="Tnip2"
                     /gene_synonym="1810020H16Rik; ABIN-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aaacgttccgggaaggctggttttcgctccccctgtgtggagaagttggagacgcccaagtccccacggaaggcctacagccatgtcgtctggggacccaaggtctggtagacaggacggggccccgcgtgcggccgcagcgctctgtggcctgtaccacgaggccggccagcaactacagcgcctgaaggatcagctggccgcgcgtgacgccctcatcgcgagcctccgcacccgcctcgcggctctggaagggcacacggcgccgtcactcgtggacgcacttctggatcaggtggagcgcttccgtgagcagctgcgacgacaggaggaaggcgcttcggagacccagctgcggcaggaagttgaaagacttacggagcgtctagaggaaaaagagagggagatgcaacagctgatgagccagcctcagcatgagcaagagaaggaggtagtcttgcttcggcgaagtgtggcagagaaggagaaagccagggccgccagtgatgttctgtgccgctccttggctgatgagacccaccaactgcgcaggacattggcagccactgcccacatgtgccaacatctggccaaatgtctggatgaacgacagtgtgcacagggagacgctggggagaaaagccctgctgagctagagcaaacaagcagcgatgcttctggccagagtgttattaagaagttacaggaagaaaatcgactgttaaaacagaaggtgactcatgtagaagacctcaatgctaagtggcagcgttatgatgcaagtagggacgaatatgtgaaggggttgcatgcccagctaaagaggcggcaggtccctctggagcctgagctgatgaagaaggagatttcccgacttaacagacagttggaggagaaaataagtgactgtgcggaagcaaaccaggagctgacagccatgaggatgtcccgggacactgcgctggagcgagtgcagatgctagaacagcagattcttgcttacaaggatgacttcaaatcagaaagggcagatcgggaacgagcgcacagtaggattcaagagctggaggaaaagatcatgtccttgatgtaccaagtgtcccagagacaggactcccgggagccaggaccctgtcggattcatacggggaacaaaactgccaagtacttagagatggatgcactggagcatgtgacccctggcggctggaggcctgagtctaggtcccaacagatggaaccttctgcagagggtgggcatgtgtgcacagcccagagaggtcagggtgaccttcagtgccctcattgcctgcggtgcttcagtgatgagcaaggcgaggcattcctcaggcacctgtctgagtgctgccaatgagccagacattgcccgtgtgacccatgaccaccatagctgctctaagggactgggaggggtcctcagactcagttttcaactcagtgtgttgcattctcctgggatctagggcccaaatgggcagggtcactggaaggtcatcttgttttcatttgaccatggtgagacttggtcagagggaactattgacagagcaggaggaagaggtggggtcagggacatcaagtggacatcagttttgtctcacgtagagtttggagtgagctgtcaattcaaagctgcaagctatcagttgtgggaatattctgaagcctgcttgcacctagagttatgccacttgctggaaggggaagttgctgtgggagcagtgtgtcctctttccagggtggtagctccatcctgttgagtagtgagatacactccctgactggtctgtgctgcattacagttacatgatacactagaaccttcccaaactcagcagagccacacagctgcatccagtaccatcaccctgcaaaacacttgtatttccaaaagggaaagcacctttatttcctaatcatttatttttataataaatggctttac

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