LOCUS       NM_018778               2368 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus claudin 8 (Cldn8), mRNA.
ACCESSION   NM_018778
VERSION     NM_018778.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2368)
  AUTHORS   Higashi,A.Y., Higashi,T., Furuse,K., Ozeki,K., Furuse,M. and
            Chiba,H.
  TITLE     Claudin-9 constitutes tight junctions of folliculo-stellate cells
            in the anterior pituitary gland
  JOURNAL   Sci Rep 11 (1), 21642 (2021)
   PUBMED   34737342
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2368)
  AUTHORS   Matei,D.E., Menon,M., Alber,D.G., Smith,A.M., Nedjat-Shokouhi,B.,
            Fasano,A., Magill,L., Duhlin,A., Bitoun,S., Gleizes,A.,
            Hacein-Bey-Abina,S., Manson,J.J., Rosser,E.C., Klein,N., Blair,P.A.
            and Mauri,C.
  CONSRTM   ABIRISK Consortium
  TITLE     Intestinal barrier dysfunction plays an integral role in arthritis
            pathology and can be targeted to ameliorate disease
  JOURNAL   Med 2 (7), 864-883 (2021)
   PUBMED   34296202
REFERENCE   3  (bases 1 to 2368)
  AUTHORS   Sassi,A., Wang,Y., Chassot,A., Komarynets,O., Roth,I., Olivier,V.,
            Crambert,G., Dizin,E., Boscardin,E., Hummler,E. and Feraille,E.
  TITLE     Interaction between Epithelial Sodium Channel gamma-Subunit and
            Claudin-8 Modulates Paracellular Sodium Permeability in Renal
            Collecting Duct
  JOURNAL   J Am Soc Nephrol 31 (5), 1009-1023 (2020)
   PUBMED   32245797
  REMARK    GeneRIF: Interaction between Epithelial Sodium Channel
            gamma-Subunit and Claudin-8 Modulates Paracellular Sodium
            Permeability in Renal Collecting Duct.
REFERENCE   4  (bases 1 to 2368)
  AUTHORS   Carpinelli,M.R., de Vries,M.E., Auden,A., Butt,T., Deng,Z.,
            Partridge,D.D., Miles,L.B., Georgy,S.R., Haigh,J.J., Darido,C.,
            Brabletz,S., Brabletz,T., Stemmler,M.P., Dworkin,S. and Jane,S.M.
  TITLE     Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues
            mid-gestation viability and secondary palate closure
  JOURNAL   Dis Model Mech 13 (3) (2020)
   PUBMED   32005677
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2368)
  AUTHORS   Liu,C., Tate,T., Batourina,E., Truschel,S.T., Potter,S., Adam,M.,
            Xiang,T., Picard,M., Reiley,M., Schneider,K., Tamargo,M., Lu,C.,
            Chen,X., He,J., Kim,H. and Mendelsohn,C.L.
  TITLE     Pparg promotes differentiation and regulates mitochondrial gene
            expression in bladder epithelial cells
  JOURNAL   Nat Commun 10 (1), 4589 (2019)
   PUBMED   31597917
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2368)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   7  (bases 1 to 2368)
  AUTHORS   Turksen,K. and Troy,T.C.
  TITLE     Permeability barrier dysfunction in transgenic mice overexpressing
            claudin 6
  JOURNAL   Development 129 (7), 1775-1784 (2002)
   PUBMED   11923212
REFERENCE   8  (bases 1 to 2368)
  AUTHORS   Niimi,T., Nagashima,K., Ward,J.M., Minoo,P., Zimonjic,D.B.,
            Popescu,N.C. and Kimura,S.
  TITLE     claudin-18, a novel downstream target gene for the T/EBP/NKX2.1
            homeodomain transcription factor, encodes lung- and
            stomach-specific isoforms through alternative splicing
  JOURNAL   Mol Cell Biol 21 (21), 7380-7390 (2001)
   PUBMED   11585919
REFERENCE   9  (bases 1 to 2368)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J Cell Biol 147 (6), 1351-1363 (1999)
   PUBMED   10601346
REFERENCE   10 (bases 1 to 2368)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK133810.1 and BE133033.1.
            
            On Nov 15, 2007 this sequence version replaced NM_018778.2.
            
            Summary: This intronless gene encodes a member of the claudin
            family. Claudins are integral membrane proteins and components of
            tight junction strands. Tight junction strands serve as a physical
            barrier to prevent solutes and water from passing freely through
            the paracellular space between epithelial or endothelial cell
            sheets, and also play critical roles in maintaining cell polarity
            and signal transductions. The protein encoded by this gene is a
            paracellular cation barrier. [provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK133810.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2356              AK133810.1         1-2356
            2357-2368           BE133033.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..2368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 51.22 cM"
     gene            1..2368
                     /gene="Cldn8"
                     /note="claudin 8"
                     /db_xref="GeneID:54420"
                     /db_xref="MGI:MGI:1859286"
     exon            1..2358
                     /gene="Cldn8"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..826
                     /gene="Cldn8"
                     /codon_start=1
                     /product="claudin-8"
                     /protein_id="NP_061248.1"
                     /db_xref="CCDS:CCDS28296.1"
                     /db_xref="GeneID:54420"
                     /db_xref="MGI:MGI:1859286"
                     /translation="

MATYALQMAALVLGGVGMVGTVAVTIMPQWRVSAFIESNIVVFENRWEGLWMNCMRHANIRMQCKVYDSLLALSPDLQASRGLMCAASVLAFLAFMTAILGMKCTRCTGDDENVKSRILLTAGIIFFITGLVVLIPVSWVANSIIRDFYNPLVDVALKRELGEALYIGWTTALVLIAGGALFCCVFCCTERSNSYRYSVPSHRTTQRSFHAEKRSPSIYSKSQYV"

     misc_feature    161..694
                     /gene="Cldn8"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    170..232
                     /gene="Cldn8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z260.1);
                     transmembrane region"
     misc_feature    392..454
                     /gene="Cldn8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z260.1);
                     transmembrane region"
     misc_feature    500..562
                     /gene="Cldn8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z260.1);
                     transmembrane region"
     misc_feature    647..709
                     /gene="Cldn8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z260.1);
                     transmembrane region"
     misc_feature    818..823
                     /gene="Cldn8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z260.1);
                     Region: Interactions with TJP1, TJP2 and TJP3.
                     /evidence=ECO:0000269|PubMed:10601346"
     regulatory      2338..2343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn8"
                     /note="hexamer: ATTAAA"
     polyA_site      2358
                     /gene="Cldn8"
                     /note="major polyA site"
ORIGIN      

gatctggccagagagggctaagctctgtgttgtgagcacatttctacaggagaactgttccctccctcccaaggcgtacagatttctgcttgaaaggaagccctacttcccgggtcagcgttccagctggatacaatttgggaggacgatggcaacctacgctcttcaaatggctgcactggtgcttggtggtgttggcatggtgggcacggtggctgtgactatcatgcctcagtggagagtgtctgccttcatcgaaagtaacattgtggtgtttgagaaccgctgggaaggcttgtggatgaattgtatgaggcatgccaacatcagaatgcagtgcaaggtctacgactccctgctggctcttagtccagacctccaggcatcccgaggactgatgtgtgctgcgtccgtcttggctttcttggctttcatgacagccatcctcggaatgaagtgcaccagatgcacgggggacgatgagaacgtgaagagccgcatcttgctgacagccggaatcatcttcttcatcaccggcttggttgtgctcatccctgtcagctgggttgccaattccatcatcagagacttctacaacccactggtggatgtggccctaaagcgcgagctgggagaagccctctacataggctggaccacagcgctggtgctgatcgctggaggagcactgttctgttgtgtgttttgttgtactgaaaggagcaacagttacaggtactcggtaccatcccatcgcaccactcaacggagtttccacgccgaaaagagatctccgagcatatactccaaaagtcagtatgtgtagttgtgtgtgtatattttagccgtagctaagcttttataaatcaccaaaccagccactattttagagaaatggagcccacactgtatccatttacctttcttaactgcctagcactcattagaggaaatatgcagcgtctatgtttccataagtgattttagcagaatgaggtattatgtgcactgcttcgattgttctagaaagcctagccatttgttttctaaaatggttcactcagctcttcctttttatcagtcactctaaacctgcacatcgaaagactgttggcttaagctgtgatttctctgtgtcatgacattatccaagtagatgcgggtggcagttatatctcacacaaatagagacaggcttatgtggttctatttaaagtggaatgccaatccatcacgctgaataaatagaactcagctattgcatttcagggggcctggggataaaagagaaggaggctgatattaattgcctaaaaacagcttaaggattagtgcactctatttgtagtgaaggttaaaatgaaggctttaatcattagtgtaaggctttctgctatcctgctttgcagcctcgaggagtaagaaattccgtcacctttatcctttccctctacacgccttaattttctgttgcctactatctcttaaagtttaaagcagatgttttggcaaaatatttttttttcctttagactacttttgtaaggctaagcagtggtcttagaaaaattaatgatttcagaaaaatgaaatcattagcttttctgtttagagaagaatgtattgtttttgaaatgaagtcatatcatgcaagggattgttcaaatgctatttttgcatagttttttctttcttttttttaggaacttatcagtatatatgagggagaaagaaggacattttcattgtcattttattaacccaaagagagacacaaaccctccaaatccaaaagcttgtccccttctaactcctgacactcaaacttatcatttctcttctgttgaagggatttccccattttctatgcctttgctaagttctattgaagtgtagtatcactctgtgtttcctcctaatttgagacaactgttattctaagtttcatatatatgacttttatattgataaattgtatctcataacaatatagcatttcttgcatcttcattctttttctttaccttgtgcaagtgtttaaaacttggtattgactcttttagtttgaacatagatattgtgttcacttttgtaatgtatgatttaaaatccacgtactttataatgacctcacatatgcactaatatttgattaatatatgaataatattaaattgcacttaggtccaatgaaatgtgtttgttgtaaatactgtgtatgtaatcatgttttaaaagatgttgtccatatgtatttcaactcctgagaattcatatgaactaaaagcagtgctgaaatgacttgggaatatacatcatatttatgtgaaggatattattaaacgtttgcaatactaaaaaaaaaaaa

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