LOCUS       NM_010711               2158 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus LIM homeobox protein 3 (Lhx3), transcript variant 2,
            mRNA.
ACCESSION   NM_010711 XM_006497740
VERSION     NM_010711.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2158)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2158)
  AUTHORS   Renaux,E., Baudouin,C., Marchese,D., Clovis,Y., Lee,S.K.,
            Gofflot,F., Rezsohazy,R. and Clotman,F.
  TITLE     Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of
            spinal V2a interneurons
  JOURNAL   Cell Mol Life Sci 81 (1), 286 (2024)
   PUBMED   38970652
  REMARK    GeneRIF: Lhx4 surpasses its paralog Lhx3 in promoting the
            differentiation of spinal V2a interneurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2158)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   4  (bases 1 to 2158)
  AUTHORS   Dang,W., Gao,D., Lyu,G., Irwin,D.M., Shang,S., Chen,J., Zhang,J.,
            Zhang,S. and Wang,Z.
  TITLE     A Nonsynonymous Substitution of Lhx3 Leads to Changes in Body Size
            in Dogs and Mice
  JOURNAL   Genes (Basel) 15 (6), 739 (2024)
   PUBMED   38927675
  REMARK    GeneRIF: A Nonsynonymous Substitution of Lhx3 Leads to Changes in
            Body Size in Dogs and Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2158)
  AUTHORS   Engelhardt,D., Marean,A., McKean,D., Petersen,J. and Niswander,L.
  TITLE     RSG1 is required for cilia-dependent neural tube closure
  JOURNAL   Genesis 62 (3), e23602 (2024)
   PUBMED   38721990
REFERENCE   6  (bases 1 to 2158)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   7  (bases 1 to 2158)
  AUTHORS   Zhadanov,A.B., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Westphal,H.
  TITLE     Genomic structure and chromosomal localization of the mouse
            LIM/homeobox gene Lhx3
  JOURNAL   Genomics 27 (1), 27-32 (1995)
   PUBMED   7665181
REFERENCE   8  (bases 1 to 2158)
  AUTHORS   Zhadanov,A.B., Bertuzzi,S., Taira,M., Dawid,I.B. and Westphal,H.
  TITLE     Expression pattern of the murine LIM class homeobox gene Lhx3 in
            subsets of neural and neuroendocrine tissues
  JOURNAL   Dev Dyn 202 (4), 354-364 (1995)
   PUBMED   7626792
REFERENCE   9  (bases 1 to 2158)
  AUTHORS   Bach,I., Rhodes,S.J., Pearse,R.V. 2nd, Heinzel,T., Gloss,B.,
            Scully,K.M., Sawchenko,P.E. and Rosenfeld,M.G.
  TITLE     P-Lim, a LIM homeodomain factor, is expressed during pituitary
            organ and cell commitment and synergizes with Pit-1
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2720-2724 (1995)
   PUBMED   7708713
REFERENCE   10 (bases 1 to 2158)
  AUTHORS   Seidah,N.G., Barale,J.C., Marcinkiewicz,M., Mattei,M.G., Day,R. and
            Chretien,M.
  TITLE     The mouse homeoprotein mLIM-3 is expressed early in cells derived
            from the neuroepithelium and persists in adult pituitary
  JOURNAL   DNA Cell Biol 13 (12), 1163-1180 (1994)
   PUBMED   7811383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773595.10, L38248.1 and CD741809.1.
            
            On or before Mar 12, 2014 this sequence version replaced
            XM_006497740.1, NM_010711.1.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon, and it thus differs in the 5' UTR and 5' coding
            region, compared to variant 1. The encoded isoform (b) has a
            distinct N-terminus and is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L38857.1, BC150689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AL773595.10        67621-67768         c
            149-2130            L38248.1           198-2179
            2131-2158           CD741809.1         1-28                c
FEATURES             Location/Qualifiers
     source          1..2158
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.44 cM"
     gene            1..2158
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="LIM homeobox protein 3"
                     /db_xref="GeneID:16871"
                     /db_xref="MGI:MGI:102673"
     exon            1..148
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1263
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="isoform b is encoded by transcript variant 2;
                     LIM/homeobox protein Lhx3; homeobox protein LIM-3;
                     homeobox protein P-LIM; LIM homeo box protein 3"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx3 isoform b"
                     /protein_id="NP_034841.2"
                     /db_xref="CCDS:CCDS71004.1"
                     /db_xref="GeneID:16871"
                     /db_xref="MGI:MGI:102673"
                     /translation="

MLLEAELDCHRERPGAPGASALCTFSRTPEIPMCAGCDQHILDRFILKALDRHWHSKCLKCSDCHVPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGSSKSDKDSIQEGQDSDAEVSFTDEPSMADMGPANGLYSSLGEPAPALGRPVGGLGSFTLDHGGLTGPEQYRELRPGSPYGIPPSPAAPQSLPGPQPLLSSLVYPDTNLSLVPSGPPGGPPPMRVLAGNGPSSDLSTESSSGYPDFPASPASWLDEVDHAQF"

     misc_feature    151..315
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="The first LIM domain of Lhx3b; Region: LIM1_Lhx3b;
                     cd09467"
                     /db_xref="CDD:188851"
     misc_feature    order(160..162,169..171,223..225,232..234,241..243,
                     250..252,301..303,310..312)
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188851"
     misc_feature    280..282
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBR4; propagated from
                     UniProtKB/Swiss-Prot (P50481.1); phosphorylation site"
     misc_feature    337..504
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="The second LIM domain of Lhx3-Lhx4 family; Region:
                     LIM2_Lhx3_Lhx4; cd09376"
                     /db_xref="CDD:188762"
     misc_feature    order(337..339,346..348,403..405,412..414,421..423,
                     430..432,490..492,499..501)
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188762"
     misc_feature    order(373..375,448..450)
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Isl binding site; other site"
                     /db_xref="CDD:188762"
     misc_feature    541..711
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    703..900
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="propagated from UniProtKB/Swiss-Prot (P50481.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    748..750
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBR4; propagated from
                     UniProtKB/Swiss-Prot (P50481.1); phosphorylation site"
     misc_feature    769..771
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBR4; propagated from
                     UniProtKB/Swiss-Prot (P50481.1); phosphorylation site"
     misc_feature    781..783
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBR4; propagated from
                     UniProtKB/Swiss-Prot (P50481.1); phosphorylation site"
     misc_feature    949..1260
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="propagated from UniProtKB/Swiss-Prot (P50481.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            149..320
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            321..523
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            524..675
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            676..844
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            845..2144
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2117..2122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="hexamer: AATAAA"
     polyA_site      2141
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="major polyA site"
ORIGIN      

ctgaaagaggtccagcacttccaggaacaccccgcacgaaccactggattagtgactgccatgctgctagaagcagaactcgattgccaccgagagaggcccggtgcccctggagcttctgccctctgtaccttcagcaggactccagagatcccgatgtgtgcaggctgtgaccagcacatcttggaccgtttcatccttaaggctctggaccgacattggcacagcaagtgtctcaagtgcagtgactgccacgtccctctggctgagcgctgcttcagccgcggggagagcgtctactgcaaagacgacttctttaagcgcttcgggaccaagtgcgccgcatgccagctgggcatcccgcccacgcaggtggtgcgccgcgcccaggacttcgtgtaccacctgcattgcttcgcctgcgtggtctgcaagcggcagctggccacgggcgacgagttctacctcatggaagacagccggctggtgtgcaaggcggactacgaaacagccaagcagcgagaagccgaggccacagccaagcggccgcgcaccaccatcaccgccaagcagctggagacgctgaagagcgcctacaacacttcgcccaagccggcgcgccacgtgcgcgagcagctctcctccgagaccggcctggacatgcgagtggtgcaggtgtggttccagaatcgccgggctaaggaaaagagactgaagaaagacgctggccggcagcgctggggacagtatttccgcaatatgaagcgctcccgcggcagttccaagtccgacaaggacagcatccaggagggacaagacagcgacgccgaagtctccttcactgatgagccgtccatggctgacatggggcctgctaatggcctgtacagcagcctgggagagcctgcccctgcgttgggccggcccgtaggaggcctgggcagctttaccctggatcacggaggcttgacgggtccagagcagtaccgagagctacgcccaggcagcccctatggcatccccccatctcctgcagccccccagagccttcctggcccccagcctctcctctccagcctggtatacccagacaccaacttgagccttgtcccttcagggcccccaggtggacccccacccatgagggtgctggctggaaatgggcccagctccgacctgtccacagagagcagttctggctacccagactttcctgctagccctgcttcctggctggatgaagtagaccatgctcagttctgaccgaggcctctgcttcccctggctctaactcaggggtcttggtgctgcctctgggtggatggctagccccatcccatgctgtccattccaaggacctctgagggaaggacagggttcccaagtgagagaatagggactgtcccacttccaggctctctggcagctccctggggctgagggactccaaagtccttccttggacacaagggtggcctgcctggtggctgtccacaagccagtgaccatttcttgtaagcatttctctttctttactggccagttaacccttgctgctatttccgacagggcaggaggctaggcctacctaatgtcctggcagaaaacaacagtaacgccttgcttcatcgcttctgatggggcttggtaggagactgtgcttgtgtccttcctggccactgacaaaacctgggagcacacctctcctccttactgctgccagctctccctccccggagtctccagatcattctgttctggaatgccgtgtgttgggggagtagagctttctggagccccttctccaaggcgtagcctctaaatgcgagaacaattccccttcggaggcacagcctccctcgggtgcaaagcagaattgtgcaccgtgaacagacacctttgccaaacagactgtggtcccgagcagggtcggggggtggttccactggaggaggctgggctgggggtcctcccaacccaatctgtctcagacacaaagcttgaccacgtgaaagttaagatcattcctgaaaacaggatcttggctacctgttggttctgtaaacaccctgtaacttttatttattccctggtgatccgctctttccaagacttcaataaatttgtcagtttcagtgctagaaaaaaaaaaaaaaaa

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