LOCUS       NM_008701               1260 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus NK2 homeobox 9 (Nkx2-9), mRNA.
ACCESSION   NM_008701 XM_484144
VERSION     NM_008701.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Sampath Kumar,A., Tian,L., Bolondi,A., Hernandez,A.A., Stickels,R.,
            Kretzmer,H., Murray,E., Wittler,L., Walther,M., Barakat,G.,
            Haut,L., Elkabetz,Y., Macosko,E.Z., Guignard,L., Chen,F. and
            Meissner,A.
  TITLE     Spatiotemporal transcriptomic maps of whole mouse embryos at the
            onset of organogenesis
  JOURNAL   Nat Genet 55 (7), 1176-1185 (2023)
   PUBMED   37414952
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Xu,P., He,H., Gao,Q., Zhou,Y., Wu,Z., Zhang,X., Sun,L., Hu,G.,
            Guan,Q., You,Z., Zhang,X., Zheng,W., Xiong,M. and Chen,Y.
  TITLE     Human midbrain dopaminergic neuronal differentiation markers
            predict cell therapy outcomes in a Parkinson's disease model
  JOURNAL   J Clin Invest 132 (14) (2022)
   PUBMED   35700056
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Kouwenhoven,W.M., von Oerthel,L., Gruppilo,M., Tian,J.,
            Wagemans,C.M.R.J., Houwers,I.G.J., Locker,J., Mesman,S. and
            Smidt,M.P.
  TITLE     Nkx2.9 Contributes to Mid-Hindbrain Patterning by Regulation of
            mdDA Neuronal Cell-Fate and Repression of a Hindbrain-Specific
            Cell-Fate
  JOURNAL   Int J Mol Sci 22 (23), 12663 (2021)
   PUBMED   34884468
  REMARK    GeneRIF: Nkx2.9 Contributes to Mid-Hindbrain Patterning by
            Regulation of mdDA Neuronal Cell-Fate and Repression of a
            Hindbrain-Specific Cell-Fate.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Wu,S., Wei,T., Fan,W., Wang,Y., Li,C. and Deng,J.
  TITLE     Cell cycle during neuronal migration and neocortical lamination
  JOURNAL   Int J Dev Neurosci 81 (2), 209-219 (2021)
   PUBMED   33448039
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Wang,C.C., Brodnicki,T., Copeland,N.G., Jenkins,N.A. and
            Harvey,R.P.
  TITLE     Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and
            Nkx2-1/2-9 in mammals
  JOURNAL   Mamm Genome 11 (6), 466-468 (2000)
   PUBMED   10818213
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Pabst,O., Herbrand,H., Takuma,N. and Arnold,H.H.
  TITLE     NKX2 gene expression in neuroectoderm but not in mesendodermally
            derived structures depends on sonic hedgehog in mouse embryos
  JOURNAL   Dev Genes Evol 210 (1), 47-50 (2000)
   PUBMED   10603087
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Briscoe,J., Sussel,L., Serup,P., Hartigan-O'Connor,D.,
            Jessell,T.M., Rubenstein,J.L. and Ericson,J.
  TITLE     Homeobox gene Nkx2.2 and specification of neuronal identity by
            graded Sonic hedgehog signalling
  JOURNAL   Nature 398 (6728), 622-627 (1999)
   PUBMED   10217145
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Pabst,O., Herbrand,H. and Arnold,H.H.
  TITLE     Nkx2-9 is a novel homeobox transcription factor which demarcates
            ventral domains in the developing mouse CNS
  JOURNAL   Mech Dev 73 (1), 85-93 (1998)
   PUBMED   9545546
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Yoshiura,K.I. and Murray,J.C.
  TITLE     Sequence and chromosomal assignment of human BAPX1, a
            bagpipe-related gene, to 4p16.1: a candidate gene for skeletal
            dysplasia
  JOURNAL   Genomics 45 (2), 425-428 (1997)
   PUBMED   9344671
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160393.2.
            
            On Aug 4, 2006 this sequence version replaced NM_008701.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y15741.1, BC150762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-373               AC160393.2         101026-101398
            374-1260            AC160393.2         102031-102917
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 24.47 cM"
     gene            1..1260
                     /gene="Nkx2-9"
                     /gene_synonym="Nkx-2.9; Nkx2-8; Nkx2.9; tinman"
                     /note="NK2 homeobox 9"
                     /db_xref="GeneID:18094"
                     /db_xref="MGI:MGI:1270158"
     exon            1..373
                     /gene="Nkx2-9"
                     /gene_synonym="Nkx-2.9; Nkx2-8; Nkx2.9; tinman"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    187..189
                     /gene="Nkx2-9"
                     /gene_synonym="Nkx-2.9; Nkx2-8; Nkx2.9; tinman"
                     /note="upstream in-frame stop codon"
     CDS             226..933
                     /gene="Nkx2-9"
                     /gene_synonym="Nkx-2.9; Nkx2-8; Nkx2.9; tinman"
                     /note="NK2 transcription factor related, locus 9; homeobox
                     protein Nkx-2.9; homeobox protein NK-2 homolog H;
                     Drosophila NK2 transcription factor related, locus 9"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.8"
                     /protein_id="NP_032727.2"
                     /db_xref="CCDS:CCDS25923.1"
                     /db_xref="GeneID:18094"
                     /db_xref="MGI:MGI:1270158"
                     /translation="

MATSGRLGFTVRSLLNLPEQDAKPRVRREQQTCVPQTAAWLESECSHYLSSDESGLETSPADSSQLASLRRESPGSDPEKRRKRRVLFSKAQTLELERRFRQQRYLSAPEREQLARLLRLTPTQVKIWFQNHRYKLKRGRAPGITEPSDMAASSDLHAAPGLLRRVVVPVLVHDRPPSNNGRGEGTSAVPQDKCSARLATACPVPGYTAFGPGSALGLFPAYQHLAPPALVSWNW"

     misc_feature    376..483
                     /gene="Nkx2-9"
                     /gene_synonym="Nkx-2.9; Nkx2-8; Nkx2.9; tinman"
                     /note="propagated from UniProtKB/Swiss-Prot (O70584.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    469..639
                     /gene="Nkx2-9"
                     /gene_synonym="Nkx-2.9; Nkx2-8; Nkx2.9; tinman"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            374..1260
                     /gene="Nkx2-9"
                     /gene_synonym="Nkx-2.9; Nkx2-8; Nkx2.9; tinman"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cactcattcaggtacttaaaaccctggacaccccgactgcggttttcaaagccctccgagtagcaagggctgttaatataaatagggattcctcccgcaaaggtgctggcgtctcaaggccagcgcatggcgagcgcctcgcacttccatccttaggagcggcgtccccagctgtccctgggtccctagcctaccctgccccccaccttcttcccctcctcggccatggccacctctggacgcctcggcttcacggtgcgcagcctcctgaatttacctgaacaggatgcgaagcctagggtgaggcgcgagcaacagacgtgcgttccacagactgctgcctggctggagtcggagtgcagccactacctgtcctcggacgagagcggcctggagacaagccctgcagactcgtcgcagctggcttcgctcaggcgggagtcccccggctccgacccggagaagaggaggaagcggcgggtgctgttctccaaggcccagaccttggagttggagcggcgctttcggcagcagcgctacctgtcggcgccggagcgggaacagctggctcgactcctgcgcctcacgcccacgcaggtcaagatctggttccagaaccaccgctacaagctgaagcgagggcgagcgcctgggatcacagagccttcggatatggcagcatcatctgatctgcacgccgctcccggcctgctgcgccgcgtagtggtacccgtgctggttcacgaccggccaccgagcaacaacggcagaggtgaggggacctctgcggtgccccaggacaagtgcagcgcacgcctggccactgcgtgtccggtgccaggctacaccgccttcggaccgggctcggcgcttggcctcttcccagcctaccagcacttagcaccaccagctctggtctcctggaactggtgaggctgctgcggagtgcctaaagccaccctagacttgggacattgctgtttggtccgccgcagtagagctacagccacaccaaagtcaggaggtgacccttgcaggagcccttcttgagtcctgggtccctggattgccctaaccggcaaacacacacacacacacacacacacacacacacacacacacacacacacacacaagggactgtctccaagactcggaatggttgcccgggcgccagtcccagagcaagattttatttcttgagcattatttgtatattttaaaatagcgacttgtatgaagcaacttatttttaaaaaa

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