LOCUS       NM_008699               2145 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus NK2 homeobox 3 (Nkx2-3), mRNA.
ACCESSION   NM_008699 XM_129268
VERSION     NM_008699.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Gao,X., Mukaibo,T., Wei,X., Faustoferri,R.C., Oei,M.S., Hwang,S.K.,
            Yan,A.J., Melvin,J.E. and Ovitt,C.E.
  TITLE     Nkx2.3 transcription factor is a key regulator of mucous cell
            identity in salivary glands
  JOURNAL   Dev Biol 509, 1-10 (2024)
   PUBMED   38311164
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Qiu,C., Martin,B.K., Welsh,I.C., Daza,R.M., Le,T.M., Huang,X.,
            Nichols,E.K., Taylor,M.L., Fulton,O., O'Day,D.R., Gomes,A.R.,
            Ilcisin,S., Srivatsan,S., Deng,X., Disteche,C.M., Noble,W.S.,
            Hamazaki,N., Moens,C.B., Kimelman,D., Cao,J., Schier,A.F.,
            Spielmann,M., Murray,S.A., Trapnell,C. and Shendure,J.
  TITLE     A single-cell time-lapse of mouse prenatal development from
            gastrula to birth
  JOURNAL   Nature 626 (8001), 1084-1093 (2024)
   PUBMED   38355799
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   Hu,M., Chen,N., Chen,M., Chen,F., Lu,Y., Xu,Y., Yang,L., Zeng,H.,
            Shen,M., Chen,X., Chen,S., Wang,F., Wang,S. and Wang,J.
  TITLE     Transcription factor Nkx2-3 maintains the self-renewal of
            hematopoietic stem cells by regulating mitophagy
  JOURNAL   Leukemia 37 (6), 1361-1374 (2023)
   PUBMED   37095209
  REMARK    GeneRIF: Transcription factor Nkx2-3 maintains the self-renewal of
            hematopoietic stem cells by regulating mitophagy.
REFERENCE   4  (bases 1 to 2145)
  AUTHORS   Gabris,F., Kiss,G., Szirmay,B., Szomor,A., Berta,G., Jakus,Z.,
            Kellermayer,Z. and Balogh,P.
  TITLE     Absence of Nkx2-3 induces ectopic lymphatic endothelial
            differentiation associated with impaired extramedullary stress
            hematopoiesis in the spleen
  JOURNAL   Front Cell Dev Biol 11, 1170389 (2023)
   PUBMED   37091975
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2145)
  AUTHORS   Khanfar,E., Olasz,K., Gabris,F., Gajdocsi,E., Botz,B., Kiss,T.,
            Kugyelka,R., Berki,T., Balogh,P. and Boldizsar,F.
  TITLE     Ameliorated Autoimmune Arthritis and Impaired B Cell
            Receptor-Mediated Ca2+ Influx in Nkx2-3 Knock-out Mice
  JOURNAL   Int J Mol Sci 21 (17), 6162 (2020)
   PUBMED   32859051
  REMARK    GeneRIF: Ameliorated Autoimmune Arthritis and Impaired B Cell
            Receptor-Mediated Ca(2+) Influx in Nkx2-3 Knock-out Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2145)
  AUTHORS   Hansen,G.M. and Justice,M.J.
  TITLE     Pten, a candidate tumor suppressor gene, maps to mouse chromosome
            19
  JOURNAL   Mamm Genome 9 (1), 88-90 (1998)
   PUBMED   9434957
REFERENCE   7  (bases 1 to 2145)
  AUTHORS   Yoshiura,K.I. and Murray,J.C.
  TITLE     Sequence and chromosomal assignment of human BAPX1, a
            bagpipe-related gene, to 4p16.1: a candidate gene for skeletal
            dysplasia
  JOURNAL   Genomics 45 (2), 425-428 (1997)
   PUBMED   9344671
REFERENCE   8  (bases 1 to 2145)
  AUTHORS   Pabst,O., Schneider,A., Brand,T. and Arnold,H.H.
  TITLE     The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme
            during pre- and postnatal mouse development
  JOURNAL   Dev Dyn 209 (1), 29-35 (1997)
   PUBMED   9142493
REFERENCE   9  (bases 1 to 2145)
  AUTHORS   Copeland,N.G., Jenkins,N.A. and Harvey,R.P.
  TITLE     The murine homeobox genes Nkx2.3 and Nkx2.6 are located on
            chromosomes 19 and 14, respectively
  JOURNAL   Genomics 22 (3), 655-656 (1994)
   PUBMED   8001981
REFERENCE   10 (bases 1 to 2145)
  AUTHORS   Price,M., Lazzaro,D., Pohl,T., Mattei,M.G., Ruther,U., Olivo,J.C.,
            Duboule,D. and Di Lauro,R.
  TITLE     Regional expression of the homeobox gene Nkx-2.2 in the developing
            mammalian forebrain
  JOURNAL   Neuron 8 (2), 241-255 (1992)
   PUBMED   1346742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072614.1.
            
            On or before Aug 30, 2004 this sequence version replaced
            XM_129268.4, NM_008699.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072614.1, AK044871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.67 cM"
     gene            1..2145
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="NK2 homeobox 3"
                     /db_xref="GeneID:18089"
                     /db_xref="MGI:MGI:97348"
     exon            1..525
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    165..167
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="upstream in-frame stop codon"
     CDS             177..1265
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="homeobox protein NK-2 homolog 3; homeobox protein
                     NK-2 homolog C; NK2 transcription factor related, locus 3"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.3"
                     /protein_id="NP_032725.1"
                     /db_xref="CCDS:CCDS29833.1"
                     /db_xref="GeneID:18089"
                     /db_xref="MGI:MGI:97348"
                     /translation="

MMLPSPVTSTPFSVKDILNLEQQRHFHGAHLQAELEQHFHSAPCMLATAEGTQFSDAGEEDEEEEGEKLSYLNSLAAAEGHGDSGLCPQSYVHTVLRDACSGPKEQEEEVVSERSQKSCQLKKSLEAAGDCKTSEDGERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGTHAPPPPPRRVAVPVLVRDGKPCVTPSAQTYGSPYGVGAGAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSGSYGCAYPTGGGGGGGGTASAATTAMQPACSATGGGSFVNVSNLGGFGSGGGAQPLHQGAAAGSACTQGTLQGIRAW"

     misc_feature    552..623
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="propagated from UniProtKB/Swiss-Prot (P97334.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    612..782
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    783..842
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="propagated from UniProtKB/Swiss-Prot (P97334.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            526..2112
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2088..2093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="hexamer: AATAAA"
     polyA_site      2112
                     /gene="Nkx2-3"
                     /gene_synonym="Nkx-2.3; nkx2-C; Nkx2.3; tinman"
                     /note="major polyA site"
ORIGIN      

caaaacccagacccccaggtcccggccaatggaggggatttagactggaccgcgtctgtcaaaagctcgactccgcaccaccgcggagtccagaagaagagctggagccaccgcactccctccccgcccccgccgggatttattgagtatttggactggacaattaagtggccctgatgatgttaccaagcccggtcacctccacccctttctcagtcaaagacattttgaatctggagcagcagcggcacttccacggagctcacttgcaggcggaattggagcagcacttccactcggcaccctgcatgctggccacggctgaagggacgcagttttccgatgcaggggaggaggacgaggaagaagagggagagaaactgtcctatttgaactcactagctgctgccgagggccatggagattcgggtctctgtcctcagagctatgtccatacagttctccgagacgcttgcagcgggcccaaggaacaagaagaggaggttgtgagcgaacggagccaaaaaagctgtcagttgaagaagtctctggaagcggcgggagactgtaagacgagcgaggacggcgagaggccgaagccgcggagccgccggaagccccgggtgctcttctcgcaagctcaggtctttgagctggagcgcaggttcaagcagcagcggtacctgtcggcgcccgagcgcgagcatctcgccagcagcctgaagctcacgtccacgcaggtgaaaatctggttccagaatcgcaggtacaagtgcaagagacagcggcaggataagtccctggagctggggacgcacgcgccgccgccgccaccccgccgcgtggcagtgccggtgctcgtgcgggacggcaagccgtgcgtcacgcccagcgcacaaacctacggctcgccctacggcgtgggcgccggcgcctactcctacaacagcttccccgcctacggctacgggaactcggccgccgcagccgctgcagccgccgcagccgcagcagcagcggcggcttacagcggcagctacggctgcgcctatccgaccggtggcggcggtggtggtggcggcacggcctccgcggcgaccaccgccatgcaacccgcctgcagcgccaccggcggtggatcctttgtgaacgtgagcaacctgggaggcttcggcagcggcggcggcgcgcaacccttgcatcaaggtgctgcagccgggtccgcgtgcacgcaggggactttgcagggcatcagggcttggtaaggcctgggcgggacacgcggcgggcgtcctactgcacgctgggcaccgcgggaatgagacacgagaaaggacagacccaagggccaggtcccctcgttaaaataaaaatacagacgtatcgctccttccaaggggccatggtcgcagctcactccaggcctggggcatggaactcagcggagaaaggatgccctggtccagtcctcaagactgagacagaaacaccggccaggcgccagggaagaggtggcctcccatcctgactctgcggagagtgcgggaggctgggactccggctgtcgcttgctctccggaggaggaggagggcttttctcttcctgctttcccttggccttctccgagtgtggtccgggaaccggaccgaacaaggggggaggggggagaaagaaagaaagaaagaaaaagaacaatttaaagaaaaagaaaggtagttggagagagaacgtgaaggagaggaaaatggggtactagcttgagaaattccaccgatccgcagccccttttgcttgcccggagcgccacaacgaagtggatttttccttttccaactgtgtcccttccaagacagactccgcccggatccctagattgtcaggggactgttcttggagaccaccaccgcagtgagatcgaaagttgggggaagggaggcagctgagcaaatccaagacctgtccgcccaacctaggttgtcgccaggttggtttcctttctgttttgtattctgtattccgcacattatctctctataactatatccacacgccgtgtacacagccgctgtcacacactacaggagtcaataaagaaggtgcaatatttctgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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