LOCUS       NM_007628               1633 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Mus musculus cyclin A1 (Ccna1), transcript variant 2, mRNA.
ACCESSION   NM_007628
VERSION     NM_007628.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1633)
  AUTHORS   Du,X., Zang,C. and Wang,Q.
  TITLE     Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming
            growth factor-beta (TGF-beta) pathway in osteoblasts
  JOURNAL   BMC Musculoskelet Disord 25 (1), 206 (2024)
   PUBMED   38454404
  REMARK    GeneRIF: Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing
            transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1633)
  AUTHORS   Chong,D., Gu,Y., Zhang,T., Xu,Y., Bu,D., Chen,Z., Xu,N., Li,L.,
            Zhu,X., Wang,H., Li,Y., Zheng,F., Wang,D., Li,P., Xu,L., Hu,Z. and
            Li,C.
  TITLE     Neonatal ketone body elevation regulates postnatal heart
            development by promoting cardiomyocyte mitochondrial maturation and
            metabolic reprogramming
  JOURNAL   Cell Discov 8 (1), 106 (2022)
   PUBMED   36220812
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1633)
  AUTHORS   Gindi,N., Grossman,H., Bar-Joseph,H., Miller,I., Nemerovsky,L.,
            Hadas,R., Nevo,N., Galiani,D., Dekel,N. and Shalgi,R.
  TITLE     Fyn and argonaute 2 participate in maternal-mRNA degradation during
            mouse oocyte maturation
  JOURNAL   Cell Cycle 21 (8), 792-804 (2022)
   PUBMED   35104175
REFERENCE   4  (bases 1 to 1633)
  AUTHORS   Ciemerych,M.A. and Sicinski,P.
  TITLE     Cell cycle in mouse development
  JOURNAL   Oncogene 24 (17), 2877-2898 (2005)
   PUBMED   15838522
  REMARK    Review article
REFERENCE   5  (bases 1 to 1633)
  AUTHORS   Wolgemuth,D.J., Lele,K.M., Jobanputra,V. and Salazar,G.
  TITLE     The A-type cyclins and the meiotic cell cycle in mammalian male
            germ cells
  JOURNAL   Int J Androl 27 (4), 192-199 (2004)
   PUBMED   15271198
  REMARK    Review article
REFERENCE   6  (bases 1 to 1633)
  AUTHORS   Winston,N.
  TITLE     Regulation of early embryo development: functional redundancy
            between cyclin subtypes
  JOURNAL   Reprod Fertil Dev 13 (1), 59-67 (2001)
   PUBMED   11545166
  REMARK    Review article
REFERENCE   7  (bases 1 to 1633)
  AUTHORS   Zeichner-David,M., Vo,H., Tan,H., Diekwisch,T., Berman,B.,
            Thiemann,F., Alcocer,M.D., Hsu,P., Wang,T., Eyna,J., Caton,J.,
            Slavkin,H.C. and MacDougall,M.
  TITLE     Timing of the expression of enamel gene products during mouse tooth
            development
  JOURNAL   Int J Dev Biol 41 (1), 27-38 (1997)
   PUBMED   9074935
REFERENCE   8  (bases 1 to 1633)
  AUTHORS   Fromm,L. and Overbeek,P.A.
  TITLE     Regulation of cyclin and cyclin-dependent kinase gene expression
            during lens differentiation requires the retinoblastoma protein
  JOURNAL   Oncogene 12 (1), 69-75 (1996)
   PUBMED   8552401
REFERENCE   9  (bases 1 to 1633)
  AUTHORS   Sweeney,C., Murphy,M., Kubelka,M., Ravnik,S.E., Hawkins,C.F.,
            Wolgemuth,D.J. and Carrington,M.
  TITLE     A distinct cyclin A is expressed in germ cells in the mouse
  JOURNAL   Development 122 (1), 53-64 (1996)
   PUBMED   8565853
REFERENCE   10 (bases 1 to 1633)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127334.3.
            
            On Mar 11, 2024 this sequence version replaced NM_007628.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X84311.1, SRR7345562.535556.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC127334.3         119590-119747       c
            159-344             AC127334.3         118958-119143       c
            345-591             AC127334.3         115474-115720       c
            592-716             AC127334.3         115171-115295       c
            717-940             AC127334.3         114303-114526       c
            941-1145            AC127334.3         113033-113237       c
            1146-1259           AC127334.3         111834-111947       c
            1260-1393           AC127334.3         110592-110725       c
            1394-1633           AC127334.3         110094-110333       c
FEATURES             Location/Qualifiers
     source          1..1633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 26.52 cM"
     gene            1..1633
                     /gene="Ccna1"
                     /note="cyclin A1"
                     /db_xref="GeneID:12427"
                     /db_xref="MGI:MGI:108042"
     exon            1..158
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            159..344
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    174..176
                     /gene="Ccna1"
                     /note="upstream in-frame stop codon"
     CDS             180..1445
                     /gene="Ccna1"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="cyclin-A1 isoform 1"
                     /protein_id="NP_031654.2"
                     /db_xref="CCDS:CCDS17356.1"
                     /db_xref="GeneID:12427"
                     /db_xref="MGI:MGI:108042"
                     /translation="

MHRQSSKSGVALPPVGQGPDACQMLSRAQLGQDPPQRTVLGVLTENEQYRRTCGQEITAIRCFSGSENVFPAAGKKVLSDHGVNEPAKRGFDIYMDDPEQGDRDTCSGKEGIIFEDVYEVDTSMLKSDLHFLLDFNTVSPMLVDPTTHAQSEEATDFGSDVINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPCLSELHKACLSIPHRPQQAIREKYKASKYLHVSLMEPPVVLPLQ"

     misc_feature    180..242
                     /gene="Ccna1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61456.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    447..611
                     /gene="Ccna1"
                     /note="Cyclin-A N-terminal APC/C binding region; Region:
                     Cyclin_N2; pfam16500"
                     /db_xref="CDD:465146"
     misc_feature    573..1061
                     /gene="Ccna1"
                     /note="first cyclin box found in cyclin-A1 (CCNA1);
                     Region: CYCLIN_CCNA1_rpt1; cd20560"
                     /db_xref="CDD:410263"
     misc_feature    order(669..671,675..683,687..692,699..701,828..830,
                     933..935,942..956,966..971,1008..1013,1020..1022,
                     1029..1034,1041..1046,1053..1061)
                     /gene="Ccna1"
                     /note="putative CDK interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410263"
     misc_feature    1071..1439
                     /gene="Ccna1"
                     /note="second cyclin box found in cyclin-A1 (CCNA1) and
                     similar proteins; Region: CYCLIN_CCNA1_rpt2; cd20563"
                     /db_xref="CDD:410266"
     misc_feature    order(1080..1085,1092..1094)
                     /gene="Ccna1"
                     /note="putative CDK interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410266"
     exon            345..591
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..716
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..940
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1145
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1259
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1393
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1633
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1608..1613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccna1"
                     /note="hexamer: AATAAA"
     polyA_site      1633
                     /gene="Ccna1"
                     /note="major polyA site"
ORIGIN      

agtggcgagcgcactagccgaggctgctggaaccggccccctggaatctctcctctccgggtcccctccctccgcgcacggccccgcccgcccggccccggccggggtgcgcttgctaatcgcccagacagagaagaacctgagaagcagggcctgctcaggctgtggcttactaggcaatgcatcgccagagctccaagagtggagtcgctctgcctccagtgggccaaggtcctgatgcttgtcaaatgctcagcagagctcagcttggccaggatcccccacagagaaccgtgctaggggtgttgactgaaaatgagcagtacaggaggacctgtggccaggagatcacagcaatcagatgtttttctggatcagaaaatgtcttccctgcggctggaaagaaagtgctctctgaccatggggtcaatgaaccagccaaacgtgggtttgatatctatatggatgatcctgaacagggggacagagatacctgctcggggaaagagggcatcatatttgaggatgtgtatgaagtcgacaccagcatgctcaagtcagatctccacttcctgctggatttcaacacagtttccccaatgctggttgaccccaccacccatgcccagtcagaggaagcaacggattttggttcagatgtgattaacgtaacggagtatgcagaggagattcatcgctaccttcgagaagctgaagtaagacacagacccaaggctcactacatgaggaagcagccggacatcacggagggcatgcgcgccatcctggtggactggctggtggaggttggggaagaatataaacttcgcacagagaccctgtacttggctgtcaacttcctggacaggtttctctcctgcatgtctgttctgagagggaaattgcagcttgtcgggacagcagctattctcctggcttcgaaatatgaagagatatatccgcccgacgtggatgagtttgtctacatcaccgacgatacgtacacaaagcgacagctactgaggatggagcatctgctactcaaagtcctggcatttgatctgaccgttccaaccaccaaccaattcctccttcagtacctaaggcgtcaaggagtgtgcatcaggactgagaatttggccaagtatgttgcagaactgagccttctggaagctgacccattcttgaagtatcttccttccttggttgctgcagcagcttactgcctggcaaactatattgtgaacagacacttctggccagaaacacttgctgcatttacgggctattcattaaatgagattgtgccttgcctgagtgagctgcataaagcatgcctcagtatcccccatcgaccgcagcaagcaatcagggagaagtacaaggcttcgaagtacctgcacgtgtccctcatggagccgcctgtagttcttcccctgcagtgaatggcaaagctcattggccacatcagcaggcttgctctgaggtttctgcgagtggggccaactaacgtcagttgtacataacaccttcaacatgagaatgttaggttctcttagatttcagtagtttataatttatatagatatagacaggtattttaaaagaataaacaacttgctgtttggctgtg

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