LOCUS       NM_001418965             795 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus claudin domain containing 2 (Cldnd2), transcript
            variant 2, mRNA.
ACCESSION   NM_001418965 XM_017312350
VERSION     NM_001418965.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 795)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149091.3 and AC154108.3.
            
            On Mar 24, 2023 this sequence version replaced XM_017312350.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.291365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC149091.3         240652-240709
            59-163              AC154108.3         203412-203516       c
            164-345             AC154108.3         203088-203269       c
            346-486             AC154108.3         202596-202736       c
            487-577             AC154108.3         201961-202051       c
            578-795             AC154108.3         201468-201685       c
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.25 cM"
     gene            1..795
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /note="claudin domain containing 2"
                     /db_xref="GeneID:74276"
                     /db_xref="MGI:MGI:1921526"
     exon            1..58
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            59..163
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    153..155
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /note="upstream in-frame stop codon"
     exon            164..345
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..779
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     claudin domain-containing protein 2"
                     /codon_start=1
                     /product="claudin domain-containing protein 2 isoform 2"
                     /protein_id="NP_001405894.1"
                     /db_xref="GeneID:74276"
                     /db_xref="MGI:MGI:1921526"
                     /translation="

MGVKKSLQTGGNLLNLLSSILTVLSTTTNYWTRQQGGHSGLWQECTHGKCSNIPCQNTVAVSAACMVLAATFSIVALGIGIRIQCREAESRRSQNTIVLLFLSGLLLLIALAVYTSKNAWKPEVFFSWSYFFGWLLLSACRHDLAEHRSHQRIPGMPMNAACLGQNKGMAFSLAPACFSAERRDRSLETTETRIKWLVES"

     misc_feature    213..272
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D9H2.1);
                     transmembrane region"
     misc_feature    243..596
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    357..419
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D9H2.1);
                     transmembrane region"
     misc_feature    462..524
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D9H2.1);
                     transmembrane region"
     exon            346..486
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            487..577
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            578..795
                     /gene="Cldnd2"
                     /gene_synonym="1700071E18Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agagaaccatcctcccttcccccaaccccgcgggctctttgtcgcaggggaccaggctgctctcacactgtagtctgcctggcccagaactcattacattactcatggcctgcccttgggcttgtgatgtcttgcctcagcctcactgaggctaggatcccagctgcctccttggcatgggggtgaagaagagccttcagactggagggaatttacttaatctcttgagcagcatcctcacagtactgtctactaccaccaactactggacccgacagcaaggggggcacagtggcctatggcaggagtgtacccatggcaaatgctccaacatcccctgccagaacaccgtggcagtgtccgcagcgtgcatggtgttggcagcaaccttcagtattgtagctttggggatcgggataaggattcagtgtcgagaggcagagtcacgacgtagccagaataccattgtcttacttttcctcagcgggttgctgctgctgattgccttggccgtatacacttcaaagaatgcctggaagccagaagtcttcttctcctggtcctactttttcggatggcttctgctttctgcttgccgacatgatcttgcagagcaccgaagccatcagcggattcccggtatgcctatgaatgcggcctgcctggggcagaataaaggaatggcttttagcctcgcccctgcgtgcttttctgcggaacgtagagacagaagcttggagactacagagacacggataaagtggcttgtagagagttaaggaggtcagaaggaat

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