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Previous release (v1)
2025-01-31 08:06:04, GGRNA.v2 : RefSeq release 227 (Nov, 2024)
LOCUS NM_001401199 4494 bp mRNA linear ROD 20-OCT-2024
DEFINITION Mus musculus myotubularin related protein 6 (Mtmr6), transcript
variant 3, mRNA.
ACCESSION NM_001401199
VERSION NM_001401199.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 4494)
AUTHORS Bedogni,F. and Hevner,R.F.
TITLE Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
Intermediate Progenitors Implicated in Axon Development
JOURNAL Front Mol Neurosci 14, 686034 (2021)
PUBMED 34321999
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 4494)
AUTHORS Maekawa,M., Terasaka,S., Mochizuki,Y., Kawai,K., Ikeda,Y.,
Araki,N., Skolnik,E.Y., Taguchi,T. and Arai,H.
TITLE Sequential breakdown of 3-phosphorylated phosphoinositides is
essential for the completion of macropinocytosis
JOURNAL Proc Natl Acad Sci U S A 111 (11), E978-E987 (2014)
PUBMED 24591580
REFERENCE 3 (bases 1 to 4494)
AUTHORS Mochizuki,Y., Ohashi,R., Kawamura,T., Iwanari,H., Kodama,T.,
Naito,M. and Hamakubo,T.
TITLE Phosphatidylinositol 3-phosphatase myotubularin-related protein 6
(MTMR6) is regulated by small GTPase Rab1B in the early secretory
and autophagic pathways
JOURNAL J Biol Chem 288 (2), 1009-1021 (2013)
PUBMED 23188820
REFERENCE 4 (bases 1 to 4494)
AUTHORS Mochizuki,Y. and Majerus,P.W.
TITLE Characterization of myotubularin-related protein 7 and its binding
partner, myotubularin-related protein 9
JOURNAL Proc Natl Acad Sci U S A 100 (17), 9768-9773 (2003)
PUBMED 12890864
REFERENCE 5 (bases 1 to 4494)
AUTHORS Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
TITLE Construction of long-transcript enriched cDNA libraries from
submicrogram amounts of total RNAs by a universal PCR amplification
method
JOURNAL Genome Res 11 (9), 1553-1558 (2001)
PUBMED 11544199
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC166113.3.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
CDS exon combination :: SRR1660813.184543.1 [ECO:0000331]
RNAseq introns :: single sample supports all introns
SAMN01164132 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-62 AC166113.3 43789-43850
63-206 AC166113.3 45783-45926
207-527 AC166113.3 54402-54722
528-623 AC166113.3 55968-56063
624-814 AC166113.3 62656-62846
815-931 AC166113.3 69426-69542
932-1094 AC166113.3 72380-72542
1095-1252 AC166113.3 74234-74391
1253-1381 AC166113.3 77214-77342
1382-1516 AC166113.3 81840-81974
1517-1649 AC166113.3 84291-84423
1650-1759 AC166113.3 85215-85324
1760-1885 AC166113.3 85681-85806
1886-1935 AC166113.3 88417-88466
1936-2136 AC166113.3 88871-89071
2137-2268 AC166113.3 90360-90491
2269-2395 AC166113.3 91212-91338
2396-4494 AC166113.3 92570-94668
FEATURES Location/Qualifiers
source 1..4494
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="14"
/map="14"
gene 1..4494
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/note="myotubularin related protein 6"
/db_xref="GeneID:219135"
/db_xref="MGI:MGI:2145637"
exon 1..62
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 63..206
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 207..527
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 528..623
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 624..814
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
misc_feature 776..778
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/note="upstream in-frame stop codon"
CDS 809..2644
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/EC_number="3.1.3.95"
/note="isoform 2 is encoded by transcript variant 3;
phosphatidylinositol-3-phosphate phosphatase;
phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6"
/codon_start=1
/product="phosphatidylinositol-3,5-bisphosphate
3-phosphatase MTMR6 isoform 2"
/protein_id="NP_001388128.1"
/db_xref="GeneID:219135"
/db_xref="MGI:MGI:2145637"
/translation="
MQVEQVKLLDRFSTNNKSLTGTLYLTATHLLFIDAQQKETWILHHHIASVEKLALTTSGCPLVIQCKNFRIVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDTERRNGWQLIDLAAEYERMGVPNANWQLSDANREYKVCETYPRELYVPRTASRPVIVGSSNFRSKGRLPVLSYCRQGTEAAICRCSQPLSGFSARCLEDEHLLQAISKANPGNRYMYVVDTRPKLNAIANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGSKGLSVNDFYSGLESSGWLRHIKAVLDAAIFLAKAIVVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTMKGFMVLIEKDWISFGHKFSERCGHLDGDPREVSPVFTQFLECVWHLTQQFPQAFEFNEAFLLQIHEHIHSCQFGNFLGNCQKEREELRLKEKTYSLWPFLLDDKKKYLNPLYSSKSQRLTVLEPNTASFNFKFWRNMYHQFDRTLHPRQSVLSIIMNMNEQSKQLEEDIKDLEAKIKQCKNGILTKELLHAVHPESPALKTSLCLKEPSLLPVKDTLRAIEGSSPADNRYCDYAEEFSKSEPTVVSLEYGVARMTC"
misc_feature 812..1093
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/note="Pleckstrin homology-like domain; Region: PH-like;
cl17171"
/db_xref="CDD:473070"
misc_feature 1178..2083
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/note="cys-based protein tyrosine phosphatase and
dual-specificity phosphatase superfamily; Region:
PTP_DSP_cys; cl28904"
/db_xref="CDD:475123"
exon 815..931
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 932..1094
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 1095..1252
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 1253..1381
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 1382..1516
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 1517..1649
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 1650..1759
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 1760..1885
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 1886..1935
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 1936..2136
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 2137..2268
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 2269..2395
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
exon 2396..4494
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/inference="alignment:Splign:2.1.0"
regulatory 4476..4481
/regulatory_class="polyA_signal_sequence"
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/note="hexamer: ATTAAA"
polyA_site 4494
/gene="Mtmr6"
/gene_synonym="4022440C11Rik; Gm38641"
/note="major polyA site"
ORIGIN
gccgcgcagggaaccctgggatcggagtggaagcggtactcgtgtgaggccgggcggatgagcatgtggtgttgagaggtgctacaatttacagagtgtggaaagttaactgaagaggggactccatctatacacttctggagaagccccctccatgctgagataagatttcatatgcagctgttttgtactcctaacccactcctctccaggttgcctcccaggcttgaacccggacatgtgagccgctagccggctcgcaacaatttggcatcccacgcggggcctgggaaaggcagaagatactggaagaaacactgctggtttagagctccatggaagaataaaagaattaaagaaaatttgtaccggggcacgaagcaacgggtaaaaggttgctaagggtgtggtactaagctggaacagcgtgctgacccgtgcgctggattcgcttaggttcagcagtgatatcagaatctaggaatgcagcaggcagtcggccgcagctttcagaagctgctttttagtctcactatgtggaacagcatgctctgaaatttacaggcaacaacttgcctctgtctctgaagtgctgggattaaagtcatgccccagcatacaagctttactattagacaacatgggcttcctctctgcgtgcttcctccaggctccatcatctcccaaccacgcctccactgtttccttactcctcggtggttccacctgcccagccgaattttctctgggttgatactgtcagtactactgcacttaaaggcctgtttgtgttccttcatcagataaaatgcaggttgaacaagtaaagttacttgaccggtttagtaccaacaacaagtcactgacaggaacactgtatcttacggccacacacctattatttattgacgctcagcaaaaagaaacctggatactacaccaccatattgcctctgtggagaaacttgctctgaccacttctggatgcccacttgtgattcagtgcaagaacttcaggattgtgcatttcattgttcccagggaaagagattgccacgatatttataactctctcctgcagctatcaaaacaagcaaaatatgaagatctctatgccttctcttataatcccaagcaaaatgatactgaacgacggaatggttggcagcttattgaccttgctgcggagtatgagaggatgggagtgcccaatgcaaactggcaactgtcggatgccaaccgagagtacaaggtctgtgagacttatcccagagagctgtatgttcctcggacagctagccggccggtgatcgtgggcagttccaacttccggagcaagggcagacttccggtcctatcctactgccggcagggcactgaggctgccatttgtcgatgtagtcagccattgtcaggcttcagtgccaggtgcctagaggatgagcatttgcttcaagccattagtaaagccaacccaggaaaccgctacatgtatgttgtggataccaggcccaagctcaatgcaatagctaacagagcagctggaaaaggttatgaaaatgaagacaactattctaatattagatttcagttcgttggaatagaaaatattcatgtcatgagatccagccttcagaaattactggaagtgaatggtagcaaggggctttctgtcaatgatttctactctggtttggaaagttcaggatggcttcgccatatcaaggctgttttggatgctgcaatcttcttagccaaagcaatagtggttgaaaatgcaagtgtgttggtccactgttccgatgggtgggacaggacctcccaagtgtgctccctcggctcactgttgttggattcctactacaggacaatgaaaggattcatggttttaatagaaaaagattggatatcatttgggcataaattttcagagaggtgtggccatttggatggagacccgagggaggtctcaccagtgttcactcagttcttggagtgtgtctggcacctgactcagcagttcccacaagccttcgagttcaacgaagcgtttcttcttcagatccatgagcacattcattcatgccaatttgggaacttccttggcaactgtcagaaggagagagaggaactcaggttaaaggagaaaacttactccctgtggccttttcttttggatgacaaaaagaagtacttaaatcctctctacagttccaaatctcagagactgacagtcttggagccaaatacagcctctttcaattttaagttttggagaaacatgtaccaccagtttgatcggacgctccatcctcggcagtctgtgctgagcataattatgaatatgaatgagcaaagcaagcagttagaggaagacattaaagacctcgaggctaaaattaagcaatgcaaaaatggcatcctaacgaaggagttgctgcatgctgtccaccctgaatcacctgccctgaaaacctcgctgtgtctcaaagagccgagtctgcttcccgtgaaggacacactccgagctatagagggcagcagcccagcagataatcgctactgtgactatgccgaggaattttctaagtcggagcctaccgtggtcagcttggagtacggggtggccagaatgacttgttagcctccttccgtgatccctggatgactgtagtgtaagaaatgtatagttgtgaggatggtctgtacacatgggcaggaggggttgttgagtgactttggggcttagcagtaagtgagaaagtaggtagctgagaaaaggatcatagcaactcttgagaggagtgagtcagctaagtgccatttgtaacaagaacatactcatttctgtaggaagtgagtgctagtgtgtgtatgtactggaaaggggttacacaggactggtgagctgacagtctgttgattcagatgttaattccagccacgctcagtagctttcctctaactctgagaaaacagacctgacaacctgaaccctcagtgactgatgtggcatgtgctttcagttctggagctgtgtgactgtggattttgcagtcacaaaaatccaaatatatagtcaaaaatatagtgacgttttaacattaaagtgccatgaaaagtacttatgggacagccttaaagtagactctcagtttattctgtgggttttatagccgaggacaggatgtttgatctctcctttaatcagccttatttcatatgaagaactaactgcactctgattacttgggggccgcacactgcagtgctccaccatggaaagttgtagacatactctgctagtttgtaattagccagctccacccgtatttaaaatcagtgttaccgaaggctttgttctcgttgtcatttgttccaagctgcagctgacagttcattattcacagcttagaggactcatttcttaggctagtataagcacatttggcatttactttcggcttactgcagtctattaattcttactctgtggttggctttaatcctttgataactgtacatttaaagtggcaaagctctaaagcgttctgagtactaaatacatttttaacttgactgtagctgcctataaactttcaggtaaaggaaaaagggaagtgcgggtagtggagattttgcttggttacgaattctaaagcaatcatttttgtgtggagcatatttccttactcttaatataggaggggcagagaagggagcactgggggagccagctaatgtccaacagaagcagctttgacgcaggaaaaggtttattttgctttataggctcattgttattctgtgcactggggcatacatatcttttctaaaaaatcacttacaactgtcagtattaccagctggctctcaaagtttaatatcattgatggtgtgtgaggtacagttcaggggcactacaaaatctgtgtacattgtcttatatacctcctgaccacacctatatctgtagtatttcttgtgttagttttgaacatatgtatcttttttttttttttgggaaaaaaaaggaaagctttatcgtatatgattttatctagtccttatttttccaattcacttctgtaagaccttatgtaataaaaacactgcattttaaaaagtaacagaaatatactaaaaattacaatgtataatgaacagtgtttagacattgagaaaggaaacttaatctctgtgtccacaacaggagggttttgtgccttggttccagtcaagttgtggttttagacttctgtggcagacttcctagtcatcttctgggttccttatgctaattttcaacttcacatgtatatatgtgtttacatgctcacacagaaaacatcctgagtgacgtacaggacatacgttggcaaaagtctgtgtaaatgtctcataaaattagatttatgttcattgtgttttgggatgtatagcatgtaaattatttcatgtattatttaaaggcaattaaatgttcatgcttta
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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