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Previous release (v1)
2026-06-12 20:53:50, GGRNA.v2 : RefSeq release 233 (Jan, 2026)
LOCUS NM_001252261 1307 bp mRNA linear ROD 07-JAN-2026
DEFINITION Mus musculus nucleophosmin 1 (Npm1), transcript variant 3, mRNA.
ACCESSION NM_001252261
VERSION NM_001252261.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 1307)
AUTHORS Datar,G.K., Khabusheva,E., Anand,A., Beale,J., Sadek,M., Chen,C.W.,
Potolitsyna,E., Alcantara-Contessoto,N., Liu,G., De La Fuente,J.,
Dollinger,C., Guzman,A., Martell,A., Wohlan,K., Maiti,A.,
Short,N.J., Yi,S.S., Andresen,V., Gjertsen,B.T., Falini,B.,
Rau,R.E., Brunetti,L., Sahni,N., Goodell,M.A. and Riback,J.A.
TITLE Disparate leukemia mutations converge on nuclear phase-separated
condensates
JOURNAL Cell 188 (25), 7118-7136 (2025)
PUBMED 41192422
REFERENCE 2 (bases 1 to 1307)
AUTHORS Miluzio,A., Scagliola,A., Ferrari,I., Yilmaz,H., D'Andrea,G.,
Cassina,L., Oliveto,S., Ricciardi,S., Boletta,A. and Biffo,S.
TITLE Recycling of ribosomes at stop codons drives the rate of
translation and the transition from proliferation to RESt
JOURNAL Mol Cell 85 (23), 4410-4425 (2025)
PUBMED 41290002
REFERENCE 3 (bases 1 to 1307)
AUTHORS Li,W., Zhang,J. and Liu,Q.
TITLE Kin17 promotes rDNA transcription, ribosomal biogenesis, and
cortical lamination
JOURNAL EMBO Rep 26 (17), 4283-4311 (2025)
PUBMED 40676207
REFERENCE 4 (bases 1 to 1307)
AUTHORS Wu,M., Wu,X., Sun,H., Wang,W., Zhang,L., Liu,X., Zhang,Y.,
Zhang,X., Liu,J., Shen,B. and Zhou,T.
TITLE VIRMA-mediated m6A modification regulates forebrain formation
through modulating ribosome biogenesis
JOURNAL Sci Adv 11 (26), eadq9643 (2025)
PUBMED 40577453
REFERENCE 5 (bases 1 to 1307)
AUTHORS Sakamoto,T., Leca,J., Zhang,X., Meydan,C., Foox,J.,
Ramachandran,P., Hendrikse,L.D., Zhou,W., Berger,T., Fortin,J.,
Chan,S.M., Chiang,M.F., Inoue,S., Li,W.Y., Chu,M.F., Duncan,G.S.,
Wakeham,A., Lemonnier,F., Tobin,C., Mcwilliam,R., Colonna,I.,
Bontoux,C., Jafari,S.M., Bowman,R.L., Nicolay,B., Ronseaux,S.,
Narayanaswamy,R., Levine,R.L., Melnick,A.M., Mason,C.E.,
Minden,M.D. and Mak,T.W.
TITLE Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct
myeloid diseases and molecular outcomes
JOURNAL Proc Natl Acad Sci U S A 122 (20), e2415779122 (2025)
PUBMED 40377995
REFERENCE 6 (bases 1 to 1307)
AUTHORS Sowden,J.C., Morrison,K., Putt,W., Beddington,R. and Edwards,Y.H.
TITLE The identification of novel sequences expressed in the mouse
notochord
JOURNAL Mamm Genome 8 (1), 42-44 (1997)
PUBMED 9021147
REFERENCE 7 (bases 1 to 1307)
AUTHORS Inouye,C.J. and Seto,E.
TITLE Relief of YY1-induced transcriptional repression by protein-protein
interaction with the nucleolar phosphoprotein B23
JOURNAL J Biol Chem 269 (9), 6506-6510 (1994)
PUBMED 8120001
REFERENCE 8 (bases 1 to 1307)
AUTHORS Van den Eynde,B., Lethe,B., Van Pel,A., De Plaen,E. and Boon,T.
TITLE The gene coding for a major tumor rejection antigen of tumor P815
is identical to the normal gene of syngeneic DBA/2 mice
JOURNAL J Exp Med 173 (6), 1373-1384 (1991)
PUBMED 1903428
REFERENCE 9 (bases 1 to 1307)
AUTHORS Biggiogera,M., Burki,K., Kaufmann,S.H., Shaper,J.H., Gas,N.,
Amalric,F. and Fakan,S.
TITLE Nucleolar distribution of proteins B23 and nucleolin in mouse
preimplantation embryos as visualized by immunoelectron microscopy
JOURNAL Development 110 (4), 1263-1270 (1990)
PUBMED 2100262
REFERENCE 10 (bases 1 to 1307)
AUTHORS Schmidt-Zachmann,M.S. and Franke,W.W.
TITLE DNA cloning and amino acid sequence determination of a major
constituent protein of mammalian nucleoli. Correspondence of the
nucleoplasmin-related protein NO38 to mammalian protein B23
JOURNAL Chromosoma 96 (6), 417-426 (1988)
PUBMED 3219912
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CA540276.1 and BC090843.1.
Transcript Variant: This variant (3) lacks two exons but has an
alternate 3' terminal exon, compared to variant 1. The resulting
isoform (3) is shorter and has a distinct C-terminus, compared to
isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC090843.1, AK005420.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-249 CA540276.1 1-249
250-1307 BC090843.1 103-1160
FEATURES Location/Qualifiers
source 1..1307
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="11"
/map="11 19.21 cM"
gene 1..1307
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="nucleophosmin 1"
/db_xref="GeneID:18148"
/db_xref="MGI:MGI:106184"
exon 1..285
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/inference="alignment:Splign:2.1.0"
CDS 228..1001
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="isoform 3 is encoded by transcript variant 3;
numatrin; nucleolar phosphoprotein B23; nucleolar protein
NO38"
/codon_start=1
/product="nucleophosmin isoform 3"
/protein_id="NP_001239190.1"
/db_xref="CCDS:CCDS56765.1"
/db_xref="GeneID:18148"
/db_xref="MGI:MGI:106184"
/translation="
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKKSVRDTPAKNAQKSNQNGKDLKPSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKAH"
misc_feature 228..782
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="propagated from UniProtKB/Swiss-Prot (Q61937.1);
Region: Required for interaction with SENP3.
/evidence=ECO:0000250"
misc_feature 228..578
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="propagated from UniProtKB/Swiss-Prot (Q61937.1);
Region: Necessary for interaction with APEX1.
/evidence=ECO:0000250"
misc_feature 228..230
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="N-acetylmethionine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); acetylation site"
misc_feature 237..239
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphoserine, by PLK1 and PLK2.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 255..257
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 279..578
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Nucleoplasmin/nucleophosmin domain; Region:
Nucleoplasmin; pfam03066"
/db_xref="CDD:460792"
misc_feature 321..323
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); acetylation site"
misc_feature 354..356
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 390..392
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Interaction between pentamers.
/evidence=ECO:0000250; propagated from
UniProtKB/Swiss-Prot (Q61937.1); other site"
misc_feature 426..428
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphotyrosine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 435..437
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:19144319,
ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 450..452
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 465..467
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Interaction between pentamers.
/evidence=ECO:0000250; propagated from
UniProtKB/Swiss-Prot (Q61937.1); other site"
misc_feature 510..512
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 600..602
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:16452087,
ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:18630941,
ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:19144319,
ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 639..971
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="propagated from UniProtKB/Swiss-Prot (Q61937.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 642..644
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 675..677
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); acetylation site"
misc_feature 681..698
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="propagated from UniProtKB/Swiss-Prot (Q61937.1);
Region: Nuclear localization signal.
/evidence=ECO:0000255"
misc_feature 687..689
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); acetylation site"
misc_feature 783..869
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="propagated from UniProtKB/Swiss-Prot (Q61937.1);
Region: Interaction with NOP2.
/evidence=ECO:0000250|UniProtKB:P06748"
misc_feature 795..815
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="propagated from UniProtKB/Swiss-Prot (Q61937.1);
Region: Nuclear localization signal.
/evidence=ECO:0000255"
misc_feature 819..821
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphothreonine, by CDK1 and CDK2.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 858..860
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); acetylation site"
misc_feature 876..878
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphothreonine, by CDK1. /evidence=ECO:0000250;
propagated from UniProtKB/Swiss-Prot (Q61937.1);
phosphorylation site"
misc_feature 900..902
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 906..908
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); acetylation site"
misc_feature 909..911
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); acetylation site"
misc_feature 921..923
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphothreonine, by CDK1.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 930..932
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphothreonine, by CDK1.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 945..947
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 948..950
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 969..971
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); acetylation site"
misc_feature 981..983
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P06748; propagated from
UniProtKB/Swiss-Prot (Q61937.1); phosphorylation site"
misc_feature 990..992
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0007744|PubMed:23806337; propagated from
UniProtKB/Swiss-Prot (Q61937.1); acetylation site"
exon 286..365
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/inference="alignment:Splign:2.1.0"
exon 366..485
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/inference="alignment:Splign:2.1.0"
exon 486..579
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/inference="alignment:Splign:2.1.0"
exon 580..686
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/inference="alignment:Splign:2.1.0"
exon 687..748
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/inference="alignment:Splign:2.1.0"
exon 749..806
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/inference="alignment:Splign:2.1.0"
exon 807..890
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/inference="alignment:Splign:2.1.0"
exon 891..992
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/inference="alignment:Splign:2.1.0"
exon 993..1288
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/inference="alignment:Splign:2.1.0"
regulatory 1267..1272
/regulatory_class="polyA_signal_sequence"
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="hexamer: AATAAA"
polyA_site 1288
/gene="Npm1"
/gene_synonym="B23; NO38; Npm"
/note="major polyA site"
ORIGIN
ggcgcacgcgcaaaagcgcgactgtgcggggagtgggagggatccagaggaggctcgcggaggcaggactagcgcagatctcgcgagatctcctgcgaccatatatacgtgcggagagcccgcgtcctttccttggcgtgattccgtcctgcgcgtctgttctgtggaacaggaggcagttgttttccgtccggcttctcccacaccgaagtgcgcgcctccacctcatggaagactcgatggatatggacatgagtcctcttaggcctcagaactaccttttcggctgtgaactaaaggctgacaaagactatcactttaaagtggataatgatgaaaatgagcaccagttgtcattaagaacggtcagtttaggagcaggggcaaaagatgagttacacatcgtagaggcagaagcaatgaactatgaaggcagtccaattaaagtaacactggcaactttgaaaatgtctgtacaaccaacagtttccctagggggctttgaaattacaccacctgtggtcttacggttgaagtgtggttcagggcctgtgcacattagtggacagcatctagtagctgtagaggaagatgcagagtctgaagatgaagatgaggaggacgtaaaactcttaggcatgtctggaaagcgatctgctcctggaggtggtaacaaggttccacagaaaaaagtaaaacttgatgaagatgatgaggacgatgatgaggacgatgaggatgatgaggatgatgatgatgatgattttgatgaagaggaaactgaagaaaaggtcccagtgaagaaatctgtacgagataccccagccaaaaatgcacaaaaatcaaaccaaaatggaaaagacttaaaaccatcaacaccgagatcaaagggtcaagagtccttcaaaaaacaggaaaagactcctaaaacaccaaaaggacctagttctgtagaagacattaaggcaaaaatgcaagcaagtatagaaaaagcgcattgaacattcctgggcactactggtaaattaagcccaaagatggggaaagaggaaaaggagaaacaaatatagtaccatcaacaatccagacatctcaatcccctttcctgattggccatccattcccccttgcaggctggaagcaatcttgtttttcctaaagcatttttcttttacttttgtgatgcagaaaactacttctctaccacttgtgcatatgcctcatttctttgaccatgttttaacctttgtatccttagctactctcaataaatttttaaatgaatcaaaaaaaaaaaaaaaaaaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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