LOCUS       NM_001177658            4192 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L15 (Mrpl15),
            transcript variant 1, mRNA.
ACCESSION   NM_001177658
VERSION     NM_001177658.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4192)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   2  (bases 1 to 4192)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 4192)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   4  (bases 1 to 4192)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 4192)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   6  (bases 1 to 4192)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4192)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 4192)
  AUTHORS   O'Brien,T.W., Fiesler,S.E., Denslow,N.D., Thiede,B.,
            Wittmann-Liebold,B., Mougey,E.B., Sylvester,J.E. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins (2). Amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 274 (51), 36043-36051 (1999)
   PUBMED   10593885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102311.10 and AC117576.11.
            
            On May 5, 2023 this sequence version replaced NM_001177658.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068230.1, SRR17784645.234189.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC102311.10        130932-131085
            155-309             AC102311.10        132553-132707
            310-475             AC102311.10        133925-134090
            476-599             AC117576.11        197346-197469       c
            600-4192            AC117576.11        193030-196622       c
FEATURES             Location/Qualifiers
     source          1..4192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.79 cM"
     gene            1..4192
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /note="mitochondrial ribosomal protein L15"
                     /db_xref="GeneID:27395"
                     /db_xref="MGI:MGI:1351639"
     exon            1..154
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..937
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /EC_number="3.6.5.3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 39S ribosomal protein L15, mitochondrial;
                     ribosomal protein, mitochondrial, L7; large ribosomal
                     subunit protein uL15m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL15m isoform 1
                     precursor"
                     /protein_id="NP_001171129.1"
                     /db_xref="CCDS:CCDS48211.1"
                     /db_xref="GeneID:27395"
                     /db_xref="MGI:MGI:1351639"
                     /translation="

MAGTARGCGTSLDLLRSLPRVSLANLKPSPNSRKRERRPRDRRRGRKCGRGHKGERQRGTRPRLGFEGGQTPFYIRIPKYGFNEGHSFRHQYQPLSLRRLQYLIDLGRVDPTQPIDLTQLVNGRGVTIQPLKRDYGVQLVEEGADTFQAKINIEVQLASELAIAAIEKNGGVVTTAFYDPRSLEILCKPIPFFLRGQPIPKRMLPPESLVPYYTDAKNRGYLADPAKFPEARLELAMKFGYVLPDITKDELFRMLSARKDPRQIFFGLAPGWVVNMADKKILKPTDENLLKYYSS"

     transit_peptide 50..109
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
     mat_peptide     110..934
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /product="large ribosomal subunit protein uL15m isoform 1"
     misc_feature    110..250
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPR5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    203..571
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /note="Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A;
                     Region: Ribosomal_L27A; pfam00828"
                     /db_xref="CDD:459951"
     exon            155..309
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /inference="alignment:Splign:2.1.0"
     exon            310..475
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /inference="alignment:Splign:2.1.0"
     exon            476..599
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /inference="alignment:Splign:2.1.0"
     exon            600..4192
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      998..1003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /note="hexamer: ATTAAA"
     polyA_site      1023
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /note="major polyA site"
     regulatory      2948..2953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /note="hexamer: AATAAA"
     polyA_site      2971
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
     polyA_site      3099
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
     regulatory      4169..4174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
                     /note="hexamer: AATAAA"
     polyA_site      4192
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; Rpml7"
ORIGIN      

aacgcggagtctacgccgcttcctgggcgcccttgaagcaccgcgggtcatggctggcacggcgcgcggctgcgggaccagcctggacctgctgcggtccttgccgagagtgagcctggccaacctgaagcccagtcctaactccagaaaacgggaaagacgtccaagagatcggagaagaggtaggaagtgtggcagaggccataaaggagaaaggcagagaggaacccggccaaggctgggctttgagggagggcagactccattttacatacgaatcccaaaatatggatttaatgaaggacatagtttcaggcaccagtatcagcctttgagtctcaggagactacagtatctcattgatttaggtcgagttgatccaactcaacctattgacctaacccagcttgtgaatgggagaggtgtgaccatccagccgcttaagagggattatggagtccagctggttgaagagggtgctgatacttttcaagcaaaaattaatattgaagtgcagctggcttcagaattagccattgctgccattgaaaaaaatggcggtgttgttactacagccttctatgacccaagaagtctagaaattctgtgcaagcctattccattctttctgcggggacaaccaattccgaaaagaatgcttccccctgagtcactggtgccctattacaccgatgcaaaaaaccggggctacctggctgaccctgccaagtttcctgaagcaagacttgaactcgccatgaagtttggctacgtccttcctgatattacgaaagatgaactcttcagaatgctcagcgctcggaaggatccgaggcagattttctttggtcttgctcctggctgggtagtgaatatggcagataagaaaattctaaaacctacagatgagaatcttctcaagtattacagctcctgaactgccttctactaaatcagacttgtgagccagacgggctgcacatggattcttgtgggtattaaagctttgggtctgttaccagccttcactgctcaggtcttttgttctttttccatcttaaatagcagacagcaaaagctgcacgagcgactgagcctttgagggtgtgtgcttgaaaatctgaacagtggcaggctttagaaaggggattaaaaagaaaaaaacctacttaaaattacctttcttttggggggtggggagactgtgttttgatacatggtttctctgtgtagccctggctgtcctggaacttgttctgtagaccaggctggctttgaactcacacagttccgcctgcttctgttgggattcaaggcatgtaccgccactgcccagcctgactaagtagtttaaaacatttctttactgtccatcttttcatggacttttcttacctacattttctgttttgtcagagtgcagggcagagattgattagtaggcctggaagcctttactgttcggggacttaaactgggccctcttggtcttctgttgtttaagacatcagacaagtcctttagctgaagtacagtgtcagtctgcagcaataggaggagagactgtagagtcgctttcctaccatgtctttgcagtttagaggttggacctgtgctgtacatactgagtgacactgccctttggctccagcttctggggggcccctgaatgacacatgcttccttgatctgaggagaactttgaccatagcctgtctgcatagaaatcaatttccttaaatgaacacgtcctgtattgtaactgtatcgggtgtgcacacatcctgtaatgtaactgtatggggtgtgctgtagccctaggaaagctattgccttgccgcctagttgtgcaggaggctttcctttggtactgcagtgtacatttgcaggtctcagagcccctgccttcccaggaagacttcttcatgggaagtgagaggaaattagtcatctgaagggagaacacattgcggccttccatctcagaatgtactttgcgggttcttggagtctcctcccccatcccttcaagcagagtggctacctcacatagaagaactgacagccaaacatgggctttcttcattttggttgtctgtggtggcatacaggtggaaggaaattggcatagagtgataaagggaagaataaaaacaggaaacagatgtctggtgaagtagaatgctggccagtgtttatttggtgacagggactttgtcacaaacagctgtatccgggttgagagactatccctacagctcattctcagccaaaatagcgccttccatggaattcacgtggtccactctagcccttgtgccagtcacaaggcgtggagcgctccagtggaggtggtagcagtttgtatcccttgagactctaccttaaaaagcaataagtcttgagtgtaggtctgtccttcctggaatgtggcctcagctttcggtgtgcacacatcctgtaatgtaactatggggtgtgctgtagcccaaggaaagctattgccttgcctcgtgcaggaggctttggtgaccaaactctaaaaacacttgagttagtgttttaaaacaatttttagtgccaggcatagttagttgtacactactttaatcccagctcccagaaggcagagaggcaggtatatctctgagcttaaggccaacctgctctataaagtgagaccctgtctccaaaagccaaagcaaacagcagacagttctagagttcggagacagatgggcaaagggttgaagtttaaactttaaagcgtttgtgagccacacagaagcttgggcatcagaagactggtcagatacctccaggctcagtggccagccagtttagctgcatggtagctcacaaccatctgttttcccaattccagggcacttgatgcactcttctgacttccatggattttcggcaagatactcaatacacataaaataataaaaaagccattgagaaaagacatctgaccagcatctggcctccatgtgtgcctgcatctggtctccatgtgtgcctgcatctggcctccatgtgtgcctgcatctgcccccacatcccatttctaaagtaagagggaaacttttgttatgatctgagtccctggtctttttttttaattgtaagtctttacaattttctttgggaagtagaaggtccttcttagggtggggagtgtcagacgggaccagtactcgtttcacttagggtggaggagagagctctgatgttagtgtgagtcccatgacggttgtctttcgtgataacttgctgtaggcagaccactacactctagcttgctcgttacatgcttggagctgcacagccatctgggtgaaacacttgagtaggactttaagcaagactagatttgggactttggcatgcaatttattctctgcctcagtttcaccatctgccaaatggagggtaaaataaaaatttggttattataaaatacaaattctcttagggattttactgctataaccagcaccatgaccaaaagccagttgggaaggaagattattttgcttacacgtccgtaacactgttcatcaaggaaggaagccaggataagaactcaaacagggcagcagctcatgtagagaccatggagcatgctgcttactgacttgctcctcatggcttgctcagcctgcttccttataaaacccgagatcaccagcccacagatggcaccacccacaatgggctgggtccttccccattaatcattaagaaaatgccctacaggtttgcctacagctggattgtacagaggcattttcttaattgagattccttcatttcagatgactgtcaagttgacataaaattagaacagttattatgcaagtcgctagtgtttgtaaagcatgtagcacatgcctgtttcgtaggcctctagagttagtgtctcttctgatccttaggtaactgccaccctgtggattctacttccttccctcttaggatttacatatagtctgtaaagcactcttgagtctcactaatgagaagaaaatgcatgatagactttatattgtttttagcaggagctaaaaaatacattttgaagaagcagcatagcagaggcagaaacatagcacccaagtctgaaacaattggcaccagtcttcccttctgcagtttgttcaataaacagaattcctaaatctaa

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