LOCUS       NM_001146318            2548 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus 2',3'-cyclic nucleotide 3' phosphodiesterase (Cnp),
            transcript variant 1, mRNA.
ACCESSION   NM_001146318
VERSION     NM_001146318.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2548)
  AUTHORS   Baudouin,L., Ades,N., Kante,K., Bachelin,C., Hmidan,H., Deboux,C.,
            Panic,R., Ben Messaoud,R., Velut,Y., Hamada,S., Pionneau,C.,
            Duarte,K., Poea-Guyon,S., Barnier,J.V., Nait Oumesmar,B. and
            Bouslama-Oueghlani,L.
  TITLE     Antagonistic actions of PAK1 and NF2/Merlin drive myelin membrane
            expansion in oligodendrocytes
  JOURNAL   Glia 72 (8), 1518-1540 (2024)
   PUBMED   38794866
REFERENCE   2  (bases 1 to 2548)
  AUTHORS   Spate,E., Zhou,B., Sun,T., Kusch,K., Asadollahi,E., Siems,S.B.,
            Depp,C., Werner,H.B., Saher,G., Hirrlinger,J., Mobius,W., Nave,K.A.
            and Goebbels,S.
  TITLE     Downregulated expression of lactate dehydrogenase in adult
            oligodendrocytes and its implication for the transfer of glycolysis
            products to axons
  JOURNAL   Glia 72 (8), 1374-1391 (2024)
   PUBMED   38587131
REFERENCE   3  (bases 1 to 2548)
  AUTHORS   Nagy,N., Hadinger,N., Toth,O., Racz,G.A., Pinter,T., Gal,Z.,
            Urban,M., Gocza,E., Hiripi,L., Acsady,L. and Vertessy,B.G.
  TITLE     Characterization of dUTPase expression in mouse postnatal
            development and adult neurogenesis
  JOURNAL   Sci Rep 14 (1), 13139 (2024)
   PUBMED   38849394
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2548)
  AUTHORS   Liu,X., Xin,D.E., Zhong,X., Zhao,C., Li,Z., Zhang,L., Dourson,A.J.,
            Lee,L., Mishra,S., Bayat,A.E., Nicholson,E., Seibel,W.L., Yan,B.,
            Mason,J., Turner,B.J., Gonsalvez,D.G., Ong,W., Chew,S.Y., Ghosh,B.,
            Yoon,S.O., Xin,M., He,Z., Tchieu,J., Wegner,M., Nave,K.A.,
            Franklin,R.J.M., Dutta,R., Trapp,B.D., Hu,M., Smith,M.A.,
            Jankowski,M.P., Barton,S.K., He,X. and Lu,Q.R.
  TITLE     Small-molecule-induced epigenetic rejuvenation promotes SREBP
            condensation and overcomes barriers to CNS myelin regeneration
  JOURNAL   Cell 187 (10), 2465-2484 (2024)
   PUBMED   38701782
REFERENCE   5  (bases 1 to 2548)
  AUTHORS   Zhang,Y., Song,Z., Wu,R., Kong,X., Zhang,H., Li,S., Gong,X.,
            Gong,S., Cheng,J., Yuan,F., Wu,H., Wang,S. and Yuan,Z.
  TITLE     PRRC2B modulates oligodendrocyte progenitor cell development and
            myelination by stabilizing Sox2 mRNA
  JOURNAL   Cell Rep 43 (3), 113930 (2024)
   PUBMED   38507412
REFERENCE   6  (bases 1 to 2548)
  AUTHORS   Kurihara,T., Monoh,K., Takahashi,Y., Goto,K. and Kondo,H.
  TITLE     2',3'-Cyclic-nucleotide 3'-phosphodiesterase. Complementary DNA and
            gene cloning for mouse enzyme and in situ hybridization of the
            messenger RNA in mouse brain
  JOURNAL   Adv Second Messenger Phosphoprotein Res 25, 101-110 (1992)
   PUBMED   1313252
  REMARK    Review article
REFERENCE   7  (bases 1 to 2548)
  AUTHORS   Rebbe,N.F., Tong,B.D., Finley,E.M. and Hickman,S.
  TITLE     Identification of nucleotide pyrophosphatase/alkaline
            phosphodiesterase I activity associated with the mouse plasma cell
            differentiation antigen PC-1
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5192-5196 (1991)
   PUBMED   1647027
REFERENCE   8  (bases 1 to 2548)
  AUTHORS   Kurihara,T., Monoh,K., Sakimura,K. and Takahashi,Y.
  TITLE     Alternative splicing of mouse brain 2',3'-cyclic-nucleotide
            3'-phosphodiesterase mRNA
  JOURNAL   Biochem Biophys Res Commun 170 (3), 1074-1081 (1990)
   PUBMED   2167669
REFERENCE   9  (bases 1 to 2548)
  AUTHORS   Monoh,K., Kurihara,T., Sakimura,K. and Takahashi,Y.
  TITLE     Structure of mouse 2',3'-cyclic-nucleotide 3'-phosphodiesterase
            gene
  JOURNAL   Biochem Biophys Res Commun 165 (3), 1213-1220 (1989)
   PUBMED   2558653
REFERENCE   10 (bases 1 to 2548)
  AUTHORS   Kurihara,T., Takahashi,Y., Fujita,N., Sato,S. and Miyatake,T.
  TITLE     Developmental expression of 2',3'-cyclic-nucleotide
            3'-phosphodiesterase mRNA in brains of normal and quaking mice
  JOURNAL   Brain Res Mol Brain Res 5 (3), 247-250 (1989)
   PUBMED   2542718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M31810.1, AK087415.1 and BY596086.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (1). This isoform is
            also known as CNP1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140280.1, M31810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1875              M31810.1           367-2241
            1876-2536           AK087415.1         1628-2288
            2537-2548           BY596086.1         484-495
FEATURES             Location/Qualifiers
     source          1..2548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.47 cM"
     gene            1..2548
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /note="2',3'-cyclic nucleotide 3' phosphodiesterase"
                     /db_xref="GeneID:12799"
                     /db_xref="MGI:MGI:88437"
     exon            1..1015
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    304..306
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /note="upstream in-frame stop codon"
     CDS             403..1605
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /EC_number="3.1.4.37"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclic nucleotide phosphodiesterase 1"
                     /codon_start=1
                     /product="2',3'-cyclic-nucleotide 3'-phosphodiesterase
                     isoform 1"
                     /protein_id="NP_001139790.1"
                     /db_xref="GeneID:12799"
                     /db_xref="MGI:MGI:88437"
                     /translation="

MSSSGAKEKPELQFPFLQDEDTVATLHECKTLFILRGLPGSGKSTLARLILEKYHDGTKMVSADAYKIIPGSRADFSEAYKRLDEDLAGYCRRDIRVLVLDDTNHERERLDQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEPKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTGLDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYGKGKPVPIHGSRKGGAMQICTII"

     misc_feature    490..>783
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /note="Predicted kinase [General function prediction
                     only]; Region: COG4639"
                     /db_xref="CDD:443677"
     misc_feature    895..1536
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /note="2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP
                     or CNPase); Region: CNPase; pfam05881"
                     /db_xref="CDD:461769"
     exon            1016..1155
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..2548
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2518..2523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /note="hexamer: AATAAA"
     polyA_site      2537
                     /gene="Cnp"
                     /gene_synonym="Cnp-1; Cnp1; CNPase"
                     /note="major polyA site"
ORIGIN      

aggcacttgctgcccttgcgtgccctgtcaccaaggtgttctgagggggagcagagagtgatccttggagccagagactaagaggttaggtagcttcagaaagattccctctaccttacaacccagctgttgaagatactgaaggatctactgcgaggaagaaaatccaccattcccctccggggaaagcatccaccattcaagggtgctttaagttaggcttggggattcctcaactgacaagcggtccccctctgggagaactcggccagagactagggtgtggtgcttgcgggctggctttgaggagccggggctgacatctcctcctcccttcttacacagaacacaagctttacccgcaaaagccacacattcctgcccaagctcttcttcaggaaaatgtcatcctcaggagcaaaggagaagccagagctgcagttccctttccttcaagatgaggacacggtggctaccctccacgagtgcaagacgctattcatcctgcgcggcctgccgggcagcggcaagtccacactggctcggctcatcctggagaagtaccacgacggcaccaagatggtgtccgctgatgcttacaagatcatccctggctctcgggcagacttctccgaggcgtacaagcgtctagacgaggacctggctggctactgccgccgggacatcagggttcttgtgcttgatgataccaaccacgagcgggagcggctggatcagctttttgaaatggcagaccagtatcagtaccaggtggtgctggtggagcccaagacagcgtggcgactagactgtgcccagctcaaggagaagaaccaatggcagctgtcggccgatgacctgaagaagctgaagcccgggctggagaaggactttctgccactctactttggctggttcctgaccaaaaagagttctgagaccctccgaaaagctggccaggtctttctggaggagctggggaatcacaaggccttcaagaaagagcttcgacactttatttctggagatgaacccaaggagaagcttgagctggtcagctactttggaaagagacctccaggtgtgctgcactgtacaaccaaattctgtgactacgggaaggccgctggggcagaagaatacgcccagcaggaggtggtgaagagatcgtatggcaaggccttcaaactgtccatctctgctctctttgtgacacccaagacagctggggcccaggtggtgctgaccgatcaggagctgcagttgtggcccagtgatctggacaagccatctgcctccgagggcctgcccccagggagccgagctcacgtcaccctaggctgtgcggccgacgtgcagccagtgcagacgggtcttgacctcttagatattttacaacaggtgaaggggggcagccaaggtgaggcggtgggtgagctcccccggggcaagctctattccctgggcaaagggcgatggatgctgagcctgactaagaagatggaggtcaaggccatcttcacggggtactatgggaagggcaaacctgtgcccatacatggcagccggaaggggggtgccatgcagatctgcaccatcatctgagggttcacaccgctgtaccactgtaccactgctgtgggtggacacagcaacatgccttccacctgatttttaagattttttttttttttactcaaagctaacgtacctgtaactttttaggagtctataaaataactaccagttccttgtgcccaccctttcttttcctcttaatactcagctctcaacacaggcgggtgggcagaggaagataccattcaggaacctggaccagaggtggtaataaaagggctgggtcattgggcctgcagcagcatctgcccagatgcatccaagaacttgttaaccctcccttagcccctgcccatccaaagctgggcacacgcctcagagctgccacatgctagggacaaacgctactgccacaggaaaacagtggtagcttagagagggctcagatccctgggtgccagttttttaatcactatagcccttgggaaggcttgggctatttactgggcggtaaaaggggtttacctctcacctttggtcattcctaagttcctatctccttcacactgtacctagggtgatggtttcggtcaggccatctccagcagcatgtctctgctgtgtggatggaggccaaggtcagaaagatgccccgagaagctccagctttgctttctgcccagcccatcttgcctgcatggtgcctctgggtctttaaaggagggtggtaggtaccaagaaccagtggaggggaccctgagctggcaagagtaagccccatctcctgctctggcaaagcctggctcctggagtacctcactctgccttctgctcagtaacaggaccttgctaattgggttgtcacccgagaatctgggatgtatgctcctaccctcaccctgtgttgcccacctcagccaccactaagactgatactgaaataaatcatgttaatcccagctgtgtgcta

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